CALIFORNIA INSTITUTE OF TECHNOLOGY Patent applications |
Patent application number | Title | Published |
20160133540 | MULTI-LAYER PACKAGING SCHEME FOR IMPLANT ELECTRONICS - The present invention provides a micropackaged device comprising: a substrate for securing a device with a corrosion barrier affixed to the substrate, wherein the corrosion barrier comprises a first thin-film layer, a metal film coating the thin-film layer and a second thin-film layer to provide a sandwich layer; and optionally at least one feedthrough disposed in the substrate to permit at least one input and or at least one output line into the micropackaged device, wherein the micropackaged device is encapsulated by the corrosion barrier. Methods of producing the micropackaged device are also disclosed. | 05-12-2016 |
20160131640 | MICROFLUIDIC DEVICE - Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples. | 05-12-2016 |
20160131564 | Systems and Methods for Determining the Effective Toughness of a Material and for Implementing Materials Possessing Improved Effective Toughness Characteristics - Systems and methods in accordance with embodiments of the invention determine the effective toughness of a given material, and also implement materials possessing improved effective toughness values. In one embodiment, a method of determining the effective toughness of a material includes: causing a crack to propagate through the material; where the relative constant velocity and the relative overall direction are prescribed and maintained for the duration of the propagation of the crack through the material; measuring the energy release rate of the crack as it propagates through the material; and defining the effective toughness of the material as the maximum value of the measured energy release rate. | 05-12-2016 |
20160131560 | METHODS FOR PHENOTYPING OF INTACT BONES BY TISSUE CLEARING AND STAINING - In various embodiments, the present application teaches methods and kits for clearing and optionally subsequently visualizing tissue containing bone. In some embodiments, the method includes serially incubating cleared bone in refractive index matching solutions with progressively higher refractive indexes. In some embodiments, the methods teach immunolabeling and/or staining tissue containing bone and optionally visualizing the immunolabeled and/or stained tissue containing bone. | 05-12-2016 |
20160123854 | METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES - In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches PACT, a protocol for passive tissue clearing and immunostaining of intact organs. In other embodiments, the present application teaches RIMS, a refractive index matching media for imaging thick tissue. In yet other embodiments, the application teaches PARS, a method for whole-body clearing and immunolabeling. | 05-05-2016 |
20160111619 | HIGH PERFORMANCE HIGH TEMPERATURE THERMOELECTRIC COMPOSITES WITH METALLIC INCLUSIONS - The present invention provides a composite thermoelectric material. The composite thermoelectric material can include a semiconductor material comprising a rare earth metal. The atomic percent of the rare earth metal in the semiconductor material can be at least about 20%. The composite thermoelectric material can further include a metal forming metallic inclusions distributed throughout the semiconductor material. The present invention also provides a method of forming this composite thermoelectric material. | 04-21-2016 |
20160109726 | CONTACT LENS WITH METERED LIQUID SYSTEM - A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid. | 04-21-2016 |
20160105973 | MICRO-FABRICATED GROUP ELECTROPLATING TECHNIQUE - Methods, and devices produced by the methods, for electroplating a multitude of micro-scale electrodes that are electrically isolated from each other on a cable or other device is described. A localized area of connections on another end of the cable is shorted together by depositing a metal sheet or other conductive material over the localized area. The metal sheet is connected to a terminal of a power supply, and the electrode end of the cable is immersed in an electrolyte solution for electrodeposition by electroplating. After the electrodes are electroplated, the metal sheet is removed from the cable in order to re-isolate the electrodes. | 04-14-2016 |
20160105968 | BIOCOMPATIBLE RIBBON CABLE WITH NARROW FOLDED SECTION - A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array. | 04-14-2016 |
20160056321 | Large-Scale Space-Based Solar Power Station: Efficient Power Generation Tiles - A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom is provided. Each solar power station includes a plurality of satellite modules. The plurality of satellite modules each include a plurality of modular power generation tiles including a photovoltaic solar radiation collector, a power transmitter and associated control electronics. Numerous embodiments relate to efficient power generation tiles. In one embodiment, an efficient power generation tile includes: at least one photovoltaic material; and at least one concentrator that redirects incident solar radiation towards a photovoltaic material such that the photovoltaic material experiences a greater solar flux relative to the case where the photovoltaic material experiences unaltered solar radiation. | 02-25-2016 |
20160051705 | FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES - Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging. | 02-25-2016 |
20160049770 | SINGLE-MODE, DISTRIBUTED FEEDBACK INTERBAND CASCADE LASERS - Single-mode, distributed feedback interband cascade lasers (ICLs) using distributed-feedback gratings (e.g., lateral Bragg gratings) and methods of fabricating such ICLs are provided. The ICLs incorporate distributed-feedback gratings that are formed above the laser active region and adjacent the ridge waveguide (RWG) of the ICL. The ICLs may incorporate a double-ridge system comprising an optical confinement structure (e.g., a RWG) disposed above the laser active region that comprises the first ridge of the double ridge system, a DFB grating (e.g., lateral Bragg grating) disposed above the laser active region and adjacent the optical confinement structure, and an electric confinement structure that passes at least partially through the laser active region and that defines the boundary of the second ridge comprises and the termination of the DFB grating. | 02-18-2016 |
20160048672 | HERMA - Heartbeat Microwave Authentication - Systems and methods for identifying and/or authenticating individuals utilizing microwave sensing modules are disclosed. A HEaRtbeat Microwave Authentication (HERMA) system can enable the active identification and/or authentication of a user by analyzing reflected RF signals that contain a person's unique characteristics related to their heartbeats. An illumination signal is transmitted towards a person where a reflected signal captures the motion of the skin and tissue (i.e. displacement) due to the person's heartbeats. The HERMA system can utilize existing transmitters in a mobile device (e.g. Wi-Fi, Bluetooth, Cellphone signals) as the illumination source with at least one external receive antenna. The received reflected signals can be pre-processed and analyzed to identify and/or authenticate a user. | 02-18-2016 |
20160047940 | SYSTEMS AND METHODS FOR ADVANCED RAPID IMAGING AND ANALYSIS FOR EARTHQUAKES - Many embodiments provide a hybrid data processing system (HySDS) of an end-to-end geodetic imaging data system enabling near-real-time science, assessment, response, and rapid recovery. The HySDS may be an operation data processing system that integrates data from many different geodetic data sources and/or sensors, including interferometric synthetic aperture radar (InSAR), GPS, pixel tracking, seismology, and/or modeling, and processes the data to generate actionable high quality science data products. The HySDS may provide for an automated imaging and analysis capabilities that is able to handle the imminent increases in raw data from new and existing geodetic monitoring sensor systems. | 02-18-2016 |
20160040199 | ENZYMATIC METHODS FOR NITROGEN-ATOM TRANSFER - The present invention provides methods for catalyzing a nitrene insertion into a C—H bond to produce a product having a new C—N bond, comprising providing a C—H containing substrate, a nitrene precursor and an engineered heme enzyme; and allowing the reaction to proceed for a time sufficient to form a regioselective product having a new C—N bond. | 02-11-2016 |
20160036226 | Distributed Gradient Descent for Solving Optimal Power Flow in Radial Networks - Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control, One embodiment includes a node controller comprising a memory containing: a plurality of node operating parameters; and a plurality of node operating parameters describing operating parameters for a set of at least one node selected from the group consisting of at least one downstream node and at least one upstream node; wherein the processor is configured by the node controller application to: receive and store in memory a plurality of coordinator parameters describing operating parameters of a node coordinator by the network interface; and calculate updated node operating parameters using an iterative gradient projection process to determine updated node parameters using node operating parameters that describe operating parameters of node and operating parameters of the set of at least one node, where each iteration is determined by the coordinator parameters. | 02-04-2016 |
20160036225 | Dynamic Frequency Control in Power Networks - Node controllers in power distribution networks in accordance with embodiments of the invention enable dynamic frequency control. One embodiment includes a node controller comprising a network interface a processor; and a memory containing a frequency control application; and a plurality of node operating parameters describing the operating parameters of a node, where the node is selected from a group consisting of at least one generator node in a power distribution network wherein the processor is configured by the frequency control application to calculate a plurality of updated node operating parameters using a distributed process to determine the updated node operating parameter using the node operating parameters, where the distributed process controls network frequency in the power distribution network; and adjust the node operating parameters. | 02-04-2016 |
20160032330 | P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS - The present invention pertains to the use of engineered variants of enzyme CYP102A, also known as P450-BM3, for cyclopropanation of olefins containing electron-withdrawing groups. One exemplary enzyme variant, referred to as BM3-HStar, contains five mutations away from wild-type P450-BM3, and demonstrates high activity towards cyclopropanation of olefinic substrates using ethyldiazoacetate (EDA) and other carbene transfer reagents. Products of these reactions are potential precursors of levomilnacipran derivatives, a class of compounds that have been shown to be selective inhibitors of monoamine transporters. In addition, cyclopropanation reactions with the P450-BM3 enzyme variants of the invention can be conducted in whole cells expressing the enzyme variants and can proceed under aerobic conditions. | 02-04-2016 |
20160023352 | SURROGATE: A Body-Dexterous Mobile Manipulation Robot with a Tracked Base - Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with one embodiment of the invention include: a memory containing a whole body motion application; a spine, where the spine has seven degrees of freedom and comprises a spine actuator and three spine elbow joints that each include two spine joint actuators; at least one limb, where the at least one limb comprises a limb actuator and three limb elbow joints that each include two limb joint actuators; a tracked base; a connecting structure that connects the at least one limb to the spine; a second connecting structure that connects the spine to the tracked base; wherein the processor is configured by the whole body motion application to move the at least one limb and the spine to perform whole body motion. | 01-28-2016 |
