| CALIFORNIA INSTITUTE OF TECHNOLOGY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120131409 | RATE-COMPATIBLE PROTOGRAPH LDPC CODE FAMILIES WITH LINEAR MINIMUM DISTANCE - Digital communication coding methods are shown, which generate certain types of low-density parity-check (LDPC) codes built from protographs. A first method creates protographs having the linear minimum distance property and comprising at least one variable node with degree less than 3. A second method creates families of protographs of different rates, all structurally identical for all rates except for a rate-dependent designation of certain variable nodes as transmitted or non-transmitted. A third method creates families of protographs of different rates, all structurally identical for all rates except for a rate-dependent designation of the status of certain variable nodes as non-transmitted or set to zero. LDPC codes built from the protographs created by these methods can simultaneously have low error floors and low iterative decoding thresholds. | 05-24-2012 |
| 20120130569 | SYSTEMS AND METHODS FOR SEA STATE PREDICTION AND AUTOMATED VESSEL NAVIGATION - Systems and methods for sea state prediction and autonomous navigation in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a method of predicting a future sea state including generating a sequence of at least two 3D images of a sea surface using at least two image sensors, detecting peaks and troughs in the 3D images using a processor, identifying at least one wavefront in each 3D image based upon the detected peaks and troughs using the processor, characterizing at least one propagating wave based upon the propagation of wavefronts detected in the sequence of 3D images using the processor, and predicting a future sea state using at least one propagating wave characterizing the propagation of wavefronts in the sequence of 3D images using the processor. Another embodiment includes a method of autonomous vessel navigation based upon a predicted sea state and target location. | 05-24-2012 |
| 20120129719 | Mechanically induced trapping of molecular interactions - The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes. | 05-24-2012 |
| 20120123133 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS - The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen atom contained within the 5-membered heterocyclic ring, wherein the nitrogen atom is directly attached to the carbenic carbon atom and is substituted by a phenyl ring, and wherein the phenyl ring has a hydrogen at either or both ortho positions and is substituted at at least one ortho or meta position. The invention also relates to an olefin metathesis reactions and particularly to the preparation of tetra-substituted cyclic olefins via a ring-closing metathesis. | 05-17-2012 |
| 20120120398 | MICRO-CAVITY GAS AND VAPOR SENSORS AND DETECTION METHODS - Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating. The coating deformation and/or a change of one or more optical properties of the optical energy circulating within the micro-cavity are used to detect the presence of the gas or vapor or molecules or particulates thereof | 05-17-2012 |
| 20120117528 | SYSTEMS AND METHODS FOR CIRCUIT LIFETIME EVALUATION - Systems and methods for estimating the lifetime of an electrical system in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes iteratively performing Worst Case Analysis (WCA) on a system design with respect to different system lifetimes using a computer to determine the lifetime at which the worst case performance of the system indicates the system will pass with zero margin or fail within a predetermined margin for error given the environment experienced by the system during its lifetime. In addition, performing WCA on a system with respect to a specific system lifetime includes identifying subcircuits within the system, performing Extreme Value Analysis (EVA) with respect to each subcircuit to determine whether the subcircuit fails EVA for the specific system lifetime, when the subcircuit passes EVA, determining that the subcircuit does not fail WCA for the specified system lifetime, when a subcircuit fails EVA performing at least one additional WCA process that provides a tighter bound on the WCA than EVA to determine whether the subcircuit fails WCA for the specified system lifetime, determining that the system passes WCA with respect to the specific system lifetime when all subcircuits pass WCA, and determining that the system fails WCA when at least one subcircuit fails WCA. | 05-10-2012 |
| 20120107177 | CLICK CHEMISTRY SURFACE FUNCTIONALIZATION FOR RESONANT MICRO-CAVITY SENSORS - Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element. | 05-03-2012 |
| 20120105182 | INTEGRATED 3-DIMENSIONAL ELECTROMAGNETIC ELEMENT ARRAYS - Systems and methods for constructing integrated three dimensional electromagnetic element arrays using a bulk resonator are illustrated. In several embodiments, the integrated three dimensional electromagnetic element arrays include electromagnetic elements buried within the bulk resonator. In many embodiments, inclusion of a third dimension in the electromagnetic element array can alleviate or eliminate the trade-offs that are experienced in conventional integrated antennas by using the third physical dimension to provide an additional degree of freedom to manipulate electromagnetic boundary conditions in the near-field of the substrate, affecting both the resulting electromagnetic near- and far-fields. In several embodiments, three dimensional electromagnetic element arrays are formed by mechanically stacking substrates on which integrated planar circuits are formed (i.e. chips) using conventional die stacking techniques. | 05-03-2012 |
| 20120103478 | HIGH ASPECT RATIO PARTS OF BULK METALLIC GLASS AND METHODS OF MANUFACTURING THEREOF - Bulk metallic articles having a high-aspect ratio that are formed of bulk metallic glass, that are net-shaped and that are produced under process conditions that maximize the quality and integrity of the parts as well as the life of the mold tool, thus minimizing production costs, and manufacturing methods for producing such articles are provided. | 05-03-2012 |
| 20120098950 | SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM - A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest. | 04-26-2012 |
| 20120098645 | REMOTELY POWERED RECONFIGURABLE RECEIVER FOR EXTREME SENSING PLATFORMS - Unmanned space programs are currently used to enable scientists to explore and research the furthest reaches of outer space. Systems and methods for low power communication devices in accordance with embodiments of the invention are disclosed, describing a wide variety of low power communication devices capable of remotely collecting, processing, and transmitting data from outer space in order to further mankind's goal of exploring the cosmos. Many embodiments of the invention include a Flash-based FPGA, an energy-harvesting power supply module, a sensor module, and a radio module. By utilizing technologies that withstand the harsh environment of outer space, more reliable low power communication devices can be deployed, enhancing the quality and longevity of the low power communication devices, enabling more data to be gathered and aiding in the exploration of outer space. | 04-26-2012 |
| 20120098594 | DISPERSION-ENGINEERED TRAVELING WAVE KINETIC INDUCTANCE PARAMETRIC AMPLIFIER - A traveling wave kinetic inductance parametric amplifier comprises a superconducting transmission line and a dispersion control element. The transmission line can include periodic variations of its dimension along its length. The superconducting material can include a high normal state resistivity material. In some instances the high normal state resistivity material includes nitrogen and a metal selected from the group consisting of titanium, niobium and vanadium. The traveling wave kinetic inductance parametric amplifier is expected to exhibit a noise temperature below 100 mK/GHz. | 04-26-2012 |
| 20120098162 | RAPID HOT PRESSING USING AN INDUCTIVE HEATER - A rapid hot press (RHP) method and system in which heat is supplied by RF induction to rapidly consolidate a material is described. Use of RF induction heating enables rapid heating and consolidation of powdered materials over a wide temperature range. Details of an exemplary system, instrumentation and performance using a thermoelectric material as an example are disclosed. The novel technique may be applied to any known sinterable materials. Notable applicable materials include thermoelectric materials, such as PbTe. An exemplary thermoelectric PbTe material may be pressed at an optimized temperature and time according to the technique to be consolidated under typical parameters and yield suitable properties of Seebeck coefficient, electrical resistivity, and thermal diffusivity. | 04-26-2012 |
| 20120097906 | HEAVILY DOPED PbSe WITH HIGH THERMOELECTRIC PERFORMANCE - The present invention discloses heavily doped PbSe with high thermoelectric performance. Thermoelectric property measurements disclosed herein indicated that PbSe is high zT material for mid-to-high temperature thermoelectric applications. At 850 K a peak zT>1.3 was observed when n | 04-26-2012 |
| 20120096234 | INFORMATION REPRESENTATION AND CODING FOR NONVOLATILE MEMORIES - A memory device having a plurality of cells, each of which stores a value, where the values of the cells are mapped to discrete levels and the discrete levels represent data, is programmed by determining a maximum number of cell levels in the memory device, and determining the set of values that are associated with each of the cell levels. The maximum number of cell levels for the memory device is determined by an adaptive programming system connected to the memory device, based on a plurality of cell values attained by at least one cell of the memory device, in response to voltage applied by the adaptive programming system to the cells of the memory device. The adaptive programming system associates, for each of the cell levels, a different set of cell values of the plurality of cell values attained by the cells to which voltage is applied. This technique increases the number of cell levels that can be configured in a memory device as compared with conventional techniques, and increases the number of data values that can be programmed into the cells of a memory device. | 04-19-2012 |
| 20120091858 | PARYLENE-C AS A PIEZOELECTRIC MATERIAL AND METHOD TO MAKE IT - A parylene C polymer that is electrically poled such that it is piezoelectric is presented. Methods for manufacturing the piezoelectric parylene C polymer with an optimal piezoelectric coefficient d33 are also disclosed. Actuators formed with piezoelectric parylene C are disclosed as well as sensor devices that incorporate piezoelectric parylene C using charge integrator circuits in which the integration time is longer than likely adiabatic temperature transients. | 04-19-2012 |
| 20120091404 | ZINTL PHASES FOR THERMOELECTRIC APPLICATIONS - The inventors demonstrate herein that various Zintl compounds can be useful as thermoelectric materials for a variety of applications. Specifically, the utility of Ca | 04-19-2012 |
| 20120091374 | MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 04-19-2012 |
| 20120091235 | HANDHELD LOW PRESSURE MECHANICAL CELL LYSIS DEVICE WITH SINGLE CELL RESOLUTION - Apparatus and methods for mechanical cell lysis with single cell resolution which requires very low applied pressure. The device can be handheld, simple to operate, requires no external power except for hand-applied pressure via a syringe, and is applicable to all cell types including yeast and bacterial cells. The device is also capable of mechanically lysing a single cell. A single cell is selected from a biological sample of interest. The single cell is lysed by application of mechanical stress in a single cell lysing apparatus having a trap structure for deterministically capturing the cell and a stress raiser that cooperates with a source of mechanical stress so as to apply sufficient force to rupture a cell. The stress raiser can be a properly designed edge of the trap or it can be a lithographically produced structure such as a nanoblade or a nanopillar. | 04-19-2012 |
| 20120090656 | SELF-TUNING OF CARRIER CONCENTRATION FOR HIGH THERMOELECTRIC PERFORMANCE - The inventors demonstrate herein that homogeneous Ag-doped PbTe/Ag | 04-19-2012 |
| 20120077692 | MULTIPLEX Q-PCR ARRAYS - This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. | 03-29-2012 |
| 20120077228 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES - Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine. | 03-29-2012 |
