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Brigham Young University

Brigham Young University Patent applications
Patent application numberTitlePublished
20120108561STORAGE-STABLE, ANTI-MICROBIAL COMPOSITIONS INCLUDING CERAGENIN COMPOUNDS AND METHODS OF USE - Storage-stable, anti-microbial compositions and products include a carrier and a ceragenin compound suspended in the carrier. Ceragenin compounds suspended in the carrier include a sterol backbone and a number of cationic groups attached to the sterol backbone via hydrolysable linkages. The carrier has a pH of 5.5 or less, which acts to stabilize the hydrolysable linkages and increase the shelf-life of the anti-microbial compositions and anti-microbial products. Nevertheless, the ceragenin compounds described herein are designed to break down relatively quickly (e.g., within about 5 days) if the pH environment of the ceragenin compounds is raised to about pH 6.5 or greater.05-03-2012
20120107382ARTICLES INCORPORATING ABSORBENT POLYMER AND CERAGENIN COMPOUND - An absorbent article includes an absorbent polymer and a ceragenin compound. The ceragenin compound has a sterol group and a plurality of cationic groups that mimic naturally occurring antimicrobial peptides. The ceragenin compound is associated with the absorbent polymer such that upon absorption of a fluid, the ceragenin compound is incorporated or maintained in the absorbent article.05-03-2012
201200289156"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES - This invention relates to galactosylceramide compounds.02-02-2012
20120020879PROCESS, COMPOSITION AND METHOD FOR ANION DEPOSITION INTO FERRITIN FOR THERAPEUTIC AND OTHER USE - Provided herein is a process for production of a metal nanoparticle, the process comprising providing a first solution containing a protein nanocage complex comprising a hydrophobic metal core and an ion-transport mechanism, providing a second solution containing a preselected anionic agent, combining the first and second solutions into a third combined solution, and applying an external method to the third combined solution to manipulate the metal core's redox state, in which reduction of the metal core causes the preselected anionic agent to be imported and incorporated into the metal core. Also provided herein is a composition from the process and a method of use.01-26-2012
20120012470METHODS AND APPARATUS FOR ANALYSIS OF CONCRETE COVER IN REINFORCED CONCRETE STRUCTURES SUBJECT TO REINFORCEMENT CORROSION - In one general aspect, a system can include a probe configured to be coupled to a concrete surface of a portion of concrete. The system can include a waveform generator configured to trigger flow of a current to the portion of concrete via the probe and configured to reference a potential of a reinforcing bar embedded within the concrete. The system can also include a current detector configured to detect a magnitude of the current.01-19-2012
20110257008METHOD FOR MAKING HIGHLY POROUS, STABLE METAL OXIDES WITH A CONTROLLED PORE STRUCTURE - Methods for making high-surface area, high-porosity, stable metal oxides, such as, but not limited to materials used as adsorbents and catalyst supports include (i) forming a solvent deficient precursor mixture from a metal salt and a base and reacting the metal ions and base ions in the solvent deficient precursor mixture to form an intermediate hydroxide product (e.g., metal hydroxide or metal oxide hydroxide), (ii) causing the intermediate hydroxide to form nanoparticles (e.g., by heating), and (iii) calcining the intermediate nanoparticles to sinter the nanoparticles together and yield a highly porous, stable metal oxide aggregate having a pore structure.10-20-2011
20110253295Integrated Optical Vapor Cell Apparatus for Precision Spectroscopy - An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate.10-20-2011
20110247404IDENTIFYING AND QUANTIFYING BIOMARKERS ASSOCIATED WITH PREECLAMPSIA - Described herein are methods for testing pregnant subjects for preeclampsia by detecting and quantifying at least one biomarker associated with preeclampsia in a biological sample from the subject.10-13-2011
20110228971ROBUST WATERMARKING FOR DIGITAL MEDIA - Embedding a watermark includes organizing variation locations in a data stream, partitioning the data stream into small blocks, determining the variation of small blocks based on the variation, categorizing small blocks into big blocks, identifying those big blocks that have a threshold level of variation, and embedding into those identified big blocks a watermark value.09-22-2011
20110226010CARBON DIOXIDE CAPTURE FROM FLUE GAS - A method for capturing carbon dioxide from a flue gas includes (i) removing moisture from a flue gas to yield a dried flue gas; (ii) compressing the dried flue gas to yield a compressed gas stream; (iii) reducing the temperature of the compressed gas stream to a temperature T09-22-2011