20160005786 | ATOMICALLY PRECISE SURFACE ENGINEERING FOR PRODUCING IMAGERS - High-quality surface coatings, and techniques combining the atomic precision of molecular beam epitaxy and atomic layer deposition, to fabricate such high-quality surface coatings are provided. The coatings made in accordance with the techniques set forth by the invention are shown to be capable of forming silicon CCD detectors that demonstrate world record detector quantum efficiency (>50%) in the near and far ultraviolet (155 nm-300 nm). The surface engineering approaches used demonstrate the robustness of detector performance that is obtained by achieving atomic level precision at all steps in the coating fabrication process. As proof of concept, the characterization, materials, and exemplary devices produced are presented along with a comparison to other approaches. | 01-07-2016 |
20150375227 | Microfabricated Crossflow Devices and Methods - This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion fluid, passed through a detection region, and then directed into a branch channel according to predetermined characteristics. For example, cells or viral particles contained in droplets of aqueous solvent are flowed past a detector in the nonpolar extrusion fluid decane, and routed into a selected branch channel for subsequent analysis or use. | 12-31-2015 |
20150371929 | IMPLANT DEVICE AND METHOD OF MAKING THE SAME - The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach a chip to the targeted thin-film (e.g., parylene) substrate so that the chip is used as an attachment to prevent delamination. | 12-24-2015 |
20150366707 | SMALL MOLECULE TRANSPORT DEVICE FOR DRUG DELIVERY OR WASTE REMOVAL - A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body. | 12-24-2015 |
20150357541 | COMPLIANT INTERFACIAL LAYERS IN THERMOELECTRIC DEVICES - A thermoelectric power generation device is disclosed using one or more mechanically compliant and thermally and electrically conductive layers at the thermoelectric material interfaces to accommodate high temperature differentials and stresses induced thereby. The compliant material may be metal foam or metal graphite composite (e.g. using nickel) and is particularly beneficial in high temperature thermoelectric generators employing Zintl thermoelectric materials. The compliant material may be disposed between the thermoelectric segments of the device or between a thermoelectric segment and the hot or cold side interconnect of the device. | 12-10-2015 |
20150357075 | METHODS AND DEVICES FOR IN SITU SYNTHESIS OF METAL OXIDES IN CARBON NANOTUBE ARRAYS - A method for controlling microstructural and nanostructural arrangement of nominally-aligned arrays of carbon nanotubes (CNTs) is disclosed. The method comprises synthesizing metal oxide particles in situ in nominally-aligned arrays of carbon nanotubes (CNTs) after synthesis of CNTs. The particles can be SnO | 12-10-2015 |
20150346753 | Systems and Methods for Convex Relaxations and Linear Approximations for Optimal Power Flow in Multiphase Radial Networks - Centralized node controllers in accordance with embodiments of the invention enable linear approximation of optimal power flow. One embodiment includes a centralized node controller including: a network interface, a processor, and a memory containing: a centralized power control application a network topology, where the network is multiphase unbalanced and comprises a plurality of connected nodes; wherein the processor is configured by the centralized controller application to: request node operating parameters from the plurality of connected nodes; calculate network operating parameters using a linear approximation of optimal power flow and the node operating parameters from the plurality of connected nodes; send network operating parameters to the plurality of connected nodes. | 12-03-2015 |
20150344932 | METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION - The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engine˜red mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes. | 12-03-2015 |
20150340863 | Systems and Methods for Optimal Power Flow on a Radial Network - Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control. One embodiment includes a node controller including a distributed power control application; a plurality of node operating parameters describing the operating parameter of a node and a set of at least one node selected from the group consisting of an ancestor node and at least one child node; wherein send node operating parameters to nodes in the set of at least one node; receive operating parameters from the nodes in the set of at least one node; calculate a plurality of updated node operating parameters using an iterative process to determine the updated node operating parameters using the node operating parameters that describe the operating parameters of the node and the set of at least one node, where the iterative process involves evaluation of a closed form solution; and adjust node operating parameters. | 11-26-2015 |
20150333482 | INDEX-COUPLED DISTRIBUTED-FEEDBACK SEMICONDUCTOR QUANTUM CASCADE LASERS FABRICATED WITHOUT EPITAXIAL REGROWTH - Quantum cascade (QC) lasers and methods of fabricating such QC lasers are provided. The QC lasers incorporate a DFB grating without requiring the use of relying on epitaxial regrowth processes. The DFB gratings are formed as sidewall gratings along the lateral length of the QC active region, or the DFB gratings are formed atop the lateral length of the QC active region, and wherein the top DFB grating is planarized with a polymeric material. | 11-19-2015 |
20150323322 | Automated Vessel Navigation Using Sea State Prediction - Systems and methods for sea state prediction and autonomous navigation in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a method of predicting a future sea state including generating a sequence of at least two 3D images of a sea surface using at least two image sensors, detecting peaks and troughs in the 3D images using a processor, identifying at least one wavefront in each 3D image based upon the detected peaks and troughs using the processor, characterizing at least one propagating wave based upon the propagation of wavefronts detected in the sequence of 3D images using the processor, and predicting a future sea state using at least one propagating wave characterizing the propagation of wavefronts in the sequence of 3D images using the processor. Another embodiment includes a method of autonomous vessel navigation based upon a predicted sea state and target location. | 11-12-2015 |
20150309011 | MICROFLUIDIC DEVICE - Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples. | 10-29-2015 |
20150308990 | SYSTEM AND METHOD FOR ANALYZING A GAS - A gas analysis system includes a fluidic channel for flow of a gas to be analyzed, a detector in the channel and adapted for measuring interactions of the gas with the detector, the detector including a resonator of the electromechanical nanosystem (NEMS) type and a heating system for heating a part of the detector, an actuation device for vibrationally actuating the resonator according to an excitation signal applied to an input of the detector, a detection device adapted for providing an output electric signal representative of the vibrations of the resonator, a read-out device connected to an input of the detector and configured for simultaneously measuring, from the output signal of the detector, the change in resonance frequency and the change in amplitude of the vibrations at the resonance frequency of the resonator, and a processing device configured for determining from the changes a fluidic characteristic of the gas. | 10-29-2015 |
20150301034 | LABEL-FREE DETECTION OF NANOPARTICLES AND BIOLOGICAL MOLECULES USING MICROTOROID OPTICAL RESONATORS - Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with a chemically or biologically active substance such as an antibody, antigen or protein. An indication of a particle bound to the functionalized outer surface of the microcavity is then detected based on a reactive interaction between the particle and the evanescent field while using frequency locking, balanced detection and various filtering techniques. The frequency locking, balanced detection and filtering techniques reduce the signal-to-noise ratio (SNR) of the detection system so that single nanoparticles (e.g. 2.5 nanometers (nm) in radius) and individual molecules (e.g. 15.5 kilo-Dalton (kDa) in size) can be detected in aqueous solution in some examples. | 10-22-2015 |
20150300884 | 340 GHz MULTIPIXEL TRANSCEIVER - A multi-pixel terahertz transceiver is constructed using a stack of semiconductor layers that communicate using vias defined within the semiconductor layers. By using a stack of semiconductor layers, the various electrical functions of each layer can be tested easily without having to assemble the entire transceiver. In addition, the design allows the production of a transceiver having pixels set 10 mm apart. | 10-22-2015 |
20150298171 | MONOLITHIC FLEXURE PRE-STRESSED ULTRASONIC HORNS - A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The provision of the external flexures has numerous advantages including the elimination of the need for a pre-stress bolt. The removal of the pre-stress bolt eliminates potential internal electric discharge points in the actuator. In addition, it reduces the chances of mechanical failure in the actuator stacks that result from the free surface in the hole of conventional ring stacks. In addition, the removal of the stress bolt and the corresponding reduction in the overall number of parts reduces the overall complexity of the resulting ultrasonic horn actuator and simplifies the ease of the design, fabrication and integration of the actuator of the present invention into other structures. | 10-22-2015 |
20150290466 | 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS - A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil. | 10-15-2015 |
20150276089 | MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 10-01-2015 |
20150274813 | Broadly-Neutralizing Anti-HIV Antibodies - The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide. | 10-01-2015 |
20150273197 | IMPLANTABLE OXYGENATOR WITH SELF-CONTAINED ELECTROLYTE - An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system. | 10-01-2015 |
20150267233 | COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS - The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof. | 09-24-2015 |
20150267232 | IN VIVO AND IN VITRO CARBENE INSERTION AND NITRENE TRANSFER REACTIONS CATALYZED BY HEME ENZYMES - This invention relates to the use of heme-containing enzymes to catalyze carbene and nitrene insertion and transfer reactions with greater selectivity, mild reaction conditions, and convenient production. | 09-24-2015 |
20150262035 | AUTOMATED FEATURE ANALYSIS, COMPARISON, AND ANOMALY DETECTION - Novel methods and systems for automated data analysis are disclosed. Data can be automatically analyzed to determine features in different applications, such as visual field analysis and comparisons. Anomalies between groups of objects may be detected through clustering of objects. | 09-17-2015 |
20150259657 | STABLE FUNGAL CEL6 ENZYME VARIANTS - The disclosure provides variant Cel6a enzymes having increased thermostability, methods of making and using such polypeptides. | 09-17-2015 |
20150253196 | UNCOOLED IR DETECTOR ARRAYS BASED ON NANOELECTROMECHANICAL SYSTEMS - We describe the use of a high-quality-factor torsional resonator of microscale dimensions. The resonator has a paddle that is supported by two nanoscale torsion rods made of a very low thermal conductivity material, such as amorphous (“a-”) silicon. The body of the torsion paddle is coated with an infrared-absorbing material that is thin and light weight, but provides sufficient IR absorption for the applications. It may be placed above a reflecting material of similar dimensions to form a quarter wave cavity. Sensing of the response of the paddle to applied electromagnetic radiation provides a measure of the intensity of the radiation as detected by absorption, and the resulting temperature change, in the paddle. | 09-10-2015 |
20150246140 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND WAKEFULNESS - In some aspects, the invention relates to methods of treating conditions associated with sleep disorders, comprising administering an agent that modulates the activity of a neuropeptide receptor or a neuropeptide receptor ligand. In some aspects, the invention relates to methods of screening agents that modulate the activity of a neuropeptide receptor in an organism, optionally using cells or organisms comprising a genetic modification that affects a neuropeptide signaling pathway. In some aspects, the invention relates to methods of characterizing a condition associated with a sleep disorder comprising sequencing a nucleic acid encoding either a neuropeptide receptor or a neuropeptide receptor ligand and comparing the sequence with a reference sequence. | 09-03-2015 |
