| ChemImage Corporation Patent applications |
| Patent application number | Title | Published |
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| 20120120393 | TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack. | 05-17-2012 |
| 20120105838 | Multipoint method for identifying hazardous agents - The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed. | 05-03-2012 |
| 20120083678 | System and method for raman chemical analysis of lung cancer with digital staining - The present disclosure provides for a system and method for diagnosing biological samples that combines the visual staining features familiar to pathologists with the accurate, reliable, and nondestructive capabilities of Raman chemical imaging. The invention disclosed herein may be applied to diagnose lung cancer samples. A method may comprise illuminating a biological sample to generate interacted photons, filtering said interacted photons using a tunable filter, and detecting interacted photons to generate a test Raman data set representative of said sample. The method may further comprise applying at least one chemometric technique and/or a digital stain to said test Raman data set. This test Raman data set may be analyzed to diagnose said sample as comprising at least one of: adenocarcinoma, mesothelioma, and combinations thereof. A system may comprise an illumination source, a tunable filter, and a detector configured to generate a test Raman data set representative of a biological sample. | 04-05-2012 |
| 20120072122 | Forensic Integrated Search Technology - A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported. | 03-22-2012 |
| 20120062888 | Method for operating an optical filter in multiple modes - A method for operating an optical filter in multiple modes. In one embodiment, an optical filter may be operated in a sensitivity mode to thereby generate a white light image representative of a region of interest. The optical filter may then be operated in a specificity mode to thereby generate a hyperspectral image representative of said region of interest. The white light image and the hyperspectral image may be fused to generate a hybrid image that provides morphological and hyperspectral data. The white light image and the hyperspectral image may be generated using a single detector, eliminating the need for image realignment. | 03-15-2012 |
| 20120062874 | System and Method for Combined Raman and LIBS Detection with Targeting - A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials. | 03-15-2012 |
| 20120062873 | SYSTEM AND METHOD FOR DIAGNOSING THE DISEASE STATE OF BREAST TISSUE USING SWIR - A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state. | 03-15-2012 |
| 20120062697 | Hyperspectral imaging sensor for tracking moving targets - The present disclosure provides for a system and method for aerial detection, identification, and/or tracking of unknown ground targets. A system may comprise collection optics, a RGB detector, a SWIR MCF, a SWIR detector, and a sensor housing affixed to an aircraft. A method may comprise generating a RGB video image, a hyperspectral SWIR image, and combinations hereof. The RGB video image and the hyperspectral SWIR image may be analyzed to detect, identify, and/or track unknown targets. The RGB video image and the hyperspectral SWIR image may be generated simultaneously. | 03-15-2012 |
| 20120057743 | System and method for fluorescence guided ingredient specific particle sizing - The present disclosure provides for a system and method for rapid, accurate, and reliable targeting and interrogation of pharmaceutical samples. An autofluorescence image of a sample may be generated and analyzed to identify areas of interest that exhibit autofluorescence characteristic of APIs. These areas of interest may then be targeted for analysis using Raman chemical imaging. This Raman chemical image may be used to determine geometric properties of particles present in a sample such as size and particle distribution. | 03-08-2012 |
| 20120041689 | System and method for particle detection in spectral domain - The present disclosure provides for a system and method for detecting, sizing, and classifying multiple particles in a sample. A Raman chemical image may be generated representative of a sample. This Raman chemical image may be analyzed to thereby determine at least one geometric property of at least one particle in the sample. Each pixel in the sample may be classified as comprising a particle associated with an active pharmaceutical ingredient of interest. This classification may be achieved by comparing a spectrum associated with each pixel with a reference spectrum. This comparison may be achieved by applying at least one chemometric technique. | 02-16-2012 |