20110210056GAS PHASE APPROACH TO IN-SITU/EX-SITU FUNCTIONALIZATION OF POROUS GRAPHITIC CARBON VIA RADICAL-GENERATED MOLECULES - Embodiments disclosed herein include graphitic stationary phase materials functionalized through a gas-phase functionalization reaction, as well as and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be prepared from high surface area porous graphitic carbon and a radical forming volatilized functionalizing agent. The radical forming volatilized functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon.09-01-2011
20110192779THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to acidified water vapor or immersion in a concentrated acid bath (e.g., HCl and methanol). At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed.08-11-2011
20110183206APPARATUS, SYSTEM, AND METHOD FOR CARBON NANOTUBE TEMPLATED BATTERY ELECTRODES - An apparatus, system, and method are disclosed for a carbon nanotube templated battery electrode. The apparatus includes a substrate, and a plurality of catalyst areas extending upward from the substrate, the plurality of catalyst areas forming a patterned frame. The apparatus also includes a carbon nanotube forest grown on each of the plurality of catalyst areas and extending upward therefrom such that a shape of the patterned frame is maintained, and a coating attached to each carbon nanotube in the carbon nanotube forest, the coating formed of an electrochemically active material. The system includes the apparatus, and a particulate cathode material distributed evenly across the apparatus such that the particulate cathode material fills the passages, a current collector film formed on top of the particulate cathode material, and a porous spacer disposed between the apparatus and the cathode.07-28-2011
20110176996COMPOSITIONS AND METHODS FOR CANCER MANAGEMENT USING ANTIBODIES BINDING TO NUCLEOTIDE SALVAGE PATHWAY ENZYMES AND COMPLEXES THEREOF - Compositions and methods are provided for the diagnosis, treatment, and medical management of cancers. The methods include the use of antibodies and other binding molecules that specifically bind to one or more nucleotide salvage pathway enzymes (SPEs) selected from the group consisting of adenine phosphoribosyltransferase (APRT), hypoxanthine-guanine phosphoribosyltransferase (HGPRT), deoxycytidine kinase (dCK); and thymidine kinase 1 (TK1) and complexes comprising SPEs, for detection of the SPE(s) on or in cancer cells and/or on or in body fluids and tissues of cancer patients. Binding of SPEs is useful in the methods provided herein for diagnosing cancer, determining prognosis of cancer and assessing the effectiveness of cancer treatments. Immunoassay systems for use in the methods are also provided, including sandwich immunoassays. In addition, an amino acid sequence comprising a novel TK1 binding site is provided, as well as nucleotide sequences encoding it.07-21-2011
20110158076DIGITAL INFORMATION MEDIA HAVING ADHESION PROMOTION LAYER ON A SUBSTRATE - Disclosed is a digital information media having an adhesion promotion layer supported on a dummy (L1) substrate that enables secure bonding of the L1 layer, directly or indirectly, to the rest of the stack of layers in the digital information media. Certain materials including metals, metal alloys, or metalloids enhance adhesion between the adhesive layer and the L1. By applying an adhesion promotion layer of such materials on an inner surface of the L1, the bond between the adhesive and the adhesion promotion layer improves bonding and reduces a tendency for the L1 to delaminate from the rest of the stack. The tendency for breakage of the media at the juncture between the adhesion promotion layer and the adhesive is reduced, and incursion of moisture or oxygen through the interface between the adhesion promotion layer and the adhesive is inhibited.06-30-2011
20110117619Method for Pretreatment of Cellulosic and Lignocellulosic Materials for Conversion into Bioenergy - A process for converting organic waste materials into usable products and products thereof is disclosed. According to the process, organic waste materials are contacted with an oxidant to form a product and then an amount of the oxidant is removed from the product to form a reactor-ready feedstock. The oxidant is removed by various means, including washing, photolysis, catalytic means, oxidation of the oxidant, reduction of the oxidant, and heat. The reactor-ready feedstock may then be introduced into a reactor, such as a digester or incubator, and the reactor-ready feedstock is converted by microorganisms into biofuel or other products.05-19-2011