20150236396 | DIELECTRIC WAVEGUIDES SPLITTER AND HYBRID/ISOLATOR FOR BIDIRECTIONAL LINK - A system, method, device, and apparatus provide a dielectric waveguide splitter/bi-directional link. A dielectric substrate fabricated into a first Y-junction waveguide with a first port splitting into a first branch leading to a second port and a second branch leading to a third port. An angle between the first branch and the second branch is below ninety degrees (90°). The dielectric waveguide splitter enables millimeter-wave (mmWave) transmission between the first port and the second port while reducing feedback of the mmWave between the second and third port. Two Y-junction waveguides may be fabricated back-to-back to provide simultaneous bidirectional mmWave transmission at a single frequency. | 08-20-2015 |
20150232822 | DNA POLYMERASES HAVING IMPROVED LABELED NUCLEOTIDE INCORPORATION PROPERTIES - The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction regions is located at portions of the O-helix, (ii) the K helix, and (iii) the inter O-P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases. | 08-20-2015 |
20150223701 | BREATHING AND HEARTBEAT FEATURE EXTRACTION AND VICTIM DETECTION - Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“CW”) radio signals that reflect back upon making contact with various objects. The life detecting radars can identify victims by analyzing data with respect to a victim's breathing and heartbeat patterns. In some embodiments, to identify victims, the return signal may be split into a heartbeat band and a breathing band using bandpass filtering. The life detecting radar system may perform parameter estimation for the breathing band and/or the heartbeat band using a non-least squares process (NLS). The life detecting radar system may analyze breathing and heartbeat results based on the heartbeat FM frequency and the breathing center frequency to identify victims. | 08-13-2015 |
20150208945 | Microwave Radar Sensor Modules - Systems and methods for detecting biometrics using microwave radar sensor modules are disclosed. Integrated microwave sensor modules can include a transmitter unit configured to generate at least one continuous wave transmit signal based upon at least one frequency control signal, a receiver unit configured to utilize a cancellation path to cancel contributions to a return signal based upon at least one cancellation path control signal, and a microcontroller unit that includes a processor, a memory containing a microcontroller application, where the microcontroller application configures the processor to generate at least one frequency control signal to generate least one CW transmit signal having a plurality of frequencies, generate at least one cancellation path control signal to automatically adjust the cancellation path in real time, receive at least one demodulated signal, digitize the at least one demodulated signal, and update the at least one frequency control and cancellation path control signals. | 07-30-2015 |
20150180000 | SEPARATOR ENCLOSURES FOR ELECTRODES AND ELECTROCHEMICAL CELLS - The disclosure provides electrochemical cells including a separator enclosure which encloses at least a portion of a positive or negative electrode. In an embodiment, the separator generates a contact force or pressure on at least a portion of the electrode which can improve the performance of the cell. The disclosure also provides methods for charging an electrochemical cell. | 06-25-2015 |
20150177380 | THREE-DIMENSIONAL TOMOGRAPHIC IMAGING CAMERA - A detection apparatus and method for FMCW LIDAR employ signals whose frequencies are modified so that low-cost and low-speed photodetector arrays, such as CCD or CMOS cameras, can be employed for range detection. The LIDAR is designed to measure the range z to a target and includes a single mode swept frequency laser (SFL), whose optical frequency is varied with time, as a result of which, a target beam which is reflected back by the target is shifted in frequency from a reference beam by an amount that is proportional to the relative range z to the target. The reflected target beam is combined with the reference beam and detected by the photodetector array. By first modulating at least one of the target and reference beams such that the difference between the frequencies of the reflected target beam and the reference beam is reduced to a level that is within the bandwidth of the photodetector array, the need for high-speed detector arrays for full-field imaging is obviated. | 06-25-2015 |
20150175667 | TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION - Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers. | 06-25-2015 |
20150155598 | Fluoride Ion Electrochemical Cell - Electrochemical cells of the present invention are versatile and include primary and secondary cells useful for a range of important applications including use in portable electronic devices. Electrochemical cells of the present invention also exhibit enhanced safety and stability relative to conventional state of the art primary lithium batteries and lithium ion secondary batteries. For example, electrochemical cells of the present invention include secondary electrochemical cells using anion charge carriers capable of accommodation by positive and negative electrodes comprising anion host materials, which entirely eliminate the need for metallic lithium or dissolved lithium ion in these systems. | 06-04-2015 |
20150145091 | Single-Band and Dual-Band Infrared Detectors - Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the detector structure consists of, sequentially, a top contact layer, a unipolar hole barrier layer, an absorber layer, a unipolar electron barrier, a second absorber, a second unipolar hole barrier, and a bottom contact layer. In addition, by substantially reducing the width of one of the absorber layers, a single-band infrared detector can also be formed. | 05-28-2015 |
20150125157 | HIGH BANDWIDTH OPTICAL LINKS FOR MICRO-SATELLITE SUPPORT - A method, systems, apparatus and device enable high bandwidth satellite communications. An onboard tracking detector, installed in a low-earth orbit satellite, detects a position of an incoming optical beam received/transmitted from a first ground station of one or more ground stations. Tracker electronics determine orientation information of the incoming optical beam based on the position. Control electronics receive the orientation information from the tracker electronics, and control a waveguide drive electronics. The waveguide drive electronics control a voltage that is provided to an electro-optic waveguide beam steering device. The electro-optic waveguide beam steering device steers an outgoing optical beam to one of the one or more ground stations based on the voltage. | 05-07-2015 |
20150112219 | INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION - Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination. | 04-23-2015 |
20150111023 | IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE - Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels. | 04-23-2015 |
20150087001 | METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES - In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches PACT, a protocol for passive tissue clearing and immunostaining of intact organs. In other embodiments, the present application teaches RIMS, a refractive index matching media for imaging thick tissue. In yet other embodiments, the application teaches PARS, a method for whole-body clearing and immunolabeling. | 03-26-2015 |
20150079342 | METHOD AND SYSTEM FOR GRAPHENE FORMATION - A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also includes introducing a carbon source into the processing chamber and initiating a microwave plasma in the processing chamber. The method further includes subjecting the substrate to a flow of the cleaning gas and the carbon source for a predetermined period of time to form the graphene. | 03-19-2015 |
20150078754 | OPTICALLY BALANCED OPTO-ELECTRICAL OSCILLATOR - An opto-electrical oscillator includes, in part, first and second optical phase modulators, a coupler, an optical-to-electrical signal conversion circuit, and a control circuit. The first optical phase modulator modulates the phase of a first optical signal in response to a first feedback signal to generate a first phase modulated signal. The second optical phase modulator modulates the phase of a second optical signal in response to a second feedback signal to generate a second phase modulated signal. The first and second optical signals travel through first and second optical paths respectively and are generated from the same optical source. The optical-to-electrical signal conversion circuit receives an optical signal from the coupler and in response generates an electrical signal applied to the control circuit. The output signals of the control circuit cause the first and second feedback signals to be out of phase. | 03-19-2015 |
20150075744 | SYSTEMS AND METHODS FOR FABRICATING STRUCTURES INCLUDING METALLIC GLASS-BASED MATERIALS USING LOW PRESSURE CASTING - Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using low-pressure casting techniques. In one embodiment, a method of fabricating an object that includes a metallic glass-based material includes: introducing molten alloy into a mold cavity defined by a mold using a low enough pressure such that the molten alloy does not conform to features of the mold cavity that are smaller than 100 μm; and cooling the molten alloy such that it solidifies, the solid including a metallic glass-based material. | 03-19-2015 |
20150073385 | REMOTE RESERVOIR MICRONEEDLE DRUG DELIVERY SYSTEMS - Transdermal drug delivery patch devices are described in which microneedle array insertion or application forces are decoupled or separated from drug delivery actuation or application forces. Dual-reservoir devices are described in detail for such purposes as are associated methods of use in various examples. | 03-12-2015 |
20150056109 | SOLAR FUEL GENERATOR - The disclosure provides conductive membranes for water splitting and solar fuel generation. The membranes comprise an embedded semiconductive/photoactive material and an oxygen or hydrogen evolution catalyst. Also provided are chassis and cassettes containing the membranes for use in fuel generation. | 02-26-2015 |
20150051411 | SYNTHETIC TRANSTAGANOLIDE AND BASILIOLIDE PRODUCTS, DERIVATIVES THEREOF, AND SYNTHESIS METHODS THEREOF - Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided. | 02-19-2015 |
20150050233 | COMPOSITIONS CONTAINING INCLUSION COMPLEXES - The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula: | 02-19-2015 |
20150047688 | METHODS AND SYSTEMS FOR SELF-CLEANING OF PHOTOVOLTAIC PANELS - Systems, devices, and methods are provided for self-cleaning photovoltaic panels that utilize piezo devices capable of causing vibrational movement in the panels. | 02-19-2015 |
20150047683 | In2Te3 Precipitates in Bulk Bi2Te3 for Thermoelectric Applications - The present invention teaches a successful synthesis regime to grow highly oriented plate-like In | 02-19-2015 |
20150044084 | METHODS FOR FABRICATING GRADIENT ALLOY ARTICLES WITH MULTI-FUNCTIONAL PROPERTIES - Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive deposition of gradient alloys represents a paradigm shift from the traditional way that metal alloys and metal/metal alloy parts are fabricated. Since a gradient alloy that transitions from one metal to a different metal cannot be fabricated through any conventional metallurgy techniques, the technique presents many applications. Moreover, the embodiments described identify a broad range of properties and applications. | 02-12-2015 |
20150036302 | LONG-TERM PACKAGING FOR THE PROTECTION OF IMPLANT ELECTRONICS - The present invention provides a micropackaged device comprising: a substrate for securing a device; a corrosion barrier affixed to said substrate; optionally at least one feedthrough disposed in said substrate to permit at least one input and or at least one output line into said micropackaged device; and an encapsulation material layer configured to encapsulate the micropackaged device. | 02-05-2015 |
