| CHEMAGIS LTD. Patent applications |
| Patent application number | Title | Published |
|---|
| 20110288042 | STABLE HIGHLY PURE AZACITIDINE AND PREPARATION METHODS THEREFOR - Disclosed herein are methods of obtaining highly pure 5-azacytidine, which contains minimal amounts of degradation impurities and methods of assessing the impurity profile of the degradation of cytidine analogues, such as 5-azacytidine | 11-24-2011 |
| 20110230496 | NOVEL PROCESS FOR PREPARING HIGHLY PURE LEVOCETIRIZINE AND SALTS THEREOF - A process for preparing pure levocetirizine and salts thereof, e.g., the levocetirizine dihydrochloride, and a pharmaceutical composition comprising levocetirizine dihydrochloride produced by the process are disclosed. | 09-22-2011 |
| 20110185796 | CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF - The present invention provides compounds which are useful, e.g., as reference markers for analyzing the purity of cisatracurium and salts thereof, a test method for determining the said purity and processes for preparing reference markers. | 08-04-2011 |
| 20110144347 | PROCESS FOR THE EPIMERIZATION OF ATOVAQUONE ISOMER, ATOVAQUONE INTERMEDIATES AND MIXTURE THEREOF - Provided is a process for the epimerization of the cis isomer of atovaquone, atovaquone intermediates and isomeric mixtures thereof into their corresponding trans-isomers resulting in higher yield of pure atovaquone. | 06-16-2011 |
| 20110137041 | PROCESS FOR PREPARING ATOVAQUONE AND ASSOCIATE INTERMEDIATES - The invention provides novel intermediates of atovaquone and use thereof for the preparation of atovaquone | 06-09-2011 |
| 20100234602 | NOVEL R,R`-ATRACURIUM SALTS - The present invention provides R,R′-atracurium salts processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate. | 09-16-2010 |
| 20100222602 | CRYSTALLINE ROTIGOTINE BASE AND PREPARATION PROCESS THEREFOR - An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome. | 09-02-2010 |
| 20100184988 | PROCESS FOR PRODUCING CISATRACURIUM COMPOUNDS AND ASSOCIATED INTERMEDIATES - The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g., cisatracurium besylate | 07-22-2010 |
| 20100174082 | (1R,1'R)-ATRACURIUM SALTS SEPARATION PROCESS - The present invention provides an improved method for obtaining cisatracurium besylate, which preferably chromatographically separating cisatracurium besylate from a mixture of (1R,1′R)-atracurium isomers via flash chromatography | 07-08-2010 |
| 20100174080 | NOVEL PALONOSETRON SALTS AND PROCESSES FOR PREPARATION AND PURIFICATION THEREOF - Provided are novel salts of 2-(1-azabicyclo-[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one, methods of using such salts, and processes for producing such salts | 07-08-2010 |
| 20100168431 | NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification | 07-01-2010 |
| 20100099878 | (1R, 1'R)-ATRACURIUM SALTS SEPARATION PROCESS - The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid. | 04-22-2010 |
| 20100087650 | (1R,1'R)-ATRACURIUM SALTS SEPARATION PROCESS - Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes eluting from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the present invention can be conveniently and inexpensively scaled up. | 04-08-2010 |
| 20100022609 | NOVEL CRYSTALLINE FORMS OF TEMOZOLOMIDE - Disclosed are novel crystalline forms of Temozolomide, methods of preparation thereof, medicaments including the novel crystalline forms of Temozolomide, and uses thereof in the treatment of medical conditions. | 01-28-2010 |
| 20090221811 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES - The present invention provides processes for preparing intermediates useful in the preparation of gemcitabine and other nucleosides, and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts. Also provided is a process for selectively isolating the D-erythro and D-threo isomers of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts, and processes for using such isomers in the preparation of nucleoside analogs such as, e.g., gemcitabine, intermediates thereof, and analogs thereof. | 09-03-2009 |
| 20090069306 | PROCESS FOR PRODUCING HIGHLY PURE MIDAZOLAM AND SALTS THEREOF - Provided is a process for producing highly pure midazolam and salts thereof, and a pharmaceutical composition containing the highly pure midazolam and/or a salt thereof. | 03-12-2009 |
| 20080275055 | IMATINIB PRODUCTION PROCESS - Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt. | 11-06-2008 |
| 20080262215 | GEMCITABINE PRODUCTION PROCESS - Provided is a process for preparing gemcitabine or a salt thereof, which preferably includes selectively precipitating the β-anomer of a 3′,5′-di-O-protected-N | 10-23-2008 |
| 20080242696 | CRYSTALLINE GRANISETRON BASE AND PRODUCTION PROCESS THEREFOR - Provided is crystalline granisetron base form I and processes for producing crystalline granisetron base form I, which is suitable for preparing, e.g., granisetron salts such as, e.g., the hydrochloride salt. Also provided is a process for producing a salt of granisetron from crystalline granisetron base form I. | 10-02-2008 |
| 20080234286 | STABLE AMORPHOUS IMATINIB MESYLATE AND PRODUCTION PROCESS THEREFOR - Provided herein is a spray dried stable amorphous imatinib mesylate as a free-flowing solid and process for producing the amorphous imatinib mesylate in highly pure form. | 09-25-2008 |
