BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Patent applications |
Patent application number | Title | Published |
20160130327 | CMV NEUTRALIZING ANTIGEN BINDING PROTEINS - The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). Also encompassed by the invention are antigen binding proteins that have been humanized. The antigen binding proteins of the invention are useful as a therapeutic agent for treating and/or preventing CMV infections in a patient in need thereof. | 05-12-2016 |
20160032480 | POROUS PARTICLES AND METHODS OF MAKING THEREOF - Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided. | 02-04-2016 |
20150231416 | ULTRASONIC BATH TO INCREASE TISSUE PERFUSION - The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method. | 08-20-2015 |
20150160951 | REMOTE LAUNCH OF APPLICATION ON MOBILE DEVICE - A system allows remotely launching an application on a remote device. The application uses a guided document to provide instructional or procedural information to a user of the mobile device. An administrator of the system may define one-time or recurring events that will cause the remote system to instruct the mobile device to launch the application with the guided document. | 06-11-2015 |
20150044669 | METHOD FOR THE DETECTION OF BIOLOGICAL MOLECULES USING A TWO PARTICLE COMPLEX - Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety also provided. | 02-12-2015 |
20150037387 | Biomatrix Composition and Methods of Biomatrix Seeding - Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided. | 02-05-2015 |
20150020147 | AUTHORIZATION POLICY FOR GROUP-CENTRIC SECURE INFORMATION SHARING - In the present specification, a methodology for incremental security policy specification at varying levels of abstraction is disclosed. The method maintains strict equivalence with respect to authorization state and is based on the group-centric secure information sharing (g-SIS) domain, which is known in the art. A g-SIS authorization policy is specified statelessly, in that it focuses solely on specifying the precise conditions under which authorization can hold in the system while only considering the history of actions that have occurred. The policy supports join, leave, add, and remove operations, which may have either strict or liberal semantics. The stateful application policy is then specified using linear temporal logic. The stateful specification is authorization equivalent to the stateless specification, and may enforce well-formedness constraints. | 01-15-2015 |
20140377387 | Compositions and Methods for Modulating Lipid Composition - This disclosure relates to novel herbal compositions comprising extracts of rosemary and oregano, and methods of using the herbal compositions to modulate inflammatory potential. One or both of the extracts may be supercritical extracts. The disclosure further relates to methods of treating inflammation, rheumatoid arthritis, osteoarthritis, or combinations thereof, using the herbal compositions. | 12-25-2014 |
20140371550 | ELECTROLYTIC BIOSENSOR - An electrolytic biosensor for use in intracorporeal leak detection may be incorporated into a surgical drain that is installed post-operatively at the site of a wound. The electrolytic biosensor may be used to monitor drain effluent flowing through the surgical drain by measuring a fluid conductivity of the drain effluent. Certain changes, patterns, or responses of the so measured fluid conductivity values may be indicative of a physiological condition of the wound. For example, when the wound is a gastrointestinal anastomosis, the fluid conductivity values measured with the electrolytic biosensor may be used to characterize a fluid integrity of the gastrointestinal anastomosis. An electrolytic biosensor system may include an application that records conductivity data and provides notifications, such as a patient alarm, when a leak is detected. | 12-18-2014 |
20140329890 | Compounds Having Anti-Adhesive Effects on Cancer Cells - Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3′→P5′ thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells. | 11-06-2014 |
20140316121 | METHODS AND COMPOUNDS USEFUL IN CONDITIONS RELATED TO REPEAT EXPANSION - Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules. | 10-23-2014 |
20140308292 | FAMILY OF PAIN PRODUCING SUBSTANCES AND METHODS TO PRODUCE NOVEL ANALGESIC DRUGS - A method may include treating pain, shock, and/or inflammatory conditions in a subject. A method may include using a therapeutically effective amount of an antibody, a lipoxygenase inhibitor, a cytochrome P-450 enzyme inhibitor, and/or an antioxidant configurable to at least partially treat pain, shock, and/or inflammatory conditions in a subject. A method of treating pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation). | 10-16-2014 |
20140233826 | SYSTEMS AND METHODS FOR AUTOMATED SCREENING AND PROGNOSIS OF CANCER FROM WHOLE-SLIDE BIOPSY IMAGES - The invention provides systems and methods for detection, grading, scoring and tele-screening of cancerous lesions. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of prostate cancer on serial sections/slides of prostate core images, or biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each system utilizes a different approach with a different feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest. Additionally, the invention provides sub-systems and methods for accurate detection and mapping of disease in whole slide digitized images by extracting new features through integration of one or more of the above-mentioned classification systems. The invention also addresses the modeling, qualitative analysis and assessment of 3-D histopathology images which assist pathologists in visualization, evaluation and diagnosis of diseased tissue. Moreover, the invention includes systems and methods for the development of a tele-screening system in which the proposed computer-aided diagnosis (CAD) systems. In some embodiments, novel methods for image analysis (including edge detection, color mapping characterization and others) are provided for use prior to feature extraction in the proposed CAD systems. | 08-21-2014 |
20140230574 | IMPACT-RESISTANT SURFACE-MOUNTED ROOF SENSORS - Various systems and techniques may be used to enhance the sensing loads on a roof surface. In some implementations, an impact-resistant surface-mounted roof sensor system may include a sensor, a protective cover, and a load transfer mechanism. The sensor may be adapted to sense a load incident thereon, and the protective cover may be configured to span at least the width of the sensor and adapted to withstand impacts from dense media and an direct incident load. The load transfer mechanism may be adapted to mechanically transfer a load applied on the protective cover to the sensor. | 08-21-2014 |