| 20110279744 | Short wave infrared multi-conjugate liquid crystal tunable filter - A SWIR hyperspectral imaging filter has serial stages along an optical signal path with angularly distributed birefringent retarders and polarizers. The retarders can include active retarders such as tunable liquid crystal birefringent elements, passive retarders such as fixed retarders, and/or combinations thereof. Distinctly different periodic transmission spectra are provided by different filter stages, each having multiple retarders, in particular with some stages having broad bandpass peaks at wide spectral spacing and other stages have very narrow closely spaced peaks. The respective spectra include at least one tunably selectable band at which the transmission spectra of the filter stages coincide, whereby the salutary narrow bandpass and wide spectral spacing ranges of different stages apply together, resulting in a high finesse wavelength filter suitable for spectral imaging. The filter may be configured to provide faster switching speed and increased angle of acceptance and may operate in the rage of approximately 850-1700 nm. | 11-17-2011 |
| 20110261351 | SYSTEM AND METHOD FOR DETECTING EXPLOSIVES USING SWIR AND MWIR HYPERSPECTRAL IMAGING - A system and method for detection of explosive agents using hyperspectral imaging. A system comprising an illumination source, a spectral encoding device, and at least one imaging detector configured for at least one of SWIR and MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, assessing interacted photons using a spectral encoding device, and detecting interacted photons using at least one of SWIR hyperspectral imaging and MWIR hyperspectral imaging. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using SWIR and MWIR hyperspectral imaging. | 10-27-2011 |
| 20110242533 | System and Method for Detecting Hazardous Agents Including Explosives - A system and method for MWIR hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising an illumination source, a tunable filter, and an imaging detector configured for MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, passing interacted photons through a tunable filter, and generating a MWIR hyperspectral image of the target. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using MWIR hyperspectral imaging. | 10-06-2011 |
| 20110208462 | System and method for instrument correction using transmission efficiency - A system and method for providing an instrument response correction based on transmission efficiency. Test data may be acquired at a first operating point. A look-up table may be searched to determine an instrument response correction. This look-up table may comprise a plurality of instrument response corrections, each instrument response correction corresponding to an intensity response of the sample at an operating point. The instrument response correction may then be applied to correct for environmental factors that may affect transmission efficiency. A system may comprise an illumination source, a collection optics, a tunable filter, a detector, a sensor and a control unit. The detector may detect interacted photons generated by illuminating a sample and generate test data. The sensor may be configured to sense an operating condition and transmit this information to the control unit which is configured to search a look-up table to determine the appropriate instrument response correction. | 08-25-2011 |
| 20110188714 | System and Method for Hyperspectral Imaging of Treated Fingerprints - The present disclosure provides for a method for analyzing treated fingerprints on a document. A sample document is provided. A digital image of the sample document is obtained. The sample document is treated with a reagent and a hyperspectral image of the document is obtained. The hyperspectral image of the document is analyzed to determine a region of interest and a hyperspectal image is obtained of the region of interest. The present disclosure also provides for a system comprising a carrier frame, an imaging station for obtaining a digital image of the sample document, a first processing station for treating the document and a second processing station for developing the treated document, a second imaging station for obtaining a hyperspectral image of at least one of the document and a region of interest of the document, and a robotic subsystem for transporting the document through the system. | 08-04-2011 |
| 20110085165 | System and Method for Combined Raman and LIBS Detection - A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis. | 04-14-2011 |
| 20110033082 | System and method for improved forensic analysis - The present disclosure provides for a system and method for analyzing questioned documents. A sample document is illuminated to thereby generate a first plurality of interacted photons. The first plurality of interacted photons are detected at a first detector to thereby generate a digital image. The digital image is analyzed to thereby identify at least one region of interest of the sample document. This region of interest is illuminated to thereby generate a second plurality of interacted photons. This second plurality of interacted photons are passed through a tunable filter and detected at a second detector to thereby generate a hyperspectral image representative of the region of interest. The hyperpsectral image may then be analyzed to evaluate changes to or differentiate different inks present in the sample document. Chemometric techniques such as k-means clustering, PCA, and/or PLSDA may also be applied. | 02-10-2011 |