| 20120077052 | MULTILAYERED CELLULAR METALLIC GLASS STRUCTURES - Multi-layered cellular metallic glass structures and methods of preparing the same are provided. In one embodiment, the cellular metallic glass structure includes at least one patterned metallic glass sheet and at least one additional sheet. The at least one patterned metallic glass sheet may include multiple sheets connected together to form a group of sheets, and the structure may include a group of sheets sandwiched between two outer sheets. The patterned metallic glass sheets may be patterned by thermoplastically forming two- and/or three-dimensional patterns in the metallic glass sheets. The metallic glass cellular structures are useful in a wide variety of applications, including but not limited to blast protection applications, energy absorption applications, structural support applications, biomedical implant applications, heat exchanger applications, thermal management applications, electrical shielding applications, magnetic shielding applications, and debris and radial | 03-29-2012 |
| 20120073710 | TOUGH IRON-BASED BULK METALLIC GLASS ALLOYS - A family of iron-based, phosphor-containing bulk metallic glasses having excellent processability and toughness, methods for forming such alloys, and processes for manufacturing articles therefrom are provided. The inventive iron-based alloy is based on the observation that by very tightly controlling the composition of the metalloid moiety of the Fe-based, P-containing bulk metallic glass alloys it is possible to obtain highly processable alloys with surprisingly low shear modulus and high toughness. Further, by incorporating small fractions of silicon (Si) and cobalt (Co) into the Fe—Ni—Mo—P—C—B system, alloys of 3 and 4 mm have been synthesized with high saturation magnetization and low switching losses. | 03-29-2012 |
| 20120070817 | ACOUSTIC-ASSISTED ITERATIVE WAVE FORM OPTIMIZATION FOR DEEP TISSUE FOCUSING - A method, apparatus, and article of manufacture for irradiating one or more targets within a sample with electromagnetic (EM) radiation. One or more targets within the sample are controllably defined with an acoustic field. The sample is irradiated with input EM radiation having an input wavefront. An amount of frequency shifted EM radiation is detected, wherein at least some of the input EM radiation that passes through the acoustic field at the targets is shifted in frequency to form the frequency shifted EM radiation. The input wavefront is modified, using feedback comprising the amount of the frequency shifted EM radiation that is detected, into a modified wavefront. The sample is irradiated using the input EM radiation comprising the modified wavefront, and the process is repeated as desired. | 03-22-2012 |
| 20120070462 | Targeted Gene Delivery to Dendritic Cells - Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers. | 03-22-2012 |
| 20120070071 | SYSTEMS AND METHODS FOR AUTOMATED WATER DETECTION USING VISIBLE SENSORS - Systems and methods are disclosed that include automated machine vision that can utilize images of scenes captured by a 3D imaging system configured to image light within the visible light spectrum to detect water. One embodiment includes autonomously detecting water bodies within a scene including capturing at least one 3D image of a scene using a sensor system configured to detect visible light and to measure distance from points within the scene to the sensor system, and detecting water within the scene using a processor configured to detect regions within each of the at least one 3D images that possess at least one characteristic indicative of the presence of water. | 03-22-2012 |
| 20120067551 | THERMAL ENERGY STORAGE USING SUPERCRITICAL FLUIDS - A thermal energy storage system is described employing latent heat storage of a supercritical fluid instead of typical phase change materials. Two fundamental thermodynamic concepts are invoked. First, by using the latent heat of liquid/vapor phase change, high energy density storage is feasible. Second, by operating the thermal energy storage system at a higher pressure, the saturation temperature is increased to operate at molten salt temperatures and above. Beyond the two-phase regime, supercritical operation permits capturing and utilizing heat taking advantage of latent and sensible heat, both in the two-phase regime as well as in supercritical regime while at the same time, reducing the required volume by taking advantage of the high compressibilities. | 03-22-2012 |
| 20120065883 | GPS/INS SENSOR FUSION USING GPS WIND UP MODEL - A method of stabilizing an inertial navigation system (INS), includes the steps of: receiving data from an inertial navigation system; and receiving a finite number of carrier phase observables using at least one GPS receiver from a plurality of GPS satellites; calculating a phase wind up correction; correcting at least one of the finite number of carrier phase observables using the phase wind up correction; and calculating a corrected IMU attitude or velocity or position using the corrected at least one of the finite number of carrier phase observables; and performing a step selected from the steps consisting of recording, reporting, or providing the corrected IMU attitude or velocity or position to another process that uses the corrected IMU attitude or velocity or position. A GPS stabilized inertial navigation system apparatus is also described. | 03-15-2012 |
| 20120065277 | MICROFLUIDIC CHEMOSTAT - A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber. | 03-15-2012 |
| 20120065245 | REGULATION OF HEMATOPOIETIC STEM CELL FUNCTIONS THROUGH MICRORNAS - The present disclosure relates to regulation of functions of hematopoietic stem cells (HSCs) by delivering of miRNAs, including miR-125b, miR-126, and miR-155, to HSCs. For example, in some embodiments, blood output in a mammal can be increased by administering miR-125b, miR-126, and/or miR-155 oligonucleotides. Also disclosed are methods for promoting hematopoietic stem cell engraftment and method for treating a myeloproliferative disorder. | 03-15-2012 |
| 20120065072 | SUPERCONDUCTING METALLIC GLASS TRANSITION-EDGE-SENSORS - A superconducting metallic glass transition-edge sensor (MGTES) and a method for fabricating the MGTES are provided. A single-layer superconducting amorphous metal alloy is deposited on a substrate. The single-layer superconducting amorphous metal alloy is an absorber for the MGTES and is electrically connected to a circuit configured for readout and biasing to sense electromagnetic radiation. | 03-15-2012 |
| 20120064552 | USING BLOOD CLOT IN MICROFLUIDIC VALVING APPLICATIONS - The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve. | 03-15-2012 |
| 20120061587 | DELAYED EMISSION DETECTION DEVICES AND METHODS - Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period. | 03-15-2012 |
| 20120061554 | QUANTITATIVE DIFFERENTIAL INTERFERENCE CONTRAST (DIC) MICROSCOPY AND PHOTOGRAPHY BASED ON WAVEFRONT SENSORS - Embodiments of the present invention relate to a wavefront sensor comprising a film and a photodetector. The film has one or more structured two dimensional apertures configured to convert a phase gradient of a wavefront into a measurable form. The photodetector is configured to receive the wavefront through the one or more 2D apertures and measure the phase gradient of the wavefront. | 03-15-2012 |
| 20120061305 | MICROFLUIDIC SIEVE VALVES - Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules. | 03-15-2012 |
| 20120060913 | WHISPERING GALLERY SOLAR CELLS - This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells layered with a nanostructure that resonates and undergoes Whispering Gallery Mode. | 03-15-2012 |
| 20120058532 | ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS - The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention. | 03-08-2012 |
| 20120046639 | MICROFLUIDIC FREE INTERFACE DIFFUSION TECHNIQUES - A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays. | 02-23-2012 |
| 20120037390 | FREE-MASS AND INTERFACE CONFIGURATIONS OF HAMMERING MECHANISMS - The design of the free-mass in an ultrasonic driller/corer (USDC) has been refined in order to improve the performance and operational reliability of the system. In one embodiment, the improvements in performance and operational reliability include decreasing the impact surface area of the free-mass to increase the transfer of impact energy from the piezoelectric transducer and reductions in the likelihood that the system will jam. | 02-16-2012 |
| 20120035065 | Aptamer Regulated Nucleic Acids and Uses Thereof - The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a primer sequence domain and an aptamer domain that is responsive to a ligand. | 02-09-2012 |
| 20120028324 | ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS - The present invention is generlly provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention. | 02-02-2012 |
| 20120026509 | ON-CHIP PHASE MICROSCOPE/BEAM PROFILER BASED ON DIFFERENTIAL INTERFERENCE CONTRAST AND/OR SURFACE PLASMON ASSISTED INTERFERENCE - A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector. | 02-02-2012 |
| 20120024010 | ENHANCING THE OPTICAL CHARACTERISTICS OF A GEMSTONE - Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In certain embodiments, the diffractive optical element comprises a diffraction grating etched on one or more facets of the gemstone. | 02-02-2012 |
| 20120014221 | MONOLITHIC FLEXURE PRE-STRESSED ULTRASONIC HORNS - A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The provision of the external flexures has numerous advantages including the elimination of the need for a pre-stress bolt. The removal of the pre-stress bolt eliminates potential internal electric discharge points in the actuator. In addition, it reduces the chances of mechanical failure in the actuator stacks that result from the free surface in the hole of conventional ring stacks. In addition, the removal of the stress bolt and the corresponding reduction in the overall number of parts reduces the overall complexity of the resulting ultrasonic horn actuator and simplifies the ease of the design, fabrication and integration of the actuator of the present invention into other structures. | 01-19-2012 |
| 20120013517 | INTEGRATED LENS ANTENNAS FOR MULTI-PIXEL RECEIVERS FOR PLANETARY AND ASTRONOMICAL INSTRUMENTS - Methods and apparatus for integrating lens antennas for receivers are disclosed. A method of fabricating a lens in accordance with one or more embodiments of the present invention comprises integrating lens material with a dielectric material and flowing the lens material into a desired lens shape. An integrated lens antenna in accordance with one or more embodiments of the present invention comprises a dielectric material, a waveguide feed, coupled to the dielectric material through a leaky wave cavity, and a lens, coupled to the dielectric material opposite the leaky wave cavity, wherein material is first deposited onto the dielectric material, flowed into a desired lens shape and the desired lens shape is transferred to the dielectric material. | 01-19-2012 |
| 20120009663 | Nucleic Acid Amplification Using Microfludic Devices - The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through the temperature regions such that the solution is exposed to different temperatures. Other microfluidic devices include an array of reaction chambers formed by intersecting vertical and horizontal flow channels, with the ability to regulate temperature at the reaction chambers. The microfluidic devices can be used to conduct a number of different analyses, including various primer extension reactions and nucleic acid amplification reactions. | 01-12-2012 |
| 20120006376 | ELECTRICAL CONTACTS FOR SKUTTERUDITE THERMOELECTRIC MATERIALS - A thermally stable diffusion barrier for bonding skutterudite-based materials with metal contacts is disclosed. The diffusion barrier may be employed to inhibit solid-state diffusion between the metal contacts, e.g. titanium (Ti), nickel (Ni), copper (Cu), palladium (Pd) or other suitable metal electrical contacts, and a skutterudite thermoelectric material including a diffusible element, such as antimony (Sb), phosphorous (P) or arsenic (As), e.g. n-type CoSb | 01-12-2012 |