20140205579 | METHODS AND COMPOSITIONS FOR ALTERATION OF A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) GENE - Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models. | 07-24-2014 |
20140194639 | METAL-ORGANIC FRAMEWORK WITH OPTIMIZED OPEN METAL SITES AND PORE SPACES FOR HIGH METHANE STORAGE AT ROOM TEMPERATURE - A 3D porous metal-organic framework and method of making are described. In some embodiments, a 3D porous metal-organic framework may be based on a trinodal (3,3,4) net of zyg topology by the self-assembly of the nonlinear hexacarboxylate (BHB) with the paddle-wheel Cu | 07-10-2014 |
20140178374 | BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO - The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof. | 06-26-2014 |
20140169682 | DETERMINING QUALITY OF AN IMAGE OR VIDEO USING A DISTORTION CLASSIFIER - Techniques and structures are disclosed in which one or more distortion categories are identified for an image or video, and a quality of the image or video is determined based on the one or more distortion categories. The image or video may be of a natural scene, and may be of unknown provenance. Identifying a distortion category and/or determining a quality may be performed without any corresponding reference (e.g., undistorted) image or video. Identifying a distortion category may be performed using a distortion classifier. Quality may be determined with respect to a plurality of human opinion scores that correspond to a particular distortion category to which an image or video of unknown provenance is identified as belonging. Various statistical methods may be used in performing said identifying and said determining, including use of generalized Gaussian distribution density models and natural scene statistics. | 06-19-2014 |
20140155818 | Burn Patient Resuscitation System - A system for operating a semi-closed loop and/or a closed loop resuscitation of a burn patient in view of patient information and other physiological data gathered by the system. The system in at least one embodiment includes an urine sensor, an infusion pump and a processor that controls the operation of the infusion pump at least in part from a signal received from the urine sensor. | 06-05-2014 |
20140154493 | APPARATUSES AND METHODS FOR THE PRODUCTION OF FIBERS - A method of producing fibers, includes placing a composition that includes one or more fluoropolymers in the body of a fiber producing device and rotating the device at a speed sufficient to eject material from the fiber producing device to form fluoropolymer microfibers and/or nanofibers. | 06-05-2014 |
20140142539 | Decision-Assist Method of Resuscitation of Patients - A method for providing decision-assist to medical staff resuscitating a burn patient includes receiving patient information, calculating an infusion rate, outputting the infusion rate, obtaining a urinary output, calculating a new infusion rate using infusion rate model based constants, and outputting the new infusion rate. In some embodiments, the method includes notifying medical staff when problems arise, displaying information regarding the resuscitation, and setting limits regarding the infusion rates. | 05-22-2014 |
20140135382 | cDNA-DERIVED NUCLEIC ACIDS ENCODING RED-SHIFTED CHANNELRHODOPSINS - Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo. | 05-15-2014 |
20140128588 | COMPOSITIONS OF MATTER THAT REDUCE PAIN, SHOCK, AND INFLAMMATION BY BLOCKING LINOLEIC ACID METABOLITES AND USES THEREOF - A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or RNA aptamer that shows high affinity for OLAMs to at least partially treat pain, shock, and/or inflammatory conditions in a subject. The DNA or RNA aptamer that shows high affinity for OLAMs may be coupled to a plasma protein binding compound or a pharmacologically active agent. A method of treating and or diagnosing pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation) using a DNA or RNA aptamer that shows high affinity for OLAMs. | 05-08-2014 |
20140116887 | ELECTROCHEMISTRY AND ELECTROGENERATED CHEMILUMINESCENCE WITH A SINGLE FARADAIC ELECTRODE - Described herein is an apparatus comprising an electrochemical cell that employs a capacitive counter electrode and a faradaic working electrode. The capacitive counter electrode reduces the amount of redox products generated at the counter electrode while enabling the working electrode to generate redox products. The electrochemical cell is useful for controlling the redox products generated and/or the timing of the redox product generation. The electrochemical cell is useful in assay methods, including those using electrochemiluminescence. The electrochemical cell can be combined with additional hardware to form instrumentation for assay methods. | 05-01-2014 |
20140112932 | Methods for Treating GI Syndrome and Graft versus Host Disease - We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases. | 04-24-2014 |
20140100351 | SOYBEAN BASED FIBERS - Fibers can be formed from monomers derived from a biorenewable source. In an embodiment, a fiber forming composition that includes a monomer or mixture of monomers with at least one monomer being derived from a biorenewable source in placed in a fiber producing device. At least a portion of the fiber forming composition is ejected through an opening of the fiber forming device. The ejected fiber forming composition is subjected to light at wavelengths sufficient to activate a reaction which causes solidification of the fiber as the fibers are ejected from the fiber producing device. | 04-10-2014 |
20140094480 | Pro-Neurogenic Compounds - This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death. | 04-03-2014 |
20140088506 | ELECTRO-OSMOTIC PUMPS WITH ELECTRODES COMPRISING A LANTHANIDE OXIDE OR AN ACTINIDE OXIDE - The present disclosure relates, according to some embodiments, to methods, devices, and systems for fluid delivery to a subject using pumps, for example, non-gassing, direct current (DC), electro-osmotic pumps. In some embodiments, delivery of an aqueous fluid may be achieved by contacting the aqueous liquid with an electro-osmotic pump comprising (i) a cathode (e.g., a cathode comprising porous carbon coated with a cerium oxide-comprising coating), (ii) an anode (e.g., an anode comprising porous carbon coated with a cerium oxide-comprising coating), and (iii) a ceramic membrane (e.g., a ceramic membrane formed by fusing uncoated silica spheres, phosphosilicic-acid-coated fused silica spheres, or borosilicic-acid-coated fused silica spheres, wherein the fused spheres are randomly packed between the cathode and the anode) and/or optionally applying (a) a constant potential difference or constant voltage between the anode and the cathode of from about 0.1 V to about 3 V between the anode and the cathode of from about 0.1 V to about 3 V such that the aqueous liquid is pumped or (b) constant current to cause a potential difference between the anode and the cathode of from about 0.1 V to about 3 V such that the aqueous liquid is pumped. | 03-27-2014 |
