CHU SAINTE-JUSTINE Patent applications |
Patent application number | Title | Published |
20160139146 | GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC SUBJECTS - Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and/or Giα3 proteins in the cell sample, and/or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor. | 05-19-2016 |
20150323553 | METHODS FOR THE PREVENTION OR TREATMENT OF SCOLIOSIS - A method for the prevention or treatment of scoliosis in a human subject comprising: (a)(i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or (ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis. | 11-12-2015 |
20130266966 | METHOD OF DETERMINING RISK OF SCOLIOSIS - A method for determining the risk for developing a scoliosis comprising monitoring osteopontin (OPN) expression in a sample from a subject over time; wherein an OPN expression that increases in the subject sample over time is indicative that the subject is at risk for developing a scoliosis. | 10-10-2013 |
20130183695 | BIOMECHANICAL-BASED METHODS OF DIAGNOSING SCOLIOSIS - Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and/or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces/stimuli are described. | 07-18-2013 |
20130029871 | METHODS OF STRATIFYING ADOLESCENT IDIOPATHIC SCOLIOSIS, ISOLATED NUCLEIC ACID MOLECULES FOR USE IN SAME AND KITS USING SAME - A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitx1) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to an AIS subclass. | 01-31-2013 |
20100029567 | METHOD OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR - Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2 propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof, are described. | 02-04-2010 |