Cambridge Enterprise Limited Patent applications |
Patent application number | Title | Published |
20150366005 | Heating Using Carbon Nanotube-Based Heater Elements - A heater element for generating heat via Joule heating, the heater element having a layer of aligned carbon nanotubes and electrical terminals located to allow, in use, an electrical current to be passed along the layer of aligned carbon nanotubes. The direction of the electrical current in use is substantially perpendicular to the alignment direction of the aligned carbon nanotubes. Also disclosed is a method of manufacturing a heater element, the method including growing carbon nanotubes in a CVD reactor and forming the layer of aligned carbon nanotubes by pulling a carbon nanotube yarn from the CVD reactor, the alignment direction being the direction of pulling from the CVD reactor. | 12-17-2015 |
20150352208 | INHIBITION OF CXCR4 SIGNALING IN CANCER IMMUNOTHERAPY - The inventions describes a method for increasing effector T cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of CXCR4 signaling. | 12-10-2015 |
20150337145 | Functional Inks Based on Layered Materials and Printed Layered Materials - An ink disclosed herein comprises a carrier liquid with a dispersion of flakes derived from a layered material. The thickness of each flake depends on the number of layers of the layered material in the flake. The thickness distribution of the flakes includes: at least 20% by number of single layer flakes; at least 40% by number cumulatively of single, double and triple layer flakes; or not more than 40% by number of flakes having ten or more layers. The layered material is selected from one or more of elemental materials such as graphene (typically derived from pristine graphite), metals (e.g., NiTe | 11-26-2015 |
20150286187 | APPARATUS AND METHODS FOR LIGHT BEAM ROUTING IN TELECOMMUNICATION - We describe a LCOS (liquid crystal on silicon) telecommunications light beam routing device, the device comprising: an optical input; a plurality of optical outputs; a LCOS spatial light modulator (SLM) in an optical path between said input and said output, for displaying a kinoform; a data processor, coupled to said SLM, configured to provide kinoform data for displaying said kinoform on said SLM; wherein said kinoform data defines a kinoform which routes a beam from said optical input to a selected said optical output; wherein said data processor is configured to input routing data defining said selected optical output and to calculate said kinoform data for routing said beam responsive to said routing data; and wherein said data processor is configured to calculate said kinoform data by: determining an initial phase pattern for said kinoform; calculating a replay field of said phase pattern; modifying an amplitude component of said replay field to represent a target replay field for said beam routing, retaining a phase component of said replay field to provide an updated replay field; performing a space-frequency transform on said updated replay field to determine an updated phase pattern for said kinoform; and repeating said calculating and updating of said replay field and said performing of said space-frequency transform until said kinoform for display is determined; and outputting said data for display on said LCOS SLM. | 10-08-2015 |
20150260303 | Electromagnetic Flexure - An electromagnetic valve comprises a yoke, a magnet having pole pieces defining a gap, a flexure assembly having one end attached to the yoke such that part of the flexure assembly extends into the gap, and a mechanism configured to polarize the magnetizable portion so that the extending part of the flexure assembly is attracted towards a pole piece by a magnetic force, thereby defining a valve state. The flexure assembly has at least one resilient portion and at least one magnetizable portion, wherein the extending part of the flexure assembly is movable between the pole pieces through an intermediate position towards which it is resiliently biased such that a resilient mechanical force is generated by deflecting the resilient portion from an undeflected position. The magnetizable portion and the resilient portion are configured such that the magnetic force defining the valve state is greater than the resilient mechanical force. | 09-17-2015 |
20150225698 | In Vitro Pancreatic Differentiation of Pluripotent Mammalian Cells - This invention relates to the in vitro differentiation of pluripotent cells into pancreatic progenitors by i) culturing pluripotent cells in a definitive endoderm (DE) medium comprising a TGFp ligand, fibroblast growth factor (FGF), bone morphogenetic protein (BMP), a PI3K inhibitor and optionally a GSK3 β inhibitor to produce a population of definitive endoderm cells, ii) culturing the definitive endoderm cells in a first pancreatic medium comprising an activin antagonist; FGF; retinoic acid; and a BMP inhibitor to produce a population of dorsal foregut cells; iii) culturing the dorsal foregut cells in a second pancreatic medium comprising FGF, retinoic acid, a BMP inhibitor, and a hedgehog signalling inhibitor, and; iv) culturing the endoderm cells in a third pancreatic medium comprising FGF. The progenitor cells thus produced may be further differentiated into pancreatic endocrine cells. These methods may be useful, for example, in producing pancreatic cells for therapy or disease modelling. | 08-13-2015 |
20150220702 | SUBSTANCE MONITORING AND CONTROL IN HUMAN OR ANIMAL BODIES - Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied. | 08-06-2015 |
20150216843 | INHIBITION OF CXCR4 SIGNALING IN CANCER IMMUNOTHERAPY - The inventions describes a method for increasing effector T cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of CXCR4 signaling. | 08-06-2015 |
20150197865 | OXYGEN GENERATION APPARATUS AND METHOD - An oxygen generator for an oxygen-generation apparatus has a proton-conducting membrane, a cathode contacting a first side, or cathodic side, of the membrane, an anode contacting a second side, or anodic side, of the membrane, and a source of water for supply to the membrane. In use, an electrolysis voltage applied between the cathode and the anode causes electrolysis of the water to generate oxygen gas at the anode. Atmospheric oxygen, i.e. oxygen in the air, is substantially prevented from coming into contact with the cathode. For an acidic proton-conducting membrane this substantially prevents the formation of hydrogen peroxide at the cathode. | 07-16-2015 |
20150174576 | Microfluidic Device for Droplet Generation - The invention relates to a microfluidic system for generating droplets, the controlled merging of two or more droplets, and the analysis of droplets. | 06-25-2015 |
20150135869 | ENERGY-HARVESTING APPARATUS AND METHOD - An energy harvester is provided for harvesting energy, and in particular electrical energy from an input vibration such as an ambient vibration. The energy harvester comprises a first mechanical amplifier responsive to the input vibration and a second mechanical amplifier coupled to the first mechanical amplifier. At least one of the first and second mechanical amplifiers comprises a parametric resonator, and a power output of the energy harvester is generated by damping the second mechanical amplifier. | 05-21-2015 |
20150105274 | Methods for the Characterisation of Interaction Sites on Target Proteins - The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein. Such identification and characterisation methods are useful in the development of research tools and/or therapeutics, such protein/peptide or small molecule therapeutics. Accordingly, the present invention also relates to methods of: identification of a ligand, such as a small molecule ligand, that binds to such a target protein; and identification a compound being a candidate modulator of said phenotype of a mammalian cell. The invention further relates to peptides or proteins, or fragments, variants and/or derivatives thereof) comprising certain amino acid sequences, nucleic acids encoding such peptides or proteins and uses of such peptides or proteins or of such nucleic acids. | 04-16-2015 |
20150073061 | COATED MICROFLUIDIC DEVICES AND METHODS OF MAKING - We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions. | 03-12-2015 |
20150037356 | ANTI-SIGLEC-15 ANTIBODIES AND USES THEREOF - This disclosure relates to anti-Siglec-15 antibodies and uses thereof, in particular in the treatment of leukaemia, such as acute myeloid leukaemia. | 02-05-2015 |