20140077269 | COMPACT REGULAR RECONFIGURABLE FABRICS - Described herein are compact regular programmable fabrics for improved logic density, yield, reliability, performance and power consumption compared with existing programmable fabric based VLSI design. Programmable fabrics facilitate technology transition from current silicon lithographic VLSI design to future non-silicon self-assembled nanoscale device based VLSI design. | 03-20-2014 |
20140058253 | Methods and Apparatus for Optoacoustic Guidance and Confirmation of Placement of Indwelling Medical Apparatus - Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed. | 02-27-2014 |
20140057900 | Pro-Neurogenic Compounds - Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. | 02-27-2014 |
20140054822 | METHOD FOR CREATING TOPOGRAPHICAL PATTERNS IN POLYMERS VIA SURFACE ENERGY PATTERNED FILMS AND THE MARANGONI EFFECT - Using a broadband light source and a photomask, surface energy gradients can be directly transferred into polymer films. The Marangoni effect causes high surface energy regions to rise upon heating the film. This leads to the formation of three-dimensional topography that can be locked in by quenching the polymer by cooling. | 02-27-2014 |
20140039150 | PHOTOPOLYMERIZABLE COMPOSITIONS FOR SOLVENTLESS FIBER SPINNING - Disclosed are methods of fiber spinning and polymer fibers that utilize multifunctional thiol and enes compounds. Also, the subject matter disclosed herein relates to uses of polymer fibers and articles prepared from such fibers. | 02-06-2014 |
20140018778 | EXTERNAL FIXATION SYSTEM FOR PERCUTANEOUS DRAINAGE PROCEDURES - An external fixation system for percutaneous drainage procedures may include a base. The base may include a first side. The first side may be positioned adjacent an exterior surface of a subject during use. The base may include a first coupler coupled to the first side of the base. The base may include a second side opposite the first side. The base may include an opening extending through the first coupler and the base such that the first coupler is in fluid communication with the second side of the base. The first coupler may be couplable to a conduit during use such that the conduit is in fluid communication with the second side of the base. In some embodiments, the second side of the base may include a second coupler configured to facilitate the attachment of a drainage bag or a mechanism to flush or evacuate a drainage catheter during use. | 01-16-2014 |
20140007796 | ENCAPSULATED ZINC COMPOUNDS AND METHODS FOR PREPARING AND USING SAME - Disclosed are encapsulated zinc compounds, together with methods for preparing and use the same. Also disclosed are methods for mixing the encapsulated zinc mixtures with a cement, and the resulting concrete compositions. | 01-09-2014 |
20130296921 | JUNCTIONAL TOURNIQUET - The present invention is a tourniquet comprising: a strap; a pelvic pad included in the strap having a pocket defined in the pelvic pad for receiving a semi-rigid stiffening member; base plates slidably attached to the strap allowing the base plates to be positioned along the strap; a threaded shaft received in each of the base plates; a pressure pad removable attached to a distal end of each of the shafts; a handle attached to a proximal end of each of the shafts having openings defined in each end of the handle; and, a rotational arresting strap attached to each base plate having a securing tab that can be received in one of the handle openings thereby preventing the shaft from rotating when the securing tab is received in sand handle opening. | 11-07-2013 |
20130245356 | HAND HELD SURGICAL DEVICE FOR MANIPULATING AN INTERNAL MAGNET ASSEMBLY WITHIN A PATIENT - A device for manipulating a magnetic coupling force across tissue in response to a monitored coupling force is described. The device includes a magnetic field source assembly that includes at least one fixed magnet and a rotatable magnet positioned within a cavity defined by the fixed magnet that provide an external magnetic field source for providing a magnetic field across tissue. An actuation assembly is operatively connected to the magnetic field force assembly. A sensor is provided that senses a magnetic coupling force and communicates changes therein to a controller which directs the accuation assembly to adjust the speed of rotation of the rotatable magnet in response to the sensed changes in magnetic coupling force to effect a change of magnetic flux generated by the rotatable magnet. | 09-19-2013 |
20130206232 | NANOWIRES AND METHODS OF MAKING AND USING - Nanorod and nanowire compositions are disclosed comprising copper indium selenide, copper indium gallium selenide, copper indium sulfide, or a combination thereof. Also disclosed are photovoltaic devices comprising the nanorod and/or nanowire compositions. Also disclosed are methods for producing the nanorod and nanowire compositions, and photovoltaic devices described herein. | 08-15-2013 |
20130201857 | DISTRIBUTED RATE ALLOCATION AND COLLISION DETECTION IN WIRELESS NETWORKS - A hybrid cellular and non-cellular multi-hop communication device, including a hand-held wireless device having one or more antennas, a cellular wireless interface connected to at least some of the one or more antennas, and a non-cellular wireless interface connected to at least some of the one or more antennas. The non-cellular wireless interface may include a rate allocator configured to select a physical-layer rate of transmission of data from the non-cellular wireless interface based on a queue length of data to be transmitted from the hand-held cellular device and a transmitter configured to wirelessly transmit data from the queue and adjust physical-layer transmission parameters based on a physical-layer rate selected by the rate allocator. | 08-08-2013 |
20130198848 | REMEDIATION OF COMPUTER SECURITY VULNERABILITIES - A computer security vulnerability remediation system (CSVRS) is disclosed, including a CSVRS client communicatively coupled to a remediation server through a network. The CSVRS client includes software having a security vulnerability, which vulnerability may be known to malicious actors who develop an exploit. In some cases, the exploit is a “zero-day exploit,” meaning the vulnerability may not be known to the CSVRS client until the exploit is deployed. A RSP receives information about the exploit and vulnerability from a team of remediation experts. The RSP may prepare a remedial exploit, which carries a self-healing pay load. The remedial exploit may be delivered either through the vulnerability itself, or through credentials granted by the CSVRS client to the RSP. The self-healing pay-load takes appropriate action, such as closing ports or disabling scripts, to prevent the vulnerability from being further exploited. | 08-01-2013 |