20150031753 | COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES - The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula: | 01-29-2015 |
20150031460 | GAMES HAVING BIOTECHNOLOGICAL CONTENT - Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically active materials are disclosed. The game apparatus includes a replaceable cartridge having a chamber in which a biologically active component such as a single-celled organism or a biologically active compound is contained. A stimulus controller accepts instructions from a human user and provides a stimulus to the biologically active component. A response receiver accepts a signal indicative of a response of the biologically active component. A display is provided to display to the user information indicative of the response of the biologically active component, and a game score. A computer-based game controller includes a set of pre-defined rules of play that define a game and that comprise pre-defined rules of scoring for the game. | 01-29-2015 |
20150031116 | INTEGRATED ACTIVE FLUX MICROFLUIDIC DEVICES AND METHODS - The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules. | 01-29-2015 |
20150030529 | ISOTHERMAL SYNTHESIS OF FUELS WITH REACTIVE OXIDES - A method for converting thermal energy to chemical energy by reducing a reactive oxide substrate at a constant temperature under a first atmosphere with a lower oxygen partial pressure, and then contacting the reduced oxide at the same temperature with a second atmosphere with a higher oxygen partial pressure, during which oxygen is driven into the reduced oxide by the oxygen chemical potential difference between the two atmospheres, thereby leaving fuel behind, i.e. producing fuel. A method for preparing the reactive oxide substrate by using liquid media as a binder and pore former and heating the mixture of the reactive oxide and the liquid media, thereby forming the reactive oxide substrate. | 01-29-2015 |
20150025126 | METHOD OF PREPARING A SUPRAMOLECULAR COMPLEX CONTAINING A THERAPEUTIC AGENT AND A MULTI-DIMENSIONAL POLYMER NETWORK - A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents. | 01-22-2015 |
20150024954 | APTAMER REGULATED NUCLEIC ACIDS AND USES THEREOF - The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a primer sequence domain and an aptamer domain that is responsive to a ligand. | 01-22-2015 |
20150020575 | SYSTEM FOR ANALYZING A GAS MIXTURE INCLUDING AT LEAST ONE CHROMATOGRAPHY COLUMN - A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system. | 01-22-2015 |
20150019179 | METHODS FOR DESIGNING QUADRUPLE-RIDGED FLARED HORN ANTENNAS - Novel methods and systems for antenna design are disclosed. A quadruple-ridged flared horn antenna can be designed based on geometry and frequency requirements. Automated optimization allows the design of antennas with decade-bandwidth. Optimized quadruple-ridged flared horn antennas can be used for radio astronomy. | 01-15-2015 |
20150018781 | SYSTEMS, DEVICES, AND METHODS FOR TOPICAL DRUG DELIVERY TO THE EYE - Systems, devices, and methods are provided for delivering a therapeutic substance to the eye of a subject with an automated apparatus. The apparatus can resemble a pair of eyeglasses that can assist in the alignment of a substance ejecting nozzle and energy sensor with the eye. The apparatus can eject the therapeutic substance and immediate response to the detection of a blink of the user's eye. The therapeutic substance can be ejected in a number of different forms including as a single droplet containing the entire prescribed dosage. | 01-15-2015 |
20150018291 | The Utility of Nematode Small Molecules - The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside. | 01-15-2015 |
20150017038 | HELICALLY ACTUATED POSITIVE-DISPLACEMENT PUMP AND METHOD - First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are correspondingly changed. The position of change of the helical fibers can be used for a pumping effect, or to change some other fluidic characteristics. One other fluidic characteristic, for example, may use the movement of the helical fibers as a valve. | 01-15-2015 |
20150014885 | SYSTEMS AND METHODS FOR ADDITIVE MANUFACTURING PROCESSES THAT STRATEGICALLY BUILDUP OBJECTS - Systems and methods in accordance with embodiments of the invention implement additive manufacturing techniques that employ different sets of deposition characteristics and/or material formation characteristics during the additive manufacture of an object so as to strategically build up the object. In many embodiments, material used to build up an object is deposited at different deposition rates during the additive manufacture of the object, and the object is thereby strategically built up. In one embodiment, a method of additively manufacturing an object includes: depositing material onto a surface at a first deposition rate so as to define a first region of the object to be additively manufactured; and depositing material onto a surface at a second deposition rate so as to define a second region of the object to be additively manufactured; where the second deposition rate is different from the first deposition rate. | 01-15-2015 |
20150010788 | Carbon Nanotubes - Graphene Hybrid Structures for Separator Free Silicon - Sulfur Batteries - Provided herein are electrochemical systems and related methods of making and using electrochemical systems. Electrochemical systems of the invention implement novel cell geometries and composite carbon nanomaterials based design strategies useful for achieving enhanced electrical power source performance, particularly high specific energies, useful discharge rate capabilities and good cycle life. Electrochemical systems of the invention are versatile and include secondary lithium ion cells, such as silicon-sulfur lithium ion batteries, useful for a range of important applications including use in portable electronic devices. Electrochemical cells of the present invention also exhibit enhanced safety and stability relative to conventional state of the art lithium ion secondary batteries by using prelithiated active materials to eliminate the use of metallic lithium and incorporating carbon nanotube and/or graphene, composite electrode structures to manage residual stress and mechanical strain arising from expansion and contraction of active materials during charge and discharge. | 01-08-2015 |
20150009149 | IMAGING SURROUND SYSTEM FOR TOUCH-FREE DISPLAY CONTROL - The subject system hardware and methodology combine disparate cameras into a cohesive gesture recognition environment. To render an intended computer, gaming, display, etc. control function, two or more cameras with non-coaxial axes are trained on a space to detect and lock onto an object image regardless of its depth coordinate. Each camera captures one 2D view of the gesture and the plurality of 2D gestures are combined to infer the 3D input. | 01-08-2015 |
20140377742 | MICROFLUIDIC DEVICE - Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples. | 12-25-2014 |
20140374631 | FLOW CAGE ASSEMBLIES - Apparatus, systems and methods for implementing flow cages and flow cage assemblies in association with high pressure fluid flows and fluid valves are provided. Flow cages and flow assemblies are provided to dissipate the energy of a fluid flow, such as by reducing fluid flow pressure and/or fluid flow velocity. In some embodiments the dissipation of the fluid flow energy is adapted to reduce erosion, such as from high-pressure jet flows, to reduce cavitation, such as by controllably increasing the flow area, and/or to reduce valve noise associated with pressure surge. | 12-25-2014 |
20140373889 | TE PERFORMANCE BY BAND CONVERGENCE IN (Bi1-XSbX)2Te3 - Disclosed herein are thermoelectric materials with high performance characteristics, and methods of use thereof Among the thermoelectric materials disclosed are those of the formula (Bi | 12-25-2014 |
20140371353 | ENGINEERED AGGREGATES FOR METAMATERIALS - Materials and Methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. The engineered aggregate generally comprise a multilayer resonant structure having at least a relatively heavy inner core surrounded by at least a compliant coating layer. The geometry and stiffness of the relative layers can be tuned to engineer a desired resonant frequency response within the aggregate for a chosen frequency range. The engineered aggregates are disposed in a matrix material to form a metamaterial. The engineered aggregates may be disposed within a mortar matrix to form a concrete metamaterial suitable for use, for example, in structural applications, including bunkers, shelters, etc. | 12-18-2014 |
20140368617 | DEFOCUSING FEATURE MATCHING SYSTEM TO MEASURE CAMERA POSE WITH INTERCHANGEABLE LENS CAMERAS - A lens and aperture device for determining 3D information. An SLR camera has a lens and aperture that allows the SLR camera to determine defocused information. | 12-18-2014 |
20140367575 | INTEGRATED TERAHERTZ IMAGING SYSTEMS - A low-power 4×4-pixel THz camera with responsivity greater than 2.5 MV/W and sub-10 pW/√Hz NEP at 0.25 THz is integrated in 130 nm silicon without using either high-resistivity substrates or silicon lenses. Imaging results with a fully integrated radiating CMOS power source demonstrate the first entirely silicon-based THz imager. | 12-18-2014 |
20140364386 | Small Molecule Compounds That Control Plant- and Insect-Pathogenic Nematodes - The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant. | 12-11-2014 |
20140362495 | Systems and Methods for Implementing High-Temperature Tolerant Supercapacitors - Systems and methods in accordance with embodiments of the invention implement high-temperature tolerant supercapacitors. In one embodiment, a high-temperature tolerant super capacitor includes a first electrode that is thermally stable between at least approximately 80° C. and approximately 300° C.; a second electrode that is thermally stable between at least approximately 80° C. and approximately 300° C.; an ionically conductive separator that is thermally stable between at least approximately 80° C. and 300° C.; an electrolyte that is thermally stable between approximately at least 80° C. and approximately 300° C.; where the first electrode and second electrode are separated by the separator such that the first electrode and second electrode are not in physical contact; and where each of the first electrode and second electrode is at least partially immersed in the electrolyte solution. | 12-11-2014 |
20140362335 | POLYMER-DOPED VERTICALLY-ALIGNED NEMATIC LIQUID CRYSTALS - A system having a vertically-aligned negative delta E nematic liquid crystal host material and a small amount of liquid crystal polymer is provided. The liquid crystal polymer improves the switching speed of a vertically aligned nematic system without sacrificing contrast or viewing angle. | 12-11-2014 |
20140354350 | SELF-HEALING TECHNIQUE FOR HIGH FREQUENCY CIRCUITS - A self-healing monolithic integrated includes an electronic circuit having a plurality of transistors. At least one sensor is disposed within and electrically coupled to the electronic circuit and configured to sense a performance metric of the electronic circuit. A plurality of actuators is disposed within the circuit. Each actuator of the plurality of actuators has electrically coupled to it a control terminal. The plurality of actuators is configured to perform a selected one of, electrically coupling at least one transistor of the plurality of transistors into the electronic circuit and electrically de-coupling at least one transistor of the plurality of transistors, in response to operation of one of the control terminals to improve the performance metric. | 12-04-2014 |
20140351960 | ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 11-27-2014 |
20140347953 | MICROFLUIDIC FREE INTERFACE DIFFUSION TECHNIQUES - A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays. | 11-27-2014 |
20140345350 | FORMING OF FERROMAGNETIC METALLIC GLASS BY RAPID CAPACITOR DISCHARGE - An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool are provided. The RCDF method utilizes the discharge of electrical energy stored in a capacitor to uniformly and rapidly heat a sample or charge of metallic glass alloy to a predetermined “process temperature” between the glass transition temperature of the amorphous material and the equilibrium melting point of the alloy in a time scale of several milliseconds or less. Once the sample is uniformly heated such that the entire sample block has a sufficiently low process viscosity it may be shaped into high quality amorphous bulk articles via any number of techniques including, for example, injection molding, dynamic forging, stamp forging, sheet forming, and blow molding in a time frame of less than 1 second. | 11-27-2014 |