20110104258TECHNIQUE FOR DRUG AND GENE DELIVERY TO THE CELL CYTOSOL - Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the group consisting of endocytosis, pinocytosis or phagocytosis, the liposome comprising a phase transforming liquid with vapor pressure capable of forming a gas at low pressure, said liquid being associated with the liposome, and the liposome further comprising at least one functional molecule selected from the group consisting of a therapeutic molecule, a detectable label, and a targeting molecule.05-05-2011
20110091376CATATONIC STEROID ANTIMICROBIAL DIAGNOSTIC, DETECTION, SCREENING AND IMAGING METHODS - The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging include administering a cationic steroid antimicrobial or CSA to a subject having or at risk of having an infection or a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in an amount effective to diagnose or detect the infection or the hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject. In a particular aspect, a detectable CSA, namely CSA-13 labeled with 04-21-2011
20110089096THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed.04-21-2011
20110082106METHODS OF ACTIVATING NKT CELLS - Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.04-07-2011
20110073634THREE-BODY JOINING USING FRICTION STIR PROCESSING TECHNIQUES - A friction stir tool is provided to perform friction stir riveting using a partially consumable pin, wherein the pin includes a cutting edge on a bottom surface thereof, wherein the tool is rotated at a first speed to enable cutting by the pin into a first material that is overlapping a second material, wherein after the pin has cut to a sufficient depth, the rotational speed of the tool is increased to thereby enable plasticization of the consumable pin, the first material, and the second material, wherein the tool is then rapidly decelerated until stopped, enabling diffusion bonding between the pin, the first material and the second material.03-31-2011
20110061385METHODS AND SYSTEMS FOR GENERATING POWER FROM A TURBINE USING PRESSURIZED NITROGEN - An air separation unit is integrated with a power generating plant to improve the efficiency of power generation. The methods and systems improve the efficiency of power generation by utilizing liquid nitrogen from the air separation unit as the working fluid in a turbine. The liquid nitrogen is pressurized while in the liquid state. After warming the pressurized nitrogen stream by cooling the air for the air separator unit, the compressed nitrogen is expanded in a turbine to perform work. After expansion, the nitrogen is vented to ambient air. The nitrogen in its pressurized state can be used for energy storage and/or for smoothing out power demand on a power grid.03-17-2011
20110056373METHODS FOR STABLE SEQUESTRATION OF CARBON DIOXIDE IN AN AQUIFER - The methods disclosed herein relate to sequestering carbon dioxide in an aquifer by trapping the CO03-10-2011
20110054573SYSTEM AND METHOD FOR TREATING SYMPTOMS OF RESTLESS LEGS SYNDROME - Disclosed herein are systems and methods for reducing effects of restless legs syndrome (RLS) in a subject. The method includes identifying, on the subject, a body region affected by RLS, placing an emitter unit in direct contact with skin of the body region, wherein the emitter unit includes at least one emitter that emits near-infrared light, and activating the emitter to emit an effective amount of near-infrared light for inducing release of nitric oxide from hemoglobin or generation in the endothelium. Also disclosed is an emitter unit that is placed in direct contact with a subject's skin associated with RLS to reduce the effects of RLS. The emitter unit emits an effective amount of near-infrared light directed to the subject's skin to induce release of nitric oxide from hemoglobin or generation in the endothelium, and a module configured to toggle the emitter unit between a transmitting and a nontransmitting mode.03-03-2011
20110041689OFF GAS PURIFICATION - Heat-exchangers and biogas conditioners including a heat exchange member disposed between upper and lower flanges of the apparatus in which at least the heat exchange member is formed of a highly thermally conductive material (e.g., at least 50 W/m−K) such as aluminum or aluminum alloy. A bed of zeolite is loaded within the apparatus so as to be in contact with the heat exchange member. The heat exchange member is shaped and configured so that any given location of the zeolite bed is no more than about 3 inches from the heat exchange member comprising the highly thermally conductive material.02-24-2011
20110027323ADJUVANTS AND METHODS OF USE - Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.02-03-2011
20110000852THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. Embodiments for TLC plates and related methods are also disclosed.01-06-2011