20140375763 | OASLM-BASED HOLOGRAPHIC DISPLAY - Provided is an optically addressable spatial light modulator (OASLM)-based holographic display and a method of operating the same. The display includes an addressing unit including a light source unit emitting a plurality of recording beams, a driving mirror array including driving mirrors that each reflect a recording beam incident thereon, and a mirror member array including mirror members that each obliquely reflect a recording beam incident thereon, in which each of the driving mirrors corresponds to one of the mirror members. The recording beams, which are transmitted by the addressing unit, are focused onto the OASLM by micro lenses of a lenslet array. The OASLM is optically addressed by the recording beams focused by the micro lenses of the lenslet array and thus modulates and diffracts a reproduction beam, incident thereon from a reproduction beam providing unit, and thus a holographic image is reproduced. | 12-25-2014 |
20140336227 | 3-AMINO LACTAMS AS ANTI-INFLAMMATORY AGENTS - Compounds, pharmaceutical compositions of general formula (I) or (I′) or a pharmaceutically acceptable salt thereof, and methods for treating an inflammatory disorder: | 11-13-2014 |
20140231118 | Materials and Methods for Insulation of Conducting Fibres, and Insulated Products - An electrical conductor comprising an electrically conducting fibre comprising carbon nanotubes and/or graphene nanoribbon and a layer of insulating material coated around the electrically conducting fibre. The insulating material substantially does not penetrate the electrically conducting fibre, or penetrates the electrically conducting fibre only to a depth that leaves a continuous conductive path along a remaining part of the electrically conducting fibre. | 08-21-2014 |
20140218691 | Visual Perimeter Measurement - In one example of the invention a patient display is provided on which a fixation graphic or video is shown in substantially the centre of the display, and then target graphics or video are shown at different positions on the display about the centre. A test subject is positioned in front of the patient display at a known distance, and a camera captures an image of the test subject's eyes, to allow gaze direction determination to be performed. The captured images are displayed to a clinician user by a controlling test application, the clinician making a determination based on the images as to whether the test subject saw a target graphic or video when it was displayed. The clinician user then makes an appropriate input into the controlling test application, which also logs the position at which the target image was displayed. By displaying target graphics at multiple locations on the screen and logging the clinician inputs, the controlling test application is able to build up a plot of the peripheral vision field of the test subject. This plot can then be graphically displayed to the clinician user, and stored with the test results for future clinical use. | 08-07-2014 |
20140209477 | ELECTRO-DEOXIDATION METHOD, APPARATUS AND PRODUCT - The subject invention concerns an electro-decomposition process wherein a cathode comprising a metal compound is contacted with a fused salt electrolyte in an electrochemical cell. The metal compound is a compound between a metal and another substance, and a voltage is applied between the cathode and an anode such that the substance is removed from the metal compound. In the improved method, the applied voltage increases with time, either continuously or stepwise, up to a predetermined maximum voltage. In addition, or in the alternative, the fused salt composition is selected so as to maintain a predetermined concentration of the substance in the fused salt during electro-decomposition. | 07-31-2014 |
20140206931 | Methods For Predicting Mammalian Embryo Viability - The invention provides methods and systems for assessing the developmental potential of mammalian embryos. The method of the invention comprises taking measurements of cytoplasmic movements in the embryo and/or periodic changes in the shape of the embryo at the single cell stage. | 07-24-2014 |
20140202353 | Train Suspension System - A suspension system for a train vehicle includes at least one inerter to minimize track wear. Track wear may be measured by direct measures such as wear work, or indirect measures such as yaw stiffness. “Minimizing” track wear means that such measures are reduced below values which are achievable with conventional technology while maintaining acceptable values of other performance metrics, such as ride comfort or least damping ratio. The suspension system may comprise at least one damper connected in series with the at least one inerter. The suspension system may be the primary or the secondary suspension system of a train vehicle. | 07-24-2014 |
20140200151 | BIOMARKERS - The invention relates to a method of differential diagnosis of schizophrenia or other psychotic disorder from a further psychiatric disorder. | 07-17-2014 |
20140200150 | BIOMARKERS - The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder. | 07-17-2014 |
20140194281 | NOX PURIFICATION CATALYST - The invention relates to a catalyst able to exhibit an NO | 07-10-2014 |
20140194280 | NOX PURIFICATION CATALYST - The present invention relates to a catalyst able to exhibit an NO | 07-10-2014 |
20140170818 | NANOROD THIN-FILM TRANSISTORS - A method for forming an electronic switching device on a substrate, wherein the method comprises depositing the active semiconducting layer of the electronic switching device onto the substrate from a liquid dispersion of ligand-modified colloidal nanorods, and subsequently immersing the substrate into a growth solution to increase the diameter and/or length of the nanorods on the substrate, and wherein the as-deposited nanorods are aligned such that their long-axis is aligned preferentially in the plane of current flow in the electronic switching device. | 06-19-2014 |
20140170214 | SUPRAMOLECULAR CAPSULES - Provided is a capsule having a shell of material that is a supramolecular cross-linked network. The network is formed from a host-guest complexation of cucurbituril (the host) and one or more building blocks comprising suitable guest functionality. The complex non-covalently crosslinks the building block and/or non-covalently links the building block to another building block thereby forming the supramolecular cross-linked network. The capsules are obtained or obtainable by the complexation of a composition comprising cucurbituril and one or more building blocks having suitable cucurbituril guest functionality thereby to form a supramolecular cross-linked network. | 06-19-2014 |
20140163086 | Methods of Modulating MicroRNAs in the Treatment of Pulmonary Arterial Hypertension - The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed. | 06-12-2014 |
20140133221 | Magnectic Structure - A method of shifting information between magnetic layers in a thin film structure. The method can comprising applying a magnetic field to the thin film structure, the field having a magnitude sufficient to switch the magnetisation direction of a predetermined one of a pair of layers within the thin film structure when that pair of layers holds a frustration between two regions of different magnetisation direction order parameter within the thin film structure. | 05-15-2014 |
20140127829 | Optical Device - An optical device has a deformable solid substrate, and a two dimensional array of metal particles which is carried by the substrate. The array provides a controlled separation between nearest-neighbour particles. Deformation of the substrate produces corresponding variation in the controlled separation such that the two dimensional array undergoes a transition between metallic and insulator surface reflectance. | 05-08-2014 |
20140127173 | POPULATIONS OF SMOOTH MUSCLE CELLS OF SPECIFIC EMBRYONIC LINEAGES - This invention relates to the production of populations of Smooth Muscle Cells (SMCs) of specific embryonic lineages, such as neuroectodermal and mesodermal SMCs. Pluripotent stem cells are cultured in one or more lineage induction media to produce progenitor cells of a defined embryonic lineage, which are then cultured in an SMC induction medium to produce a population of SMCs of the embryonic lineage. Populations of SMCs of defined lineages may be useful, for example, in in accurately modelling vascular disease. | 05-08-2014 |
20140118806 | Apparatus and Method for Displaying a Video Image - A method of displaying a video image comprises receiving sequential image frames at a processor. Each image frame is processed to obtain a kinoform. A programmable diffractive element such as an SLM represents the sequence of kinoforms allowing reproduction of the image using a suitable illumination beam. | 05-01-2014 |
20140113808 | NOx PURIFICATION CATALYST AND METHOD OF PRODUCING THE SAME - [Problem] The present invention provides a NO | 04-24-2014 |
