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Bracco Imaging S.p.A.

Bracco Imaging S.p.A. Patent applications
Patent application numberTitlePublished
20120115741Reagents For The Atherosclerotic Coronary Plaque And Uses Thereof - The present invention discloses antibodies or fragments thereof able to bind isolated coronary plaque samples and processes for their production using host cells containing DNA sequences encoding for said antibodies of fragments thereof. Methods for screening ligands to said isolated samples are also described, and compositions containing said antibodies are also provided.05-10-2012
20120088926PROCESS FOR THE PREPARATION OF A IODINATING AGEN - The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.04-12-2012
20120065365Stable Radiopharmaceutical Compositions and Methods for Their Preparation - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor).03-15-2012
20120041224Process For The Iodination Of Aromatic Compounds - The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.02-16-2012
20120009122GASTRIN RELEASING PEPTIDE COMPOUNDS - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure:01-12-2012
20110280802Linkers For Radiopharmaceutical Compounds - A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N—O—P-Q, wherein M is the diagnostic or therapeutic moiety, N—O—P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N—O—P-M, wherein M is independently a diagnostic or therapeutic moiety and N—O—P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds.11-17-2011
20110275850Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives - The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof.11-10-2011
20110256067Contrast agents endowed with high relaxivity - The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.10-20-2011
20110250133GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means.10-13-2011
20110207960Process For The Preparation Of Iodinated Contrast Agent - The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.08-25-2011
20110206650Probiotic Formulations - The present invention relates to probiotic compositions and kits thereof, comprising live bacteria belonging to the natural flora of the human body cavity such as intestine and vaginal tract, in particular, strains of 08-25-2011
20110206606STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREPARATION - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds, and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor).08-25-2011
20110178393Process for the Preparation of Aqueous Solutions of Hyperpolarized Molecules - The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.07-21-2011
20110176710Method and system for automatic processing and evaluation of images, particularly diagnostic images - Method for automatic processing and evaluation of images, particularly diagnostic images, comprising an image processing tool in the form of a software program which is executable by the computer hardware and which image processing tool processes image data of a digital input image generating a modified digital output image whose image data are outputted in a graphical and/or alphanumerical format highlighting certain predetermined features or qualities of the corresponding regions of an imaged body or object, characterized in that the image processing tool comprises a first image detecting module which is an image processing module based on image processing non expert algorithms and which furnishes at its output a modified image file which modified image data are further processed by a classification or evaluation module which is a second image processing module comprising an image processing tool consisting in an expert image processing algorithm such as a classification or prediction algorithm the output of which is a further modified image file in which the pixels or voxels are highlighted corresponding to imaged object having a predetermined feature or quality.07-21-2011
20110152671MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS - An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.06-23-2011
20110124653ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS - The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R05-26-2011
20110117015Diagnostic Agents Selective Against Metalloproteases - The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R05-19-2011
20110100880Method and Apparatus for Producing Stationary Intense Wave Fields of Arbitrary Shape - Method for producing a stationary wave field of arbitrary shape comprising the steps of defining at least one volume being limited in the direction of the axis of propagation of a beam, of the type 0≦z≦L; defining an intensity pattern within the said region 0≦z≦L by a function F(z), describing the said localized and stationary intensity pattern, which is approximated by means of a Fourier expansion or by a similar expansion in terms of (trigonometric) orthogonal functions; providing a generic superposition of Bessel or other beams highly transversally confined; calculating the maximum number of superimposed Bessel beams the amplitudes, the phase velocities and the relative phases of each Bessel beam of the superposition, and the transverse and longitudinal wavenumbers of each Bessel beam of the superposition.05-05-2011
20110082280Methods Of Coupling Multidentate AZA Ligands To Targeting Molecules - Methods of coupling targeting molecules to multidentate aza ligands of general formula (I):04-07-2011
20110052491GASTRIN RELEASING PEPTIDE COMPOUNDS - New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.03-03-2011
