CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS Patent applications |
Patent application number | Title | Published |
20140178408 | METHOD OF PRODUCING AN ANTIBODY - The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model. | 06-26-2014 |
20110055939 | METHOD FOR INTRODUCING FOREIGN GENE INTO EARLY EMBRYO OF PRIMATE ANIMAL AND METHOD FOR PRODUCING TRANSGENIC PRIMATE ANIMAL COMPRISING SUCH METHOD - An object of the present invention is to provide a method for introducing a gene into an embryo for production of a human disease model primate animal using a non-human primate animal such as a marmoset. The present invention relates to a method for introducing a foreign gene into an early embryo of a non-human primate animal, which comprises placing early embryos of a non-human primate in a 0.2 M to 0.3 M sucrose solution, so as to increase the volume of the perivitelline spaces, and then injecting a viral vector containing a human foreign gene operably linked to a promoter into the perivitelline spaces of the early embryos. | 03-03-2011 |
20090081221 | METHOD FOR SUPPRESSING CANCER CELL METASTASIS AND PHARMACEUTICAL COMPOSITION FOR USE IN THE METHOD - The present invention provides a novel method for inhibiting cancer cell metastasis using an antibody against TM7XN1, a pharmaceutical composition to be used for the method, and a cancer-metastasis-suppressing agent comprising an antibody against TM7XN1 as an active ingredient. | 03-26-2009 |