20140113382 | PLASMONIC JUNCTIONS FOR SURFACE-ENHANCED SPECTROSCOPY - The invention relates to the use of a construct for the detection of an analyte using surface enhanced spectroscopic techniques. The construct includes linked surfaces, where the link is formed by a linker providing a fixed inter-surface separation between the linked surfaces, wherein the linker is a linking compound, and at least one of the surfaces is the surface of a nanoparticle. The linking compound is suitable for interacting with the analyte. The linking compound may be a cucurbituril. The surface enhanced spectroscopic technique may be surface enhanced Raman spectroscopy (SERS). | 04-24-2014 |
20140110886 | Method of Production of a Holographic Sensor - A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor. | 04-24-2014 |
20140104664 | OPTICALLY ADDRESSABLE SPATIAL LIGHT MODULATOR DIVIDED INTO PLURALITY OF SEGMENTS, AND HOLOGRAPHIC THREE-DIMENSIONAL IMAGE DISPLAY APPARATUS AND METHOD USING THE LIGHT MODULATOR - Provided are an optically addressable spatial light modulator (OASLM) divided into a plurality of segments, and an apparatus and method for displaying a holographic three-dimensional (3D) image using the OASLM. The holographic 3D image display apparatus includes a first light source which emits a write beam, an electric addressable spatial light modulator (EASLM) which modulates the write beam emitted from the first light source according to hologram information regarding a 3D image, a second light source which emits a read beam, an OASLM which receives the write beam modulated by the EASLM and modulates the read beam emitted from the second light source according to hologram information included in the modulated write beam, a scanning optical unit which projects the write beam modulated by the EASLM onto the OASLM, and a Fourier lens which focuses the read beam modulated by the OASLM onto a predetermined space to form the 3D image. | 04-17-2014 |
20140093963 | Cellular Substrate for Nuclear Reprogramming - This invention relates to the use of late out-growth endothelial progenitor cells (L-EPCs) as a cellular substrate for the generation of Induced pluripotent stem cells (iPSCs). This may be useful in the production of patient-specific tissues for disease modelling, drug and toxicology screening, tissue replacement and delivery of gene therapy. | 04-03-2014 |
20140093541 | TREATMENT FOR PEANUT ALLERGY - The present invention relates to oral immunotherapy for the desensitisation of patients who are hypersensitive to peanut allergen. The immunotherapy comprises increasing the oral dose daily dose of peanut protein administered to the patient at intervals of at least 2 weeks in a series of increments from an initial dose to a maximum dose, the series of dose increments including 2 mg, 5 mg, 12.5 mg, 25 mg, 50 mg, 100 mg, 200 mg, 400 mg and 800 mg; administering a daily oral dose of the maximum dose of peanut protein for at least 2 years and then administering a weekly oral dose of the maximum dose of peanut protein for at least 2 years. | 04-03-2014 |
20140087481 | SCD FINGERPRINTS - The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting and assessing the progression of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described. | 03-27-2014 |
20140081236 | INTEGRATED CLOSED-LOOP MEDICATION DELIVERY WITH ERROR MODEL AND SAFETY CHECK - A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery. | 03-20-2014 |
20140057801 | MAMMALIAN HAPLOID EMBRYONIC STEM CELLS - The invention relates to mammalian haploid embryonic stem cells and methods for the production of such stem cells. The inventions also relates to a cell culture and a cell line of mammalian haploid embryonic stem cells. | 02-27-2014 |
20140027745 | BLENDED POLYMER FETS - A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material. | 01-30-2014 |
20130313544 | ORGANIC SEMICONDUCTORS - An optoelectronic device comprising a charge transfer layer including a first semiconductive polymer comprising one or more zwitterions. | 11-28-2013 |
20130309473 | Carbon Materials Comprising Carbon Nanotubes and Methods of Making Carbon Nanotubes - The present invention relates to carbon materials comprising carbon nanotubes, powders comprising carbon nanotubes and methods of making carbon nanotubes. In the methods of the present invention, the size and/or formation of floating catalyst particles is closely controlled. The resulting carbon nanotubes typically exhibit armchair chirality and typically have metallic properties. The carbon nanotubes produced by this method readily form bulk materials, which typically have a conductivity of at least 0.7×106 Sm″1 in at least one direction. The invention has particular application to the manufacture of components such as electrical conductors. Suitable electrical conductors include wires (e.g. for electrical motors) and cables (e.g. for transmitting electrical power). | 11-21-2013 |
20130298675 | MEMS Inertial Sensor and Method of Inertial Sensing - The invention comprises an inertia! sensor comprising a frame, a proof mass; a first resonant element having a proximal end and a distal end, the first resonant element being fixed to the frame at its proximal end and coupled to the proof mass at its distal end, a second resonant element having a proximal end and a distal end, the second resonant element being fixed to the frame at its proximal end, adjacent to the first resonant element such that there is no coupling between the second resonant element and the proof mass, a means for coupling the first resonant element to the second resonant element; a drive means coupled to the first and second resonant elements for vibrating the first and second resonant elements; and a sensor assembly for detecting the amplitude of vibration of the resonant elements. | 11-14-2013 |
20130288035 | Manufacture of Composite Optical Materials - A polymer opal material comprises a three dimensionally periodic arrangement of core particles in a matrix material and exhibits structural colour via Bragg reflection. IN a process for manufacturing such a material, a sandwich structure is provided, of a precursor composite material held between first and second sandwiching layers. A relative shear strain of at least 10% is imposed on the precursor composite material by curling the sandwich structure around a roller. The shear strain is cycled, in order to promote the formation of the three dimensional periodic arrangement. | 10-31-2013 |
20130255754 | PHOTOVOLTAIC DEVICE AND METHOD OF FABRICATING THEREOF - An organic/inorganic hybrid photovoltaic device architecture. In some variations, power conversion efficiencies approach 1%. Some variations include an unexpected order of magnitude improvement of power conversion efficiency approaching 5%. Methods of fabricating a photovoltaic device, including depositing over a first electrode an organic semiconductor layer; depositing over the organic semiconductor layer a cross-linking ligand layer; depositing over the cross-linking ligand layer an inorganic nanocrystal layer; and depositing a second electrode over the inorganic nanocrystal layer. | 10-03-2013 |
20130243036 | THERMOCOUPLE APPARATUS AND METHOD - In a thermocouple, a pair of thermoelements extend within a protective sheath. The thermoelements are spaced from the sheath by an insulator. The sheath comprises an outer sheath formed from a metal alloy adapted to provide mechanical support and corrosion resistance during use of the thermocouple, typically at elevated temperature. The sheath further comprises an inner sheath positioned between the outer sheath and the thermoelements and formed from a nickel-based alloy containing less than 10 wt % Cr, to prevent diffusion of Cr and/or Mn from the outer sheath to the thermoelements. | 09-19-2013 |
20130210184 | PATTERNING - A method for patterning an article, the article comprising a first layer of a first material, a first major surface of the first layer being in intimate contact with some or all of a first major surface of a second layer of a second different material the method comprising providing a first thread carrying a first species to remove at least a portion of the first layer, and providing a second thread aligned with and adjacent the first thread and contacting the first and second threads with the first layer to remove at least part of the first layer. | 08-15-2013 |
20130196156 | CHEMICAL TREATMENT OF CARBON NANOTUBE FIBRES - The polymerisation of material contained within and/or added to high temperature reactor produced carbon nanotube fibre wherein the contained material is crosslinked. | 08-01-2013 |