| 20120006085 | ELECTROMAGNETIC FORMING OF METALLIC GLASSES USING A CAPACITIVE DISCHARGE AND MAGNETIC FIELD - An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool in combination with an electromagnetic force generated by the interaction of the applied current with a transverse magnetic field. The RCDF method utilizes the discharge of electrical energy stored in a capacitor to uniformly and rapidly heat a sample or charge of metallic glass alloy to a predetermined “process temperature” between the glass transition temperature of the amorphous metal and the equilibrium melting point of the alloy in a time scale of several milliseconds or less, at which point the interaction between the electric field and the magnetic field generates a force capable of shaping the heated sample into a high quality amorphous bulk article via any number of techniques including, for example, injection molding, dynamic forging, stamp forging, and blow molding in a time scale of less than one second. | 01-12-2012 |
| 20120004562 | DYNAMIC MOTION CONTRAST AND TRANSVERSE FLOW ESTIMATION USING OPTICAL COHERENCE TOMOGRAPHY - The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale motion of scatterers associated with Brownian motion and other non-flow motion. The inventive method of calculating motion contrast from the phase variance can differentiate regions of different mobility based on the motion contrast differences, and can use the phase information to characterize mobility properties of the scatterers. In flow regions, the inventive method for acquiring and analyzing motion contrast can identify the regions as well as characterize the motion. Furthermore, the inventive method can determine quantitative flow estimation, the index of refraction variations, and absorption variations within flow regions. | 01-05-2012 |
| 20110319294 | STABLE, FUNCTIONAL CHIMERIC CELLOBIOHYDROLASE CLASS I ENZYMES - The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides. | 12-29-2011 |
| 20110316110 | ATOMIC LAYER DEPOSITION OF CHEMICAL PASSIVATION LAYERS AND HIGH PERFORMANCE ANTI-REFLECTION COATINGS ON BACK-ILLUMINATED DETECTORS - A back-illuminated silicon photodetector has a layer of Al | 12-29-2011 |
| 20110315636 | Soluble Anion Exchangers From Hyperbranched Macromolecules - Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve their binding capacity or selectivity with particular water contaminants such as bromide, nitrate, and sulfate. The macromolecules may be either recyclable or non-recyclable, and may be recovered or separated from water using means such as ultrafiltration, flocculation, or immobilization on a substrate. | 12-29-2011 |
| 20110313030 | PKR ACTIVATION VIA HYBRIDIZATION CHAIN REACTION - The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR via RNA-HCR can be used to treat a wide variety of diseases and disorders by specifically targeting diseased cells. | 12-22-2011 |
| 20110309974 | ANNIHILATION METHOD FOR GPS INTEGER AMBIGUITY WITH RESIDUAL PROBABILITY SCORING - A method of locating a first GPS receiver relative to a second GPS receiver. The method includes the steps of: providing a first and second GPS receiver, the first and second GPS receiver spaced apart by a distance D along a baseline; receiving a finite number of observables from a plurality of GPS satellites in a finite period of time; performing in a batch mode the following series of calculations on the finite number of observables: calculating a least squares estimate position for each of the first GPS receiver and the second GPS receiver; calculating a plurality of single difference residuals; calculating a plurality of double difference residuals; calculating an estimate of a geometry free solution; applying geometric annihilation to the geometry free solution; and calculating a least squares solution to provide a measurement of the distance D. A batch processing mode differential GPS apparatus is also described. | 12-22-2011 |
| 20110309267 | ITERATIVE TIME-REVERSAL ENHANCED TRANSMISSION SOLVING APPROACH - A method, apparatus, and article of manufacture for irradiating a sample with electromagnetic (EM) radiation. A number of passes of EM radiation through a sample are formed and/or selected, wherein the EM radiation in each of the passes comprises (1) input EM radiation incident on the sample, and (2) transmitted EM radiation exiting the sample formed from the input EM radiation that is transmitted through the sample. A phase conjugate of the transmitted EM radiation is used as the input EM radiation in a next pass of the EM radiation. The number of passes results in one or more EM fields of the input EM radiation having at least a threshold transmittance through the sample. | 12-22-2011 |
| 20110307647 | SYSTEMS AND METHODS FOR RAPID PROCESSING AND STORAGE OF DATA - Systems and methods of building massively parallel computing systems using low power computing complexes in accordance with embodiments of the invention are disclosed. A massively parallel computing system in accordance with one embodiment of the invention includes at least one Solid State Blade configured to communicate via a high performance network fabric. In addition, each Solid State Blade includes a processor configured to communicate with a plurality of low power computing complexes interconnected by a router, and each low power computing complex includes at least one general processing core, an accelerator, an I/O interface, and cache memory and is configured to communicate with non-volatile solid state memory. | 12-15-2011 |
| 20110306758 | METHOD AND MATERIALS FOR THE COOPERATIVE HYBRIDIZATION OF OLIGONUCLEOTIDES - A two-stranded intermediary complex and cooperative hybridization method are provided. The complex has been designed so that target oligonucleotides of independent sequence can cooperatively and simultaneously hybridize to it. The cooperative hybridization mechanism is robust and modular, smoothly integrating with other dynamic DNA components to form cascaded reaction networks that can perform a variety of functions. | 12-15-2011 |
| 20110306522 | MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY - The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth. | 12-15-2011 |
| 20110304022 | SURFACE PASSIVATION BY QUANTUM EXCLUSION USING MULTIPLE LAYERS - A semiconductor device has a multilayer doping to provide improved passivation by quantum exclusion. The multilayer doping includes a plurality M of doped layers, where M is an integer greater than 1. The dopant sheet densities in the M doped layers need not be the same, but in principle can be selected to be the same sheet densities or to be different sheet densities. M-1 interleaved layers provided between the M doped layers are not deliberately doped (also referred to as “undoped layers”). Structures with M=2, M=3 and M=4 have been demonstrated and exhibit improved passivation. | 12-15-2011 |
| 20110294206 | METHODS AND DESIGN OF MEMBRANE FILTERS - The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, drive pressure and filtration time. | 12-01-2011 |
| 20110288832 | SYSTEM AND METHOD FOR NUCLEIC ACID SEQUENCE DESIGN - Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium. | 11-24-2011 |
| 20110284744 | METHOD AND SYSTEM FOR 4D TOMOGRAPHY AND ULTRAFAST SCANNING ELECTRON MICROSCOPY - A 4D electron tomography system includes a stage having one or more degrees of freedom, an electron source, and electron optics operable to direct electron pulses to impinge on a sample supported on the stage. A pulse of the electron pulses impinges on the sample at a first time. The system also includes a laser system and optics operable to direct optical pulses to impinge on the sample. A pulse of the optical pulses impinges on the sample at a second time. The system further includes a detector operable to receive the electron pulses passing through the sample, a controller operable to independently modify an orientation of the stage and at least one of the first time or the second time, a memory operable to store sets of images, and a processor operable to form a 4D tomgraphic image set from the sets of images. | 11-24-2011 |
| 20110284648 | METHOD TO GENERATE MICRO SCALE GAS FILLED LIQUID BUBBLES AS TRACER PARTICLES OR INHALER MIST FOR DRUG DELIVERY - A method and apparatus that enables the production of micron-scale free-standing bubbles made of liquids containing surfactants are provided. The method and apparatus of the invention overcomes the limitations of conventional bubble forming techniques by using a controlled cavitation process in a liquid media. | 11-24-2011 |
| 20110275523 | METHODS AND KITS FOR ANALYZING POLYNUCLEOTIDE SEQUENCES - The present invention features methods for analyzing a sequence of a target polynucleotide by detecting incorporation of a nucleotide into its complementary strand, where the polynucleotides may be bound at high density and at single molecule resolution. The invention also features labeling moieties and blocking moieties, which facilitate chain termination or choking. Certain aspects provide for temporal detection of the incorporations; some allow for asynchronous analysis of a plurality of target polynucleotides and the use of short sequencing cycles. Surface chemistry aspects of the sequencing methods are also provided. The method may also be used in kits, said kits designed to carry out and facilitate the methods provided herein. | 11-10-2011 |
| 20110275062 | Systems And Methods For Integrating A Single DNA Molecule Into A Molecular Electronic Device - The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“SWNTs”) and integrating a single nucleic acid molecule (e.g., a DNA molecule) into a gap formed into the carbon nanotubes. In one aspect, a method of fabricating a molecular electronic device includes disposing a SWNT on a base layer, forming a gap in the SWNT using a lithographic process, and disposing a single DNA strand across the gap so that each end of the nucleic acid contacts a gap termini. The disclosed subject matter also provides techniques for measuring the electrical properties (charge transport) of a DNA molecule which is integrated into an SWNT. Furthermore, a molecular electronic device including an SWNT with an integrated nucleic acid molecule is disclosed. | 11-10-2011 |
| 20110260802 | PARAMETRIC FEEDBACK OSCILLATORS - A parametric feedback oscillator includes a resonator which has at least one transduction element and at least one electromechanical resonating element. The resonator is configured to accept as input a parametric excitation signal at a frequency | 10-27-2011 |
| 20110258716 | MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 - The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed. | 10-20-2011 |
| 20110256655 | LOW VOLTAGE LOW LIGHT IMAGER AND PHOTODETECTOR - Highly efficient, low energy, low light level imagers and photodetectors are provided. In particular, a novel class of Della-Doped Electron Bombarded Array (DDEBA) photodetectors that will reduce the size, mass, power, complexity, and cost of conventional imaging systems while improving performance by using a thinned imager that is capable of detecting low-energy electrons, has high gain, and is of low noise. | 10-20-2011 |
| 20110256104 | COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES - The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula: | 10-20-2011 |
| 20110250376 | SIMPLE METHOD FOR PRODUCING SUPERHYDROPHOBIC CARBON NANOTUBE ARRAY - The present invention provides efficient methods for producing a superhydrophobic carbon nanotube (CNT) array. The methods comprise providing a vertically aligned CNT array and performing vacuum pyrolysis on the CNT array to produce a superhydrophobic CNT array. These methods have several advantages over the prior art, such as operational simplicity and efficiency. The invention also relates to superhydrophobic CNT arrays. | 10-13-2011 |
| 20110234757 | SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING - A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object. | 09-29-2011 |
| 20110230370 | Discovery And Applications Of The Proteolytic Function of N-Terminal Acetylation Of Cellular Proteins - Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway. | 09-22-2011 |
| 20110229872 | Microfabricated Cell Sorter - The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis unit includes a main channel, having a sample inlet channel, typically at one end, and a detection region along a portion of its length. Adjacent and downstream from the detection region, the main channel has a discrimination region or branch point leading to at least two branch channels. The analysis unit may further include additional inlet channels, detection points, branch points, and branch channels as desired. A stream containing cells is passed through the detection region, such that on average one cell occupies the detection region at a given time. The cells can be sorted into an appropriate branch channel based on the presence or amount of a detectable signal such as an optical signal, with or without stimulation, such as exposure to light in order to promote fluorescence. | 09-22-2011 |
