| Brookhaven Science Associates, LLC. Patent applications |
| Patent application number | Title | Published |
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| 20120129826 | Method of Treating Depression - Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K | 05-24-2012 |
| 20120121050 | Method and Apparatus for Analog Pulse Pile-Up Rejection - A method and apparatus for pulse pile-up rejection are disclosed. The apparatus comprises a delay value application constituent configured to receive a threshold-crossing time value, and provide an adjustable value according to a delay value and the threshold-crossing time value; and a comparison constituent configured to receive a peak-occurrence time value and the adjustable value, compare the peak-occurrence time value with the adjustable value, indicate pulse acceptance if the peak-occurrence time value is less than or equal to the adjustable value, and indicate pulse rejection if the peak-occurrence time value is greater than the adjustable value. | 05-17-2012 |
| 20120117694 | Novel Monolignol 4-O-Methyltransferases and Uses Thereof - Modified (iso)eugenol 4-O-methyltransferase enzymes having novel capacity for methylation of monolignols and reduction of lignin polymerization in plant cell wall are disclosed. Sequences encoding the modified enzymes are disclosed. | 05-10-2012 |
| 20120063569 | Two-Axis Sagittal Focusing Monochromator - An x-ray focusing device and method for adjustably focusing x-rays in two orthogonal directions simultaneously. The device and method can be operated remotely using two pairs of orthogonal benders mounted on a rigid, open frame such that x-rays may pass through the opening in the frame. The added x-ray flux allows significantly higher brightness from the same x-ray source. | 03-15-2012 |
| 20120039446 | INTERWOVEN MULTI-APERTURE COLLIMATOR FOR 3-DIMENSIONAL RADIATION IMAGING APPLICATIONS - An interwoven multi-aperture collimator for three-dimension radiation imaging applications is disclosed. The collimator comprises a collimator body including a plurality of apertures disposed in a two-dimensional grid. The collimator body is configured to absorb and collimate radiation beams emitted from a radiation source within a field of view of said collimator. The collimator body has a surface plane disposed closest to the radiation source. The two-dimensional grid is selectively divided into at least a first and a second group of apertures, respectively defining at least a first view and a second view of an object to be imaged. The first group of apertures is formed by interleaving or alternating rows of the grid, and the second group of apertures is formed by the rows of apertures adjacent to the rows of the first group. Each aperture in the first group is arranged in a first orientation angle with respect to the surface plane of said collimator body, and each aperture in the second group is arranged in a second orientation angle with respect to the surface plane of said collimator body such that the apertures of the first group are interwoven with the apertures of the second group. | 02-16-2012 |
| 20120028191 | Azide Functionalized Poly(3-Hexylthiophene) and Method of Forming Same - The invention relates azide functionalized poly(3-hexylthiophene)s. Various azide functionalized poly(3-hexylthiophene)s and intermediates are disclosed and described, as well as method for making novel monomers that are synthesized and transformed into P3HT-N | 02-02-2012 |
| 20110321194 | ACCUMULATION OF OMEGA-7 FATTY ACIDS IN PLANT SEEDS - Compositions and methods include genetically encoding and expressing a novel Δ | 12-29-2011 |
| 20110286576 | Compact Endocavity Diagnostic Probes for Nuclear Radiation Detection - This invention relates to the field of radiation imaging. In particular, the invention relates to an apparatus and a method for imaging tissue or an inanimate object using a novel probe that has an integrated solid-state semiconductor detector and complete readout electronics circuitry. | 11-24-2011 |
| 20110272589 | Hybrid Anode for Semiconductor Radiation Detectors - The present invention relates to a novel hybrid anode configuration for a radiation detector that effectively reduces the edge effect of surface defects on the internal electric field in compound semiconductor detectors by focusing the internal electric field of the detector and redirecting drifting carriers away from the side surfaces of the semiconductor toward the collection electrode(s). | 11-10-2011 |
| 20110245465 | Methods for Detection of Methyl-CpG Dinucleotides - The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5′-C | 10-06-2011 |