20130197825 | SURFACE-MOUNTED MONITORING SYSTEM - A surface mounted monitoring system is disclosed that is useful for detecting the presence of both ordinary and excessive loads on a surface, and for providing real-time or near real-time trending data. The system includes an array of force transducers disposed on the exterior surface of a structural member such as a roof. In an exemplary embodiment, transducers may be placed on an interior surface, such as embedded within insulation. The force transducers detect the magnitude of a load force acting on the surface. A data analysis module (DAM) may record force readings in a circular memory buffer, so that recent data can be recovered in the event of a catastrophic collapse. The DAM may also communicate with a monitoring device that can display real-time loading data to a user and perform other analysis. | 08-01-2013 |
20130191098 | METHODS AND SYSTEMS FOR SIMULATIONS OF COMPLEX BIOLOGICAL NETWORKS USING GENE EXPRESSION INDEXING IN COMPUTATIONAL MODELS - A method has been developed for using genome-wide transcription profile (i.e., gene-expression level) values to derive a gene expression index used as a kinetic value for every biological reaction and process assigned to each and every gene. This kinetic value is used in computational biology programs, i.e., mathematical models integrating genome, transcriptome, proteome, reactome, fluxome, metabolome, physiome, and phenome, in any combination, for simulations or theoretical systematic analyses of all life forms. This approach allows a model to be generated for any individual organism at any state of life, health condition, or disease/traumatic process. The model can include any or all biological reactions and processes, because an exact kinetic value becomes available; and, thereby, the outcomes represent stable or dynamic states of the individual organism at the time the biological specimen or sample was collected. Model systems without and with regulatory steps and mechanisms can be used to assess the present state of the specimen or sample and an acute response to an intervention within the system for the former and to predict some future state or status of treatment by testing single or multiple interventions within the regulated, dynamically responsive system for the latter; providing a prognostic value. Additionally, for multicellular organisms, the model can be tissue or cell type specific, depending on the source of the sample. Because of this capability, combined simulations can be generated with subsets of cells/tissues/organs/organ systems represented in a single model, in essence a reconstruction of the partial or complete organism in a single (or separate but integrated) computational model(s). Because all gene-expression values become available with genome-wide transcriptomic methods, surrogate tissue or cell samples can be used to predict other cells, tissues, or whole organism-level status; a utility essential for personalized individual medical care and history recording. This hierarchical computational approach is based upon the assumption that the transcriptome drives the reactome; and the proteome and metabolome, and other organism-level functions thereby effected, are resultant accompaniments to this basic integrative process in all organisms. If the genome and gene annotation (function) are known, or once they become known, for an organism and the transcriptome can be generated (even if from the genome of another related species, e.g., bovine genome used for buffalo), then this method can be used to generate a computational model representing that organism, inclusive of all living domains, Archaea, Bacteria, and Eukarya. The secondary data sets generated by the simulations are used for commercial and health care or promotion purposes of maximized yield or biomass production, health monitoring for improvement or sustained quality (for plants and animals, as well as smaller multicellular or unicellular organisms, such as insects and parasites, and microbes in ecological and environmental management, toxicology, agriculture, horticulture, and health management in general), bioremediation and biomining of pollutants, toxic substances, and precious metals, metabolic management for weight control, biomarker identification for commercial value (e.g., novel biofuels and sources), disease identification and management for prognosis, drug target identification, development, and testing, wound and tissue healing, overcoming drug resistances of bacteria, fungus, and cancer cells, development of novel singular or multiple therapies to individualize cancer treatments to the patient and specific molecular characteristics of the cancer cells or for treatment of metabolic disorders, and, in general, any biology-based approach to impact the improvement of humankind where study and testing of cellular based specimens is included. Additionally, the linking of the biological reactions to the life-sustaining and life-reproducing processes within the simulations generates data sets on individuals and ever increasing numbers of group samples in diverse categories in order that more global applications such as epidemiology, ecobiology, longitudinal growth and development analytics, and population dynamics studies can be implemented and performed. | 07-25-2013 |
20130190339 | Pro-Neurogenic Compounds - This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death. | 07-25-2013 |
20130190273 | Methods for Treating Amyotrophic Lateral Sclerosis Using Pro-Neurogenic Compounds - This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. | 07-25-2013 |
20130184301 | Methods of Treating Post-Traumatic Stress Disorder Using Pro-Neurogenic Compounds - This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death. | 07-18-2013 |
20130184300 | Methods of Treating Traumatic Brain Injury Using Pro-Neurogenic Compounds - This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death. | 07-18-2013 |
20130184271 | Methods for Treating Parkinson's Disease Using Pro-Neurogenic Compounds - This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. | 07-18-2013 |
20130177995 | HIGHLY EPITAXIAL THIN FILMS FOR HIGH TEMPERATURE/HIGHLY SENSITIVE CHEMICAL SENSORS FOR CRITICAL AND REDUCING ENVIRONMENT - An oxygen sensor includes an epitaxial oxide thin film double perovskite oxygen sensor formed on a single crystal oxide substrate. The thin film includes a lanthanide element, barium, cobalt, and oxygen. | 07-11-2013 |
20130164725 | CLASSROOM RESPONSE SYSTEM - A classroom response system is disclosed, comprising a classroom response system (CRS) server, at least one instructor console, and at least one student console. The CRS server includes a plurality of software modules, including a runtime server, a master server, a simulator, a query editor, a report generator, a report editor, a seating chart tool, and a simulator. An optional secondary instructor console may be provided, for example for use by a instructor's assistant. In use, the instructor may use the CRS to keep track of attendance, pose questions to students, and receive answers, including open-ended answers. Students may also be allowed to evaluate one another's work. The instructor may display aggregated answers and other anonymous data. | 06-27-2013 |