20130187040 | IONISATION MASS SPECTROMETRY - Systems that employ microdroplets are used in embodiments for Microdroplet Electrospray Ionisation Mass Spectrometry (ESI MS). Thus, a method of detecting an analyte includes providing an oil composition comprising oil and an aqueous microdroplet comprising the analyte, the oil composition comprising a surfactant to stabilise the aqueous microdroplet in the oil composition; and performing ionisation mass spectrometry analysis of the oil composition. | 07-25-2013 |
20130180920 | NANOPOROUS MATERIALS, MANUFACTURE OF NANOPOROUS MATERIALS AND APPLICATIONS OF NANOPOROUS MATERIALS - A nanoporous material is disclosed having a plurality of lamellae. Through each lamella is an array of penetrating pores. Adjacent lamellae are spaced apart by an intervening spacing layer. The spacing layer comprises an array of spacing elements integrally formed with and extending between the adjacent lamellae. The spacing layer has interconnected porosity extending within the spacing layer. Such a nanoporous material can be manufactured using block copolymer materials. First, a morphology is formed comprising a three dimensional array of isolated islands in a continuous matrix. The islands are formed of at least one island component of the block copolymer and the matrix is formed of at least one matrix component of the block copolymer. Next, channels are formed in the matrix between at least some of the islands. The island component is then selectively removed to leave the matrix with an array of interconnected pores. | 07-18-2013 |
20130178385 | BIOMARKERS - The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder. | 07-11-2013 |
20130172319 | Alpha-AminoCycloLactam Ligands for G-Protein Coupled Receptors, and Methods of Using Same - The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors (GPCRs). | 07-04-2013 |
20130156743 | VITRO HEPATIC DIFFERENTIATION - This invention relates to the induction of hepatic differentiation by culturing induced pluripotent stem (iPS) cells in an endoderm induction medium to produce a population of anterior definitive endoderm (ADE) cells and then culturing the population of ADE cells in a hepatic induction medium to produce a population of hepatic progenitor cells, which may be optionally differentiated into hepatocytes. The endoderm induction medium is a chemically defined medium which has fibroblast growth factor activity, stimulates SMAD2 and SMAD3 mediated signalling pathways and SMAD1, SMAD5 and SMAD9 mediated signalling pathways, and inhibits phosphatidylinositol 3-kinase (PI3K) and glycogen synthase kinase 3β (GSK3β); and the hepatic induction medium is a chemically defined medium which stimulates SMAD2 and SMAD3 mediated signalling pathways. These methods may be useful, for example, in producing hepatocytes and hepatic progenitor cells for cell-based therapies or disease modelling. | 06-20-2013 |
20130156679 | METHOD AND APPARATUS FOR FORMING NANOPARTICLES - A first layer of a catalyst material is formed on a substrate and heat treated to form a first plurality of nanoparticles. A second layer of a catalyst material is then formed over the substrate and the first plurality of nanoparticles and heat treated to form a second plurality of nanoparticles. The first layer of nanoparticles is advantageously not affected by the deposition or heat treatment of the second layer of catalyst material, for example being pinned or immobilised, optionally by oxidation, before formation of the second layer. | 06-20-2013 |
20130152652 | SPIN FORMING PROCESS AND APPARATUS FOR MANUFACTURING ARTICLES BY SPIN FORMING - A spin forming process and apparatus is disclosed. A workpiece (e.g. sheet metal) is rotated with respect to a forming roller which bears against one of the outer and inner surfaces of the workpiece to deform the workpiece towards a required shape. First and second support rollers bears against the opposite surface of the workpiece. Computer control of the positions of the forming roller and the first and second support rollers allow non-axisymmetric shapes to be manufactured by spin-forming. | 06-20-2013 |
20130149287 | Corticogenesis of Human Pluripotent Cells - This invention relates to in vitro methods for the induction of corticogenesis in human pluripotent cells, such as iPS cells, by culturing the cells under conditions which stimulate retinoid signalling and inhibit TGFβ superfamily signalling. This may be useful in production of cortical neurons, in particular patient-specific cortical neurons; the modelling of juvenile and adult-onset neurological diseases; and the development of therapeutics. | 06-13-2013 |
20130139477 | METHOD OF PROVIDING A CHEMICAL OR BIOLOGICAL MATERIAL IN QUANTISED FORM AND SYSTEM THEREFOR - This invention relates to methods and systems for providing chemical and/or biological materials. Thus we describe a method of providing a chemical or biological material in a quantised form, the method comprising: preparing an emulsion comprising a plurality of microdroplets each holding a controlled amount of said material; storing said chemical or biological material in said microdroplets in said emulsion; transferring a portion of said emulsion microdroplets to a container for transportation; transporting said container to a user of said material, wherein said user receives said material in a quantised form in said microdroplets of said emulsion; and de-emulsifying said received microdroplets containing said material in quantised form to extract said material for subsequent use. | 06-06-2013 |
20130084008 | METHODS AND SYSTEMS FOR SEMANTIC LABEL PROPAGATION | 04-04-2013 |
20130069043 | Electro Optic Devices - An electro optic device comprising a first electrode and a second electrode and an emissive layer located between the first and second electrodes, the emissive layer comprising a polymeric semiconductor, or semiconducting and luminescent material having a thickness of 200 nm to 3000 nm. | 03-21-2013 |
20130065785 | PROGNOSIS OF OESOPHAGEAL AND GASTRO-OESOPHAGEAL JUNCTIONAL CANCER - The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices. | 03-14-2013 |
20130064768 | LIPOPHILIC CATIONIC PROBE FOR PET-IMAGING - The present invention provides an imaging probe which comprises a lipophilic cation, a hydrophobic moiety and a PET nucleus. The present invention also provides a precursor molecule for the production of such an imaging probe and methods for using the probe for analysing mitochondrial membrane potential in a subject. | 03-14-2013 |
20130053372 | 5-HT RECEPTOR MODULATORS - The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment. | 02-28-2013 |
20130043406 | LUMINESCENT COMPOUNDS - A crystalline phosphor of formula: | 02-21-2013 |
20130012721 | METHODS FOR THE PURIFICATION OF CUCURBITURIL - A method for purifying a cucurbituril from a mixture. The method includes the step of forming a complex between the cucurbituril and a cucurbituril guest. The complex has altered physical and/or chemical properties to the cucurbituril which allow the complex to be separated from at least one other component of the mixture. The mixture includes the cucurbituril, the other component and a solvent. | 01-10-2013 |
20130011913 | IMMUNOASSAYS, METHODS FOR CARRYING OUT IMMUNOASSAYS, IMMUNOASSAY KITS AND METHOD FOR MANUFACTURING IMMUNOASSAY KITS - The invention relates to immunoassays, methods for carrying out immunoassays, immunoassay kits and methods for manufacturing immunoassay kits. In particular, the invention has relevance to capillary (especially microcapillary) immunoassay technology. | 01-10-2013 |
20120310203 | APPARATUS AND METHOD - This invention relates to medical devices for labelling a syringe filled from an ampoule, and to safer devices for filling a syringe from an ampoule, and to associated methods. We describe a device for attaching to an ampoule to label a syringe filled from the ampoule, the device comprising: an ampoule-mounting portion for mounting the device to a filled ampoule; a syringe-fitting portion to enable the device to be fitted onto said syringe; and a label holder to hold a label for contents of said ampoule; and wherein one of said syringe and said ampoule is detachable from said device; and wherein said label is configured such that in conjunction with a filling operation of said syringe and detachment of said one of said syringe and said ampoule from said device said syringe is labelled by said label. | 12-06-2012 |
