BRUKER DALTONICS, INC. Patent applications |
Patent application number | Title | Published |
20140145076 | APPARATUS AND METHOD FOR CROSS-FLOW ION MOBILITY SPECTROMETRY - A cross-flow ion mobility spectrometer consists of two parallel plates defining a volume between them. Analyte ions flow along an axis from an entrance end to an exit end through the volume. An RF confining field tends to guide ions along the axis. An analytical gas flow is established orthogonal to the axis. A DC electrostatic analytical field is oriented in opposition to the analytical gas flow such that the “drag force” on ions of the selected mobility due to the analytical gas flow is balanced by the force on the ions due to the electrostatic analytical field. The selected ions are thereby able to follow a stable path to the exit end of the cross-flow mobility analyzer. However, the force on ions of other than the selected mobility is unbalanced and these ions are deflected and lost. | 05-29-2014 |
20140061500 | ATMOSPHERIC PRESSURE ION SOURCE WITH EXHAUST SYSTEM - An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber. | 03-06-2014 |
20140054457 | MASS SPECTROMETER WITH RIGID CONNECTION ASSEMBLIES - In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized. | 02-27-2014 |
20140014747 | ASSEMBLY FOR AN ELECTROSPRAY ION SOURCE - An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source. | 01-16-2014 |
20130277570 | METHOD AND DEVICE FOR GAS-PHASE ION FRAGMENTATION - The invention relates to a device for performing electron capture dissociation on multiply charged cations. Provided is an electron emitter which, upon triggering, emits a plurality of low energy electrons suitable for efficient electron capture reactions to occur. Further, the device contains a particle emitter being located proximate to the electron emitter and being capable, upon triggering, to emit a plurality of high energy charged particles substantially in a direction towards the electron emitter in order that the electron emitter receives a portion of the emitted plurality of high energy charged particles and emission of the plurality of low energy electrons is triggered. A volume capable of containing a plurality of multiply charged cations is located in opposing relation to the electron emitter such that the volume receives the plurality of low energy electrons upon emission as to allow electron capture dissociation to occur. | 10-24-2013 |
20130175441 | ION GUIDE AND ELECTRODE FOR ITS ASSEMBLY - An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself. | 07-11-2013 |
20130018621 | Dynamic Range Improvement For Mass SpectrometryAANM Telasang; ShankarAACI FremontAAST CAAACO USAAGP Telasang; Shankar Fremont CA US - Embodiments of the present disclosure provide methods of controlling an ion detector to minimize false peaks when utilizing extended dynamic range techniques. In one exemplary example, methods of controlling an ion detector are provided, comprising the steps of: determining an electronic baseline signal of the ion detector; receiving one or more ion input signals at the ion detector; comparing the ion input signal to the electronic baseline signal; and multiplying the ion input signal by a selected compensation factor when the ion input signal exceeds the electronic baseline signal. | 01-17-2013 |
20130015767 | STABILIZED ELECTRON MULTIPLIER ANODEAANM Steiner; UrsAACI BranfordAAST CTAACO USAAGP Steiner; Urs Branford CT USAANM Moeller; Roy P.AACI San LeandroAAST CAAACO USAAGP Moeller; Roy P. San Leandro CA USAANM Deford; DavidAACI PleasontonAAST CAAACO USAAGP Deford; David Pleasonton CA US - Methods and systems to compensate for distortions created by dynamic voltage applied to an electron multiplier used in mass spectrometry. An electron multiplier has a cathode end accepting ion flow, an opposite emitter end and an interior surface. The electron multiplier produces an electron output from ions colliding with the interior surface. A variable power supply has a voltage output coupled to the cathode end and the emitter end of the electron multiplier. The voltage output changes dynamically to adjust the electron output from the electron multiplier. An anode is located in proximity to the electron multiplier. An electrometer is coupled to the anode in proximity to the electron multiplier to measure the current generated by the electron output. A low pass filter circuit is coupled to the emitter end to the ground of the electrometer to attenuate emitter voltage changes. A bias circuit is coupled to the emitter end to stabilize emitter to anode voltage difference. | 01-17-2013 |
20130015349 | LENS FREE COLLISION CELL WITH IMPROVED EFFICIENCY - An ion collision cell is fabricated by four semi-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a semi-circular channel with a semi-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. semi-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. | 01-17-2013 |
20130015348 | CURVED HEATED ION TRANSFER OPTICS - An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler. | 01-17-2013 |
20130015347 | MASS SPECTROMETER WITH PRECISELY ALIGNED ION OPTIC ASSEMBLIES - A mass spectrometer has a manifold and at least one ion optical assembly that is composed of a support and electrodes attached to the support. The support is aligned to at least one reference surface machined integrally with the manifold such that the number of interfaces between the reference surface of the manifold and the electrodes is minimized. With such a design the positional and/or alignment precision of ion optical assemblies in a mass spectrometer can be improved. | 01-17-2013 |