20130162988 | SUPERIOR ANALYZER FOR RAMAN SPECTRA WITH HIGH ACCEPTANCE CONE, RESOLUTION, TRANSMISSION, QUANTUM EFFICIENCY, AND STRONG BACKGROUND REDUCTION - A Raman analyzer for analyzing light emitted from a Raman cell is provided that has a beam splitter configured to split the light emitted from the Raman cell into a first beam and a second beam. An atomic vapor filter can be used to filter a Raman scattered line from the first beam and a chopper system can periodically interrupt the first and second beams that are directed towards a photo detector, which can convert light from the first and second beams into an electrical signal. The signal output from the photo detector can optionally be amplified, digitized, Fourier filtered, and/or subjected to Fourier analysis. | 06-27-2013 |
20130143855 | METHOD TO ALLEVIATE DIABETIC END STAGE RENAL DISEASE - A method of alleviating end-stage renal disease (ESRD), comprising administering an effective amount of a gel-danamycin derivative. | 06-06-2013 |
20130128692 | EXTRACTING SV SHEAR DATA FROM P-WAVE MARINE DATA - A system and method of processing seismic data obtained using a plurality of towed single-component receivers in a marine environment is described, the towed single-component receivers configured to measure compressional P waves. The method comprises retrieving seismic data from a storage device, the seismic data comprising P-P data and shear mode data, wherein the P-P data and shear mode data were both received at the towed single-component receivers configured to measure compressional P waves to generate the seismic data. The method further comprises processing the seismic data to extract SV-P shear mode data and generating shear mode image data based on the extracted shear mode data. | 05-23-2013 |
20130116343 | Salivary Protein Markers for Detection of Breast Cancer - A method of diagnosing a patient's risk of breast cancer comprises measuring in a saliva sample from the patient a concentration of at least a first protein marker, wherein the first protein marker is either ubiquitin or cytochrome p450, to provide a set of test data comprising a concentration value of each protein marker in the saliva sample. The test values are then compared to a reference panel comprising a Reference Control Value and a Reference Breast Cancer Value, and a diagnosis of either increased or decreased risk of breast cancer is determined for the patient based on a result of that comparison. A test kit for identifying a person at increased risk of breast cancer is also provided. | 05-09-2013 |
20130071371 | Method of Producing Physiological and Therapeutic Levels of Nitric Oxide Through an Oral Delivery System - A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity. | 03-21-2013 |
20130071329 | THERANOSTIC DELIVERY SYSTEMS WITH MODIFIED SURFACES - The present invention pertains to therapeutic compositions and delivery systems comprising at least one microparticle or nanoparticle. In various embodiments, the surface of the microparticle or nanoparticle is modified or functionalized with at least a portion of an isolated cellular membrane, such as an isolated plasma membrane. In addition, the microparticle or nanoparticle contains at least one active agent, such as a therapeutic and/or imaging agent. In additional embodiments, the compositions and delivery systems of the present invention may be used for targeted delivery of an active agent. Also provided are methods of making the therapeutic compositions and delivery systems of the present invention. | 03-21-2013 |
20130071326 | UNIVERSAL CELL-DIRECTED THERANOSTICS - The present invention provides modified stem cells that comprise a delivery system that comprises at least one microparticle or nanoparticle, wherein the at least one microparticle or nanoparticle comprises an active agent. The present invention also provides delivery methods that comprise the administration of the modified stem cells to a subject. Additional aspects of the present invention pertain to methods of making said modified stem cells. | 03-21-2013 |
20130066047 | RED-SHIFTED CHANNELRHODOPSINS - Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo. | 03-14-2013 |
20130046219 | NEONATAL CRANIAL SUPPORT BONNET - A neonatal cranial support bonnet is configured to prevent a premature child's head from deforming under the force of its own weight, because of underdeveloped cranial plates. The bonnet includes a thin cotton shell with contoured gel packs inside. The gel packs are configured to distribute weight around the skull and eliminate or reduce high-pressure points so as to maintain proper shape of the cranium. The bonnet is also configured to not interfere with development, and to not obstruct airways for breathing, so as to meet current Sudden Infant Death Syndrome prevention guidelines. | 02-21-2013 |
20130046207 | APPARATUSES AND SYSTEMS FOR GENERATING HIGH-FREQUENCY SHOCKWAVES, AND METHODS OF USE - Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves. | 02-21-2013 |
20130041353 | ELECTRO-OSMOTIC PUMPS, SYSTEMS, METHODS, AND COMPOSITIONS - The present disclosure relates, according to some embodiments, to compositions, methods, devices, and systems for delivering a composition (e.g., a fluid composition) to a subject. For example, the present disclosure relates to non-gassing, direct current (DC), electro-osmotic pumps in some embodiments. A pump may comprise an anode (e.g., a porous silver/silver oxide anode), a cathode (e.g., a porous silver/silver oxide cathode), and a membrane (e.g., a porous ceramic membrane) positioned at least partially between the anode and the cathode in some embodiments. A pump system may comprise an electro-osmotic pump, a reservoir comprising a pump fluid chamber in fluid communication with the electro-osmotic pump and a delivery fluid chamber in fluid communication with the electro-osmotic pump; a controller assembly in electrical communication with the anode and the cathode; and a cannula and/or a needle in fluid communication with the delivery fluid chamber. A pump fluid may comprise water and/or a delivery fluid may comprise a drug, in some embodiments. | 02-14-2013 |
20130040977 | Pro-Neurogenic Compounds - This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. | 02-14-2013 |
20120329173 | METHOD AND FOR THE DETECTION OF BIOLOGICAL MOLECULES USING A TWO PARTICLE COMPLEX - Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety also provided. | 12-27-2012 |