20120301006 | CONTROLLER - A controller is provided for manoeuvring an interrogation plane relative to a reference surface. The interrogation plane intersects the reference surface and is associated with a pole about which the interrogation plane is rotatable. The pole has an adjustable angle of inclination relative to the reference surface. The controller has a base, a handle, and an arm extending from a connection with the base to a connection with the handle. The arm has hingeable joints which hinge to allow the handle to be translated relative to the base in arbitrary directions across a user surface. The controller further has position sensors which measure the translation of the handle relative to the base on the user surface. The translation provides a corresponding translation of the interrogation plane relative to the reference surface. The handle is rotatable about a rotation axis and is tillable about a tilt axis to allow the handle to be angularly moved relative to the user surface. The controller further has angle sensors which respectively detect the rotation about the rotation axis and the tilt about the tilt axis. The rotation about the rotation axis and the tilting about the tilt axis provide angular movement of the interrogation plane relative to the reference surface corresponding to the angular movement of the handle relative to the user surface. | 11-29-2012 |
20120298200 | PHOTOVOLTAIC CELL - An organic photovoltaic cell ( | 11-29-2012 |
20120294925 | BIOMATERIAL - A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould. | 11-22-2012 |
20120251105 | METHOD AND APPARATUS FOR PROVIDING A LINE OF SPOTS LAUNCH OF LIGHT INTO AN END OF A MULTIMODE OPTICAL FIBER - A method and an apparatus are provided for launching light into an entrance facet of a MMF of an optical MMF link in a way that excites one or more targeted higher-order mode groups in the MMF. The light is launched into the entrance facet of the MMF as a line of phase-modulated spots, referred to herein as a “line launch”. The line launch causes one or more targeted higher-order mode groups to be excited in the MMF. The use of the line launch to excite one or more higher-order mode groups in the MMF increases the bandwidth of the link and allows overall link lengths to be increased. In addition, the use of the line launch is reliable and robust despite defects in the MMF and despite connector offsets. Thus, the use of the line launch ensures that a sufficient increase in link bandwidth will be achieved despite the existence of defects in the MMF and even if there is some amount of optical misalignment due to the connector being offset relative to the corresponding receptacle. | 10-04-2012 |
20120237500 | SCD Fingerprints - This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample. | 09-20-2012 |
20120224758 | IMAGE DATA PROCESSING SYSTEMS - We describe a method of estimating the thickness of a tissue structure, in particular cortical bone thickness from tomographic imaging data such as CT data. The method models the tissue structure as a variation of an imaging parameter along a line; models a variation of the tomographic imaging data along the line as a blurred version of the variation of the imaging parameter modelling the; and fits the blurred tomographic imaging model to data from the tomographic imaging by holding a tissue modelling parameter at a constraining value and allowing variation of a blurring parameter and at least one parameter defining the thickness of the tissue structure to determine an estimate of the thickness of the structure. | 09-06-2012 |
20120207739 | TREATMENT OF PRE-TERM NEONATES - This invention relates to the treatment of pre-term neonates with paraoxonase 3 (PON3) or serum amyloid A like protein 3 (SAA3) to reduce or prevent the morbidity and mortality associated with prematurity. | 08-16-2012 |
20120199428 | Force-Controlling Hydraulic Device - A device for use in the control of mechanical forces is provided. The device includes first and second terminals for connection to components in a system for controlling mechanical forces and independently moveable. The device further comprises a hydraulic device connected between the terminals and containing a liquid. The hydraulic device is configured to produce upon relative movement of the terminals, a liquid flow to generate an inertial force due to the mass of the liquid to control the mechanical forces at the terminals such that they are substantially proportional to the relative acceleration between the terminals. | 08-09-2012 |
20120190568 | GENETIC MARKERS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION, METHODS OF DETECTION AND USES THEREOF - Disclosed is a method for identifying an individual who has an altered risk for developing age related macular degeneration comprising detecting a single nucleotide polymorphism (SNP) | 07-26-2012 |
20120184457 | Modulation of miRNA Activity - Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity. | 07-19-2012 |
20120154751 | Visual perimeter measurement system and method - In one example of the invention a patient display is provided on which a fixation graphic or video is shown in substantially the centre of the display, and then target graphics or video are shown at different positions on the display about the centre. A test subject is positioned in front of the patient display a known distance therefrom, and a camera captures an image of the test subject's eyes, to allow gaze direction determination to be performed. The captured images are displayed to a clinician user by a controlling test application, the clinician making a determination based on the images as to whether the test subject saw a target graphic or video when it was displayed. The clinician user then makes an appropriate input into the controlling test application, which also logs the position at which the target image was displayed. By displaying target graphics at multiple locations on the screen and logging the clinician inputs, the controlling test application is able to build up a plot of the peripheral vision field of the test subject. This plot can then be graphically displayed to the clinician user, and stored with the test results for future clinical use. | 06-21-2012 |
20120115742 | METHODS FOR IDENTIFICATION - The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agents as anti-inflammatory medicaments. In one aspect, there is provided a method for the identification of a compound or agent with BSCI activity comprising the steps of (a) firstly one or more candidate compounds or agents are screened for binding to a somatostatin receptor such as the type 2 somatostatin receptor (sstr2); then (b) compounds or agents which show binding to the somatostatin receptor are tested for BSCI activity in a functional assay. | 05-10-2012 |
20120112178 | OPTOELECTRONIC DEVICES - An optoelectronic device comprises electon donor D and acceptor A semiconducting species and an intervening co-oligomeric or copolymeric species provided to alter the energy transfer characteristics of excitons to or from the interface between the said electron acceptor and donor species. The intervening species may be of the form A | 05-10-2012 |
20120087905 | TREATMENT OF DISEASES RELATED TO HYPERACTIVITY OF THE COMPLEMENT SYSTEM - Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-inflammatory effects of iC3b. Methods, agents, and compositions for treatment of such diseases are described. | 04-12-2012 |
20120065401 | METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE - Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided. | 03-15-2012 |
20120046198 | Ligand Libraries for Screening GPCRs - The invention provides compounds of general formulae (I)-(IV) or pharmaceutically acceptable salts thereof: | 02-23-2012 |
20120038842 | Phase Modulation Devices for Optical Applications - An optical phase modulation device having a layer of flexoelectro-optic effect liquid crystal material and electrode for applying an electric field to the layer of liquid crystal material. In this way, the optic axis of the liquid crystal layer can be deflected. This provides a phase shift to light transiting the liquid crystal layer. The substrate of the device is based on a liquid crystal over silicon (LCOS) microdisplay. The device is capable of providing multilevel phase shifts, e.g. for holographic displays. | 02-16-2012 |
20120037516 | HYDROGEN SENSING APPARATUS AND METHOD - An apparatus and methods are provided for the accurate determination of hydrogen content in fluid media at elevated temperatures. The apparatus consists of a proton conducting solid electrolyte in contact with an internal metal/hydrogen reference standard, in which the electrolyte and the reference material are in a chemically stable contact. The electrical signal generated is a function of the hydrogen concentration on the measuring side. | 02-16-2012 |
20120032994 | WIDE TEMPERATURE-RANGE SMECTIC LIQUID CRYSTAL MATERIALS - A method of making a wide temperature-range smectic liquid crystal material comprises taking a wide temperature-range nematic mixture and doping this with a mesogenic silicon-containing material. Aspects of the invention provide wide temperature-range smectic materials and devices using the smectic materials. | 02-09-2012 |
