BRACCO SUISSE SA Patent applications |
Patent application number | Title | Published |
20160074539 | TARGETING CONSTRUCTS - Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging. | 03-17-2016 |
20150343097 | GAS-FILLED MICROVESICLES - A formulation for preparing gas-filled microvesicles which comprises a phospholipid and a mixture of saturated and unsaturated fatty acids. The gas-filled microvesicles having a stabilizing layer comprising said composition show an increased stability with respect to microvesicles containing only a saturated or an unsaturated fatty acid. | 12-03-2015 |
20140286864 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 09-25-2014 |
20140206837 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 07-24-2014 |
20140205545 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 07-24-2014 |
20140163366 | Automatic Liquid Injection System and Method - A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds. | 06-12-2014 |
20140161732 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 06-12-2014 |
20140031520 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 01-30-2014 |
20130295147 | GAS-FILLED MICROVESICLES FOR USE AS VACCINE - Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells. | 11-07-2013 |
20130156706 | TARGETED GAS-FILLED MICROVESICLES - Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging. | 06-20-2013 |
20130101522 | Ultrasound Contrast Agents And Process For The Preparation Thereof - Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbubbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles. | 04-25-2013 |
20130101520 | ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM - The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents. | 04-25-2013 |
20130060135 | INITIALIZATION OF FITTING PARAMETERS FOR PERFUSION ASSESSMENT BASED ON BOLUS ADMINISTRATION - An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent. | 03-07-2013 |
20120315220 | Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 12-13-2012 |
20120258043 | Linkable Lewis X Analogs - Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe | 10-11-2012 |
20120237098 | PARAMETRIC IMAGES BASED ON DYNAMIC BEHAVIOR OVER TIME - An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location. | 09-20-2012 |
20120128581 | Sincalide Formulations - The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations. | 05-24-2012 |
20120093732 | ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM - The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents. | 04-19-2012 |
20120082359 | AUTO-SCALING OF PARAMETRIC IMAGES - An embodiment is proposed for analyzing a body-part. A corresponding embodiment of a data-processing method includes the steps of providing a parametric map including a plurality of parameter values each one characterizing a corresponding location of the body-part, and determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations. In an embodiment, the step of determining at least one statistical indicator includes, for each distribution of the analysis parameter values, determining a saturation value partitioning an ordered sequence of processing parameter values, corresponding to selected processing locations at least including the analysis locations, into a first subset and a second subset consisting of a number of the processing parameter values being determined according to a predefined auto-scaling percentage, generating an auto-scaled map including, for each processing location, an auto-scaled value being equal to the corresponding processing parameter value if included in the second subset, or the saturation value if the corresponding processing parameter value is included in the first subset, and determining the at least one statistical indicator from the auto-scaled values corresponding to the analysis locations. | 04-05-2012 |
20110311446 | PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (CMET) AND USES THEREOF - A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed. | 12-22-2011 |
20110282185 | Gasket for Pre-Filled Syringe and Pre-Filled Syringe - The present invention relates to a gasket ( | 11-17-2011 |
20110245664 | DEVICE FOR BOLUS ADMINISTRATION OF CONTRAST AGENT - A device for administering a liquid preparation comprising a pharmaceutical agent, particularly a contrast agent, in the form of a bolus. The device comprises in particular a core cylinder and an external cylinder, the core cylinder comprising a conduit ( | 10-06-2011 |
20110236320 | Ultrasound Contrast Agents And Process For The Preparation Thereof - Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbubbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles. | 09-29-2011 |
20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
20110015522 | QUANTIFICATION ANALYSIS OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS - An embodiment of a solution is proposed for analyzing a body part of a patient, which is perfused with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system includes means for providing an echo signal indicative of a response over time to an interrogation signal of the body part, means for associating the echo signal with a model function of time modeling an evolution over time of the contrast agent in the body part, the model function including a combination of a circulation function modeling the circulation of the contrast agent and a decay function modeling a decay of the echo signal from the immobilized contrast agent, and means for estimating at least one kinetics indicator of the contrast agent from the model function. | 01-20-2011 |