| 20110012916 | System and method for component discrimination enhancement based on multispectral addition imaging - A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene. | 01-20-2011 |
| 20100322471 | Motion invariant generalized hyperspectral targeting and identification methodology and apparatus therefor - The present disclosure relates to a method and system for enhancing the ability of nuclear, chemical, and biological (“NBC”) sensors, specifically mobile sensors, to detect, analyze, and identify NBC agents on a surface, in an aerosol, in a vapor cloud, or other similar environment. Embodiments include the use of a two-stage approach including targeting and identification of a contaminant. Spectral imaging sensors may be used for both wide-field detection (e.g., for scene classification) and narrow-field identification. | 12-23-2010 |
| 20100309464 | Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection - The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection. | 12-09-2010 |
| 20100280762 | System and Method for Analyzing Biological Samples Using Raman Molecular Imaging - A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression. | 11-04-2010 |
| 20100265498 | METHOD AND APPARATUS FOR MICROLENS ARRAY/FIBER OPTIC IMAGING - A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fiber bundle of M fibers; a second optical fiber bundle of N fibers; an optical fiber switch; and a charge coupled device, wherein the image comprises plural sub-images, and wherein each sub-image is formed from photons scattered from a predetermined two spatial dimension portion of the sample, and wherein the scattered photons forming each sub-image have a predetermined wavelength different from a predetermined wavelength of scattered photons forming the other sub-images, and wherein the scattered photons for each sub-image are collected substantially simultaneously. | 10-21-2010 |
| 20100265320 | System and Method for Improved Forensic Analysis - A system and method for analyzing a forensic sample. A forensic sample is illuminated nondestructively with light of a first wavelength λ | 10-21-2010 |
| 20100225911 | System and Method for Classifying a Disease State Using Representative Data Sets - System and method for determining a disease state of a sample. A sample is positioned in a field of view and a first spectroscopic data set is obtained. The positional information is stored and the sample is treated with a contrast enhancing agent. The sample is repositioned in the field of view and a digital image is obtained. The spectroscopic data is linked with the digital image and a database comprising representative spectroscopic data sets is searched to classify the disease state of the sample. The disclosure also provides for the step of obtaining a processed derivative image and searching a database comprising representative processed derivative images to classify a disease state of the sample. | 09-09-2010 |
| 20100225899 | Chemical Imaging Explosives (CHIMED) Optical Sensor using SWIR - A sample is illuminated to thereby generate a plurality of first interacted photons selected. The first interacted photons are assessed using a visible imaging device to thereby determine an area of interest in the sample. The area of interest is illuminated to thereby generate a plurality of second interacted photons. The second interacted photons are assessed using a spectroscopic device to thereby generate a SWIR data set representative of said area of interest. A database is searched wherein said database comprises a plurality of known SWIR data sets associated with an explosive material. The data sets comprise at least one of: a plurality of SWIR spectra and a plurality of spatially accurate wavelength resolved SWIR images. An explosive material in the area of interest is thereby identified as a result of the search. | 09-09-2010 |
| 20100213376 | Method and Apparatus for Compact Spectrometer for Multipoint Sampling of an Object - A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof. | 08-26-2010 |
| 20100179770 | AUTOMATION OF INGREDIENT-SPECIFIC PARTICLE SIZING EMPLOYING RAMAN CHEMICAL IMAGING - A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved. | 07-15-2010 |
| 20100148073 | System and Method for Structured Illumination and Collection for Improved Optical Confocality of Raman Fiber Array Spectral Translator Imaging and Interactive Raman Probing - The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample. | 06-17-2010 |
| 20100033717 | Raman Chemical Imaging of Implantable Drug Delivery Devices - A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. Tile spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device. | 02-11-2010 |
