Board of Governors for Higher Education, State of Rhode Island and Providence Plantations Patent applications |
Patent application number | Title | Published |
20150191508 | Selective Delivery of Molecules into Cells or Marking of Cells in Diseased Tissue Regions Using Environmentally Sensitive Transmembrane Peptide - A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH. | 07-09-2015 |
20140295533 | Enhanced Microfluidic Valves for Media Diagnostics - The invention provides a micro-fluidic device that includes a pre-loaded sample that begins to flow only when a sample is provided in the device. In certain embodiments, the invention provides a micro-fluidic device including at least two paper flow path layers providing fluid flow in substantially parallel planar directions, and at least one valve positioned between the at least two paper flow paths, wherein the at least one valve for providing flow in a direction that is orthogonal to the substantially planar directions. | 10-02-2014 |
20140198883 | Systems and Methods for Highly Accurate and Efficient Pulse Prediction - A method is disclosed for predicting a pulse periodicity in a signal. The method includes the steps of receiving a signal that includes a component that is periodic having an unknown periodicity and a noise component; comparing the signal to an adjustable reference signal, and varying at least one of the phase and the periodicity of the reference signal until a best fit match is obtained between the signal and the reference signal. | 07-17-2014 |
20140188811 | SYSTEMS AND METHODS FOR PROVIDING CONTINUOUS FILE PROTECTION AT BLOCK LEVEL - A system and method are disclosed for providing continuous file protection in a computer processing system. In accordance with an embodiment, the system includes a configuration module, a filter driver, and a storage module. The configuration module permits a user to elect certain files or folders for protection. The configuration module runs at an application layer without involving the computer processing system's operating system. The filter driver intercepts and splits write input and outputs addressed at protected files or folders. The storage module is also run without involving the computer processing system's operating system. The storage module is for performing functions including data logging, version managements, and data recovery. | 07-03-2014 |
20140179786 | Treatment of Alzheimer's Disease Using Tolfenamic Acid - A method is disclosed of reducing the level of tau protein in a subject's brain for the treatment of tau tangles. The method includes administrating an effective dose of drug that reduced Sp1 levels to the subject to lower tau mRNA and protein levels, CDK5 mRNA and protein levels, as well phosphorylated tau in the brain. | 06-26-2014 |
20140039862 | Apparatus for Neuron Emulation and Testing - A method and a device are disclosed for an electronic neuron emulator for representing both passive and active electrical properties of a live neuron. The currents used to generate action potentials are derived from a pre-charged capacitor. The present invention provides for a more physiological state for testing neuroscience instruments such as the single-electrode voltage clamp and the patch clamp. The device can also include multiple pre-charged capacitors to represent ionic channels with more accurate physiologically parameters. | 02-06-2014 |
20130152848 | LOW TEMPERATURE IRREVERSIBLE THERMOCHROMIC COMPOSITIONS - Provided herein are novel polythiophene compounds having polyalkoxyl sidechains and low temperature irreversible upon activation (IUA) thermochromic compounds/compositions thereof. The IUA thermochromic compounds or compositions are activated and exhibit an IUA color by heating to or above a reversible thermochromic transition temperature (RTTT) and cooling to or below an irreversible thermochromic transition temperature (IRTTT) in less than 2 seconds. The activated IUA thermochromic compounds or compositions will retain their IUA color as long as the compounds or compositions are kept at or below about 5° C. below the IRTTT. The activated IUA thermochromic compounds or compositions will be deactivated and show a different color upon exposure to a temperature equal to or higher than about 5° C. below the IRTTT unless the compounds or compositions are activated again. The IUA thermochromic compounds/composition can be used to prepare IUA thermochromic indicators which can monitor subjects stored below a pre-determined temperature and detect the subjects that have been exposed to a temperature above the pre-determined temperature. | 06-20-2013 |
20130130213 | ACTIVITY MONITOR AND ANALYZER WITH VOICE DIRECTION FOR EXERCISE - A system is disclosed for monitoring and analyzing activity of a subject. The system includes a condition setting unit for setting a schedule for the subject in association with a clock, a voice recording and play-back unit for recording a set of personalized messages for the subject, and a motion detection unit for monitoring, in association with the clock, whether an expected activity has occurred. The voice recording and play-back unit plays one of the set of personalized messages responsive to whether the expected activity has occurred. | 05-23-2013 |
20130079860 | BIOMEDICAL ELECTRODE SYSTEM AND METHOD FOR DETECTING LOCALIZED ELECTRICAL SIGNALS AND PROVIDING ELECTRICAL STIMULATION - A biomedical electrode is disclosed that includes at least first and second electrical nodes for connection to medical equipment. The biomedical electrode includes a first electrical node including a disc of conductive material having a diameter d | 03-28-2013 |
20130078711 | SYSTEMS AND METHODS FOR PROVIDING MICROFLUIDIC DEVICES - A microfluidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region. | 03-28-2013 |
