CHROMOCELL CORPORATION Patent applications |
Patent application number | Title | Published |
20160130239 | SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN AND DIABETES - Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I′: | 05-12-2016 |
20160046617 | SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN - Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I: | 02-18-2016 |
20160015064 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE - The present invention provides edible compositions comprising a sweet taste modulator of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste in a food product. | 01-21-2016 |
20150050410 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE - The present invention provides edible compositions comprising a sweet taste modulator of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste in a food product. | 02-19-2015 |
20140377381 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTER TASTE - The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product. | 12-25-2014 |
20140248639 | ASSAYS FOR IDENTIFYING COMPOUNDS THAT MODULATE BITTER TASTE - The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists. | 09-04-2014 |
20130323726 | METHODS AND MATERIALS USING SIGNALING PROBES - The present invention relates to methods of isolating cells, generating cell lines, and detecting RNAs in cells using signaling probes that produce a signal upon hybridization to a target sequence. Other methods that utilize the signaling probe include methods of detecting or quantifying the effect of an agent on RNAs in a cell, methods of quantifying the level of RNA expression, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. The invention also provides protease probes. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures are provided. | 12-05-2013 |
20130101684 | Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste - The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product. | 04-25-2013 |
20130096209 | Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste - The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product. | 04-18-2013 |
20120276572 | METHODS AND COMPOSITIONS FOR IDENTIFYING AND VALIDATING MODULATORS OF CELL FATE - The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs. The invention relates to methods for making cells comprising one or more reporter nucleic acid constructs using fluorogenic oligonucleotides. The methods relate to high throughput screens. | 11-01-2012 |
20120131701 | IMPROVED PLANTS, MICROBES, AND ORGANISMS - The present invention relates to methods for identification, isolation, and enrichment of plant cells, plants, microbial cells, and organisms comprising desired genetic profiles and to plant cells, plants, microbial cells, and organisms resulting from these methods. In certain aspects, organisms obtained by the methods of the invention are not genetically engineered organisms. | 05-24-2012 |
20120058918 | CELL LINES EXPRESSING CFTR AND METHODS OF USING THEM - Disclosed herein are cells and cell lines that stably express CFTR and methods for using those cells and cell lines. The invention also includes techniques for creating these cells and cell lines. The cells and cell lines of this invention are physiologically relevant. They are highly sensitive and provide consistent and reliable results in cell-based assays. | 03-08-2012 |
20120028278 | CELL LINES EXPRESSING GUANYLATE CYCLASE-C AND METHODS OF USING THEM - Cell lines that stably express GC-C and methods for using those cell lines are disclosed herein. The invention includes cell lines that express GC-C and techniques for creating cell lines. The GC-C-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results in cell-based assays, e.g., high throughput screening assays. | 02-02-2012 |
20120015841 | NOVEL CELL LINES AND METHODS - The invention relates to novel cells and cell lines, and methods for making and using them. | 01-19-2012 |
20110312533 | CELL LINES EXPRESSING NaV AND METHODS OF USING THEM - Cells and cell lines that express voltage-gated sodium ion channels (NaV) and methods for using the cells and cell lines are disclosed herein. The NaV-expressing cells and cell lines are useful in cell-based assays, e.g., high throughput screening assays. | 12-22-2011 |
20110003711 | CELL LINES EXPRESSING GABA RECEPTOR AND METHODS USING THEM - The invention relates to Gamma-aminobutyric acid receptors (GABA receptors) as well as cells and cell lines stably expressing a GABA receptor. The invention includes cell lines that express various subunit combinations of GABA receptors. The GABA receptor- and GABA receptor subunit-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results. The invention further provides methods of making such cells and cell lines. The GABA receptor- and GABA receptor subunit-expressing cells and cell lines provided herein are useful in identifying modulators of GABA receptors. | 01-06-2011 |
20100298167 | NOVEL CELL LINES EXPRESSING ENAC AND METHODS USING THEM - Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit combinations and various proteolyzed isoforms of ENaC and techniques for creating cell lines. The ENaC-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results. | 11-25-2010 |
20100297674 | NOVEL CELL LINES EXPRESSING NaV AND METHODS USING THEM - Cells and cell lines that express voltage-gated sodium ion channels (NaV) and methods for using the cells and cell lines are disclosed herein. The NaV-expressing cells and cell lines are useful in high throughput screening assays. | 11-25-2010 |
20100212040 | ISOLATION OF LIVING CELLS AND PREPARATION OF CELL LINES BASED ON DETECTION AND QUANTIFICATION OF PRESELECTED CELLULAR RIBONUCLEIC ACID SEQUENCES - The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired characteristics. Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others. | 08-19-2010 |
20080220432 | Optimized host cells for protein production - The present invention relates to methods for isolating cells that express increased levels of an RNA or protein of interest, wherein the cells exhibit altered growth profiles, such as cells with increased or decreased rates of proliferation, increased or decreased rates of apoptosis, or cells with a biphasic growth profile. | 09-11-2008 |