20120028903 | MODULATION OF THE ACTIVITY AND DIFFERENTIATION OF CELLS EXPRESSING THE OSTEOCLAST-ASSOCIATED RECEPTOR - This invention relates to the finding that collagen peptides bind to the osteoclast-associated receptor (OSCAR) and stimulate the activation and/or differentiation of OSCAR expressing cells, such as osteoclasts and osteoclast precursor cells. Collagen peptides are described which may be useful in the modulation of the differentiation and/or activation of OSCAR expressing cells, for example in the treatment of bone defects and disorders characterized by altered differentiation and/or activation of OS-CAR expressing cells. | 02-02-2012 |
20120027811 | Formulations of Viable Cells for Oral Delivery - This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation significantly increases the survival of the cells in the intestinal tract and facilitates delivery of the viable cells to the intestine. | 02-02-2012 |
20120010600 | METHOD OF OVERNIGHT CLOSED-LOOP INSULIN DELIVERY WITH MODEL PREDICTIVE CONTROL AND GLUCOSE MEASUREMENT ERROR MODEL - A closed-loop method for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery. | 01-12-2012 |
20120003228 | METHODS FOR PREDICTING AUTOIMMUNE DISEASE RISK - The invention relates to means and methods for determining whether a subject is at high or low risk of autoimmune disease progression by determining the CD8 or CD4 cell subtype of the subject. Autoimmune diseases of particular interest include vasculitis, systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. The invention also relates to means and methods for determining the CD8 or CD4 cell subtype of a subject, e.g. for predicting responses to infection, vaccination and/or transplantation. | 01-05-2012 |
20110319268 | SUPERCONDUCTOR FABRICATION - A seed crystal for the fabrication of a superconductor is grown from a rare-earth oxide having the basic formula X | 12-29-2011 |
20110280573 | OPTICAL BEAM STEERING - This invention generally relates to an optical beam steering apparatus and a method of manufacturing an optical beam steering apparatus, and more particularly to an optical add drop multiplexer (OADM) such as a reconfigurable OADM (ROADM) comprising the optical beam steering apparatus. In one embodiment, the apparatus comprises a slab and a plurality of optical elements in or on a first surface of said slab, the plurality of optical elements including at least one liquid crystal on silicon element, the apparatus being arranged such that at least one optical beam can propagate freely in the slab from one of said plurality of optical elements to another one of said plurality of optical elements via a reflection from a second surface of the optical beam steering apparatus. | 11-17-2011 |
20110273657 | OPTICAL BEAM STEERING - The invention relates to optical beam steering. There is described an optical beam steering apparatus, comprising: a splitter arranged to split an optical beam into at least a first part having a first polarisation and a second part having a second polarisation, said first and second polarisations being substantially mutually orthogonal; a first liquid crystal device region arranged to receive said first part and to have director orientation substantially aligned to said first polarisation; and a second liquid crystal device region arranged to receive said second part and to have director orientation substantially aligned to said second polarisation. | 11-10-2011 |
20110202238 | ACTIVE STEERING CONTROLLER - A system for controlling a vehicle. The vehicle has a steerable front axle and at least one further steerable axle and the system comprises means for determining the path of a reference lead point at the front of the vehicle. There is also means for determining the path of a follow point at the rear of the vehicle, and means for driving the at least one further steerable axle of the vehicle such that the deviation between the path of the lead point of the vehicle and the follow point is within a predetermined range whilst the vehicle is in motion. | 08-18-2011 |
20110185449 | Modified Xylan Production - Methods and means for producing xylan structures in plants having a non-native saccharide moiety substitution side chain component, plants and plant cells comprising modified xylan structures, methods of identifying mutant plants comprising xylan structures in plants having a non-native saccharide moiety substitution pattern side chain component, uses thereof, and isolated xylan structures and uses thereof. | 07-28-2011 |
20110165554 | METHODS AND BIOMARKERS FOR DIAGNOSING AND MONITORING PSYCHOTIC DISORDERS - A method of diagnosing or monitoring a psychotic disorder, or predisposition thereto, comprises measuring, in a sample taken from a subject, the levels of one or more peptide biomarkers listed herein. | 07-07-2011 |
20110163280 | Optical Nanomaterial Compositions - The present invention provides compositions (“Optical Nanomaterial Compositions”) comprising one or more nanomaterials and an optical coupling gel or an optical adhesive. The invention also provides methods for using the Optical Nanomaterial Compositions as an index-matching gel, an optical adhesive or an optical film, all of which are suitable for optical and sensing devices applications, including but not limited to noise suppression, passive Q-switching, mode-locking, waveform shaping, optical switching, optical signal regeneration, phase conjugation, in filter devices, dispersion compensation, wavelength conversion, soliton stabilization, microcavity applications, in interferometers (such as the Gires-Tournois interferometer), optical, magneto-optical or electro-optical modulation, biochemical sensors and photodetectors. | 07-07-2011 |
20110150873 | ANTI-INFLAMMATORY COMPOSITIONS AND COMBINATIONS - The invention relates to the use of Broad-Spectrum Chemokine Inhibitors (BSCIs), and in particular members of the acylaminolactam class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of inflammatory diseases. In particular, improved compositions consisting of BSCI agents combined with one or more additional active pharmaceutical agents in order to achieve improved anti-inflammatory efficacy with a reduced side-effect profile are described and claimed. | 06-23-2011 |
20110140091 | Electro-optic Diode Devices - A light emissive or photovoltaic device comprising: a cathode structure for injecting electrons, the cathode structure having one or more constituent regions; an anode structure for injecting holes, the anode structure having one or more constituent regions; and an organic light emissive component located between the anode structure and the cathode structure; the refractive indices and the thicknesses of the or each constituent region of the cathode and anode structures and of the light emissive component being such that the emission or absorption spectrum of the device is substantially angularly dependent. | 06-16-2011 |
20110136670 | HIGH TEMPERATURE SUPERCONDUCTORS - Compositions are disclosed of a matrix of a high temperature superconductive oxide such as YBCO, with non-superconductive particles distributed in the matrix. The non-superconductive particles comprise at least one rare earth element (RE) and at least one of tantalum (Ta) and niobium (Nb). Of particular interest are non-superconductive particles of composition RE-Ta | 06-09-2011 |
20110038798 | AGENTS FOR DETECTING AND IMAGING CELL DEATH - This invention relates to molecular imaging agents comprising an S78C mutant synaptotagmin I C2A domain. These agents may be useful in detecting or assessing cell death in vitro and in vivo, for example in tumours following cancer treatment. | 02-17-2011 |
20110035155 | PROTEIN AGGREGATION PREDICTION SYSTEMS - We describe methods for identifying aggregation-prone regions in structured—that is folded—proteins. Embodiments of the method use a local propensity for aggregation (A | 02-10-2011 |
20110021943 | NEURAL INTERFACE - This invention relates to the neural interface comprising one or more electrode-coupled microchannels. Each electrode-coupled microchannel comprises a microchannel for accommodating regenerating nerve axons; and one or more electrodes exposed to the interior of said microchannel. The one or more electrodes may comprise (i) a stimulation array suitable for generating an extracellular stimulus current which induces an action potential in an axon in the microchannel; and/or (ii) a recording array which detects an extracellular signal in the microchannel indicative of an action potential in an axon in the microchannel. Interfaces as described may be useful in blocking pain, treating misrouted motor nerves; repair or treating nerve injury; or controlling or providing sensation and/or proprioception from a prosthesis. | 01-27-2011 |