| 20110151356 | Electrocatalyst for Oxygen Reduction with Reduced Platinum Oxidation and Dissolution Rates - The invention relates to platinum-metal oxide composite particles and their use as electrocatalysts in oxygen-reducing cathodes and fuel cells. The invention particularly relates to methods for preventing the oxidation of the platinum electrocatalyst in the cathodes of fuel cells by use of these platinum-metal oxide composite particles. The invention additionally relates to methods for producing electrical energy by supplying such a fuel cell with an oxidant, such as oxygen, and a fuel source, such as hydrogen. | 06-23-2011 |
| 20110120517 | Synthesis of High-Efficiency Thermoelectric Materials - A process for the fabrication of high efficiency thermoelectric materials using non-equilibrium synthesis routes is described. In one embodiment a molten alloy comprising a predetermined ratio of elements which will constitute the thermoelectric material is quenched at a cooling rate in excess of, for example, 10 | 05-26-2011 |
| 20110116092 | Wide Size Range Fast Integrated Mobility Spectrometer - A mobility spectrometer to measure a nanometer particle size distribution is disclosed. The mobility spectrometer includes a conduit and a detector. The conduit is configured to receive and provide fluid communication of a fluid stream having a charged nanometer particle mixture. The conduit includes a separator section configured to generate an electrical field of two dimensions transverse to a dimension associated with the flow of the charged nanometer particle mixture through the separator section to spatially separate charged nanometer particles of the charged nanometer particle mixture in said two dimensions. The detector is disposed downstream of the conduit to detect concentration and position of the spatially-separated nanometer particles. | 05-19-2011 |
| 20100276731 | Inorganic Nanocrystal Bulk Heterojunctions - A bulk heterojunction comprising an intermixed blend of fully inorganic n- and p-type particles and its method of manufacture are described. The particles are preferably nanometer-scale, spherical-shaped particles known as nanocrystals which are assembled into a densely packed three-dimensional array. The nanocrystals are preferably fabricated from a photo-active material which, in combination with the nanocrystal shape and size, can be engineered to produce a bulk heterojunction with a specific absorption spectrum. The bulk heterojunction is preferably formed by dispersing a predetermined ratio of the desired n- and p-type nanocrystals in an organic solvent and employing low-cost solution processing techniques to deposit a film having the desired thickness, relative concentration of nanocrystal types, and degree of intermixing onto a substrate. When incorporated as the active layer in optoelectronic devices such solar cells, fully inorganic bulk heterojunctions offer significant improvements in performance while maintaining the low costs associated with organic processing techniques. | 11-04-2010 |
| 20100230620 | Achromatic and Uncoupled Medical Gantry - A medical gantry that focus the beam from the beginning of the gantry to the exit of the gantry independent of the rotation angle of the gantry by keeping the beam achromatic and uncoupled, thus, avoiding the use of collimators or rotators, or additional equipment to control the beam divergence, which may cause beam intensity loss or additional time in irradiation of the patient, or disadvantageously increase the overall gantry size inapplicable for the use in the medical treatment facility. | 09-16-2010 |
| 20100216632 | High Stability, Self-Protecting Electrocatalyst Particles - High-stability, self-protecting particles encapsulated by a thin film of a catalytically active noble metal are described. The particles are preferably nanoparticles comprising a passivating element having at least one metal selected from the group consisting of columns IVB, VB, VIB, and VIIB of the periodic table. The nanoparticle is preferably encapsulated by a Pt shell and may be either a nanoparticle alloy or a core-shell nanoparticle. The nanoparticle alloys preferably have a core comprised of a passivating component alloyed with at least one other transition metal. The core-shell nanoparticles comprise a core of a non-noble metal surrounded by a shell of a noble metal. The material constituting the core, shell, or both the core and shell may be alloyed with one or more passivating elements. The self-protecting particles are ideal for use in corrosive environments where they exhibit improved stability compared to conventional electrocatalyst particles. | 08-26-2010 |