20130015344 | BACKGROUND NOISE CORRECTION IN QUADRUPOLE MASS SPECTROMETERS - In a quadrupole mass spectrometer, which measures ion currents of a single mass with substantially constant RF and DC voltages during a measuring period and measures ions of different masses by varying the RF and DC voltages, a statistical evaluation is performed during data acquisition by a determination of the distribution of the measured and digitized noise values around an average noise level in the mass spectrometer output signal. The determined noise levels are subtracted from the signal output values separately for each measurement period. | 01-17-2013 |
20130015343 | Radio Frequency Voltage Temperature StabilizationAANM Steiner; UrsAACI BranfordAAST CTAACO USAAGP Steiner; Urs Branford CT USAANM Jones; Lawrence B.AACI San JoseAAST CAAACO USAAGP Jones; Lawrence B. San Jose CA US - A temperature-regulated radio frequency management system for use in a mass spectrometer is described. The temperature-regulated radio frequency management system having one or more radio frequency components disposed in a vacuum environment. The temperature-regulated radio frequency management system including a radio frequency detection circuit configured to provide feedback indicative of a radio frequency signal in one or more of the radio frequency components. In addition, the temperature-regulated radio frequency management system includes a temperature regulation circuit disposed in the vacuum environment and configured to reduce temperature-induced variations in the detection circuit. | 01-17-2013 |
20130015342 | Fixed Connection Assembly For an RF Drive Circuit in a Mass SpectrometerAANM Steiner; UrsAACI BranfordAAST CTAACO USAAGP Steiner; Urs Branford CT USAANM Jones; Lawrence B.AACI San JoseAAST CAAACO USAAGP Jones; Lawrence B. San Jose CA US - In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized. | 01-17-2013 |
20130015341 | MULTIPOLE ASSEMBLY AND METHOD FOR ITS FABRICATION - A multipole rod assembly, such as used as mass analyzer, is fabricated using rods adhesively attached to shoes, which are then attached to isolation rings. A fixture is used in conjunction with precision-made spacers to precisely assemble the ion mass analyzer. The rods and shoes can be made of metal, while the isolation rings are preferably made of insulator, such as ceramic. The shoes and isolation rings need not be made to high precision, as the spacer ensures high accuracy in alignment and symmetry of the rods. Consequently, the rods are the only precision machined parts in the ion mass analyzer assembly. | 01-17-2013 |
20130015340 | MULTIPOLE ASSEMBLY HAVING A MAIN MASS FILTER AND AN AUXILIARY MASS FILTER - A multipole rod assembly for use in a mass spectrometer has a plurality of rods aligned around and parallel to a common ion optical axis. Each rod consists of two rod pieces that are collinear with one another. Each rod piece has an opposing face that is perpendicular to the axis and faces the other rod. One rod piece has a recess is its face. The rod pieces are physically connected together with an insulating piece located between the two rod pieces to electrically de-couple the rod pieces. The insulating piece has a shape and size that allows it to fit entirely within the recess so that, during operation of the mass spectrometer, the insulating piece is substantially screened from the ion optical axis. | 01-17-2013 |
20130009051 | ABRIDGED ION TRAP - TIME OF FLIGHT MASS SPECTROMETER - An improved trap-TOF mass spectrometer has a set of electrodes arranged to produce both a quadrupolar RF confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the RF field and then, at a selected time, the RF confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a TOF MS analysis. The apparatus of the present invention may be used alone or in conjunction with other analyzers to produce mass spectra from analyte ions. | 01-10-2013 |
20130009050 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION, TRAPPING AND ANALYSIS OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can be used to excite ions into secular motion, inductively detect the ions, and thereby generate a mass spectrum. | 01-10-2013 |
20120305759 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION AND TRAPPING OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps. | 12-06-2012 |
20120305758 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT AND SELECTION OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. | 12-06-2012 |
20120298860 | MEANS AND METHOD FOR FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary. | 11-29-2012 |
20110121170 | APPARATUS AND METHOD FOR PARALLEL FLOW ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions entrained in a carrier gas are analyzed by parallel flow ion mobility spectrometry prior to analysis by a mass analyzer. An extended ion funnel is located in the vacuum system of the mass analyzer and has an ion focusing section and an ion mobility analyzing section. The carrier gas together with entrained ions is introduced into the ion focusing section where the ions are focused to the axis of the funnel by applied RF voltages. In the ion mobility section, the action of an RF quadrupolar field, the movement of the carrier gas and axial DC field, separates the ions on the basis of their mobilities. The mobility separated ions are released into the mass analyzer where the ions may be further separated on the basis of mass. | 05-26-2011 |