20140342179 | SYSTEMS AND METHODS FOR SHAPING SHEET MATERIALS THAT INCLUDE METALLIC GLASS-BASED MATERIALS - Systems and methods in accordance with embodiments of the invention advantageously shape sheet materials that include metallic glass-based materials. In one embodiment, a method of shaping a sheet of material including a metallic glass-based material includes: heating a metallic glass-based material within a first region within a sheet of material to a temperature greater than the glass transition temperature of the metallic glass-based material; where the sheet of material has a thickness of between 0.1 mm and 10 mm; where at least some portion of the sheet of material does not include metallic glass-based material that is heated above its respective glass transition temperature when the metallic glass-based material within the first region is heated above its respective glass transition temperature; and deforming the metallic glass-based material within the first region while the temperature of the metallic glass-based material within the first region is greater than its respective glass transition temperature. | 11-20-2014 |
20140340178 | MULTI-STEP DEEP REACTIVE ION ETCHING FABRICATION PROCESS FOR SILICON-BASED TERAHERTZ COMPONENTS - A multi-step silicon etching process has been developed to fabricate silicon-based terahertz (THz) waveguide components. This technique provides precise dimensional control across multiple etch depths with batch processing capabilities. Nonlinear and passive components such as mixers and multipliers waveguides, hybrids, OMTs and twists have been fabricated and integrated into a small silicon package. This fabrication technique enables a wafer-stacking architecture to provide ultra-compact multi-pixel receiver front-ends in the THz range. | 11-20-2014 |
20140335131 | PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER - Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbiota in the subject via administering to the subject a composition comprising | 11-13-2014 |
20140332120 | BULK FERROMAGNETIC GLASSES FREE OF NON-FERROUS TRANSITION METALS - Ferrous metal alloys including Fe, Co and optionally Ni with metalloids Si, B and P are provided that are substantially close to the peak in glass forming ability and have a combination of both good glass formability and good ferromagnetic properties. In particular, Fe/Co-based compositions wherein the Co content is between 15 and 30 atomic percent and the metalloid content is between 22 and 24 atomic percent at a well-defined metalloid moiety, have been shown to be capable of forming bulk glassy rods with diameters as large as 4 mm or larger. In addition, incorporating a small content of Ni under 10 atomic percent and additions of Mo, Cr, Nb, Ge, or C at an incidental impurity level of up to 2 atomic percent are not expected to impair the bulk-glass-forming ability of the present alloys. | 11-13-2014 |
20140329880 | EXONUCLEASE RESISTANT POLYNUCLEOTIDE AND RELATED DUPLEX POLYNUCLEOTIDES, CONSTRUCTS, COMPOSITIONS, METHODS AND SYSTEMS - Provided herein are exonuclease resistant polynucleotides and related constructs, compositions, methods and systems. | 11-06-2014 |
20140329706 | AFFINITY TAGS, AND RELATED AFFINITY LIGANDS, ENGINEERED PROTEINS, MODIFIED SUPPORTS, COMPOSITIONS, METHODS AND SYSTEMS - Affinity tags and ligands comprising a PDZ domain peptide and a PDZ binding carboxy terminal peptide and related engineered protein, engineered labels, compositions, methods and systems. | 11-06-2014 |
20140328862 | HUMAN IMMUNODEFICIENCY VIRUS NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF - The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection. | 11-06-2014 |
20140323699 | METHOD OF DETECTING CANCER BASED ON GLYCAN BIOMARKERS - The present invention provides a method for labeling or detecting a protein with certain glycosyl groups. The methods are particularly useful for detecting cancer cells comprising the detected glycosyl groups. The present invention further provides labeling agents and detection agents, labeled proteins and mixtures, and kits and arrays thereof. | 10-30-2014 |
20140322489 | MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS - A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. | 10-30-2014 |
20140316697 | REAL-TIME AND POST-PROCESSED ORBIT DETERMINATION AND POSITIONING - Novel methods and systems for the accurate and efficient processing of real-time and latent global navigation satellite systems (GNSS) data are described. Such methods and systems can perform orbit determination of GNSS satellites, orbit determination of satellites carrying GNSS receivers, positioning of GNSS receivers, and environmental monitoring with GNSS data. | 10-23-2014 |
20140316518 | HANDLE MECHANISM AND FUNCTIONALITY FOR REPOSITIONING AND RETRIEVAL OF TRANSCATHETER HEART VALVES - Improved catheter devices for delivery, repositioning and/or percutaneous retrieval of percutaneously implanted heart valves are described, including a medical device handle that provides an array of features helpful in conducting a percutaneous heart valve implantation procedure while variously enabling radial expansion or contraction and/or lateral positioning control over the heart valve during the medical procedure. | 10-23-2014 |
20140316261 | Life Detecting Radars - Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“CW”) radio signals that reflect back upon making contact with various objects. The signal can be systematically varied in frequency to provide a signal that is essentially continuous with short gaps between transmissions at different frequencies. The reflected return signals are received by one or more receive antennas and processed to detect one or more targets. The received signal can include a static (i.e. constant phase) signal corresponding to reflections from objects that do not move. The received signal can also include a phase varying signal that corresponds to reflections from a living target having measurable biometrics including (but not limited to) breathing patterns and heartbeats. Clutter can be removed and the remaining portions of the received signal are analyzed for target detection. | 10-23-2014 |
20140316149 | ALDEHYDE-SELECTIVE WACKER-TYPE OXIDATION OF UNBIASED ALKENES - This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising:
| 10-23-2014 |
20140315093 | USE AND FABRICATION OF MICROSCAFFOLDS AND NANOSCAFFOLDS - A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns. The core can be a solid, liquid or a gas. In some instances, one or more shell layers are positioned on the core. | 10-23-2014 |
20140312739 | HIGH TEMPERATURE ULTRASONIC PROBE AND PULSE-ECHO PROBE MOUNTING FIXTURE FOR TESTING AND BLIND ALIGNMENT ON STEAM PIPES - A high temperature ultrasonic probe and a mounting fixture for attaching and aligning the probe to a steam pipe using blind alignment. The high temperature ultrasonic probe includes a piezoelectric transducer having a high temperature. The probe provides both transmitting and receiving functionality. The mounting fixture allows the high temperature ultrasonic probe to be accurately aligned to the bottom external surface of the steam pipe so that the presence of liquid water in the steam pipe can be monitored. The mounting fixture with a mounted high temperature ultrasonic probe are used to conduct health monitoring of steam pipes and to track the height of condensed water through the wall in real-time. | 10-23-2014 |
20140312098 | SYSTEMS AND METHODS FOR FABRICATING STRUCTURES INCLUDING METALLIC GLASS-BASED MATERIALS USING ULTRASONIC WELDING - Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using ultrasonic welding. In one embodiment, a method of fabricating an object that includes a metallic glass-based material includes: ultrasonically welding at least one ribbon to a surface; where at least one ribbon that is ultrasonically welded to a surface has a thickness of less than approximately 150 μm; and where at least one ribbon that is ultrasonically welded to a surface includes a metallic glass-based material. | 10-23-2014 |
20140309415 | CONVERSION OF GLUCOSE TO SORBOSE - The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a topology of a 12 membered-ring or larger, an ordered mesoporous silica material, or an amorphous silica, said structure containing Lewis acidic Ti | 10-16-2014 |
20140303360 | Small Molecule Compounds for the Control of Nematodes - The present invention relates to compounds involved in nematode signaling. | 10-09-2014 |
20140303102 | Small Molecule Compounds that Control Mammal-Pathogenic Nematodes - The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal. | 10-09-2014 |
20140301418 | PHOTONIC CRYSTAL CAVITIES AND RELATED DEVICES AND METHODS - Photonic crystal cavities and related devices and methods are described. The described cavities can be used as lasers, photovoltaic sources, and single photon sources. The cavities can be both optically and electrically pumped. A fabrication process of the cavities is also described. | 10-09-2014 |
20140296780 | POLYMER COMPOSITE CARBON NANOTUBE MICRONEEDLE DEVICES AND THEIR FABRICATION - Composite CNT microneedle fabrication and finally-constructed delivery device embodiments are described. The microneedles can provide a self-administered, painless alternative to standard hypodermic injection. | 10-02-2014 |
20140295513 | High-Performance Ketol-Acid Reductoisomerases - The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 80% identical to SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 28, SEQ ID NO: 40, or SEQ ID NO: 58. The present invention also relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 99% identical to SEQ ID NO: 64. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol. | 10-02-2014 |
20140295512 | Ketol-Acid Reductoisomerases With Improved Performance Properties - The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol. | 10-02-2014 |
20140290381 | INTEGRATED ENVIRONMENTAL SENSORS FOR HARSH ENVIRONMENT APPLICATIONS - Systems and methods in accordance with embodiments of the invention implement integrated environmental sensors that can operate in rigorous environments. In one embodiment, an integrated environmental sensor includes: at least one sensor and a substrate; where: the at least one sensor is disposed on the substrate; the at least one sensor can detect at least two environmental properties including: the surrounding temperature; the surrounding pressure; the flow rate of surrounding fluids; and the surrounding composition; the at least one sensor is capable of detection in an environment that has: a temperature greater than 150° C.; a pressure greater than 100 bar; and/or an inclusion of one of liquid hydrocarbons, H | 10-02-2014 |
20140289246 | Systems and Methods for the Distributed Categorization of Source Data - Systems and methods for the crowdsourced clustering of data items in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining categories for a set of source data includes obtaining a set of source data, determining a plurality of subsets of the source data, where a subset of the source data includes a plurality of pieces of source data in the set of source data, generating a set of pairwise annotations for the pieces of source data in each subset of source data, clustering the set of source data into related subsets of source data based on the sets of pairwise labels for each subset of source data, and identifying a category for each related subset of source data based on the clusterings of source data and the source data metadata for the pieces of source data in the group of source data. | 09-25-2014 |
20140288319 | CROSS-METATHESIS REACTION OF FUNCTIONALIZED AND SUBSTITUTED OLEFINS USING GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS METATHESIS CATALYSTS - The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration. | 09-25-2014 |