| 20110229759 | ELECTRODES INCORPORATING NANOSTRUCTURED POLYMER FILMS FOR ELECTROCHEMICAL ION STORAGE - Ion storage electrodes formed by coating an underlying substrate with a nanofibrillar film of structured conjugate polymer nanofibers and methods of forming such electrodes are described herein. The electrical properties of the electrodes may be customized by modifying the structure of the polymer nanofibers, the thickness of the nanofiber film, and the pore size of the nanofiber films. | 09-22-2011 |
| 20110226972 | Reflective Focusing and Transmissive Projection Device - Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a surface layer with first and second surfaces, and a detecting layer outside the second surface. The set of reflective-focusing components is in the surface layer. Each reflective-focusing component has a contouring element and a curved reflective element conformed to the contouring element. The curved reflective element is configured to reflect light of a first type, transmit light of a second type and focus the light of the first type outside the first surface of the surface layer. The light detector is in the detecting layer, and is configured to receive light and generate light data associated with the received light. Also, the contouring element can be configured to focus the light of the second type on the light detector. | 09-22-2011 |
| 20110222577 | In-Service Monitoring of Steam Pipe Systems at High Temperatures - A system and method for monitoring the properties of a fluid, such as water, in a steam pipe without mechanically penetrating the wall of the pipe. The system uses a piezoelectric transducer to launch an ultrasonic probe signal into the pipe. Reflected ultrasonic signals are captured in a transducer, which can be the same transducer that launched the probe signal. The reflected signals are subjected to data processing, which can include filtering, amplification, analog-to-digital conversion and autocorrelation analysis. A result is extracted which is indicative of a property of the fluid, such as a height of the condensed fluid, a cavitation of the condensed fluid, and a surface perturbation of the condensed fluid. The result can be recorded, displayed, and/or transmitted to another location. One embodiment of the system has been constructed and tested based on a general purpose programmable computer using instructions recorded in machine-readable non-volatile memory. | 09-15-2011 |
| 20110220792 | PHOTON INDUCED NEAR FIELD ELECTRON MICROSCOPE AND BIOLOGICAL IMAGING SYSTEM - A method of obtaining PINEM images includes providing femtosecond optical pulse, generating electron pulses, and directing the electron pulses towards a sample. The method also includes overlapping the femtosecond optical pulses and the electron pulses spatially and temporally at the sample and transferring energy from the femtosecond optical pulses to the electron pulses. The method further includes detecting electron pulses having an energy greater than a zero loss value, providing imaging in space and time. | 09-15-2011 |
| 20110217732 | METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION - The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes. | 09-08-2011 |
| 20110216804 | POLYMER NEMS FOR CELL PHYSIOLOGY AND MICROFABRICATED CELL POSITIONING SYSTEM FOR MICRO-BIOCALORIMETER - A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene. | 09-08-2011 |
| 20110212530 | METHOD OF TARGETED GENE DELIVERY USING VIRAL VECTORS - Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency. | 09-01-2011 |
| 20110210811 | INTEGRATED PASSIVE IRON SHIMS IN SILICON - A magnetic apparatus having at least one magnetic shim situated between faces of two permanent magnets. The magnetic shim helps to make the magnetic field that is accessible between the two permanent magnets a more uniform field. The magnetic shim is constructed on a thinned semiconductor wafer, such as silicon, by photolithographically defining locations on the wafer where magnetic material, such as iron or iron-nickel materials, are deposited. The shim can additional have photolihographically defined coil regions, in which conductive material such as copper can be deposited. Current contacts are provided to allow currents to be passed through the coil regions. Protective layers can be deposited to protect the deposited metals from mechanical or environmental damage. | 09-01-2011 |
| 20110209531 | DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATORAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT - Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC. | 09-01-2011 |
| 20110207923 | ISOMERIZATION OF SUGARS - Disclosed are processes for isomerizing saccharides. Also disclosed are processes for converting saccharides to furan derivatives. Also disclosed are processes for converting starch to furan derivatives. | 08-25-2011 |
| 20110205352 | HIGH RESOLUTION IMAGING DEVICES WITH WIDE FIELD AND EXTENDED FOCUS - Embodiments of the present invention relate to a high-resolution imaging device with wide field and extended focus comprising a beam generator for generating a plurality of nondiffracting beams and a scanning mechanism for moving the plurality of nondiffracting beams relative to the object to illuminate a volume of the object. The high-resolution imaging device also comprises surface element and a body having a light detector layer outside the surface element. The light detector layer has a light detector configured to measure light data associated with the plurality of nondiffracting beams illuminating the volume of the object. In some cases, the high-resolution imaging device also includes a lens inside of the light detector layer. The lens is configured to focus the light on the light detector surface. | 08-25-2011 |
| 20110205339 | NONDIFFRACTING BEAM DETECTION DEVICES FOR THREE-DIMENSIONAL IMAGING - Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light transmissive region, a microaxicon, and a light detector. The microaxicon receives light through the light transmissive region from outside the first surface and generates one or more detection nondiffracting beams based on the received light. The light detector receives the nondiffracting beams and generates three-dimensional image data associated with an object located outside the first surface based on the one or more detection nondiffracting beams received. In some cases, the light detector can localize a three-dimensional position on the object associated with each detection nondiffracting beam received. In other cases, the light detector can determine perspective projections based on the detection nondiffracting beams received and generates the three-dimensional image data, using tomography, based on the determined perspective projections. | 08-25-2011 |
| 20110203704 | BULK METALLIC GLASS MATRIX COMPOSITES - A method of forming bulk metallic glass engineering materials, and more particularly a method for forming coarsening microstructures within said engineering materials is provided. Specifically, the method forms ‘designed composites’ by introducing ‘soft’ elastic/plastic inhomogeneities in a metallic glass matrix to initiate local shear banding around the inhomogeneity, and matching of microstructural length scales (for example, L and S) to the characteristic length scale R | 08-25-2011 |
| 20110201009 | Microfabricated Crossflow Devices and Methods - A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix. Biological material within the droplets can be analyzed and/or sorted by detecting a predetermined characteristic of the biological sample in each droplet and sorting the droplet accordingly. | 08-18-2011 |
| 20110196651 | Sensor Web - A Sensor Web formed of a number of different sensor pods. Each of the sensor pods include a clock which is synchronized with a master clock so that all of the sensor pods in the Web have a synchronized clock. The synchronization is carried out by first using a coarse synchronization which takes less power, and subsequently carrying out a fine synchronization to make a fine sync of all the pods on the Web. After the synchronization, the pods ping their neighbors to determine which pods are listening and responded, and then only listen during time slots corresponding to those pods which respond. | 08-11-2011 |
| 20110195901 | ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 08-11-2011 |
| 20110193942 | Single-Lens, Single-Aperture, Single-Sensor 3-D Imaging Device - A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens having a substantially oblong aperture, a sensor operable for capturing light transmitted from an object through the lens and the substantially oblong aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. The aperture may have an asymmetrical shape for distinguishing objects in front of versus in back of the focal plane. The aperture may also be rotatable, where the orientation of the observed pattern relative to the oblong aperture is varied with time thereby removing the ambiguity generated by image overlap. The disclosed device further comprises a light projection system configured to project a predetermined pattern onto a surface of the desired object thereby allowing for mapping of unmarked surfaces in three dimensions. | 08-11-2011 |
| 20110182864 | COMPOSITIONS CONTAINING INCLUSION COMPLEXES - The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula: | 07-28-2011 |
| 20110181884 | OPTOFLUIDIC MICROSCOPE DEVICE WITH PHOTOSENSOR ARRAY - Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices. | 07-28-2011 |
| 20110177499 | Methods and Systems for Molecular Fingerprinting - This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device that analyzes the polynucleotides according to restriction fragment length polymorphism. In a microfabricated device according to the invention, DNA fragments or other molecules can be rapidly and accurately typed using relatively small samples, by measuring for example the signal of an optically-detectable (e.g., fluorescent) reporter associated with the polynucleotide fragments. | 07-21-2011 |
| 20110176577 | SUPERPIXEL MULTI-WAVEBAND PHOTODETECTOR ARRAY FOR REMOTE TEMPERATURE MEASUREMENT - A multi-waveband temperature sensor array, in which each superpixel (e.g., 2×2 pixel cell) operates at a distinct thermal infrared (IR) waveband (e.g. four wavebands) is disclosed. Using an example high spatial resolution, four-band thermal IR band photodetector array, accurate temperature measurements on the surface of an object can be made without prior knowledge of the object emissivity. The multiband photodetector may employ intersubband transition in III-V semiconductor-based quantum layered structures where each photodetector stack absorbs photons within the specified wavelength band while allowing the transmission of photons in other spectral bands, thus efficiently permitting multiband detection. This produces multiple, spectrally resolved images of a scene that are recorded simultaneously in a single snapshot of the FPA. From the multispectral images and calibration information about the system, computational algorithms are used to produce the surface temperature map of a target. | 07-21-2011 |
| 20110175602 | INDUCTORS WITH UNIFORM MAGNETIC FIELD STRENGTH IN THE NEAR-FIELD - An integrated inductor includes a plurality of coils. Each of the plurality of coils is electromagnetically coupled together to form an inductor between a first inductor terminal and a second inductor terminal. At least one of the plurality of coils is disposed in a layer on an integrated structure and at least another of one of the plurality of coils disposed in a layer of the integrated structure. One of the plurality of coils is spaced with respect to another of the plurality of coils to cause a substantially uniform magnetic field strength across a surface of the integrated inductor. An integrated magnetic particle sensor system, an integrated inductor having a section having a different width than another section, an integrated inductor having at least one gradual transition section, and an integrated inductor having at least one floating metal structure are also described. | 07-21-2011 |
| 20110174964 | CONTINUOUS FLOW MOBILITY CLASSIFIER INTERFACE WITH MASS SPECTROMETER - A continuous flow mobility classifier provide the ability to perform two-dimensional separation in mass spectrometry. An ionization system is used to ionize a sample. A differential mobility analyzer (DMA) (e.g., a nano-radial DMA) is coupled to the ionization system and to a mass spectrometer. The nano-RDMA is configured to separate the ionized sample by mobility for subsequent mass analysis by the mass spectrometer. | 07-21-2011 |