20120312700 | ELECTROCHEMISTRY AND ELECTROGENERATED CHEMILUMINESCENCE WITH A SINGLE FARADAIC ELECTRODE - A method is provided for determining the presence or amount of an analyte in a sample and includes the steps of contacting a faradaic working electrode to a solution comprising the optionally pre-processed sample and an electrolyte, contacting a capacitive counter electrode to the solution, supplying electrical energy between the faradaic working electrode and the capacitive counter electrode sufficient to provide for faradaic charge transfer at the faradaic working electrode, and measuring at least one of (i) light, (ii) current, (iii) voltage, and (iv) charge to determine the presence or amount of the analyte in the sample. | 12-13-2012 |
20120231067 | VESICLE COMPOSITIONS - Vesicle compositions are provided that comprise a therapeutic compound. The vesicle compositions may be capable of releasing the therapeutic compound in response to the presence of an external trigger. The vesicle compositions may comprise a plurality of biocompatible vesicles. The biocompatible vesicles may comprise a therapeutic compound for treatment of a patient in need thereof, and one or more cross-linkages between two or more of the biocompatible vesicles, each cross-linkage comprising a chemical sensing moiety and a sensed moiety. In some embodiments, the therapeutic compound may be any compound that provides palliative, curative, or otherwise beneficial effects to a patent. | 09-13-2012 |
20120148574 | Diagnostic Markers for Ankylosing Spondylitis - The present invention discloses methods and agents for diagnosing the presence or risk of development of ankylosing spondylitis (AS) in mammals, which are based on the detection of polymorphisms within any one or more of the ARTS-1 gene, the IL-23R gene, the TNFR1 gene locus, the TRADD gene locus, the IL-1R1 gene locus, the IL-1R2 gene locus, the CD74 gene locus and the chromosome loci 2P15, 2Q31.3 and 4Q13.1. The present invention also features methods for the treatment or prevention of AS based on the diagnostic methods. | 06-14-2012 |
20120058475 | Detection of Chromosomal Inversions - A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. | 03-08-2012 |
20120045396 | POROUS STRUCTURES WITH MODIFIED BIODEGRADATION KINETICS - Biodegradation kinetics of biodegradable porous objects, such as porous silicon objects, can be controlled by a molecular weight of polymer chains, such as polyethylene glycol chains, disposed on an outer surface of the object. Provided are biodegradable porous objects, which have their biodegradation kinetics controlled by a molecular weight of the disposed polymer chains. Also provided are methods of making such biodegradable porous objects as well as methods of using such biodegradable porous objects for delivery of active agents, such as therapeutic agents and/or imaging agents. | 02-23-2012 |
20120039875 | DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER - Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. | 02-16-2012 |
20120022096 | PRO-NEUROGENIC COMPOUNDS - This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. | 01-26-2012 |
20120003159 | COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING - Examples of compositions of liposomes and methods of making the same containing high concentrations of contrast-enhancing agents for computed tomography are provided. Example compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes stable, that is, resistant to leakage of the contrast-enhancing agents, including the extrusion of the liposomes at high pressures and at high flow rates per total pore area of the extrusion filters. | 01-05-2012 |
20110312899 | HDL Particles for Delivery of Nucleic Acids - Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits. | 12-22-2011 |
20110311452 | INFLAMMATION TARGETING PARTICLES - Opsonizable micro- or nanoparticles, that contain at least one active agent, such as an imaging or therapeutic agent; that have a positive surface charge and that do not contain on their surface targeting ligands, such as antibodies, peptides or aptamers, can be used to treating and/or monitoring a condition associated with an inflammation, such as a cytokine stimulated inflammation. | 12-22-2011 |
20110274624 | CONTRAST AGENTS IN POROUS PARTICLES - MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed. | 11-10-2011 |
20110266521 | POROUS AND NON-POROUS NANOSTRUCTURES - Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object. | 11-03-2011 |
20110200567 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF LUNG DISEASES AND DISORDERS - A method of treating injured or diseased alveolar epithelial tissue in the lung of a mammal comprising transplanting into the lung a population of differentiated transgenic stem cells, or progeny thereof, which have an alveolar type II phenotype, effective to repair at least a portion of the injured or diseased alveolar epithelial tissue; an expression vector for transgenically modifying stem cells, comprising a DNA sequence encoding human surfactant protein C promoter operably linked to a DNA sequence encoding at least one drug-resistance gene; transgenic stem cells comprising such expression vector; and a method of preparing such transgenic stem cells and progeny thereof, a high percentage of which have an alveolar type II phenotype. | 08-18-2011 |
20110199084 | METHOD AND SYSTEM FOR DIFFUSION TENSOR IMAGING - Methods and systems for displaying microstructural integrity and/or connectivity of a region of interest (ROI) in a patient are disclosed. Methods and systems for tissue segmentation and atlas-based tissue segmentation in ROI of a patient using diffusion MRI data are also described. A method for studying microstructural integrity and/or connectivity of a region of interest (ROI) in a patient includes acquiring, via an imaging system, diffusion magnetic resonance (MRI) data in the ROI by using an Icosahedral Diffusion Tensor Encoding Scheme (IDTES); computing, via the imaging system, mean diffusivity (MD) and fractional anisotropy (FA) by using logarithm-moment algorithm (LMA); and displaying, on a display, the microstructural integrity and/or connectivity of ROI based on the computed MD and FA. The diffusion MRI data includes diffusion-weighted imaging (DWI) data or diffusion tensor imaging (DTI) data. In some cases, displaying the microstructural integrity and/or connectivity of ROI takes place in real time. | 08-18-2011 |
20110189220 | MUSHROOM COMPOSITIONS AND METHODS FOR MAKING AND USING - The present subject matter relates to a novel mushroom composition and methods for making and using the same. In one aspect, the subject matter involves a composition comprising a combination of mushrooms or components derived from mushrooms selected from the group consisting of Reishi | 08-04-2011 |