20140281345 | Distributed Storage Allocation for Heterogeneous Systems - Allocation of storage budget in a computer-based distributed storage system is described, where associated computer-based storage nodes have heterogeneous access probabilities. The problem is to allocate a given storage budget across the available computer-based nodes so as to store a unit-size data object (e.g. file) with a higher reliability (e.g. increased probability for the storage budget to be recovered). Efficient algorithms for optimizing over one or more classes of allocations are presented. A basic one-level symmetric allocation is presented, where the storage budget is spread evenly over an appropriately chosen subset of nodes. Furthermore, a two-level symmetric allocation is presented, where the budget is divided into two parts, each spread evenly over a different subset of computer-based storage nodes, such that the amount allocated to each node in the first subset is twice that of the second subset. Further expansion of the two-level symmetric allocation is provided with a three-level and a generic k-level symmetric allocation. | 09-18-2014 |
20140272500 | SYSTEMS AND METHODS FOR DETECTING ABNORMALITIES IN ELECTRICAL AND ELECTROCHEMICAL ENERGY UNITS - A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality. | 09-18-2014 |
20140259887 | ASSOCIATIVE POLYMERS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Described herein are associative polymers capable of controlling one or more physical and/or chemical properties of non-polar compositions and related compositions, methods and systems. | 09-18-2014 |
20140256114 | SILICON-ON-INSULATOR CHANNELS - Novel methods to fabricate biological sensors and electronics are disclosed. A silicon-on-insulator wafer can be employed by etching a pattern of holes in the silicon layer, then a pattern of cavities in the insulating layer, and then sealing the top of the cavities. Further, n or p doped regions and metallic regions can be defined in the processed wafer, thereby enabling integration of biological sensing and electronic capabilities in the same wafer. | 09-11-2014 |
20140255991 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES - Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine. | 09-11-2014 |
20140255807 | DIRECT METHANOL FUEL CELL OPERABLE WITH NEAT METHANOL - A fuel cell system running on direct neat methanol. Back diffusion of water from the cathode to the anode is sufficiently high so that water is not accumulated at the cathode, thereby leading to fuel cell systems without the need for a pump system to remove circulate water from the cathode to the anode. Other embodiments are described and claimed. | 09-11-2014 |
20140255806 | METHANE-BASED POWER GENERATION WITH ZERO-CARBON EMISSIONS - The present invention provides a method of converting a hydrocarbon into H | 09-11-2014 |
20140255763 | METHOD AND DEVICE FOR DENDRITE RESEARCH AND DISCOVERY IN BATTERIES - An electrolytic coin cell that has been used to study the growth of lithium dendrites by optical observation is described. The cell makes possible observation of the growth of the dendrites in response to various applied conditions, such as applied electrical signals, chemical effects, and temporal effects in a real coin cell geometry. | 09-11-2014 |
20140250301 | NETWORK CODING-BASED ANONYMOUS COMMUNICATION - A computer-based peer-to-peer anonymous networking using a coding scheme with a formal information theoretic security characterization to construct a corresponding overlay subgraph is presented. A code construction based on linear coding which can be used for data transfer in an anonymous network is also presented. Various performance and simulation of the presented codes are provided in the Annex A1 which makes part of the present disclosure. | 09-04-2014 |
20140248216 | DRUG DELIVERY BY CARBON NANOTUBE ARRAYS - The invention generally relates to carbon nanotube based drug delivery methods, devices, and compositions. More particularly, the invention relates to controlled drug delivery using anchored carbon nanotube arrays. | 09-04-2014 |
20140246809 | SYSTEMS AND METHODS IMPLEMENTING ADDITIVE MANUFACTURING PROCESSES THAT UTILIZE MULTIPLE BUILD HEADS - Systems and methods in accordance with embodiments implement additive manufacturing processes that utilize multiple build heads. In one embodiment, an additive manufacturing apparatus includes: a plurality of build heads, each of which being adapted to cause the formation of a structure onto a surface; a substrate; and a translation system, where the translation system is associated with at least one of the plurality of build heads and the substrate, such that the spatial relationship between the plurality of build heads and the substrate can be controlled. | 09-04-2014 |
20140245522 | SOUND PROOF HELMET - Novel methods and systems for acoustic proofing are disclosed. A sound proof helmet can be designed by optimizing several layers of different materials, thickness, and physical properties. The thickness of the layers can be smaller than the wavelength of the sound waves which are meant to be reduced. | 09-04-2014 |
20140243545 | Methods for providing bond activation catalysts and related catalysts, systems, and methods - Described herein are catalysts for activation of an R—H bond in a R—H substrate and related catalytic matrices, compositions, methods and systems. | 08-28-2014 |
20140243483 | Chiral Polymers for the Self-Assembly of Photonic Crystals - Described herein are copolymers constructed from chiral, non-racemic monomers, which self-assemble to photonic crystals. The difficulty of incorporating chiral elements into photonic crystals has limited the ability to generate unique bandstructures for different circular polarizations of light. The materials and methods described herein relate to easily, predictably fabricating chiral photonic crystals having desirable optical properties. | 08-28-2014 |
20140242647 | IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES - The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention. | 08-28-2014 |
20140234974 | USE OF GENE REGULATORY NETWORK LOGIC FOR TRANSFORMATION OF CELLS - Described herein is a gene regulatory network based focused approach to cell transformation. The methods described herein allow for identification of circuit and sub-circuit repertoires for which modification in a starting cell type can result in generation of a transformed cell type in a durable and persistent manner, without requiring potentially deleterious genome modification. The described methods and compositions produced by the methods find widespread application in regenerative medicine applications. | 08-21-2014 |
20140234848 | Cryptographic Methods Using Nucleic Acid Codes - Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing. Unique organisms can also be used for identification. The nucleic acids can be encapsulated in organic materials such as saccharide-based desiccants. | 08-21-2014 |
20140234097 | HORIZONTAL-TYPE WIND TURBINE WITH AN UPSTREAM DEFLECTOR - Horizontal axis wind turbine (HAWT) systems are described that include a turbine with deflector in front of the turbine in order to change flow encountered by the turbine's blades. Such an arrangement improves turbine efficiency and may be embodied in a range of size scales for numerous wind (or water) power generation applications. | 08-21-2014 |
20140223591 | ANTIBODY-MEDIATED IMMUNOCONTRACEPTION - The present disclosure generally relates to methods and compositions for contraception. In some embodiments, vector based approaches for contraception are provided. | 08-07-2014 |
20140222964 | CODING FOR REAL-TIME STREAMING UNDER PACKET ERASURES - A computer-based real-time streaming system under packet erasures wherein created messages can be decoded within a fixed delay form their creation is presented. Various code construction methods and corresponding hardware implementation for different cases of erasure link models are also presented. | 08-07-2014 |
20140221827 | ENHANCED OPTICAL ANGIOGRAPHY USING INTENSITY CONTRAST AND PHASE CONTRAST IMAGING METHODS - The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon intensity. The methods of the invention use logarithm operation to convert the multiplicative amplitude or intensity fluctuations (speckle) into the additive variations and recovers the motion contrasts by removing the speckle free signals (static regions) through statistical analysis. | 08-07-2014 |
20140221799 | METHODS AND SYSTEMS FOR EXCHANGING SIGNALS WITH MEDICAL OR PHYSIOLOGICAL INSTRUMENTATION - A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader. | 08-07-2014 |
20140220049 | MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS - The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIFlα, Sla, Cepbβ, and Bach1, and the like. | 08-07-2014 |
20140213471 | CHROMOPHORE-BASED CHARACTERIZATION AND DETECTION METHODS - This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes. | 07-31-2014 |
20140212876 | TARGETING C-REL O-GLCNACYLATION AND USES THEREOF - Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines. | 07-31-2014 |
20140205829 | METHOD FOR CONTROLLING MICROSTRUCTURAL ARRANGEMENT OF NOMINALLY-ALIGNED ARRAYS OF CARBON NANOTUBES - A method for controlling the microstructural arrangement of nominally-aligned arrays of carbon nanotubes (CNTs) and a foam structure of CNTs are disclosed. The method includes a functionalization of CNT surfaces, for example, a non-covalent functionalization. The non-covalent functionalization of CNT surfaces can be obtained by way of a wetting process, for example by the use of a solution of surfactant or silica (SiO | 07-24-2014 |
20140204382 | MINIATURE TUNABLE LASER SPECTROMETER FOR DETECTION OF A TRACE GAS - An open-path laser spectrometer (OPLS) for measuring a concentration of a trace gas, the OPLS including an open-path multi-pass analysis region including a first mirror, a second mirror at a distance and orientation from the first mirror, and a support structure for locating the mirrors, a laser coupled to the analysis region and configured to emit light of a wavelength range and to enable a plurality of reflections of the emitted light between the mirrors, a detector coupled to the analysis region and configured to detect a portion of the emitted light impinging on the detector and to generate a corresponding signal, and an electronic system coupled to the laser and the detector, and configured to adjust the wavelength range of the emitted light from the laser based on the generated signal, and to measure the concentration of the trace gas based on the generated signal. | 07-24-2014 |
20140203623 | TERRAIN TRAVERSING DEVICE HAVING A WHEEL WITH MICROHOOKS - A terrain traversing device is described. The device includes an annular rotor element with a plurality of co-planar microspine hooks arranged on the periphery of the annular rotor element. Each microspine hook has an independently flexible suspension configuration that permits the microspine hook to initially engage an irregularity in a terrain surface at a preset initial engagement angle and subsequently engage the irregularity with a continuously varying engagement angle when the annular rotor element is rotated for urging the terrain traversing device to traverse a terrain surface. Improvements related to the design, fabrication and use of the microspine hooks in the device are also described. | 07-24-2014 |
20140202595 | SYSTEMS AND METHODS FOR FABRICATING OBJECTS INCLUDING AMORPHOUS METAL USING TECHNIQUES AKIN TO ADDITIVE MANUFACTURING - Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first layer of molten metallic alloy such that it solidifies and thereby forms a first layer including amorphous metal; subsequently applying at least one layer of molten metallic alloy onto a layer including amorphous metal; cooling each subsequently applied layer of molten metallic alloy such that it solidifies and thereby forms a layer including amorphous metal prior to the application of any adjacent layer of molten metallic alloy; where the aggregate of the solidified layers including amorphous metal forms a desired shape in the object to be fabricated; and removing at least the first layer including amorphous metal from the surface. | 07-24-2014 |
20140201980 | LONGITUDINAL ALIGNMENT OF MICROWIRES - A method of aligning microwires includes modifying the microwires so they are more responsive to a magnetic field. The method also includes using a magnetic field so as to magnetically align the microwires. The method can further include capturing the microwires in a solid support structure that retains the longitudinal alignment of the microwires when the magnetic field is not applied to the microwires. | 07-24-2014 |