| 20110171107 | SYSTEM FOR HALTING THE INCREASE IN ATMOSPHERIC CARBON DIOXIDE AND METHOD OF OPERATION THEREOF - A system and method for collecting carbon dioxide present in the terrestrial atmosphere and sequestering the carbon dioxide. A renewable energy source, such as a wind turbine, provides electrical power without generating carbon dioxide emissions. The electricity is used to electrolyze seawater, providing a cathodic solution enriched in NaOH. By aeration of the cathodic solution, carbon dioxide is captured as Na | 07-14-2011 |
| 20110170237 | LOW TEMPERATURE DOUBLE-LAYER CAPACITORS USING ASYMMETRIC AND SPIRO-TYPE QUATERNARY AMMONIUM SALTS - Double-layer capacitors capable of operating at extremely low temperatures (e.g., as low as −80° C.) are disclosed. Electrolyte solutions combining a base solvent (e.g., acetonitrile) and a cosolvent are employed to lower the melting point of the base electrolyte. Example cosolvents include methyl formate, ethyl acetate, methyl acetate, propionitrile, butyronitrile, and 1,3-dioxolane. A quaternary ammonium salt including at least one of triethylmethylammonium tetrafluoroborate (TEMATFB) and spiro-(1,1′)-bipyrrolidium tetrafluoroborate (SBPBF | 07-14-2011 |
| 20110170100 | Single-Lens 3-D Imaging Device Using Polarization Coded Aperture Masks Combined with Polarization Sensitive Sensor - A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, at least one polarization-coded aperture obstructing the lens, a polarization-sensitive sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the at least one polarization-coded aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. | 07-14-2011 |
| 20110169160 | REAL TIME MONITORING OF INDIUM BUMP REFLOW AND OXIDE REMOVAL ENABLING OPTIMIZATION OF INDIUM BUMP MORPHOLOGY - A method, apparatus, system, and device provide the ability to form one or more solder bumps on one or more materials. The solder bumps are reflowed. During the reflowing, the solder bumps are monitored in real time. The reflow is controlled in real time, thereby controlling a morphology of each of the solder bumps. Further, the wetting of the solder bumps to a surface of the materials is controlled in real time. | 07-14-2011 |
| 20110169119 | METHODS TO FABRICATE AND IMPROVE STAND-ALONE AND INTEGRATED FILTERS - Embodiments of the invention provide for fabricating a filter, for electromagnetic radiation, in at least three ways, including (1) fabricating integrated thin film filters directly on a detector; (2) fabricating a free standing thin film filter that may be used with a detector; and (3) treating an existing filter to improve the filter's properties. | 07-14-2011 |
| 20110165540 | GAMES HAVING BIOTECHNOLOGICAL CONTENT - Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically active materials are disclosed. The game apparatus includes a replaceable cartridge having a chamber in which a biologically active component such as a single-celled organism or a biologically active compound is contained. A stimulus controller accepts instructions from a human user and provides a stimulus to the biologically active component. A response receiver accepts a signal indicative of a response of the biologically active component. A display is provided to display to the user information indicative of the response of the biologically active component, and a game score. A computer-based game controller includes a set of pre-defined rules of play that define a game and that comprise pre-defined rules of scoring for the game. | 07-07-2011 |
| 20110159241 | ADHESIVE TAPE WITH ADHESION ENHANCEMENT AND DIRECTIONALITY BY MATERIAL, STRUCTURAL, AND ADHESIVE HETEROGENEITY - An adhesive system with material and structural heterogeneity is described. The adhesive system comprises a tape having a spatially heterogeneous physical property, the spatially heterogeneous physical property is configured to enhance the adhesive strength of the adhesive system when the adhesive system is in contact with a substrate and/or attain adhesion directionality. The spatially heterogeneous physical property can include a bending stiffness. Heterogeneous variations in the bending stiffness can be achieved by variations in the tape's thickness, elastic modulus and/or Poisson's ratio. Heterogeneity in thickness can be attained by mold pressing and/or patterned laminated structures. Elastic modulus heterogeneity can be achieved by masked irradiation of the tape, where the tape is made of an irradiation-sensitive material. Also described is an adhesive system with a patterned film that exhibits adhesion directionality when the adhesive system is in contact with a substrate. | 06-30-2011 |
| 20110151499 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 06-23-2011 |
| 20110151498 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 06-23-2011 |
| 20110144190 | METHOD OF PREPARING A SUPRAMOLECULAR COMPLEX CONTAINING A THERAPEUTIC AGENT AND A MULTI-DIMENSIONAL POLYMER NETWORK - A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents. | 06-16-2011 |
| 20110143944 | LINEAR CYCLODEXTRIN COPOLYMERS - Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents. | 06-16-2011 |
| 20110140772 | SELF-HEALING POWER AMPLIFIER: METHODS AND APPARATUS - An integrated power amplifier includes a divider and a combiner. The integrated power amplifier also includes two or more amplifiers. Each of the amplifier input terminals is electrically coupled to a divider output terminal and each of the amplifier output terminals is electrically coupled to a combiner input terminal. At least one power sensor is configured to provide a power amplifier performance metric. The divider and the combiner include a plurality of actuators. Each actuator has at least one actuator control terminal which is configured to provide an actuator setting. The actuators are configured via the actuator control terminals to optimize the power amplifier performance metric. Methods to simulate the operation of a self-healing power amplifier and a process for the operation of a self-healing circuit are also described. | 06-16-2011 |
| 20110140246 | DELTA-DOPING AT WAFER LEVEL FOR HIGH THROUGHPUT, HIGH YIELD FABRICATION OF SILICON IMAGING ARRAYS - Systems and methods for producing high quantum efficiency silicon devices. A silicon MBE has a preparation chamber that provides for cleaning silicon surfaces using an oxygen plasma to remove impurities and a gaseous (dry) NH | 06-16-2011 |
| 20110134521 | DUAL-MODE RASTER POINT SCANNING/LIGHT SHEET ILLUMINATION MICROSCOPE - An apparatus for and method of performing light sheet microscopy (LISH) and light scanning microscopy (RAPS) in a single device are provided. The dual-mode imaging microscope allows for the use of both LISH and RAPS in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples. In addition, the device will reduce the high costs and space requirements associated with owning two different microscopes (LISH and RAPS). | 06-09-2011 |
| 20110124868 | RUTHENIUM OLEFIN METATHESIS CATALYSTS BEARING N-HETEROCYCLIC CARBENE LIGANDS WITH SUBSTITUTED BACKBONE - This invention relates generally to olefin metathesis, more particularly, to tri- or tetra-substituted imidazolinium salts which are precursors to N-heterocyclic carbene (NHC) ligands with tri- or tetra-substituted imidazolinium rings, organometallic ruthenium complexes comprising gem di-substituted imidazolinium NHC ligands, organometallic ruthenium complexes comprising tri- or tetra-substituted imidazolinium NHC ligands, and to olefin metathesis methods using them. The catalysts and methods of the invention have utility in the fields of catalysis, organic synthesis, and industrial chemistry. | 05-26-2011 |
| 20110122488 | MULTIPLE-PHOTON EXCITATION LIGHT SHEET ILLUMINATION MICROSCOPE - An apparatus for and method of performing multi-photon light sheet microscopy (MP-LISH), combining multi-photon excited fluorescence with the orthogonal. illumination of light sheet microscopy are provided. With live imaging of whole | 05-26-2011 |
| 20110122416 | TURBIDITY SUPPRESSION BY OPTICAL PHASE CONJUGATION USING A SPATIAL LIGHT MODULATOR - A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light. | 05-26-2011 |
| 20110115482 | ULTRASENSITIVE DETECTION PLATFORM FOR SENSING MAGNETIC AND/OR ELECTRICAL ENERGY CHANGE - A scalable and ultrasensitive frequency-shift magnetic array scheme. The theoretical limit of the sensor noise floor is shown to be dominated by the phase noise of the sensing oscillators. To increase the sensitivity, a noise suppression technique, Correlated Double Counting (CDC), is described with no power overhead. As an implementation example, a 64-cell sensor array is designed in a standard 65 nm CMOS process. The CDC scheme achieves an additional 6 dB noise suppression. The magnetic sensing capability of the presented sensor is verified by detecting micron size magnetic particles with an SNR of 14.6 dB for a single bead and an effective dynamic range of at least 74.5 dB. Applications in biosensing are contemplated, among other possible uses. Measurement of electrical properties is also contemplated. | 05-19-2011 |
| 20110111412 | Uses of Parylene Membrane Filters - The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes. | 05-12-2011 |
| 20110109962 | OPTICAL PHASE CONJUGATION 4 PI MICROSCOPE - A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point. | 05-12-2011 |
| 20110108707 | ACOUSTIC ASSISTED PHASE CONJUGATE OPTICAL TOMOGRAPHY - A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample. | 05-12-2011 |
| 20110104676 | HYBRIDIZATION CHAIN REACTION AMPLIFICATION FOR IN SITU IMAGING - The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of interest and an initiator region that is able to initiate polymerization of nucleic acid monomers. After contacting a sample with the probe, labeled monomers are provided that form a tethered polymer. Triggered probes and self-quenching monomers can be used to provide active background suppression. | 05-05-2011 |
| 20110094765 | PERCUSSIVE AUGMENTER OF ROTARY DRILLS FOR OPERATING AS A ROTARY-HAMMER DRILL - A percussive augmenter bit includes a connection shaft for mounting the bit onto a rotary drill. In a first modality, an actuator percussively drives the bit, and an electric slip-ring provides power to the actuator while being rotated by the drill. Hammering action from the actuator and rotation from the drill are applied directly to material being drilled. In a second modality, a percussive augmenter includes an actuator that operates as a hammering mechanism that drives a free mass into the bit creating stress pulses that fracture material that is in contact with the bit. | 04-28-2011 |
| 20110087032 | PREPARATION OF SATURATED IMIDAZOLINIUM SALTS AND RELATED COMPOUNDS - Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaloethane and an optional base are disclosed. Alternatively, the imidazolinium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields. | 04-14-2011 |
| 20110085219 | Holographically Illuminated Imaging Devices - Embodiments of the present invention relate to holographically illuminated imaging devices including a holographic element for transforming an illumination beam into a focal array of light spots, a scanning mechanism for moving an object across one or more light spots in the focal array of light spots, and a light detector for detecting light associated with the focal array of light spots and generating light data associated with the received light. | 04-14-2011 |
| 20110074932 | Accurate 3D Object Reconstruction Using a Handheld Device with a Projected Light Pattern - A lens and aperture device for determining 3D information. A projector projects an optical pattern toward a surface. The camera has at least two off-axis apertures thereon, arranged to obtain an image of the projected pattern including defocused information. The camera is movable between different positions to image the surface from said different positions, and the projector is at a specified angle of at least 5° relative to said camera. A processor carries out a first operation using information received through the apertures to determine a pose of said camera, and to determine three dimensional information about the object based on a degree of deformation of said optical pattern on said surface indicative of a three dimensional surface. An embodiment projects a grid of laser dots and uses laser-dot defocusing for approximate Z and thus grid correspondence, which can greatly increase the working depth of the system. | 03-31-2011 |
| 20110063623 | ON-CHIP PHASE MICROSCOPE/BEAM PROFILER BASED ON DIFFERENTIAL INTERFERENCE CONTRAST AND/OR SURFACE PLASMON ASSISTED INTERFERENCE - A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector. | 03-17-2011 |