| 20100197490 | Platinum-Coated Non-Noble Metal-Noble Metal Core-Shell Electrocatalysts - Core-shell particles encapsulated by a thin film of a catalytically active metal are described. The particles are preferably nanoparticles comprising a non-noble core with a noble metal shell which preferably do not include Pt. The non-noble metal-noble metal core-shell nanoparticles are encapsulated by a catalytically active metal which is preferably Pt. The core-shell nanoparticles are preferably formed by prolonged elevated-temperature annealing of nanoparticle alloys in an inert environment. This causes the noble metal component to surface segregate and form an atomically thin shell. The Pt overlayer is formed by a process involving the underpotential deposition of a monolayer of a non-noble metal followed by immersion in a solution comprising a Pt salt. A thin Pt layer forms via the galvanic displacement of non-noble surface atoms by more noble Pt atoms in the salt. The overall process is a robust and cost-efficient method for forming Pt-coated non-noble metal-noble metal core-shell nanoparticles. | 08-05-2010 |
| 20100177462 | Platinum-Based Electrocatalysts Synthesized by Depositing Contiguous Adlayers on Carbon Nanostructures - High-surface-area carbon nanostructures coated with a smooth and conformal submonolayer-to-multilayer thin metal films and their method of manufacture are described. The preferred manufacturing process involves the initial oxidation of the carbon nanostructures followed by immersion in a solution with the desired pH to create negative surface dipoles. The nanostructures are subsequently immersed in an alkaline solution containing non-noble metal ions which adsorb at surface reaction sites. The metal ions are then reduced via chemical or electrical means and the nanostructures are exposed to a solution containing a salt of one or more noble metals which replace adsorbed non-noble surface metal atoms by galvanic displacement. Subsequent film growth may be performed via the initial quasi-underpotential deposition of a non-noble metal followed by immersion in a solution comprising a more noble metal. The resulting coated nanostructures may be used, for example, as high-performance electrodes in supercapacitors, batteries, or other electric storage devices. | 07-15-2010 |
| 20100171096 | Segmented Nanowires Displaying Locally Controllable Properties - Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au—Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy. | 07-08-2010 |
| 20100160300 | Method of Treating Depression - Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K | 06-24-2010 |
| 20100159618 | Assembly of ordered carbon shells on semiconducting nanomaterials - In some embodiments of the invention, encapsulated semiconducting nanomaterials are described. In certain embodiments the nanostructures described are semiconducting nanomaterials encapsulated with ordered carbon shells. In some aspects a method for producing encapsulated semiconducting nanomaterials is disclosed. In some embodiments applications of encapsulated semiconducting nanomaterials are described. | 06-24-2010 |
| 20100144029 | Facilitating Protein Solubility by Use of Peptide Extensions - Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions. | 06-10-2010 |
| 20100102248 | Transmission Electron Microscope Sample Holder with Optical Features - A sample holder for holding a sample to be observed for research purposes, particularly in a transmission electron microscope (TEM), generally includes an external alignment part for directing a light beam in a predetermined beam direction, a sample holder body in optical communication with the external alignment part and a sample support member disposed at a distal end of the sample holder body opposite the external alignment part for holding a sample to be analyzed. The sample holder body defines an internal conduit for the light beam and the sample support member includes a light beam positioner for directing the light beam between the sample holder body and the sample held by the sample support member. | 04-29-2010 |
| 20100099012 | Electrocatalyst Synthesized by Depositing a Contiguous Metal Adlayer on Transition Metal Nanostructures - Transition metal nanostructures coated with a contiguous, conformal submonolayer-to-multilayer noble metal film and their method of manufacture are described. The manufacturing process involves the initial formation of suitably sized transition metal or alloy nanostructures which may be nanorods, nanobars, or nanowires. A monolayer of a non-noble metal is deposited onto the surface of the nanostructures by underpotential deposition. This is followed by the galvanic displacement of the non-noble metal by a second metal to yield a conformal coating of a monolayer of the second metal on the surface of the nanostructures. The replacement of atoms of the first metal by atoms of the second metal is an irreversible and spontaneous redox reaction which involves the replacement of a non noble metal by a more noble metal. The process can be controlled and repeated to obtain the desired film coverage. The resulting coated nanostructures provide heightened catalytic activity and can be used as high-performance electrodes in fuel cells. | 04-22-2010 |