20100331567PROCESS FOR THE IODINATION OF AROMATIC COMPOUNDS - The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2,4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3,5-disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).12-30-2010
20100316563Method For The Preparation Of New Oligoclonal Antibodies - A process is provided for the preparation of antibodies or fragments thereof using a prokaryotic host cell containing DNA sequences encoding for said antibodies of fragments thereof, wherein said DNA sequence is derived from a coronary plaque sample. Compositions containing said antibodies are also provided. Ligands to said antibodies and compositions containing said ligands are also described.12-16-2010
20100280505Device for Localized Thermal Ablation of Biological Tissue, Particularly Tumoral Tissues or the Like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that it comprises in combination means for controlled distribution of the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size, which means are composed of a fluid or a mixture or a combination of heat storing and/or conveying fluids or substances there being provided means for distributing, conveying and/or containing said fluid or fluids or said substance or substances inside the area to be treated or for conveying or containing said fluid or fluids or said substance or substances outside the area to be treated.11-04-2010
20100241111Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that in combination it comprises means for monitoring the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size and operating on the basis of a transferring function of generated heat on a measuring sensor provided at a predetermined distance and position with respect to the source emitting the electromagnetic irradiation.09-23-2010
20100234834Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that in combination it comprises means for the controlled distribution of the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size. The invention relates also to a method for localized thermal ablation.09-16-2010
20100202967FIBRIN BINDING PEPETIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.08-12-2010
20100166656Diagnostic And Radiotherapeutic Contrast Agents And Process For Their Preparation - The present invention refers to diagnostically or radiotherapeutically useful compounds which are able to selectively bind to lectins, having formula (I) wherein R, R′, R07-01-2010
20100158814Fibrin-Binding Peptides and Conjugates Thereof - Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.06-24-2010
20100138422Image processing system, particularly for use with diagnostic images - An image processing system particularly for use with diagnostic images, comprises at least one processing unit, which receives digital images acquired by one or more imaging apparatus and provides output images, processed by means of an image processing program loaded in the memory of the processing unit and executed thereby, characterized in that it consists of a central service unit, comprising an interface to be accessed by remote users, which connect to said central unit by remote communication means.06-03-2010
20100135574Image processing using neural network - Image processing method wherein each image is composed of an array of image points, so called pixels or voxels particularly in a two-, three-, or more dimensional space respectively each image point being univocally defined by its position within the array of image points and by one or more numerical parameters defining the image point appearance as regards characteristics of brightness, grey, colour shade or the like, and wherein each image point is considered to be a node of an artificial neural network, the image being processed as a function of parameters defining the appearance of each pixel as values of the nodes of said artificial neural network and as a function of connections of each pixel under processing with neighbouring pixels composed of pixels of a predetermined subset of pixels, particularly with neighbouring pixels of said pixel under processing, so called pixel window, while pixels of the new image i.e. of the processed image are obtained by iterative evolution steps of parameters defining the appearance such as evolution steps of the value of nodes or by iterative evolution steps of values of the set of connections or by a combination of said evolutions, wherein the processing occurs by evolution iterative steps where each step is a function also of connections of neighbouring pixels with the pixel under examination, when each of said neighbouring pixels of the pixel under examination is considered also as a neighbouring pixel of one ore more or all pixels adjacent to said neighbouring pixel, which function is an immediate feedback contribution for determining appearance values of all other pixels.06-03-2010
20100135544Method of registering images, algorithm for carrying out the method of registering images, a program for registering images using the said algorithm and a method of treating biomedical images to reduce imaging artefacts caused by object movement - In a method for registering biomedical images such as at least a first and a second digital or digitalized image or set of cross-sectional images of the same object, within the first image or set of images a certain number of landmarks, so called features are individuated by selecting a certain number of pixels or voxels. The position of each pixel or voxel selected as a feature is tracked from the first to the second image or set of images by determining the optical flow vector from the first to the second image or set of images for each pixel or voxel selected as a feature. Registration of the first