20110020574 | EXTRUDED MATERIALS HAVING CAPILLARY CHANNELS - The present invention’ provides extrusion-processable materials having a plurality of capillary channels therethrough, and apparatus and methods for manufacturing such materials. The capillaries may be occupied by gases, liquids or other phases. The materials may be anisotropic foams which have high voidage. The methods and apparatus include quench cooling ( | 01-27-2011 |
20110003792 | ANTI-INFLAMMATORY AGENTS - The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, | 01-06-2011 |
20110002912 | COMPOSITION - The present invention relates to a composition for improving stem cell integration. The present invention also relates to a method of improving stem cell integration and kits for improving stem cell integration. | 01-06-2011 |
20100330677 | Improved Reprogramming of Mammalian Cells, and Cells Obtained - Expression of reprogramming factors such as Sox2, klf4, c-myc, Nanog, LIN28 and Oct4 followed by culture in a MEK inhibitor and a GSK3 inhibitor reprograms tissue cells. The invention provides new uses of these inhibitors, for example in inducing completion of the transcriptional resetting of so-called pre-pluripotent (pre-iPS) stem cells, for example as obtained from mammalian neural stem cells or epiblast stem cells treated with single or combinations of the reprogramming factors, expressed transiently or by integrative vectors. Also provided are systems for reprogramming an epiplast stem cells independently of the use of there inhibitors. | 12-30-2010 |
20100327653 | AIR BRAKING SYSTEM - An air braking unit for use in an air braking system. The air braking unit is arranged to be positioned, in use, at a vehicle wheel, and comprises an inlet for receiving, in use, compressed air from a central source. At least one first valve is arranged to selectively allow compressed air from the inlet to enter a wheel brake chamber in use. At least one second valve is arranged to selectively allow air from the brake chamber to be released via an outlet to the atmosphere in use and control means controls the first and second valves to operate to selectively control the air pressure in the brake chamber in use. | 12-30-2010 |
20100324089 | Anti-inflammatory composition - The invention relates to 3-(2′,2′-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory disorders. | 12-23-2010 |
20100291597 | SECRETOGRANIN AND VGF PEPTIDE BIOMARKERS AND USES THEREOF - Secretogranin II and VGF peptides are biomarkers for major depressive disorder. They are useful in methods of diagnosing, monitoring and screening. | 11-18-2010 |
20100280441 | OVERNIGHT CLOSED-LOOP INSULIN DELIVERY WITH MODEL PREDICTIVE CONTROL AND GLUCOSE MEASUREMENT ERROR MODEL - A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery. | 11-04-2010 |
20100248368 | BIOMATERIAL - A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation. | 09-30-2010 |
20100247477 | SUPRAMOLECULAR HANDCUFFS IN POLYMERIC ARCHITECTURE - This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, wherein the first and second CB[8] guest molecules form a ternary host-guest complex with a CB[8] molecule which non-covalently links the polymeric molecule and the attachment compound in a supramolecular polymer. These polymers are useful as vehicles for delivery of a therapeutic compound for use in a method of treatment of the human or animal body, in particular for use in a method of delivering the therapeutic compound to a target site in an individual. The invention also provides methods for the preparation of the supramolecular polymers. | 09-30-2010 |
20100242592 | SHEAR STRESS SENSORS - This invention relates to hot film shear stress sensors and their fabrication. We describe a hot film shear stress sensor comprising a silicon substrate supporting a membrane having a cavity underneath, said membrane bearing a film of metal and having electrical contacts for heating said film, and wherein said membrane comprises a silicon oxide membrane, where in said metal comprises aluminium or tungsten, and wherein said membrane has a protective layer of a silicon-based material over said film of metal. In preferred embodiments the sensor is fabricated by a CMOS process and the metal comprises aluminium or tungsten. | 09-30-2010 |
20100203650 | BIOMOLECULE BINDING LIGANDS - The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or a compound of formula (IV): wherein for compounds of formula (I) one of R | 08-12-2010 |
20100190201 | Methods - The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cells; (i) the proportion of stem cells, proliferating cells and differentiated cells in said cell population; or (ii) the size of stem cell clusters in said cell population; or (iii) the separation of stem cell clusters in said cell population; and comparing said at least one characteristic to a reference value, wherein a difference between the determined value and the reference value indicates an altered behaviour in said population of cells. Preferably the cells are mammalian, more preferably human epithelial cells, more preferably human epidermal cells. | 07-29-2010 |
20100136542 | NUCLEIC ACID AMPLIFICATION AND TESTING - Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described. | 06-03-2010 |
20100134629 | Strain Image Display Systems - A method of displaying strain image data for an imaged object, the method comprising: capturing strain image data defining deformation of said object over an imaged region of said object; processing said strain image data to determine local image quality data, said local image quality data comprising a measure of the quality of said strain image data varying over said imaged region; and displaying a representation of said strain image data for said imaged region of said object, using said local image quality data to provide a visual indication of the quality of said displayed representation varying over said imaged region or to improve a quality of said displayed representation of said strain image data. | 06-03-2010 |
20100128877 | Systems and Methods for Providing Opportunistic Security for Physical Communication Channels - Systems and methods of providing opportunistic security for physical communication channels are disclosed. One disclosed method is for opportunistic secure communication on a main channel between a sender device and a receiver device when an eavesdropper device is listening on an eavesdropper channel. This example method includes transmitting, in a first time period in which signal quality on the main channel is better than signal quality on the eavesdropper channel, symbols that are randomly selected from a set of symbols. The method also includes transmitting, in a second time period in which signal quality on the main channel is not better than signal quality on the eavesdropper channel, coding information associated with the randomly selected symbols. The method also includes reconciling the randomly selected symbols using the coding information. | 05-27-2010 |
20100113518 | METHODS OF USING ANTI-INFLAMMATORY COMPOUNDS - The invention relates to the use of 3-(2′,2′-dimethylpropanoylamino)-tetrahydropyridin-2-one for preparing a medicament intended to prevent or treat inflammatory disorders. | 05-06-2010 |
20100060326 | CONTROL OF POWER SEMICONDUCTOR DEVICES - This invention relates to a control method and a circuit for MOS-gated power semiconductor switching devices such as IGBTs or MOSFETs, which allows control and optimisition of the current and voltage commutation of a power semiconductor switching device and freewheel diode pair in the basic half-bridge circuit found in a wide range of equipment. The method comprises the stages of: applying, upon receipt of a switch-on command signal, a voltage function to the control terminal or the gate of the power semiconductor switching device that allows a regulated current rise in the device whilst maintaining the voltage across the device falling at a predetermined rate; and at the instant when the voltage across the diode begins to change from the on-state towards the off-state level, applying a voltage function to the control terminal or the gate of the power semiconductor switching device to enable the voltage falling across the power semiconductor switching device to track the voltage falling across the diode in order to ensure a fast and controlled completion of the switching operation without diode reverse voltage overshoot. The gate drive automatically modifies the voltage function according to the working condition thereby accounting for the actual operating conditions. | 03-11-2010 |