| 20100097742 | Electrodes Synthesized from Carbon Nanostructures Coated with a Smooth and Conformal Metal Adlayer - High-surface-area carbon nanostructures coated with a smooth and conformal submonolayer-to-multilayer thin metal films and their method of manufacture are described. The preferred manufacturing process involves the initial oxidation of the carbon nanostructures followed by a surface preparation process involving immersion in a solution with the desired pH to create negative surface dipoles. The nanostructures are subsequently immersed in an alkaline solution containing a suitable quantity of non-noble metal ions which adsorb at surface reaction sites. The metal ions are then reduced via chemical or electrical means. The nanostructures are exposed to a solution containing a salt of one or more noble metals which replace adsorbed non-noble surface metal atoms by galvanic displacement. The process can be controlled and repeated to obtain a desired film coverage. The resulting coated nanostructures may be used, for example, as high-performance electrodes in supercapacitors, batteries, or other electric storage devices. | 04-22-2010 |
| 20100081174 | Methods for Detection of Methyl-CpG Dinucleotides - The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5′-C | 04-01-2010 |
| 20100051818 | Method and Apparatus for the Measurement of Signals from Radiation Sensors - The preferred embodiments of the present invention include a device for measuring an ionizing event in a radiation sensor. The device can include a charge amplifier and a timing shaper. The charge amplifier receives a cathode signal and is configured to output an amplified cathode signal. The timing shaper is operatively connected to the charge amplifier to receive the amplified cathode signal. The timing shaper is configured to generate a first pulse in response to a beginning of the ionizing event and a second pulse in response to an end of the ionizing event. The first and second pulses are associated with a depth of interaction of the ionizing event and are generated in response to a slope of the amplified cathode signal changing. | 03-04-2010 |
| 20100049459 | High Dynamic Range Charge Measurements - A charge amplifier for use in radiation sensing includes an amplifier, at least one switch, and at least one capacitor. The switch selectively couples the input of the switch to one of at least two voltages. The capacitor is electrically coupled in series between the input of the amplifier and the input of the switch. The capacitor is electrically coupled to the input of the amplifier without a switch coupled therebetween. A method of measuring charge in radiation sensing includes selectively diverting charge from an input of an amplifier to an input of at least one capacitor by selectively coupling an output of the at least one capacitor to one of at least two voltages. The input of the at least one capacitor is operatively coupled to the input of the amplifier without a switch coupled therebetween. The method also includes calculating a total charge based on a sum of the amplified charge and the diverted charge. | 02-25-2010 |
| 20100038552 | Gantry for Medical Particle Therapy Facility - A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of fixed field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of fixed field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing fixed field magnets. | 02-18-2010 |
| 20100037674 | Test Surfaces Useful for Calibration of Surface Profilometers - The present invention provides for test surfaces and methods for calibration of surface profilometers, including interferometric and atomic force microscopes. Calibration is performed using a specially designed test surface, or the Binary Pseudo-random (BPR) grating (array). Utilizing the BPR grating (array) to measure the power spectral density (PSD) spectrum, the profilometer is calibrated by determining the instrumental modulation transfer function (IMTF). | 02-18-2010 |
| 20100021471 | CARBON NANOTUBE-BASED DRUG DELIVERY SYSTEMS AND METHODS OF MAKING SAME - The present invention includes a conjugates comprising a carbon nanotube with at least one covalently attached recognition module, and at least one covalently attached pharmaceutical compound or a precursor of the pharmaceutical compound, | 01-28-2010 |
| 20100012851 | Multi-Anode Ionization Chamber - The present invention includes a high-energy detector having a cathode chamber, a support member, and anode segments. The cathode chamber extends along a longitudinal axis. The support member is fixed within the cathode chamber and extends from the first end of the cathode chamber to the second end of the cathode chamber. The anode segments are supported by the support member and are spaced along the longitudinal surface of the support member. The anode segments are configured to generate at least a first electrical signal in response to electrons impinging thereon. | 01-21-2010 |