20140200376 | TANDEM TRANSFER HYDROGENATION AND OLIGOMERIZATION FOR HYDROCARBON PRODUCTION - The disclosure provides for hydrocarbon production by hydrogenation and oligomerizaton and, more particularly, to catalysis of alkanes and alkenes by a tandem transfer hydrogenation and oligomerization. | 07-17-2014 |
20140199713 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 07-17-2014 |
20140196748 | PROTECTIVE DEVICES AND METHODS FOR PRECISION APPLICATION OF CLEANING POLYMER TO OPTICS - Novel devices and methods for cleaning optics are disclosed. A polymer can be sprayed onto the surface of an optic to capture contaminants. A spray cone can be used to limit the area of the polymer application. As the polymer solidifies, contaminants are captured and subsequently removed together with the polymer. | 07-17-2014 |
20140194604 | PROCESS FOR THE SYNTHESIS OF KETONES FROM INTERNAL ALKENES - The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C | 07-10-2014 |
20140190255 | ULTRA HIGH RESOLUTION GRAVITY GRADIOMETERY TECHNIQUE - A method and system provide the ability to measure relative displacement and rotation. A first light is continuously shined from a first light source that is fixed on a first entity to a first two-dimensional (2D) plate fixed on a second entity. The first direction of propagation of the first light does not change relative to the first entity. A second light is shined from a second light source that is fixed on the first entity to a second 2D plate fixed on the second entity. A second direction of propagation of the second light does not change relative to the first entity and is different from the first direction of propagation. The displacement of the lights on plates is directly monitored to determine a 3D displacement vector that represents a relative displacement between the first entity and the second entity. Thus, a three dimensional gravity gradient tensor is constructed. | 07-10-2014 |
20140188879 | SYSTEMS AND METHODS FOR DISTRIBUTED DATA ANNOTATION - Systems and methods for distributed data annotation in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a distributed data annotation server system includes a storage device configured to store source data, one or more annotators, annotation tasks and a processor, wherein a distributed data annotation application configures the processor to receive source data including one or more pieces of source data, select one or more annotators, create one or more annotation tasks for the selected annotators and source data, request one or more annotations for the source data using the annotation tasks, receive annotations, determine source data metadata for at least one piece of source data using the received annotations, generate annotator metadata for at least one annotator using the received annotations and the source data, and estimate the ground truth for the source data using the source data metadata and the annotator metadata. | 07-03-2014 |
20140184748 | SINGLE-SENSOR SYSTEM FOR EXTRACTING DEPTH INFORMATION FROM IMAGE BLUR - Hardware and software methodology are described for three-dimensional imaging in connection with a single sensor. A plurality of images is captured at different degrees of focus without focus change of an objective lens between such images. Depth information is extracted by comparing image blur between the images captured on the single sensor. | 07-03-2014 |
20140182361 | PIEZORESISTIVE NEMS ARRAY NETWORK - A sensor for detecting analytes, a method of making the sensor, and a method of using the sensor. In one embodiment, the present invention comprises at least one array comprising a plurality of resonators. The resonators can be arranged in a plurality of rows and a plurality of columns, and can be connected in a combined series-parallel configuration. The resonators can be adapted to vibrate independently at about the same resonance frequency and about the same phase. The sensor can also comprise an actuator and a signal detector electrically coupled to the array. The sensor can also further comprise an analyte delivery system and can be functionalized for detection of at least one analyte. | 07-03-2014 |
20140180361 | NEUROSTIMULATOR - A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator. | 06-26-2014 |
20140179918 | METALLOCORROLES - Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications. | 06-26-2014 |
20140176203 | SYNCHRONIZATION OF NANOMECHANICAL OSCILLATORS - Synchronization of oscillators based on anharmonic nanoelectromechanical resonators. Experimental implimentation allows for unprecedented observation and control of parameters governing the dynamics of synchronization. Close quantitative agreement is found between experimental data and theory describing reactively coupled Duffing resonators with fully saturated feedback gain. In the synchonized state, a significant reduction in the phase noise of the oscillators is demonstrated, which is key for applications such as sensors and clocks. Oscillator networks constructed from nanomechanical resonators form an important laboratory to commercialize and study synchronization—given their high-quality factors, small footprint, and ease of co-integration with modern electronic signal processing technologies. Networks can be made including one-, two-, and three-dimensional networks. Triangular and square lattices can be made. | 06-26-2014 |
20140175893 | SMART RF LENSING: EFFICIENT, DYNAMIC AND MOBILE WIRELESS POWER TRANSFER - An RF lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic EM waves whose phases are modulated so as to concentrate the radiated power in a small volume of space in order to power an electronic device positioned in that space. Accordingly, the waves emitted by the radiators are caused to interfere constructively at that space. The multitude of radiators are optionally formed in a one-dimensional or two-dimensional array. The electromagnetic waves radiated by the radiators have the same frequency but variable amplitudes. | 06-26-2014 |
20140171912 | DRUG-ELUTING ANGIOPLASTY BALLOON SYSTEMS - Systems, devices, and methods are provided for drug-eluting angioplasty balloons. An underlying balloon core member is protected by a core-screen from mechanical and flow shear forces during delivery. Inflation of the balloon opens the screen and pores in the screen permitting drug transfer and absorption. Upon deflation, the screen can be compressed and withdrawn with the balloon. | 06-19-2014 |
20140167257 | FABRICATION OF THREE-DIMENSIONAL HIGH SURFACE AREA ELECTRODES - A method for fabricating three dimensional high surface electrodes is described. The methods including the steps: designing the pillars; selecting a material for the formation of the pillars; patterning the material; transferring the pattern to form the pillars; insulating the pillars and providing a metal layer for increased conductivity. Alternative methods for fabrication of the electrodes and fabrication of the electrodes using CMOS are also described. | 06-19-2014 |
20140163362 | CARDIAC MICROWAVE SIGNAL DETERMINATION OF CARDIOVASCULAR DISEASES - A microwave transceiver and feature extraction system is described. This system is adapted for measuring both electrical (ECG-related waveforms) and mechanical activity (heart sound and wall motion) of the heart and vessels, determining which signal features are related to which mechanical properties, and measurement of important hemodynamic parameters such as pressure, flow, and vessel's wall displacement. This system is non-invasive, portable, non-contacting and can remotely collect data at distances of <1 m to several meters that make it a perfect device for telemedicine. | 06-12-2014 |
20140162048 | MULTI-LAYER LIQUID-DIODE FABRIC AND PRODUCTS - Multi-layer fabrics and products incorporating the same are described in which the fabrics are configured to provide asymmetric resistance to liquid flow from one side of the fabric to the other. In garments or other products worn by a user, the effect can be utilized to prevent penetration of liquids (e.g., rain droplets) and contact of liquids from the exterior with the user's skin while allowing for extraction of droplets (e.g., sweat) in contact with an inner layer of the fabric out of contact with the skin and accelerating their evaporation. Medical and industrial applications of the fabric are contemplated as well. | 06-12-2014 |
20140161464 | OPTICALLY DRIVEN ACTIVE RADIATOR - A multi-port radiator radiates electromagnetic signal in response to a beat frequency of a pair of optical signals. The radiator includes a multitude of optical paths each carrying an optical signal having first and second wavelengths. A multitude of frequency conversion elements convert the optical signals to electrical signals and deliver them to the radiator's multiple ports. The frequency of the electrical signals, and hence the frequency of the electromagnetic wave, is defined by the difference between the first and second wavelengths. The phases of the optical signals received by the frequency conversion elements are shifted with respect to one another. Optionally, the difference between the phases of the optical signals travelling through each pair of adjacent paths is 90°. The first and second wavelengths are generated by a pair of optical sources and are optionally modulated before being combined and delivered to the optical paths. | 06-12-2014 |
20140158883 | CHARACTERIZATION OF NANOSCALE STRUCTURES USING AN ULTRAFAST ELECTRON MICROSCOPE - The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a component of the 4D UEM technique to provide high spatial and temporal resolution unavailable using conventional techniques. Other embodiments of the present invention relate to methods and systems for convergent beam UEM, focusing the electron beams onto the specimen to measure structural characteristics in three dimensions as a function of time. Additionally, embodiments provide not only 4D imaging of specimens, but characterization of electron energy, performing time resolved electron energy loss spectroscopy (EELS). | 06-12-2014 |
20140156224 | SINGLE-PROTEIN NANOMECHANICAL MASS SPECTROMETRY IN REAL TIME - Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution. | 06-05-2014 |
20140155666 | PALLADIUM-CATALYZED DECARBONYLATION OF FATTY ACID ANHYDRIDES FOR THE PRODUCTION OF LINEAR ALPHA OLEFINS - The present invention is directed to methods of forming olefins, especially linear alpha olefins from fatty acids or anhydrides, each method comprising: contacting an amount of precursor carboxylic acid anhydride with a palladium catalyst comprising a bidentate bis-phosphine ligand in a reaction mixture so as to form an olefin in a product with the concomittant formation and removal of CO and water from the reaction mixture, either directly or indirectly, wherein the reaction mixture is maintained with a sub-stoichiometric excess of a sacrificial carboxylic acid anhydride, an organic acid, or both, said sub-stoichiometric excess being relative to the amount of the precursor carboxylic acid anhydride. The precursor carboxylic acid anhydride may be added to the reaction mixture directly or formed in situ by the reaction between at least one precursor carboxylic acid with a stoichiometric amount of the sacrificial acid anhydride. | 06-05-2014 |
20140153368 | COMMUNICATION IN PIPES USING ACOUSTIC MODEMS THAT PROVIDE MINIMAL OBSTRUCTION TO FLUID FLOW - A plurality of phased array acoustic communication devices are used to communicate data along a tubulation, such as a well. The phased array acoustic communication devices employ phased arrays of acoustic transducers, such as piezoelectric transducers, to direct acoustic energy in desired directions along the tubulation. The system is controlled by a computer-based controller. Information, including data and commands, is communicated using digital signaling. | 06-05-2014 |
20140148074 | SYSTEMS AND METHODS FOR IMPLEMENTING ROBUST CARBON NANOTUBE-BASED FIELD EMITTERS - Systems and methods in accordance with embodiments of the invention implement carbon nanotube-based field emitters. In one embodiment, a method of fabricating a carbon nanotube field emitter includes: patterning a substrate with a catalyst, where the substrate has thereon disposed a diffusion barrier layer; growing a plurality of carbon nanotubes on at least a portion of the patterned catalyst; and heating the substrate to an extent where it begins to soften such that at least a portion of at least one carbon nanotube becomes enveloped by the softened substrate. | 05-29-2014 |