| 20110059531 | METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL - The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated. | 03-10-2011 |
| 20110058740 | METHOD AND SYSTEM FOR FAST THREE-DIMENSIONAL IMAGING USING DEFOCUSING AND FEATURE RECOGNITION - Described is a method and system for fast three-dimensional imaging using defocusing and feature recognition is disclosed. The method comprises acts of capturing a plurality of defocused images of an object on a sensor, identifying segments of interest in each of the plurality of images using a feature recognition algorithm, and matching the segments with three-dimensional coordinates according to the positions of the images of the segments on the sensor to produce a three-dimensional position of each segment of interest. The disclosed imaging method is “aware” in that it uses a priori knowledge of a small number of object features to reduce computation time as compared with “dumb” methods known in the art which exhaustively calculate positions of a large number of marker points. | 03-10-2011 |
| 20110057712 | SELF-HEALING TECHNIQUE FOR HIGH FREQUENCY CIRCUITS - A self-healing monolithic integrated includes an electronic circuit having a plurality of transistors. At least one sensor is disposed within and electrically coupled to the electronic circuit and configured to sense a performance metric of the electronic circuit. A plurality of actuators is disposed within the circuit. Each actuator of the plurality of actuators has electrically coupled to it a control terminal. The plurality of actuators is configured to perform a selected one of, electrically coupling at least one transistor of the plurality of transistors into the electronic circuit and electrically de-coupling at least one transistor of the plurality of transistors, in response to operation of one of the control terminals to improve the performance metric. | 03-10-2011 |
| 20110057682 | Electronic self-healing methods for radio-frequency receivers - Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective action can be the application of a correction signal or a modification of one or more parameters or characteristics of an element in the circuit. The calculated corrective action, if needed, is applied to bring the operational parameters or characteristics of the circuit or device within the desired range. Optionally, the operational parameters or characteristics of the circuit or the device after the correction is effectuated can be checked. | 03-10-2011 |
| 20110057653 | NEW TECHNIQUE FOR PERFORMING DIELECTRIC PROPERTY MEASUREMENTS AT MICROWAVE FREQUENCIES - A method, system, apparatus, and computer readable medium has been provided with the ability to obtain a complex permittivity ∈ or a complex permeability μ of a sample in a cavity. One or more complex-valued resonance frequencies (f | 03-10-2011 |
| 20110057164 | CARBON NANOTUBE FIELD EMISSION DEVICE WITH OVERHANGING GATE - A carbon nanotube field emission device with overhanging gate fabricated by a double silicon-on-insulator process. Other embodiments are described and claimed. | 03-10-2011 |
| 20110056713 | SINGLE PIEZO-ACTUATOR ROTARY-HAMMERING (SPARH) DRILL - A Single Piezo-Actuator Rotary-Hammering (SPaRH) Drill includes a horn actuator having high power piezoelectric materials and a flexure pre-stress to increase the actuators effectiveness. The drill is a low mass, low power, compact coring drill measuring 20-cm high by 7-cm diameter and having a total weight of 2 kg including drive electronics. Using an average power of 50-Watts, the drill basalt is expected to cut basalt at a rate of 0.2 cm/min down to depth of 10-cm and create cuttings and an intact core. The drill is expected to operate under different environments including Martian ambient (6 Torr and down to −50° C.), and liquid nitrogen temperatures (77 K) and low pressure (<<1 Torr) to simulate lunar polar and Europa conditions. Materials expected to be sampled include Kaolinite, Saddleback Basalt, Limestone, Volcanic Breccia, Siltstone, ice, permafrost and layered rocks with different hardness. | 03-10-2011 |
| 20110053152 | METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS - The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications. | 03-03-2011 |
| 20110047047 | METHOD AND APPARATUS FOR PROVIDING A MARKET ENVIRONMENT - The system provides two-sided local markets that enable local and/or intermittent resource allocation through a market model. The system provides a method for defining goods, services or assets are to be exchanged among a large but limited number of participants (e.g. between 10 and 100). In one embodiment, all participants may have both needs and endowments of the goods, services and assets to be traded and who may at times want to simultaneously buy and sell multiple units. Alternatively the market may have participants who are either sellers or buyers. The system provides a market mechanism where participants can submit orders (through limit orders and market orders) in user defined time frames. | 02-24-2011 |
| 20110037832 | Defocusing Feature Matching System to Measure Camera Pose with Interchangeable Lens Cameras - A lens and aperture device for determining 3D information. An SLR camera has a lens and aperture that allows the SLR camera to determine defocused information. | 02-17-2011 |
| 20110024617 | SWITCHED FERROELECTRIC PLASMA IONIZER - A novel ion source for ambient mass spectrometry (switched ferroelectric plasma ionizer or “SwiFerr”), which utilizes the ambient pressure plasma resulting from a sample of barium titanate [001] whose polarization is switched by an audio frequency electric field. High yields of both anions and cations are produced by the source and detected using an ion trap mass spectrometer. Protonated amines and deprotonated volatile acid species, respectively, are detected in the observed mass spectra. Aerodynamic sampling is employed to analyze powders of drug tablets of loperamide and ibuprofen. A peak corresponding to the active pharmaceutical ingredient for each drug is observed in the mass spectra. Pyridine is detected at concentrations in the low part-per-million range in air. The low power consumption of the source is consistent with incorporation into field portable instrumentation for detection of hazardous materials and trace substances in a variety of different applications. | 02-03-2011 |
| 20110020359 | METHODS AND COMPOSITIONS FOR TREATING NEURONAL DAMAGE OR DEGENERATION - This invention provides methods and compositions for reducing chondroitin-sulfate-proteoglycan-mediated inhibition of neuronal growth. The methods and compositions provided herein are particularly useful for treatment of neuronal damage or degeneration. | 01-27-2011 |
| 20110014659 | ISOLATION OF UNKNOWN REARRANGED T-CELL RECEPTORS FROM SINGLE CELLS - Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains. | 01-20-2011 |
| 20110008828 | METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS - The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs. | 01-13-2011 |
| 20110004096 | ELECTROMAGNETIC CELLULAR TOMOGRAPHY - The invention provides an electromagnetic cellular tomograph and methods of operating such a device. An array of structures is configured to apply probe signals to cells or tissues of interest that are held in a sample holder. The array also includes structures that can receive a response signal from the sample of interest. Data processing and control circuits are provided to manipulate and analyze the response and to allow the result to be recorded, transmitted to other data systems, or displayed to a user. | 01-06-2011 |
| 20110003683 | NANOSTRUCTURED PLATINUM ALLOYS FOR USE AS CATALYST MATERIALS - A series of binary and ternary Pt-alloys, that promote the important reactions for catalysis at an alloy surface; oxygen reduction, hydrogen oxidation, and hydrogen and oxygen evolution. The first two of these reactions are essential when applying the alloy for use in a PEMFC. | 01-06-2011 |
| 20110001980 | OPTICAL PHASE PROCESSING IN A SCATTERING MEDIUM - An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium. | 01-06-2011 |
| 20110001392 | HIGHLY EFFICIENT, CHARGE DEPLETION-MEDIATED, VOLTAGE-TUNABLE ACTUATION EFFICIENCY AND RESONANCE FREQUENCY OF PIEZOELECTRIC SEMICONDUCTOR NANOELECTROMECHANICAL SYSTEMS RESONATORS - A nanoelectromechanical systems (NEMS) device and method for using the device provide for a movable member that includes a region of low conductivity over which an electric field is developed. A region width is within a factor of ten (10) of a thickness of the NEMS device. The region is formed between a junction that incorporates piezoelectric material. A first voltage is applied across the region which alters a width of an active portion of the region thereby adjusting a movement of the movable member induced by a second voltage. The second voltage is applied across the region to produce a strain on the active portion of the region. The strain results in a defined movement of the movable member. | 01-06-2011 |
| 20100331976 | PROSTHETIC DEVICES AND METHODS AND SYSTEMS RELATED THERETO - Prosthetic devices, methods and systems are disclosed. Eye position and/or neural activity of a primate are recorded and combined. The combination signal is compared with a predetermined signal. The result of the comparison step is used to actuate the prosthetic device. | 12-30-2010 |
| 20100330455 | ADVANCED SOLID ACID ELECTROLYTE COMPOSITES - Solid acid/surface-hydrogen-containing secondary component electrolyte composites, methods of synthesizing such materials, electrochemical device incorporating such materials, and uses of such materials in fuel cells, membrane reactors and hydrogen separations are provided. The stable electrolyte composite material comprises a solid acid component capable of undergoing rotational disorder of oxyanion groups and capable of extended operation at a wide temperature range and a secondary compound with surface hydrogen atoms, which when intimately mixed, results in a composite material with improved conductivity, mechanical and thermal properties, when compared to pure solid acid compound. | 12-30-2010 |
| 20100319746 | HIGH EFFICIENCY THERMOELECTRIC POWER GENERATION USING ZINTL-TYPE MATERIALS - The invention disclosed herein relates to thermoelectrically-active p-type Zintl phase materials as well as devices utilizing such compounds. Such thermoelectric materials and devices may be used to convert thermal energy into electrical energy, or use electrical energy to produce heat or refrigeration. Embodiments of the invention relate to p-type thermoelectric materials related to the compound Yb | 12-23-2010 |
| 20100316172 | INCOMPRESSIBLE RF RECEIVER - An incompressible receiver for minimizing undesired higher-order nonlinear distortion products includes a first receiver path configured to receive an input signal having at least one non-baseband frequency. A second receiver path is also configured to receive the input signal. The second receiver path includes at least one odd-order nonlinear distortion reference component and at least one even-order nonlinear distortion reference component. The distortion reference components are configured to be in an “on” state or in an “off” state. A combining element is configured to combine input signals from the first and second receiver paths such that the higher-order nonlinear distortion signals are substantially attenuated at an output of the combining element. An incompressible receiver that has an odd-order nonlinear distortion reference generator including a cubic term and at least one additional term of order greater than 3 and an incompressible receiver front end amplifier (IRFEA) are also described. | 12-16-2010 |
| 20100307551 | FABRICATION OF HIGH-TEMPERATURE THERMOELECTRIC COUPLE - The present invention relates to a high-temperature thermoelectric couple and the method for making the same. The method requires a very small number of fabrication steps. It includes an act of fabricating an n-type leg that, in a stacked configuration, includes a low electrical contact resistance metallization foil that is connected to each of the two sides of Lanthanum Telluride via a thin metallic adhesion layer. Additionally, a p-type leg is fabricated that, in a stacked configuration, includes a low electrical contact resistance metallization foil that is connected to each of the two sides of 14-1-11 Zintl. Finally, CTE-matched, low electrical and thermal resistance plate interconnects are used for each of the two legs to interface with the heat source and heat sink and form an electrical connection. | 12-09-2010 |
| 20100304464 | STABLE, FUNCTIONAL CHIMERIC CELLOBIOHYDROLASES - The present disclosure relates to CBH II chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides. | 12-02-2010 |