| 20100004133 | Fluorinated Precursors of Superconducting Ceramics, and Methods of Making the Same - This invention provides a method of making a fluorinated precursor of a superconducting ceramic. The method comprises providing a solution comprising a rare earth salt, an alkaline earth metal salt and a copper salt; spraying the solution onto a substrate to provide a film-covered substrate; and heating the film-covered substrate in an atmosphere containing fluorinated gas to provide the fluorinated precursor. | 01-07-2010 |
| 20090317880 | Simple, Rapid Method for the Preparation of Isotopically Labeled Formaldehyde - Isotopically labeled formaldehyde (*C | 12-24-2009 |
| 20090302232 | MULTI-WINDOW SIGNAL PROCESSING ELECTRONICS ARCHITECTURE FOR PHOTON COUNTING WITH MULTI-ELEMENT SENSORS - A radiation detection and counting system ( | 12-10-2009 |
| 20090291045 | Regeneration of Aluminum Hydride - The present invention provides methods and materials for the formation of hydrogen storage alanes, AlH | 11-26-2009 |
| 20090275465 | DNA-Guided Nanoparticle Assemblies - In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices. | 11-05-2009 |
| 20090258355 | Nanoscale Clusters and Methods of Making Same - The present invention is a method of making a nanocluster. The method comprises providing a surface comprising at least one anchoring biomolecule, wherein the surface is in a solution; adding an initial recognition-nano-component to the solution wherein the initial recognition-nano-component comprises i) a nanoparticle and one specifically-bindable-biomolecule, or ii) a nanoparticle and two different types of specifically-bindable-biomolecules, wherein a biomolecule of the initial recognition-nano-component specifically binds to the anchoring biomolecule; and adding a releasing biomolecule to the solution, wherein the releasing biomolecule binds to the anchoring biomolecule with a greater binding strength than the anchoring biomolecule binds to the initial recognition-nano-component, or wherein the releasing biomolecule binds to the initial recognition-nano-component with a greater binding strength than anchoring biomolecule binds to the initial recognition-nano-component, thereby making a nanocluster. | 10-15-2009 |
| 20090258051 | Microbes Encapsulated Within Crosslinkable Polymers - The invention relates to porous films comprising crosslinked electrospun hydrogel fibers. Viable microbes are encapsulated within the crosslinked electrospun hydrogel fibers. The crosslinked electrospun hydrogel fibers are water insoluble and permeable. The invention also relates to methods of making and using such porous films. | 10-15-2009 |
| 20090253190 | Enhanced Metabolite Generation - The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor accepts electrons from the microbe after oxidation of the carbon source. Other transfers of electrons can take place to enhance the production of the metabolite, such as acids, biofuels or brewed beverages. | 10-08-2009 |
| 20090177025 | Mercury Contamination Extraction - Mercury is removed from contaminated waste by firstly applying a sulfur reagent to the waste. Mercury in the waste is then permitted to migrate to the reagent and is stabilized in a mercury sulfide compound. The stable compound may then be removed from the waste which itself remains in situ following mercury removal therefrom. | 07-09-2009 |
| 20090171592 | Homology Models of Mammalian Zinc Transporters and Methods of Using Same - The present invention is a method of identifying a compound that has a sufficient level of binding with a target site on a mammalian zinc transporter, or a portion thereof. The method comprises (a) providing a homology model of a mammalian zinc transporter, or portion thereof, comprising at least one target site; and (b) employing computational means to evaluate the level of binding of the compound with the target site, or a portion thereof. If a sufficient level of binding is found, then a compound is identified. | 07-02-2009 |
| 20090137398 | High Temperature Interfacial Superconductivity - High-temperature superconductivity confined to nanometer-scale interfaces has been a long standing goal because of potential applications in electronic devices. The spontaneous formation of a superconducting interface in bilayers consisting of an insulator (La | 05-28-2009 |
| 20090117384 | Titania Nanocavities and Method of Making - Disclosed herein are compositions of metal oxide nanoparticles having regular polyhedral nanocavities, where the metal oxide can be titania, and where the nanoparticles be nanorods. Also disclosed are titania nanoparticles with nanocavities that are doped with dopants. Methods of making metal oxide nanoparticles with nanocavities are also disclosed. Also disclosed are ultraviolet-blocking compositions including metal oxide nanoparticles with nanocavities, as well as methods of enhancing ultraviolet absorbance efficiency of an ultraviolet blocking composition. Additional uses of metal oxide nanoparticles with nanocavities include solar energy conversion systems and lithium-ion batteries. | 05-07-2009 |