20100325577WINDOW BROKER ARCHITECTURE - Retrieving information from a display server. Information about all visible windows displayed on a display by the display server is retrieved. Descriptive information about visible windows displayed on the display, and windows on a shelf is retrieved from the display server or window broker. Notifications of changes to windows are received. Based on information retrieved from the display server or window broker and received notifications, a user interface displays windows displayed on the display and windows on the shelf. A user request is received at the user interface for a change to what is displayed by the display server. The user request is sent, directly or indirectly to the window broker. The window broker approves, denies or makes arbitrary changes to windows to accommodate the user request and sends a window broker request to the display server. The window broker notifies window managers of changes that have been made.12-23-2010
20100325576DISTRIBUTING MULTIPLE CLIENT WINDOWS USING A DISPLAY SERVER - Displaying overlapping windows from a client device. Windows are displayed at a client device with a first window overlapping a second window on a single display. The first window is a current window. The current window is based on front to back ordering of windows displayed at the client device. Pixels in a region of the first window are captured and sent to a display server. At the display server, the first window is displayed on a first display region. The second window becomes the current window, resulting in capturing and sending pixels in a region of the second window to the display server. At the display server, the second window is displayed on a second display region. At the display server, the first and second windows are displayed in a non-overlapping fashion by displaying the first window and the second window on separate display regions12-23-2010
20100325574PRESENTATION SCRATCH SPACES - Implementing scratch spaces to display one or more windows or slides previously streamed while displaying a currently streamed window or slide. A method includes using at least one of a plurality of screens, displaying a source window or slide. A first scratch space location is identified. The first scratch space location is a special window intended to contain a copy of pixels taken from a source window. The method further includes determining that the source window or slide should be copied to the first scratch space location either by detecting user input selecting an accelerator or by identifying a trigger image. As a result of determining that the source window or slide should be copied to the first scratch space location, pixels of the source window or slide are copied to the first scratch space location.12-23-2010
20100266495Anti-Cancer Activity of an Anti-Thymidine Kinase Monoclonal Antibody - Methods of diagnosing and treating cancers that overexpress thymidine kinase 1 on their cell surfaces are provided. These methods utilize monoclonal antibodies that bind specifically to thymidine kinase 1 to inhibit or prevent proliferation of the cancer cells.10-21-2010
20100241847ENCRYPTED EMAIL BASED UPON TRUSTED OVERLAYS - Sending and receiving encrypted emails. At a web browser, user input is received requesting a compose email page user interface for a web-based email system. The compose email page user interface is requested from a server for the web-based mail system. Web page code is received from the server for the compose email page user interface. The web page code for the compose email page user interface is parsed to determine screen locations of one or more user input interface elements. The compose email page user interface is rendered in the browser. One or more browser-based interface elements implemented integral to the browser are overlaid onto the compose email page user interface. User input is received in the browser user interface elements. The user input received is encrypted. The encrypted user input is transferred into one or more elements of the compose email page user interface.09-23-2010
20100228770GENEALOGY CONTEXT PRESERVATION - Preserving context and providing suggestions for genealogy searching. A method includes storing in a storage medium previous user interaction with a genealogical research system from a previous genealogical research session. Initiation of a new genealogical research session is detected. In response to the new research session and based on the previous user interaction with the research system, the system provides suggestions for continuing genealogical research.09-09-2010
20100221481OPTICAL DATA STORAGE MEDIA CONTAINING SUBSTANTIALLY INERT LOW MELTING TEMPERATURE DATA LAYER - Optical information media that contain a data layer material that is substantially inert to oxidation and has a defined melting point range are disclosed. The inertness to oxidation and melting point range make the media particularly attractive for long-term information storage.09-02-2010