and second images or set of images is carried out by applying the inverse optical flow to the pixels or voxels of the second image or set of images. The invention provides for an automatic trackable landmark selection step consisting in defining a pixel or voxel neighbourhood around each pixel or voxel of the first image or first set of cross-sectional images; for each target pixel or voxel determining one or more characteristic parameters which are calculated as a function of the parameters describing the appearance of the said target pixel or voxel and of each or a part of the pixels or voxels of the window and as a function of one or more characteristic parameters of either the numerical matrix or of a transformation of the said numerical matrix representing the pixels or voxels of the said window. The pixels or voxels coinciding with validly trackable landmarks are determined as a function of the said characteristic parameters of the target pixels or voxels.06-03-2010
20100087505Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors - The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below04-08-2010
20100069628Multidentate AZA Ligands Able to Complex Metal Ions And The Use Thereof In Diagnostics And Therapy - Compounds of the formula:03-18-2010
20100028912IMAGING USING RADIOACTIVE MONOCATIONS IN COMBINATION WITH A RECEPTOR BINDING LIGAND THAT STIMULATES THE INFLUX OF CATIONS - A novel method of imaging, comprising administration of a radioactive mono-cation, such as, for example, 02-04-2010
20090306424PROCESS FOR THE PREPARATION OF CONTRAST AGENTS - The present invention refers to a process for preparing a compound of formula (I)12-10-2009
20090239829THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE - There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R09-24-2009
20090234221RESPONSIVE PARAMAGNETIC MRI CONTRAST AGENTS - A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.09-17-2009
20090202580METHOD FOR THE PREPARATION OF SPECIFIC ANTIBODIES AGAINST SACCHARIDIC ANTIGENS - The present invention relates to new compounds useful for the stimulation of the production of antibodies. Said compounds comprises a saccharidic tumor antigen and a polymeric scaffold. The present invention also encompasses conjugated compounds useful in ELISA assay for the selection of antibodies against saccharidic antigens.08-13-2009
20090175786Gastrin Releasing Peptide Compounds - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure:07-09-2009
20090118537Process for the Preparation of Contrast Agents - The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.05-07-2009
20080317668Integrin Targeted Synthetic Ligands for Diagnostic and Therapeutic Applications - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.12-25-2008
20080292214Method and Computer Program Product for Registering Biomedical Images with Reduced Imaging Artifacts Caused by Object Movement - A method of registering biomedical images to reduce imaging artefacts caused by object movement is disclosed, wherein a certain number of features or landmarks is automatically defined and tracked in a first and second image to be registered to determine the optical flow vector between the first and second image. Registration then takes place by applying the inverse optical flow to the second image. The automatic feature selection step is carried out by determining the mean signal intensity in a defined neighborhood for every pixel, which mean signal intensity is then compared to a predetermined threshold. If the mean signal intensity value of said neighborhood is higher than the predetermined threshold the pixel is defined as a feature and is added to a list of features to be tracked. 11-27-2008
20080267869RADIOACTIVE TRANSITION METAL-IMIDO HETERO-DIPHOSPHINE COMPLEXES, THEIR PREPARATION AND RADIOPHARMACEUTICAL COMPOSITIONS THEREOF - The present invention provides radioactive metal heterocomplexes of formula (I): [(Me=N—R)L10-30-2008
20080247946Gastrin Releasing Peptide Compounds - New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.10-09-2008
20080212887Method For Coding Pixels or Voxels of a Digital Image and a Method For Processing Digital Images - A method for coding pixels or voxels of a digital or digitalized two dimensional or three dimensional image, comprises the steps of: providing a digital image consisting in a two dimensional array of pixels or in a three dimensional array of voxels, each pixel or voxel being defined by at least one variable as its intensity in a grey scale image or the HSV (Hue, Saturation and Value) or the RGB values in a colour image; each pixel or voxel and for each target pixel or voxel a neighborhood being formed by a pixel or voxel windows comprising the said target pixel or voxel and a certain number of surrounding pixels or voxels for each target pixel or voxel generating a vector univocally associated to the said target pixel or voxel, the components of the said vectors being generated as a function of the values of the said target pixel or voxel and of each of the pixels or voxels of the said pixel or voxel window. The function of the values of the said target pixel or voxel and of each of the pixels or voxels of the said pixel or voxel window correspond to the characteristic parameters of the numerical matrix representing the pixels or voxels of the said window or of a transformation of the said numerical matrix. The invention relates also to an image processing method in which image data coded according to the above method are processed by means of a predictive algorithm as for example an artificial neural network.09-04-2008

Patent applications by Bracco Imaging S.p.A.