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Centre National De La Recherche Scientifque CNRS
| Centre National De La Recherche Scientifque CNRS Patent applications | ||
| Patent application number | Title | Published |
|---|---|---|
| 20110217307 | SYNTHETIC PEPTIDES CORRESPONDING TO OVERLAPPING NEUTRALIZING DETERMINANTS IN THE CBD1 EPITOPE INDUCE BROADLY NEUTRALIZING ANTIBODIES - The present invention relates to chimeric peptides having a caveolin-1 binding domain of an HIV-1 gp41 (CBD1) peptide or a variant of said CBD1, fused to a T helper epitope. In one aspect, the T epitope is from a peptide selected from the group consisting of a tetanus toxin, an HIV-1 Gag p24 and an HIV-1 Env-gp120. Compositions containing these chimeric peptides and pharmaceutical and immunogenic compositions as well as vaccines comprising these chimeric peptides also are part of the present invention. Methods to induce neutralizing antibodies against HIV-1 activity and uses of the chimeric peptides to treat or to prevent HIV-1 infection are also disclosed. | 09-08-2011 |
| 20100163432 | MICROSENSOR FOR DETECTION OF D-AMINO-ACIDS - The instant invention is about a microelectrode, in particular for measuring the concentration of a D-amino acid, said microelectrode comprising means for oxidation of said D-amino acid into at least a compound B, means for optimising the detection of said compound B, and means for reducing interferences, in particular interferences due to the oxidation of other species than compound B; a device comprising such a microelectrode; a method for making such a microelectrode, a method for detecting and/or measuring the concentration of a D-amino-acid in a medium. | 07-01-2010 |