20100046695 | APPARATUS AND METHOD FOR ACQUIRING SECTIONAL IMAGES - Disclosed is a computer implemented method of interrogating volumetric data, the method including the steps of: defining a reference surface relative to the volumetric data; providing an interrogation window lying in a movable interrogation plane intersecting the reference surface and the interrogation window intersecting the volumetric data, said interrogation plane having a pole lying in it about which pole said interrogation plane is rotatable, wherein movement of the interrogation plane provides a corresponding movement of the interrogation window; for each movement of the interrogation plane, determining the point of intersection of said pole and said reference surface, determining the relative angle of rotation of said interrogation plane about said pole and determining the angle of inclination of said pole to said reference surface; and on the basis of said determinations, providing a sectional image through the volumetric data corresponding to the position of the interrogation window within the volumetric data. Also disclosed is a computer system for implementing the method according to any one of the preceding claims, the system includes a processor for performing the steps of the method and a visual display for displaying said sectional image. | 02-25-2010 |
20100044684 | BLENDED POLYMER FETS - A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material. | 02-25-2010 |
20100043837 | METHOD OF CONTROLLING CONTAMINATION OF A SURFACE - A method is described of controlling contamination of a surface exposed to a carbonaceous material and ionising radiation, such as EUV radiation, DUV radiation or electrons. The method comprises cyclically supplying to the surface a first gas comprising an oxidising species, for example NO, for reacting with carbonaceous deposits formed on the surface from the carbonaceous material, followed by a second gas comprising a reducing species, for example CO, for reacting with oxidising species on the surface. | 02-25-2010 |
20100040938 | LEAD RECYCLING - The present invention describes a method of recycling lead from lead containing waste, the method comprising the steps of mixing the battery paste with aqueous citric acid solution so as to generate lead citrate; isolating lead citrate from the aqueous solution; and converting the lead citrate to lead and/or lead oxide. | 02-18-2010 |
20100003528 | Nanomaterial Polymer Compositions and Uses Thereof - The present invention is directed to compositions (“Nanomaterial Polymer Compositions”) comprising a silicone polymer and a nanomaterial, including but not limited to, a single or multi-walled nanotube, a nanowire, a nanodot, a quantum dot, a nanorod, a nanocrystal, a nanotetrapod, a nanotripod, a nanobipod, a nanoparticle, a nanosaw, a nanospring, a nanoribbon, a branched nanomaterial, or any combination thereof. The Nanomaterial Polymer Compositions are useful for optical and sensing devices including but not limited to noise suppression, passive Q-switching, mode-locking, waveform shaping, optical switching, optical signal regeneration, phase conjugation or filter devices, dispersion compensation, wavelength conversion, a soliton stabilization, microcavity applications, interferometers; optical, magneto-optical or electro-optical modulation; and biochemical sensors and photodetectors. The Nanomaterial Polymer Compositions are also useful in soft lithography processes. | 01-07-2010 |
20100002324 | Optical Nanomaterial Compositions - The present invention provides compositions (“Optical Nanomaterial Compositions”) comprising one or more nano-materials and an optical coupling gel or an optical adhesive. The invention also provides methods for using the Optical Nanomaterial Compositions as an index-matching gel, an optical adhesive or an optical film, all of which are suitable for optical and sensing de-vices applications, including but not limited to noise suppression, passive Q-switching, mode-locking, waveform shaping, optical switching, optical signal regeneration, phase conjugation, in filter devices, dispersion compensation, wavelength conversion, soliton stabilization, microcavity applications, in interferometers (such as the Gires-Tournois interferometer), optical, magneto-optical or electro-optical modulation, biochemical sensors and photodetectors. | 01-07-2010 |
20090317413 | DETECTION OF HUMAN PLATELET ANTIGEN (HPA) ANTIBODIES - This invention relates to recombinant GPIIIa molecules that lack the ligand binding βA domain and bind to HPA-1 antibodies in monomeric form. These GPIIIa molecules can be recombinantly expressed at high levels and may be useful, for example, in the detection of HPA-1 antibodies. Such detection may be useful, for example, in the diagnosis and therapy of HPA antibody disorders such as Neonatal Alloimmune Immune Thrombocytpenia (NAIT), Post Transfusion Purpura (PTP) and Platelet Refractoriness (PR). | 12-24-2009 |
20090203535 | ACOUSTIC WAVE TRANSDUCER SUBSTRATE AND MEASUREMENTS USING THE SAME - An acoustic wave transducer substrate is provided, the substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites. The growth-promotion sites are preferably for promoting fibril formation. The invention also provides a method of screening a candidate compound for an effect on fibril growth, including the steps of: providing an acoustic wave transducer substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites; causing oscillation of the substrate; contacting the substrate surface with a sample fluid comprising polypeptide molecules and a candidate compound; and measuring one or more parameters of the substrate oscillation to monitor the accumulation of said polypeptide molecules of interest in the presence and absence of said candidate compound. Alteration of the accumulation of said polypeptide molecules of interest in the presence of said candidate compound as compared with that in the absence of said candidate compound indicates that the candidate compound has an effect of fibril growth. | 08-13-2009 |
20090186196 | Multistable Structural Member and Method for Forming a Multistable Structural Member - Disclosed is a multistable structural member ( | 07-23-2009 |
20090158749 | Magnetocaloric Refrigerant - The invention provides the use of a material of general formula (I): | 06-25-2009 |
20090128875 | Phase retrieval and phase hologram synthesis - A method of retrieving phase information from input intensity information, representative of a target image, in which a Fourier transform is performed on data and the result used in forming a phase estimate, the phase estimate being inverse Fourier transformed, thereby producing magnitude and phase replay, and wherein not only is the phase reply component but also data derived from the magnitude replay component, iteratively fed back. | 05-21-2009 |
20090128872 | Method of forming an image and image projection device - A method of forming an image comprising providing a device for imparting respective phase shifts to different regions of an incident wavefront, wherein the phase shifts give rise to an image in a replay field, and causing zero-order light to be focused into a region between the replay field and the device. | 05-21-2009 |
20090116128 | Viewing device - A viewing device comprises: a pair of optically aligned lenses which are moveable relative to each other to vary the gap between facing surfaces of the lenses, and a linkage for controlling the relative motion. The linkage includes first and second elongate members which crossover each other at a crossover pivot connection. The first elongate member extends between a slidably moveable pivot connection which is arranged to transmit relative motion to the first lens of the pair and a pivot connection which is arranged to transmit relative motion to the second lens of the pair. The second elongate member extends between a slidably moveable pivot connection which is arranged to transmit relative motion to the second lens and a pivot connection which is arranged to transmit relative motion to the first lens. The connections are arranged such that the linkage can open and close in a concertina- or scissor-like fashion. | 05-07-2009 |
20090022771 | BIOMATERIAL - A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould. | 01-22-2009 |
20090008261 | Oxygen Generation Apparatus and Method - An oxygen generator for an oxygen-generation apparatus has a proton-conducting membrane ( | 01-08-2009 |
20080274901 | COMPOSITE ELECTRICAL CONDUCTORS AND METHOD FOR THEIR MANUFACTURE - An elongate composite electrical conductor with at least one superconducting core region including processed core material surrounded by sheath material such as Cu. The processed core material has a peripheral portion of ex situ reacted MgB | 11-06-2008 |