20110171681 | METHODS AND COMPOSITIONS FOR REGULATION OF STEM CELL SURVIVAL, PROLIFERATION, AND DIFFERENTIATION BY PROTEIN UBIQUITINATION - Compositions and methods for regulating in vitro cell growth are disclosed, and for providing undifferentiated stem cells or embryonic cells that are suitable for transplantation into damaged tissues or organs, or for use in tissue repair. A representative method includes causing the overexpression or underexpression of GalT binding protein (GtBP), also referred to as GalT associated protein (GTAP), in a cell such that ubiquitination of at least one cellular protein associated with cell adhesion and/or cell-to-cell interaction is correspondingly increased or decreased, causing inhibition of cell growth when GTAP is overexpressed and causing enhanced cell growth when GTAP is underexpressed by the cell. As a result, growth of the cell is altered or regulated. | 07-14-2011 |
20110150868 | DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER - Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. | 06-23-2011 |
20110104124 | MESODERMAL-LIKE CELL POPULATION FOR TREATING ISCHEMIA IN MAMMALS - Compositions containing an effective amount of mesodermal-like multipotent mammalian mononuclear cells that express both CD34 and M-cadherin cell surface markers are used for preventing, treating or reducing the severity of tissue ischemia or an ischemia associated disorder in a mammal. Such uses may include repopulating an in vivo site with new myocytes and/or vascularizing an ischemic or adjacent tissue. Detection of the level and/or distribution of CD34 | 05-05-2011 |
20110071403 | FUNCTIONAL NEAR-INFRARED FLUORESCENCE LYMPHATIC MAPPING FOR DIAGNOSING, ACCESSING, MONITORING AND DIRECTING THERAPY OF LYMPHATIC DISORDERS - Methods and imaging agents are used to functionally image lymph structures and to identify, diagnose, assess, monitor and direct therapies for lymphatic disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques capable of rapid temporal resolution to non-invasively track or monitor packets of imaging agents flowing in one or more lymphatic structures in human patients to provide quantitative information regarding lymph propulsion and functionality of the lymphatic structures. An imaging agent comprises a fluorophore labeled peptide capable of binding integrin α | 03-24-2011 |
20110071306 | BIOMASS REFINING BY SELECTIVE CHEMICAL REACTIONS - A method is disclosed for the acid hydrolysis of carbohydrates in or from biomass, using a solvent system including an aqueous ether, where the ether form a majority of the system, which affords high yields to the platform chemicals such as 2-furfural and 5-hydroxymethylfurfural (5-HMF). The later can also undergo a domino reaction to chemicals including levulinic acid, particularly with oxygenated anions and greater water content. A total dissolution and reaction of biomass occurs under a range of relatively mild conditions (combined Severity range ˜2.2-2.6). Lignin and lignin derived products can be easily separated by precipitation. | 03-24-2011 |
20110066208 | ILEAL ELECTRICAL STIMULATION - The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means. | 03-17-2011 |
20110060222 | METHOD AND APPARATUS FOR CHARACTERIZING INHOMGENEITIES USING AXIAL SHEAR STRAIN ELASTOGRAPHY - The present invention relates to systems and methods for characterizing inhomogeneities in deformable target bodies. More particularly, the disclosure relates to methods and systems for axial-shear strain elastography (ASSE) and their use in analyzing inclusions such as but not limited to, tumors as well as directing cancer therapies such as HIFU. | 03-10-2011 |
20110052660 | CERAMIC SCAFFOLDS FOR BONE REPAIR - Ceramic articles as functional biodegradable scaffolds with graded porosity are made by a process that includes a hardening step in which the liquid of a liquid-containing ceramic composition is extracted from the ceramic composition by exposing the ceramic composition to a solvent in which the liquid in the composition is soluble before the ceramic composition is solidified into the final ceramic article. An exemplary calcium phosphate porous ceramic article constructed in accordance with the process is useful as an implant to repair a bone defect. | 03-03-2011 |
20110052591 | Variants of Thyroid Stimulating Hormone Beta - Polynucleotide and polypeptide sequences that encode novel variants of mouse or human thyroid stimulating hormone-β proteins are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications to prevent, treat or reduce the severity of thyroid stimulating hormone-β-related disorders. | 03-03-2011 |
20110028331 | DETECTION OF MUTATIONS IN ACTA2 AND MYH11 FOR ASSESSING RISK OF VASCULAR DISEASE - A method of detecting in an individual an increased risk of hyperplastic vasculomyopathy, or a vascular disease resulting therefrom is disclosed. The method comprises obtaining a DNA genome sample from the individual and detecting in the sample a missense mutation in a gene which is a component of a smooth muscle cell contractile unit. In some embodiments the gene is ACTA2 and in some embodiments the gene is MYH11. In some embodiments, the gene is sequenced and then compared to a panel of control gene sequences which are representative of the same gene in individuals without vascular disease or who are at low risk of developing hyperplastic vasculomyopathy, to detect any missense mutations in the gene. The presence of a missense mutation in the gene indicates an increased risk of hyperplastic vasculomyopathy. | 02-03-2011 |
20110020479 | METHODS FOR MODULATING EICOSANOID METABOLISM - The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases. | 01-27-2011 |
20110015695 | GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS - A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors. | 01-20-2011 |
20110008457 | COMPOSITIONS AND METHODS FOR MODULATING LIPID COMPOSITION - The present subject matter relates to a novel herbal and oil composition and methods for modulating fatty acid composition and metabolism in an animal. In one aspect, the subject matter involves a composition comprising rosemary extract, oregano extract, and a polyunsaturated oil. In a particular embodiment, the polyunsaturated oil is fish oil or a derivative thereof. In some embodiments, the present subject matter relates to methods for modulating essential dietary fatty acid composition of lipoprotein particles or cell membranes, modulating essential fatty acid metabolism, regulating the activity of lipoxygenases and cyclooxygenases, improving cardiovascular health, and/or inhibiting cell proliferation diseases and disorders. | 01-13-2011 |
20100310527 | LIPOSOME MEDIATED DELIVERY OF LINEAGE DETERMINING FACTORS - Methods and compositions are provided for lineage predetermination of cellular transplants including through liposome mediated transfection with aqueous protein extracts from populations of differentiated mammalian cells, or cellular fractions thereof, wherein the differentiated mammalian cells are enriched in one or more of adipocytes, chondrocytes, endothelial cells, hepatocytes, cardiomyocytes, smooth muscle cells, skeletal muscle cells, cardiac pacemaker cells, Schwann cells, pancreatic islet cells, hematopoietic cells, myeloblasts, neurons, and osteoblasts. | 12-09-2010 |