20140147192 | SILICON ALIGNMENT PINS: AN EASY WAY TO REALIZE A WAFER-TO-WAFER ALIGNMENT - A silicon alignment pin is used to align successive layers of components made in semiconductor chips and/or metallic components to make easier the assembly of devices having a layered structure. The pin is made as a compressible structure which can be squeezed to reduce its outer diameter, have one end fit into a corresponding alignment pocket or cavity defined in a layer of material to be assembled into a layered structure, and then allowed to expand to produce an interference fit with the cavity. The other end can then be inserted into a corresponding cavity defined in a surface of a second layer of material that mates with the first layer. The two layers are in registry when the pin is mated to both. Multiple layers can be assembled to create a multilayer structure. Examples of such devices are presented. | 05-29-2014 |
20140144009 | Microfabrication Technique of Silicon Microlens Array for Terahertz Applications - A set of antenna geometries for use in integrated arrays at terahertz frequencies are described. Two fabrication techniques to construct such antennas are presented. The first technique uses an advanced laser micro-fabrication, allowing fabricating advanced 3D geometries. The second technique uses photolithographic processes, allowing the fabrication of arrays on a single wafer in parallel. | 05-29-2014 |
20140142664 | HIGHLY MULTIPLEXED OPTOGENETIC NEURAL STIMULATION USING INTEGRATED OPTICAL TECHNOLOGIES - A neural probe is provided. The probe includes: a base that includes an optical demultiplexer, and one or more shanks extending from the base, with each shank including one or more waveguides. In the neural probe, the optical demultiplexer is optically connected to the one or more waveguides of each shank. A system including the neural probe and an optical multiplexer optically connected to the demultiplexer of the neural probe is also provided. Further, a method of emitting light from a neural probe is provided. The method includes receiving and demultiplexing multiplexed optical signals at a base of a neural probe, and emitting the demultiplexed optical signals from one or more shanks of the neural probe. | 05-22-2014 |
20140141686 | SYSTEMS AND METHODS FOR FABRICATING CARBON NANOTUBE-BASED VACUUM ELECTRONIC DEVICES - Systems and methods in accordance with embodiments of the invention proficiently produce carbon nanotube-based vacuum electronic devices. In one embodiment a method of fabricating a carbon nanotube-based vacuum electronic device includes: growing carbon nanotubes onto a substrate to form a cathode; assembling a stack that includes the cathode, an anode, and a first layer that includes an alignment slot; disposing a microsphere partially into the alignment slot during the assembling of the stack such that the microsphere protrudes from the alignment slot and can thereby separate the first layer from an adjacent layer; and encasing the stack in a vacuum sealed container. | 05-22-2014 |
20140141498 | NUCLEIC ACID AMPLIFICATION USING MICROFLUIDIC DEVICES - The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certaom devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through the temperature regions such that the solution is exposed to different temperatures. Other microfluidic devices include an array of reaction chambers formed by intersecting vertical and horizontal flow channels, with the ability to regulate temperature at the reaction chambers. The microfluidic devices can be used to conduct a number of different analyses, including various primer extension reactions and nucleic acid amplification reactions. | 05-22-2014 |
20140141497 | MICROFLUIDIC CHEMOSTAT - A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat is described. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber. | 05-22-2014 |
20140141164 | Systems and Methods Implementing Layers of Metallic Glass-Based Materials - Systems and methods in accordance with embodiments of the invention implement layers of metallic glass-based materials. In one embodiment, a method of fabricating a layer of metallic glass includes: applying a coating layer of liquid phase metallic glass to an object, the coating layer being applied in a sufficient quantity such that the surface tension of the liquid phase metallic glass causes the coating layer to have a smooth surface; where the metallic glass has a critical cooling rate less than 1000 K/s; and cooling the coating layer of liquid phase metallic glass to form a layer of solid phase metallic glass. | 05-22-2014 |
20140140652 | Integrated Light Source Independent Linewidth Reduction of Lasers Using Electro-Optical Feedback Techniques - An integrated optical linewidth reduction system includes a phase modulator adapted to modulate the phase of an incoming optical signal in response to a feedback control signal defined by a first electrical signal. The phase modulator is further adapted to generate a first optical signal travelling through a first optical path. The first electrical signal is representative of a phase noise of the first optical signal. An optical linewidth of the first optical signal is less than an optical linewidth of the incoming optical signal. | 05-22-2014 |
20140139840 | Spatial Frequency Swept Interference Illumination - Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency. | 05-22-2014 |
20140135198 | DEVICES AND METHODS FOR NUCLEIC ACID EXTRACTION CAPTURE AND CONCENTRATION USING ELECTRIC FIELDS AND CENTRIFUGATION - Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device has centrifuge tubes and elements to create electric fields. The shear forces applied to the cells inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR. | 05-15-2014 |
20140133702 | Methods for Rapid Distinction between Debris and Growing Cells - Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris. | 05-15-2014 |
20140131574 | CONTROL IMAGING METHODS IN ADVANCED ULTRAFAST ELECTRON MICROSCOPY - An optical system includes a beam splitter disposed along an optical axis and a set of mirrors optically coupled to the beam splitter. The set of mirrors are oriented perpendicular to each other. The optical system also includes a turning mirror optically coupled to a second mirror of the set of mirrors and a detector optically coupled to the turning mirror. | 05-15-2014 |
20140128494 | ON-DEMAND PHOTOINITIATED POLYMERIZATION - Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides structure to the lens. The masking compound is capable of blocking polymerization or crosslinking of the prepolymer, until photoisomerization of the compound is triggered, and the compound is converted from a first isomer to a second isomer having a different absorption profile. The prepolymer is a composition that can undergo a polymerization or crosslinking reaction upon photoinitiation to alter one or more of the properties of the lenses. | 05-08-2014 |
20140127796 | INSTRUMENTS FOR BIOLOGICAL SAMPLE-TO-ANSWER DEVICES - Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. | 05-08-2014 |
20140127790 | INSTRUMENTS FOR BIOLOGICAL SAMPLE PREPARATION DEVICES - Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. | 05-08-2014 |
20140127777 | METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS - The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and chemical stability of such polypeptides is improved compared to those properties of its corresponding wild type proteins. | 05-08-2014 |
20140127162 | REVERSIBLE GENE EXPRESSION - According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest. | 05-08-2014 |
20140126691 | Fourier Ptychographic X-ray Imaging Systems, Devices, and Methods - Methods, systems, and devices of Fourier ptychographic X-ray imaging by capturing a plurality of variably-illuminated, low-resolution intensity X-ray images of a specimen and computationally reconstructing a high-resolution X-ray image of the specimen by iteratively updating overlapping regions in Fourier space with the variably-illuminated, low-resolution intensity X-ray images. | 05-08-2014 |
20140118529 | Fourier Ptychographic Imaging Systems, Devices, and Methods - Systems, devices, and methods of Fourier ptychographic imaging by computationally reconstructing a high-resolution image by iteratively updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space. | 05-01-2014 |
20140112779 | FEATURES FOR FLAG-TYPE POWER GENERATION - Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change. Leading-edge and trailing-edge mounted flag architectures are described with various applications including flapping flag arrays and Vertical Axis Wind Turbines (VAWTs). | 04-24-2014 |
20140112778 | FLEXIBLE BLADES FOR WIND TURBINE DESIGN - Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change. Leading-edge and trailing-edge mounted flag architectures are described with various applications including flapping flag arrays and Vertical Axis Wind Turbines (VAWTs). | 04-24-2014 |
20140110944 | FLAG INSTABILITY FOR DIRECT MECHANICAL POWER GENERATION - Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change. Leading-edge and trailing-edge mounted flag architectures are described with various applications including flapping flag arrays and Vertical Axis Wind Turbines (VAWTs). | 04-24-2014 |
20140110612 | HYDRAULIC HIGH PRESSURE VALVE CONTROLLER USING THE IN-SITU PRESSURE DIFFERENCE - A hydraulic vale controller that uses an existing pressure differential as some or all of the power source for valve operation. In a high pressure environment, such as downhole in an oil or gas well, the pressure differential between the inside of a pipe and the outside of the pipe may be adequately large to drive a linear slide valve. The valve is operated hydraulically by a piston in a bore. When a higher pressure is applied to one end of the bore and a lower pressure to the other end, the piston moves in response to the pressure differential and drive a valve attached to it. If the pressure differential is too small to drive the piston at a sufficiently high speed, a pump is provided to generate a larger pressure differential to be applied. The apparatus is conveniently constructed using multiport valves, which can be rotary valves. | 04-24-2014 |
20140107983 | SYSTEMS AND METHODS OF DESIGNING NUCLEIC ACIDS THAT FORM PREDETERMINED SECONDARY STRUCTURE - Described is a system and process for designing the equilibrium base-pairing properties of a test tube of interacting nucleic acid strands. A target test tube is specified as a set of desired ‘on-target’ complexes, each with a target secondary structure and target concentration, and a set of undesired ‘off-target’ complexes, each with vanishing target concentration. Sequence design is performed by optimizing the test tube ensemble defect, corresponding to the concentration of incorrectly paired nucleotides at equilibrium evaluated over the ensemble of the test tube. | 04-17-2014 |
20140107954 | APPARATUS FOR AND METHOD OF MONITORING CONDENSED WATER IN STEAM PIPES AT HIGH TEMPERATURE - A system and method for monitoring the properties of a fluid, such as water, in a steam pipe without mechanically penetrating the wall of the pipe. The system uses a piezoelectric transducer to launch an ultrasonic probe signal into the pipe. Reflected ultrasonic signals are captured in a transducer, which can be the same transducer that launched the probe signal. The reflected signals are subjected to data processing, which can include filtering, amplification, analog-to-digital conversion and autocorrelation analysis. A result is extracted which is indicative of a property of the fluid, such as a height of the condensed fluid, a cavitation of the condensed fluid, and a surface perturbation of the condensed fluid. The result can be recorded, displayed, and/or transmitted to another location. One embodiment of the system has been constructed and tested based on a general purpose programmable computer using instructions recorded in machine-readable non-volatile memory. | 04-17-2014 |
20140106960 | Z-SELECTIVE OLEFIN METATHESIS CATALYSTS AND THEIR SYNTHETIC PROCEDURE - The invention relates to C—H activated olefin metathesis catalyst compounds, the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, the use of such catalysts in Z selective olefin metathesis reactions. In general, the catalyst compounds of the invention comprise a Group 8 metal (M), an alkylidene moiety (═CR | 04-17-2014 |