20100213131POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES - In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.08-26-2010
20100195468OPTICAL DATA STORAGE MEDIA CONTAINING METAL AND METAL OXIDE DARK LAYER STRUCTURE - Optical data storage media containing a “dark” layer structure are disclosed. Layered metals and metal oxides provide a dark background that enhances detection of changes in the data layer of the storage media. Combinations such as chromium metal and chromium oxide, and molybdenum metal and molybdenum oxide are offered as examples of suitable materials.08-05-2010
20100185006NOVEL SIRTUIN ACTIVATING COMPOUNDS AND PROCESSES FOR MAKING THE SAME - The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from P07-22-2010
20100182894OPTICAL DATA STORAGE MEDIA CONTAINING AN ENCAPSULATED DATA LAYER - Optical information media containing encapsulated data layers are disclosed. Selective layering of materials in inner radial, middle radial, and outer radial zones allows for the faces and edges of at least the data layers to be encapsulated by other materials, resulting in increased resistance to harmful environmental agents such as oxygen and moisture.07-22-2010
20100163721SERUM PROTEOMICS SYSTEM AND ASSOCIATED METHODS - Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum.07-01-2010
20100151356FUEL CELL AND METHOD FOR GENERATING ELECTRIC POWER - A non-microbial fuel cell utilizing an organic fuel containing a hydroxyl group and a non-metallic catalyst is disclosed. Compositions for use in and methods for generating electric energy from chemical energy using fuel cells are also disclosed. Compositions for use in and methods of storing energy using fuel cells are also disclosed.06-17-2010
201001372316"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES - This invention relates to galactosylceramide compounds.06-03-2010
20100135147HIGH POWER OPTICAL DISC DRIVES - High power optical disc drives are disclosed. The drives are configured to deliver laser energy having a power of at least about 25 mW as measured at DVD 1X write speed upon first contact with the surface of an optical disc.06-03-2010
20100115436FORM-BASED ONTOLOGY CREATION AND INFORMATION HARVESTING - Extracting data from web pages. User input is received defining a tabular form. User input is received correlating portions of the form with user selected data items contained in one or more first web pages. The user input is correlated to create an ontology defining relationships between the user selected data items based on the definition of the tabular form. One or more other web pages are accessed, and based on a context of the one or more data items in the first web page being similar to a context of the selected data items in the one or more first web pages, one or more similar data items are extracted from the one or more other web pages. The extracted data items are correlated to each other in accordance with the ontology defining relationships between the user selected data items and are output as a user searchable data structure.05-06-2010
20100114902HIDDEN-WEB TABLE INTERPRETATION, CONCEPTULIZATION AND SEMANTIC ANNOTATION - Indexing hidden web information. First and second web pages are accessed, which include data organized in table format. The tables from the first and second web page are compared. Based on the comparison, a determination is made as to which table cells contain category labels and which contain instance data. The category labels from the first web page are compared to the category labels from the second web page. A general structure of individual tables is inferred based on the act of comparing the category labels. The general structure is chosen from among standard table templates. Data in two or more web pages organized according to the selected table templates is identified. Data from the two or more web pages is stored by associating the table data from two or more web pages to one or more of the selected table templates.05-06-2010
20100110860DATA STORAGE MEDIA CONTAINING MAGNESIUM METAL LAYER - Optical information media containing a magnesium metal layer and a reactive material layer are disclosed. The magnesium metal can react directly with the reactive material layer, or with a chemical evolved from the reactive material layer after application of energy from a source such as a laser.05-06-2010
20100103795DATA STORAGE MEDIA CONTAINING INORGANIC NANOMATERIAL DATA LAYER - Optical information media having a support substrate and an inorganic nanomaterial data layer are disclosed. The data layer provides enhanced stability and optical performance as compared to conventional data layers.04-29-2010
20100087519USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.04-08-2010