| 20100300148 | TOUGH IRON-BASED BULK METALLIC GLASS ALLOYS - A family of iron-based, phosphor-containing bulk metallic glasses having excellent processibility and toughness, methods for forming such alloys, and processes for manufacturing articles therefrom are provided. The inventive iron-based alloy is based on the observation that by very tightly controlling the composition of the metalloid moiety of the Fe-based, P-containing bulk metallic glass alloys it is possible to obtain highly processable alloys with surprisingly low shear modulus and high toughness. | 12-02-2010 |
| 20100294041 | MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS - A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure. | 11-25-2010 |
| 20100291385 | FABRICATION OF VERTICALLY ALIGNED METALLIC NANOPILLARS - Solid and hollow cylindrical nanopillars with nanoscale diameters are provided. Also provides is a method of making such nanopillars using electron beam lithography followed by the electroplating. | 11-18-2010 |
| 20100290049 | OPTOFLUIDIC MICROSCOPE DEVICE - An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging elements in the bottom of the fluid channel may be used to image the object. | 11-18-2010 |
| 20100287822 | ASSOCIATIVE POLYMERS FOR MIST-CONTROL - Polymeric mist control materials, methods of forming polymeric mist control materials, and methods of using such materials for mist control are provided. The polymeric mist control additives are formed of molecules comprised predominantly of monomers that confer high solubility in fuel and include associative groups that attract each other in donor-acceptor manner, and are incorporated such that multiple associative groups are in close proximity (“clusters”), such that the clusters are separated by very long non-associative sequences. | 11-18-2010 |
| 20100283502 | ASYNCHRONOUS NANO-ELECTRONICS - Asynchronous nanoelectronic circuits that operate according to principles of quasi-delay insensitive design are described. Circuit or logic elements comprising n-type devices are fabricated in a first n-plane, p-type devices are fabricated in a p-plane, and connections are formed in a routing plane of a compute tile. A state-holding element comprising a selected one of a C-element, a precharge function-block, and a read-write register is described. The state-holding element can hold a value of an output of a logic element during a time when the output is disconnected from a reference voltage. Isochronic forks having an adversary path designed to make state transitions safe are explained. | 11-11-2010 |
| 20100281963 | NANOINDENTER TIP FOR UNIAXIAL TENSION AND COMPRESSION TESTING - The invention is an indenter tip that is modified to permit both compression testing and tensile testing on samples having dimensions smaller than approximately 1 μm. The modified indenter tip has both a surface that can be used to apply compressive forces, and tines that can be used to engage a free end of a specimen to be tested in tension. The apparatus used to perform the tests includes elements of a scanning electron microscope that permit visualization of the specimen to be tested and the modified indenter tip, so as to permit appropriate alignment and engagement of the same. The apparatus also includes elements of a microindenter that provide mechanical manipulation of the relative position and orientation of the modified indenter tip and of the specimen to be tested, as well as the necessary controls and instrumentation to perform the test and to collect, record and manipulate data. | 11-11-2010 |
| 20100280756 | HIGH RESOLUTION WIND MEASUREMENTS FOR OFFSHORE WIND ENERGY DEVELOPMENT - A method, apparatus, system, article of manufacture, and computer readable storage medium provide the ability to measure wind. Data at a first resolution (i.e., low resolution data) is collected by a satellite scatterometer. Thin slices of the data are determined. A collocation of the data slices are determined at each grid cell center to obtain ensembles of collocated data slices. Each ensemble of collocated data slices is decomposed into a mean part and a fluctuating part. The data is reconstructed at a second resolution from the mean part and a residue of the fluctuating part. A wind measurement is determined from the data at the second resolution using a wind model function. A description of the wind measurement is output. | 11-04-2010 |
| 20100267169 | ELECTROMAGNETIC MOLECULAR SENSORS AND METHODS OF USING SAME - Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors, and a binding moiety. The device can include an electromagnetic material that can be detected by the detector. The device is configured such that binding of an analyte to the binding moiety changes the relationship between the electromagnetic detector and the electromagnetic material such that a change in electromagnetic field is detected by the electromagnetic detector. | 10-21-2010 |
| 20100267146 | METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL - In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. | 10-21-2010 |
| 20100265680 | Pocket-enabled chip assembly for implantable devices - Systems and methods for providing biologically compatible pockets or envelopes that can contain chips and other circuit elements and can make electrical connection between those elements and living organisms. The assembled biologically compatible pockets and circuit components can have biomedical applications, such as bioimplantable devices such as retinal, cochlear and cortical prosthesis implants, muscular stimulators, and other uses. In various embodiments, the described technology explains how to make and use pocket systems for dealing with chips having connectors on one or two surfaces, and with other circuit components such as resistors, capacitors, inductors and transistors. Operation of chips encapsulated according to the described technology is demonstrated. Accelerated life testing suggests that the pocket systems described will survive for years at 37 degrees C. | 10-21-2010 |
| 20100263732 | Microfluidic Free Interface Diffusion Techniques - A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays. | 10-21-2010 |
| 20100261652 | Tissue Adhesive Using Engineered Proteins - There is provided in one embodiment of the disclosure a tissue adhesive composition comprising an engineered protein having repeated blocks of an elastin domain and at least one cell-binding domain and further comprising a polymer crosslinker. When the engineered protein and the polymer crosslinker are introduced onto a tissue, the engineered protein and the polymer crosslinker initiate an in situ crosslinking reaction to form an adhesive bond that is mechanically strong, transparent, biocompatible, and stimulates regrowth of one or more tissue layers over the adhesive bond. In another embodiment of the disclosure there is provided a molded corneal onlay and method of making the same. | 10-14-2010 |
| 20100261228 | MULTIPLEXED SITES FOR POLYMER SYNTHESIS - Disclosed herein are methods, devices, and other components for synthesizing polymers. In some embodiments, numerous sites can be multiplexed together to allow for effective nucleic acid synthesis. | 10-14-2010 |
| 20100258785 | Superlattice nanopatterning of wires and complex patterns - Fabrication of metallic or non-metallic wires with nanometer widths and nanometer separation distances without the use of lithography. Wires are created in a two-step process involving forming the wires at the desired dimensions and transferring them to a planar substrate. The dimensions and separation of the wires are determined by the thicknesses of alternating layers of different materials that are in the form of a superlattice. Wires are created by evaporating the desired material onto the superlattice that has been selectively etched to provide height contrast between layers. The wires thus formed upon one set of superlattice layers are then transferred to a substrate. | 10-14-2010 |
| 20100255545 | INTEGRATED - LIGAND-RESPONSIVE MICRORNAS - The present application relates to nucleic acids that encode an miRNA and a sensor domain that can respond to a ligand. In some embodiments, the sensor domain is an RNA aptamer that modulates processing of the miRNA by an RNA processing enzyme, for example, Drosha. | 10-07-2010 |
| 20100255542 | POLYPEPTIDES HAVING CELLULASE ACTIVITY - The present disclosure relates to CBH II chimera fusion polypetides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides. | 10-07-2010 |
| 20100248327 | CYTOCHROME P450 OXYGENASES - Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3. | 09-30-2010 |
| 20100247433 | Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells - The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc. | 09-30-2010 |
| 20100245844 | 3-Dimensional Imaging by Acoustic Warping and Defocusing - The present invention relates to a system for three-dimensional (3-D) acoustic imaging of a scattering structure using information from a two-dimensional (2-D) image. The system uses a characterized sensor array to emit a signal from the sensor array into an object of interest to generate at least one 2-D representation of the object of interest. The 2-D representation comprises a plurality of x and y coordinate pairs and at least one candidate scattering structure. The candidate scattering structure comprises a shape defined by at least one pair of x and y coordinates. The candidate scattering structure shape is restricted to at least one pair of x and y coordinates. The pair of x and y coordinates of the candidate scattering structure shape are then compared with a first coordinate-dependent response function to assign an x, y, and z position of a scattering structure in 3-D space. | 09-30-2010 |
| 20100245100 | NOISE SUPPRESSION TECHNIQUES IN HIGH PRECISION LONG-TERM FREQUENCY/TIMING MEASUREMENTS - A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one target source is communicatively coupled to the reference source. A frequency timing measurement block has a first input terminal electrically coupled to the reference source output terminal. A second input terminal is electrically coupled to the target source output terminal and at least one output terminal. The frequency timing measurement block is configured to perform a noise shaping technique to reduce measurement error attributable to a phase noise that is correlated between the reference source and the target source, and to provide a reduced correlated noise measurement at the at least one output terminal. A method to reduce correlated noise is also described. | 09-30-2010 |
| 20100243018 | METALLIZATION FOR ZINTL-BASED THERMOELECTRIC DEVICES - A thermoelectric power generation device using molybdenum metallization to a Zintl thermoelectric material in a thermoelectric power generation device operating at high temperature, e.g. at or above 1000° C., is disclosed. The Zintl thermoelectric material may comprise Yb | 09-30-2010 |
| 20100241213 | Impedance Pump Used in Bypass Grafts - A pump installed inside a graft in a body such as the human body to force fluid such as blood through that graft. The pump can be one which operates totally from the outside of the graft, forcing fluid through the graft without extending inside the graft. The pump can be an impedance pump, that operates based on the fluidic mismatches between the graft, and other fluid carrying vessels within the human body. | 09-23-2010 |
| 20100241015 | OPTICAL SYSTEMS FOR DIAGNOSING AND MONITORING DERMAL MICROVASCULAR HEALTH - The invention generally relates to a device for assessing dynamic microvascular refill (DMR), a novel measure of microvascular function. Microvascular refill is determined under dynamic conditions by monitoring changes in fingernail reflectance spectra in response to small shear forces applied to the fingernail. A hemodynamic model is described to examine the physiological significance of observed signals. The invention will provide healthcare workers with a simple, user friendly, non-invasive method of rapidly assessing microvascular function that would greatly facilitates the early detection and monitoring of the onset and treatment of vascular diseases. | 09-23-2010 |
| 20100233820 | MULTIPURPOSE ANALYSIS USING SECOND HARMONIC GENERATING NANOPROBES - Second harmonic nanoprobes for multipurpose imaging of samples and a method of using such probes to monitor nucleotide sequencing in a Multi-SHG Detection Imaging (MSDI) modality and to monitor external electric field using voltage sensitive second harmonic generating (SHG) nanoprobes are provided. The SHG nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging for a wide-range of biological and non-biological processes and devices. | 09-16-2010 |