| 20090093863 | Method and Devices for Performing Stereotactic Microbeam Radiation Therapy - A radiation delivery system generally includes either a synchrotron source or a support frame and a plurality of microbeam delivery devices supported on the support frame, both to deliver a beam in a hemispherical arrangement. Each of the microbeam delivery devices or synchrotron irradiation ports is adapted to deliver at least one microbeam of radiation along a microbeam delivery axis, wherein the microbeam delivery axes of the plurality of microbeam delivery devices cross within a common target volume. | 04-09-2009 |
| 20090068505 | Electrocatalyst for Alcohol Oxidation at Fuel Cell Anodes - In some embodiments a ternary electrocatalyst is provided. The electrocatalyst can be used in an anode for oxidizing alcohol in a fuel cell. In some embodiments, the ternary electrocatalyst may include a noble metal particle having a surface decorated with clusters of SnO | 03-12-2009 |
| 20090057649 | Assembly of Ordered Carbon Shells on Semiconducting Nanomaterials - In some embodiments of the invention, encapsulated semiconducting nanomaterials are described. In certain embodiments the nanostructures described are semiconducting nanomaterials encapsulated with ordered carbon shells. In some aspects a method for producing encapsulated semiconducting nanomaterials is disclosed. In some embodiments applications of encapsulated semiconducting nanomaterials are described. | 03-05-2009 |
| 20090048510 | Fiducial Marker for Correlating Images - The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains. | 02-19-2009 |
| 20090026371 | High-Energy Detector - The preferred embodiments are directed to a high-energy detector that is electrically shielded using an anode, a cathode, and a conducting shield to substantially reduce or eliminate electrically unshielded area. The anode and the cathode are disposed at opposite ends of the detector and the conducting shield substantially surrounds at least a portion of the longitudinal surface of the detector. The conducting shield extends longitudinally to the anode end of the detector and substantially surrounds at least a portion of the detector. Signals read from one or more of the anode, cathode, and conducting shield can be used to determine the number of electrons that are liberated as a result of high-energy particles impinge on the detector. A correction technique can be implemented to correct for liberated electron that become trapped to improve the energy resolution of the high-energy detectors disclosed herein. | 01-29-2009 |
| 20080279781 | Glycosylated Carboranylporphyrins and Uses Thereof - The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity glycosylated carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, and head and neck. The invention is also directed to using these glycosylated carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. | 11-13-2008 |
| 20080247512 | Sagittal Focusing Laue Monochromator - An x-ray focusing device generally includes a slide pivotable about a pivot point defined at a forward end thereof, a rail unit fixed with respect to the pivotable slide, a forward crystal for focusing x-rays disposed at the forward end of the pivotable slide and a rearward crystal for focusing x-rays movably coupled to the pivotable slide and the fixed rail unit at a distance rearward from the forward crystal. The forward and rearward crystals define reciprocal angles of incidence with respect to the pivot point, wherein pivoting of the slide about the pivot point changes the incidence angles of the forward and rearward crystals while simultaneously changing the distance between the forward and rearward crystals. | 10-09-2008 |
| 20080241907 | Extracellular Bioreduction - A method for processing environmental or industrial samples to remove, reclaim or otherwise reduce the level of chemical species present in the sample that act as redox active species. The redox active species is kept in a waste chamber and is separated from an aqueous bacterial culture that is held in a culture chamber. The waste chamber and the culture chamber are separated by a porous membrane through which electron transfer can occur but through which the aqueous bacterial culture cannot pass. The redox active species substantially remains in the waste chamber and is in non-contact with the aqueous bacterial culture during the process of removal, reduction or reclamation. | 10-02-2008 |
| 20080233047 | Symmetric and Asymmetric Halogen-Containing Metallocarboranylporphyrins and Uses Thereof - The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. | 09-25-2008 |