20100072137FUNCTIONALIZED GRAPHITIC STATIONARY PHASE AND METHODS FOR MAKING AND USING SAME - Embodiments disclosed herein include functionalized graphitic stationary phase materials and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be manufactured from high surface area porous graphitic carbon and a radical forming functionalizing agent. The radical forming functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon.03-25-2010
20100068445Optical Data Media Containing An Ultraviolet Protection Layer - Optical information media containing an ultraviolet protection layer are described. The protection layer will reduce or eliminate damage to the media's data layer and substrate.03-18-2010
20100056740ADSORPTION-RESISTANT ACRYLIC COPOLYMER FOR FLUIDIC DEVICES - A copolymer is used for fluidic devices that require surfaces nonreactive with biomolecules. The copolymer is the reaction product of Compound A having the formula:03-04-2010
20090277839POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES - In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography, and solid phase extraction.11-12-2009
20090231978LONG-TERM DIGITAL DATA STORAGE - Embodiments are directed to recording digital data on an optically ablatable digital storage media. In one embodiment, a device configured to ablate portions of ablatable material on an optically ablatable digital storage media receives digital data that is to be recorded on a recording layer of an optically ablatable digital storage media. The recording layer is formed on a substrate with zero or more intervening layers between the recording layer and the substrate. The recording layer includes ablatable material capable of storing digital data. The device ablates the ablatable material in the recording layer according to a sequence defined by the received digital data such that the ablated portions correspond to data points of the received digital data.09-17-2009
20090221773METHODS FOR DIRECT ATTACHMENT OF POLYMERS TO DIAMOND SURFACES AND DIAMOND ARTICLES - A method for forming a polymer on a substrate is disclosed. The method may include providing a substrate having a substrate surface, the substrate surface being at least partially hydrogen-terminated and reacting the substrate surface in a solution comprising at least one radical initiator and at least one monomer to form a polymer on the substrate surface. The monomer may comprise at least one of a monofunctional monomer and a polyfunctional monomer. A stationary phase for use in separation applications such as chromatography and solid-phase extraction is also disclosed. The stationary phase may include a plurality of diamond bodies and a polymeric compound covalently bonded to at least a surface portion of the plurality of diamond particles.09-03-2009
20090218276FUNCTIONALIZED DIAMOND PARTICLES AND METHODS FOR PREPARING THE SAME - A functionalized particle is disclosed. The functionalized particle may include a diamond-particle substrate and a coating comprising at least one polymeric compound on at least a surface portion of the diamond-particle substrate, the at least one polymeric compound having at least one amine group. Additionally, the at least one polymeric compound may be at least partially reacted. The at least one polymeric compound may also be at least partially cured. The diamond substrate may be porous. In addition, a second coating coupled to at least a surface portion of the first coating. A separation apparatus may have a stationary phase including a plurality of diamond particles and a coating comprising at least one polymeric compound on at least a surface portion of the plurality of diamond particles is also disclosed. A method for forming a functionalized particle is also disclosed.09-03-2009
20080320205LONG-TERM DIGITAL DATA STORAGE - Embodiments are directed to recording digital data on an optically ablatable digital storage media. In one embodiment, a device configured to ablate portions of ablatable material on an optically ablatable digital storage media receives digital data that is to be recorded on a recording layer of an optically ablatable digital storage media. The recording layer is formed on a substrate with zero or more intervening layers between the recording layer and the substrate. The recording layer includes ablatable material capable of storing digital data. The device ablates the ablatable material in the recording layer according to a sequence defined by the received digital data such that the ablated portions correspond to data points of the received digital data.12-25-2008
20080279894Bacterial Glycolipid Activation of Cd1d-Restricted Nkt Cells - Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.11-13-2008
20080278710Integrated Optical Vapor Cell Apparatus for Precision Spectroscopy - An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate.11-13-2008
20080207891Methods For Selective N-9 Glycosylation of Purines - A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs.08-28-2008

Patent applications by Brigham Young University