| 20100233242 | ENGINEERED PROTEINS, AND METHODS OF MAKING AND USING - The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes. | 09-16-2010 |
| 20100233180 | ANTIBODIES THAT BIND TO AN EPITOPE ON THE HUNTINGTON'S DISEASE PROTEIN - The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to the use of such anti-huntingtin antibodies in the diagnosis and treatment of Huntington's disease. | 09-16-2010 |
| 20100231452 | MM-WAVE FULLY INTEGRATED PHASED ARRAY RECEIVER AND TRANSMITTER WITH ON-CHIP ANTENNAS - A phased array mm-wave device includes a substrate, a mm-wave transmitter integrated onto the substrate configured to transmit a mm-wave signal and/or a mm-wave receiver integrated onto the substrate and configured to receive a mm-wave signal. The mm-wave device also includes a phased array antenna system integrated onto the substrate and including two or more antenna elements. The phased array mm-wave device also includes one or more dielectric lenses. A distributed mm-wave distributed combining tree circuit includes at least two pairs of differential transconductors with regenerative degeneration and accepts at least two differential input signals. Two mm-wave loopback methods measure the phased array antenna patterns and the performance of an integrated receiver transmitter system. | 09-16-2010 |
| 20100229910 | ALUMINA PASTE SUBLIMATION SUPPRESSION BARRIER FOR THERMOELECTRIC DEVICE - Alumina as a sublimation suppression barrier for a Zintl thermoelectric material in a thermoelectric power generation device operating at high temperature, e.g. at or above 1000K, is disclosed. The Zintl thermoelectric material may comprise Yb | 09-16-2010 |
| 20100228409 | METHOD AND APPARATUS FOR POWERED DESCENT GUIDANCE - A method and apparatus for landing a spacecraft having thrusters with non-convex constraints is described. The method first computes a solution to a minimum error landing problem for a convexified constraints, then applies that solution to a minimum fuel landing problem for convexified constraints. The result is a solution that is a minimum error and minimum fuel solution that is also a feasible solution to the analogous system with non-convex thruster constraints. | 09-09-2010 |
| 20100227120 | COMPOSITE NANOSTRUCTURE SOLID ACID FUEL CELL ELECTRODES VIA ELECTROSPRAY DEPOSITION - The present invention provides a method of preparing a nanostructure material on a substrate. The method includes spraying an aqueous solution from a capillary to the substrate, wherein the aqueous solution includes an electrolyte and an alcohol. The method also includes applying an electrical bias between the capillary and the substrate, such that the electrolyte deposits on the substrate forming the nanostructure material. The present invention also provides the nanostructure material prepared by this method. | 09-09-2010 |
| 20100219914 | WIRING NANOSCALE SENSORS WITH NANOMECHANICAL RESONATORS - A system, device, method, and apparatus provide the ability to wire a voltage sensitive device to a nanoelectromechanical system (NEMS) resonator. A voltage sensitive device is configured to detect one or more voltage signals and output one or more electrical potentials in real-time. An array of piezoelectric NEMS resonators (with each resonator tuned to a unique frequency) is used to receive the output electrical potentials and convert each output electrical potential to a corresponding resonance frequency varying signal. The output signal from each resonator varies in linear proportion to the resonator's corresponding frequency variation arising from the applied elecrical potential. The frequency varying signals are multiplexed together into a single readout signal path that is monitored to determine variations in vibrational amplitude. A demodulation device deconvolves the multiplexed frequency varying signals to recover and uniquely identify the output electrical signal. | 09-02-2010 |
| 20100216282 | LOW COST BONDING TECHNIQUE FOR INTEGRATED CIRCUIT CHIPS AND PDMS STRUCTURES - Methods of bonding a structure fabricated in polydimethylsiloxane (PDMS) and an integrated circuit chip. The procedures for bonding include providing a substrate, affixing the integrated circuit to the substrate, as needed preparing the surface of the integrated circuit chip to permit bonding, aligning the PDMS structure and the features of the integrated circuit chip, and applying a bonding agent. The bonding agent is cured by exposure to a thermal regime for a suitable length of time. Depending on relative sizes, in some cases, a plural number of PDMS structures can be attached to one chip, or a single PDMS structure can be bonded to multiple chips. In some cases, the integrated circuit chip operates wirelessly. In other situations, the substrate provides electrical communication from the integrated circuit chip to electronic components. | 08-26-2010 |
| 20100203630 | IN VITRO HUMAN B LYMPHOPOIESIS CULTURE SYSTEM - The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating antibody-producing B cells from hematopoietic stem/progenitor cells (HSPCs). | 08-12-2010 |
| 20100200782 | Microfabricated Elastomeric Valve And Pump Systems - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 08-12-2010 |
| 20100197522 | Microfluidic Chaotic Mixing Systems And Methods - Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump coupled to the mixing channel to circulate the analyte solution through the reaction chamber and the mixing channel, and an input port in fluid communication with the mixing channel and the reaction chamber to supply the analyte solution to the microfluidic system. The input port can be closed to create a closed circulation path for the analyte solution through the reaction chamber and the mixing channel. | 08-05-2010 |
| 20100196892 | Methods and Systems for Molecular Fingerprinting - This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device that analyzes the polynucleotides according to restriction fragment length polymorphism. In a microfabricated device according to the invention, DNA fragments or other molecules can be rapidly and accurately typed using relatively small samples, by measuring for example the signal of an optically-detectable (e.g., fluorescent) reporter associated with the polynucleotide fragments. | 08-05-2010 |
| 20100187105 | Microfabricated Elastomeric Valve And Pump Systems - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 07-29-2010 |
| 20100184193 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES - Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine. | 07-22-2010 |
| 20100179364 | Process for the Production of a Hydrocarbon - A process for the production of a hydrocarbon which comprises contacting, in a reactor, methanol and/or dimethyl ether with a catalyst comprising a metal halide, such as a zinc halide, in which the methanol and/or dimethyl ether is contacted with the catalyst in the presence of at least one phosphorus compound having at least one P—H bond. | 07-15-2010 |
| 20100176981 | SPLIT ANALOG/DIGITAL POLYNOMIAL NONLINEAR TERM GENERATOR WITH REDUCED NUMBER OF ANALOG-TO-DIGITAL CONVERTERS - A polynomial nonlinear term generator is configured to receive an RF signal. An analog cubic term generator generates an analog cubic term signal and an analog square term generator generates an analog square term signal, both derived from the RF signal. A cubic term mixer assembly mixes a local oscillator (LO) signal with the cubic term signal to generate a synthetic IM3 signal. A square term ADC provides a digital square term signal and a cubic term ADC provides a digital cubic term signal. At least one digital multiplier has a first multiplier input terminal configured to receive a selected one of the digital square term signal and the digital cubic term signal, and a second multiplier input terminal configured to receive the digital square term signal. The multiplier provides as output a digital IMn product where n is greater than 3. A corresponding method is also described. | 07-15-2010 |
| 20100176841 | SEU TOLERANT ARBITER - Single Event Upset (SEU, also referred to as soft error) tolerant arbiters, bare arbiters, and filters are disclosed. An arbiter provides a filter section, and a bare arbiter, coupled to the filter section. The bare arbiter includes a redundant first input and a redundant second input, and a redundant first output and a redundant second output. A pull-down transistor in the bare arbiter conditionally overpowers a corresponding pull-up transistor in the bare arbiter when a contention condition is present in the bare arbiter. | 07-15-2010 |
| 20100175767 | Microfabricated Elastomeric Valve and Pump Systems - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 07-15-2010 |
| 20100172195 | ULTRA-LOW-POWER VARIATION-TOLERANT RADIATION-HARDENED CACHE DESIGN - A random access memory (RAM) cell provides a control section and a storage section coupled to the storage section. The storage section includes complementary metal-oxide semiconductor (CMOS) transistors and the storage section is read by precharging the control section to a virtual drain voltage. | 07-08-2010 |
| 20100171954 | Method and Apparatus for Analysis and Sorting of Polynucleotides Based on Size - The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size. | 07-08-2010 |
| 20100170797 | DEVICE AND METHOD FOR SINGLE CELL AND BEAD CAPTURE AND MANIPULATION BY DIELECTROPHORESIS - A rapid and robust device and method for the capture and manipulation of single cells and beads in a microfluidic environment using positive dielectrophoresis (pDEP) is provided. The capture device uses a highly localized and non-uniform pDEP electric field gradient to allow for the simultaneous capture and manipulation of single cells and beads in standard cell growth media. | 07-08-2010 |
| 20100155777 | DIGITAL ALLOY ABSORBER FOR PHOTODETECTORS - In order to increase the spectral response range and improve the mobility of the photo-generated carriers (e.g. in an nBn photodetector), a digital alloy absorber may be employed by embedding one (or fraction thereof) to several monolayers of a semiconductor material (insert layers) periodically into a different host semiconductor material of the absorber layer. The semiconductor material of the insert layer and the host semiconductor materials may have lattice constants that are substantially mismatched. For example, this may performed by periodically embedding monolayers of InSb into an InAsSb host as the absorption region to extend the cutoff wavelength of InAsSb photodetectors, such as InAsSb based nBn devices. The described technique allows for simultaneous control of alloy composition and net strain, which are both key parameters for the photodetector operation. | 06-24-2010 |
| 20100154890 | Microfluidic Large Scale Integration - High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories. | 06-24-2010 |
| 20100145491 | METHOD AND APPARATUS FOR THE CONTROLLED FABRICATION OF MICRO AND NANOSCALE STRUCTURES BY THERMOCAPILLARY LITHOGRAPHY - An apparatus and method of controllably stimulating the growth and evolution of 2D and 3D structures from a thin film mass transfer process such that complex devices can be designed and fabricated having engineered features of different heights and separation distances in a single or few process steps are provided. More specifically, the apparatus and method allows for the construction of engineered temperature gradient fields capable of controlling for, and taking into account, proximity effects during the growth and evolution of adjacent structures, which in turn allows for the production of technologically significant micro and nanoscale devices in a number of fields. | 06-10-2010 |
| 20100144987 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS - This invention relates to olefin metathesis catalysts general formula (I): | 06-10-2010 |
| 20100143945 | DNA-DAMAGE-INDUCED PROTEOLYSIS - The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt. | 06-10-2010 |
| 20100140066 | VERY LOW VOLTAGE, ULTRAFAST NANOELECTROMECHANICAL SWITCHES AND RESONANT SWITCHES - The invention provides lateral nanoelectromechanical switches useful for integration into circuitry fabricated using standard semiconductor processing methods, or using techniques compatible with the mainstream semiconductor processing technologies. Methods of fabricating the switches are described. Some exemplary designs for two and three terminal switches are provided. Descriptions of structural features and the operating parameters for some exemplary switches are given. The switches are expected to be compatible with circuitry that is operable in computer-based systems. | 06-10-2010 |