20100279419 | DETECTION OF SALIVA PROTEINS MODULATED SECONDARY TO DUCTAL CARCINOMA IN SITU OF THE BREAST - A method of differentiating among the presence of ductal carcinoma in situ in the breast, benign fibroadenoma of the breast, and non-cancerous breast tissue in a subject is disclosed. The method comprises: measuring the concentration of at least one protein biomarker selected from a group of forty-nine differentially expressed proteins in the saliva of persons with DCIS, or benign fibroadenoma, or in persons who are cancer-free. The resulting test data is compared to a reference panel. From the comparison the presence in the subject of either ductal carcinoma in situ of the breast, or benign fibroadenoma of the breast is determined. | 11-04-2010 |
20100172845 | COMPOSITIONS AND METHODS FOR TREATING MYCOBACTERIAL INFECTIONS - Disclosed are compositions and improved methods for effective treatment of Mycobacterial infections in susceptible animals. Also disclosed are regimens for preventing, reducing, or ameliorating the emergence of symptoms of | 07-08-2010 |
20100074958 | METHODS AND COMPOSITIONS FOR TARGETING FENESTRATED VASCULATURE - Targeting of a fenestrated vasculature at a body site by micro or nanoparticles can be increased by using particles that have a radius substantially equal to a critical radius of a normal vasculature at the body site. The particles can be used for treating or monitoring a physiological condition responsible for the fenestrated vasculature. A method of improving an ability of micro or nanoparticles to target fenestrated blood vessels in a body site by selecting particles from a population of the micro or nanoparticles, where the selected particles have a radius that permits enhanced delivery into the fenestrated blood vessels. | 03-25-2010 |
20100063423 | ULTRASONIC BATH TO INCREASE TISSUE PERFUSION - The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath adapted to hold media and to permit the immersion of an extremity and comprising one or more ultrasonic transducers to generate and transmit ultrasonic energy to the extremity or the inventive method | 03-11-2010 |
20100021443 | METHOD OF PREPARING LUNG ALVEOLAR EPITHELIAL TYPE II CELLS DERIVED FROM EMBRYONIC STEM CELLS - A method of preparing a population of in vitro cultured cells of alveolar epithelial type II (ATII) cell lineage derived from at least one embryonic stem cell is disclosed which comprises (a) culturing said at least one embryonic stem cell in vitro in a medium comprising Matrigel®, to produce differentiated cells without formation of an embryonic body, wherein at least some of the differentiated cells are of ATII cell phenotype; (b) identifying the differentiated cells of ATII cell phenotype by detecting expression of at least one biomarker of ATII cells; (c) isolating the differentiated cells having ATII cell phenotype; and (d) cloning the isolated cells to produce a population of cells having ATII cell phenotype. The resulting cells are preferably >99% pure ATII phenotype lineage and are potentially useful therapeutically for treating lung injury and disease. | 01-28-2010 |
20100003271 | NITRIC OXIDE INCREASES SWITCHING OF T CELLS INTO T REGULATORY CELLS - An ex vivo method of expanding a population of regulatory T-cells includes culturing a starting population of cells containing CD4 | 01-07-2010 |
20090270758 | DEVICE AND METHOD FOR MEASURING INFORMATION PROCESSING SPEED OF THE BRAIN - A device is disclosed which comprises a display adapted to display a sequence of rapidly alternating images, and a keypad electrically coupled to the display, for entering a perceived sequence by a user. The device is configured to compare a perceived sequence input by the user to the displayed sequence, and to measure the speed of visual perception of the user. Also disclosed are methods of visually, non-invasively assessing an individual's speed of visual perception (visual window of integration), or detecting any changes that have occurred in the individual's speed of visual perception. | 10-29-2009 |
20090210956 | COMPOSITION AND METHOD FOR CLUSTERIN-MEDIATED STEM CELL THERAPY FOR TREATMENT OF ATHEROSCLEROSIS AND HEART FAILURE - Methods and compositions are disclosed for inhibiting, deterring or preventing apoptosis of cardiac myocytes, transplanted stem cells, vascular stem cells, and vascular smooth muscle cells by means of expressing or synthesizing clusterin. Also disclosed are methods and compositions for producing recombinant clusterin, or its biologically active peptides, and for induction of clusterin-associated lipoproteins or enzymes for deterring or preventing inflammatory injury and apoptosis induced by oxLDL, oxysterols, cytokines, and Fas Ligand. Also disclosed is an induction method and composition for enhancing expression of ALDH and ALDH-associated enzymes or co-factors to prevent cytotoxicity or detoxification. Therapeutic methods providing new expression or overexpression of clusterin in vascular or cardiac tissue are expected to inhibit the formation of atherosclerotic lesions, stabilize existing atherosclerotic plaques, and repair failing or damaged cardiac tissue. | 08-20-2009 |
20080311607 | Methods and Compositions for Regulation of Stem Cell Survival, Proliferation, and Differentiation by Protein Ubiquitination - Compositions and methods for regulating in vitro cell growth are disclosed, and for providing undifferentiated stem cells or embryonic cells that are suitable for transplantation into damaged tissues or organs, or for use in tissue repair. A representative method includes causing the overexpression or underexpression of GalT binding protein (GtBP), also referred to as GalT associated protein (GTAP), in a cell such that ubiquitination of at least one cellular protein associated with cell adhesion and/or cell-to-cell interaction is correspondingly increased or decreased, causing inhibition of cell growth when GTAP is overexpressed and causing enhanced cell growth when GTAP is underexpressed by the cell. As a result, growth of the cell is altered or regulated. | 12-18-2008 |
20080277578 | Nanoporous substrates for the analytical methods - Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range. | 11-13-2008 |
20080206344 | ENDOCYTOTIC PARTICLES - Endocytosis of an active agent into a cell having surface receptors can be enhanced by using particles that have a radius no less than an endocytotic threshold determined based on a surface density of the receptors, a surface density of the moieties and interaction parameters that include at least one of a receptor-moiety spring constant and a non-specific interaction strength. | 08-28-2008 |