| 20090161101 | METHOD AND APPARATUS FOR DETERMINING CHANGE IN AN ATTRIBUTE OF A SAMPLE DURING NUCLEATION, AGGREGATION, OR CHEMICAL INTERACTION - The present disclosure describes methods and apparatus to produce a streaming image of a sample during a time period when an attribute of the sample is changing. The streaming image can be viewed in such a manner so as to be able to follow a visible change in an attribute of the sample. The sample may be undergoing nucleation, aggregation, or chemical interaction. The present disclosure also describes methods and apparatus to determine a change in an attribute of a sample by detecting, analyzing, and comparing spectra of the sample taken at different times during the time period when the attribute of the sample is changing. The sample may be undergoing nucleation, aggregation, or chemical interaction. | 06-25-2009 |
| 20090122309 | Raman Spectral Analysis of Pathogens - A method of assessing occurrence of a plant pathogen in a sample. The method comprises irradiating the sample and assessing radiation scattered from the sample for radiation that exhibits a Raman scattering characteristic of the pathogen. Detection of scattered radiation that exhibits a Raman shift characteristic of the pathogen is an indication that the pathogen occurs in the sample. | 05-14-2009 |
| 20090086203 | Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue - A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set. | 04-02-2009 |
| 20090046363 | WAVELENGTH DISCRIMINATION FILTER FOR INFRARED WAVELENGTHS - An optical comb filter has polarizers placed before and after two or more birefringent elements, each having a fixed retarder and an aligned tunable liquid crystal. The birefringent elements are equal in birefringence and thickness and are tuned in unison. As few as two birefringent elements are provided, thereby minimizing transitions where infrared absorption occurs. The birefringent elements are in a symmetrical array of rotational angles, encompassing 90° of span in a bandpass configuration where the polarizers are parallel. Polarization components from the input polarizer or a given birefringent element are coupled in unequal proportions to the fast and slow axes of the next birefringent element, by using a relative angle that is distinctly different from 45°. The filter is tolerant of rotational alignment errors. A two element filter uses angles of 22.5 and 67.5°; a three element version has 12.5, 45 and 77.5°; and a four element filter has 7.5, 29.5, 60.5 and 82.5°; all these angles being ±5°. | 02-19-2009 |
| 20090040517 | RAMAN DIFFERENCE SPECTRA BASED DISEASE CLASSIFICATION - A method to diagnosis a disease state of an unknown sample. A test Raman data set for an unknown sample is generated. A reference Raman database is provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman difference data sets. The reference Raman difference data set is generated by determining a difference between a first reference Raman data set and a second reference Raman data set. A first reference Raman data set is associated with first known sample and associated with one or more of: a first known disease state and a first known clinical outcome. A second reference Raman data set is associated with a second known sample and associated with one or more of: a second known disease state and a second known clinical outcome. A diagnosis is provided of whether the unknown sample has a first disease state or a second disease state by comparing the test Raman dataset to said plurality of reference Raman difference data sets in the reference Raman database using a chemometric technique. | 02-12-2009 |
| 20090033930 | Spectral Imaging of Biofilms - A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching. | 02-05-2009 |
| 20090021730 | METHOD AND APPARATUS FOR SUPER MONTAGE LARGE AREA SPECTROSCOPIC IMAGING - The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby produce from the object scattered and/or emitted (interchangeably “scattered”) light for each of a plurality of wavelengths; (b) producing separately for each of the plurality of wavelengths a plurality of substantially contiguous sub-images of the object; (c) compensating for spatial aberrations in ones of the sub-images for a select one of the plurality of wavelengths; (d) compensating for intensity aberrations between ones of the substantially contiguous sub-images for one of the plurality of wavelengths; and (e) combining the sub-images for the select one wavelength to thereby produce said spectroscopic image of the object. | 01-22-2009 |
| 20090002702 | DISTINGUISHING BETWEEN RENAL ONCOCYTOMA AND CHROMOPHOBE RENAL CELL CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state. | 01-01-2009 |
| 20080319324 | DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state. | 12-25-2008 |
| 20080297789 | Raman Spectral Analysis of Pathogens - A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of the viable biological pathogen, and delivering an ablating agent to the identified portion. | 12-04-2008 |
| 20080227142 | Invasive chemometry - The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest. | 09-18-2008 |
| 20080198365 | TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTION - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack. | 08-21-2008 |
| 20080197287 | SYSTEM AND METHOD FOR SUPER RESOLUTION OF A SAMPLE IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM - The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample. | 08-21-2008 |