20130046011 | HOT-MELT EXTRUDED COMPOSITIONS CONTAINING PLANT-DERIVED PHENOLIC MATERIALS AND PROCESSES FOR THE PREPARATION THEREOF - A hot-melt extruded composition is disclosed that includes about 20-80% wt. of a plant-derived phenolic material; about 20-85% wt. of one or more edible or bioerodible excipients; about 0-40% wt. of a surface active material; about 0-40% wt. of an oral absorption enhancer; and about 0-10% wt. of one or more pharmaceutical or food grade additives. The composition has been hot-melt extruded at a temperature substantially below the melting point of the plant-derived phenolic material to produce a hot-melt extruded composition wherein substantial degradation of the plant-derived phenolic material has not occurred. | 02-21-2013 |
20130024985 | MALE AND FEMALE STERILITY LINES USED TO MAKE HYBRIDS IN GENETICALLY MODIFIED PLANTS - A method is disclosed for producing a hybrid perennial plant system for plant breeding of co-sexual plants for increased yields and for having increased gene confinement capabilities. The method includes the steps of (a) contacting a first compatible perennial plant with a male vector, wherein the male vector comprises a SL expression cassette to create a plant line (A) with disrupted male development; (b) contacting a second compatible perennial plant with a female vector, wherein the female vector comprises a SL expression cassette to create a plant line (B) with disrupted female development; and (c) crossing plant line (A) with plant line (B) to produce the hybrid perennial plant having increased heterozygocity gene confinement. | 01-24-2013 |
20120300576 | PLANAR LABYRINTH MICROMIXER SYSTEMS AND METHODS - A planar labyrinth micromixer is disclosed that includes an inlet port, a plurality of curved channels, a plurality of abrupt turns, and an outlet port. The inlet port is for receiving a plurality of input fluids to be mixed. The plurality of curved channels induce transverse Dean vortices that rotate processing streams. The plurality of abrupt turns fold laminar flow of the processing streams, shift elliptical points corresponding to centers of Dean flow regions, and disrupt flow islands. The output port is for providing the processing streams as a mixture of the plurality of input fluids. | 11-29-2012 |
20120290279 | SYSTEM AND METHOD FOR PROVIDING ASSESSMENT OF RISK OF ENCOUNTER WITH TICKS - A tick encounter and tick-borne disease prevention decision support system is disclosed for permitting a user to obtain a risk calculation of encountering disease-causing ticks. The tick encounter and tick-borne disease prevention decision support system includes several components. A location component is for receiving data from a user regarding a user's geographic location. A landscape component is for receiving data from the user regarding a type of landscape that exists where the user lives. An animals component is for receiving data from the user regarding any of wildlife or pets that exist where the user lives. A human activity component is for receiving data from the user regarding the user's activities in their yard. The score computation module is for generating a tick risk calculation number based on output data from each of the components. | 11-15-2012 |
20120201865 | HOT-MELT EXTRUDED COMPOSITIONS CONTAINING PLANT-DERIVED PHENOLIC MATERIALS AND PROCESSES FOR THE PREPARATION THEREOF - A hot-melt extruded composition is disclosed that includes about 20-80% wt. of a plant-derived phenolic material; about 20-85% wt. of one or more edible or bioerodible excipients; about 0-40% wt. of a surface active material; about 0-40% wt. of an oral absorption enhancer; and about 0-10% wt. of one or more pharmaceutical or food grade additives. The composition has been hot-melt extruded at a temperature substantially below the melting point of the plant-derived phenolic material to produce a hot-melt extruded composition wherein substantial degradation of the plant-derived phenolic material has not occurred. | 08-09-2012 |
20120191017 | STUMBLE DETECTION SYSTEMS AND METHODS FOR POWERED ARTIFICIAL LEGS - A stumble detection system is disclosed for use with a powered artificial leg for identifying whether a stumble event has occurred. The stumble detection system includes an acceleration sensor for providing acceleration data indicative of the magnitude of acceleration of a person's foot, and a detector that determines whether a stumble event has occurred responsive to the acceleration data and provides an output signal. | 07-26-2012 |
20120150011 | BIOMEDICAL ELECTRODE - A biomedical electrode is disclosed that includes at least first and second electrical nodes for connection to medical equipment. The biomedical electrode includes a first electrical node including a disc of conductive material having a diameter d | 06-14-2012 |
20110316189 | SELF-MENDING COMPOSITES INCORPORATING ENCAPSULATED MENDING AGENTS - A cement mixture is disclosed that includes an aqueous mending agent that is disbursed within but isolated from the cement mixture, wherein the aqueous mending agent will form molecular bonds with hardened cement that is formed by the cement mixture when the mending agent is permitted to flow within the hardened cement. | 12-29-2011 |
20110281369 | ANALYSIS OF MYCOPHENOLIC ACID IN SALIVA USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY - A method for mass spectrometric analysis of a saliva sample possibly containing mycophenolic acid or its metabolites mycophenolic acid phenyl glucuronide (MPAG) or mycophenolic acid acyl-glucuronide (Acyl-MPAG), including the steps: (a) providing a saliva sample containing one or more drug or metabolites; (b) deproteinating the sample; (c) separating the one or more drug or metabolites from the saliva sample; and (d) analyzing the one or more drug or metabolites using a mass spectrometer. The sample containing one or more MPA or metabolites is obtained from in an oral fluid based biological samples i.e. whole saliva or saliva obtained by chemical or mechanical stimulation or from specific salivary glands. The size of the sample contains one or more MPA or metabolites is at least about 100 microL. A kit for use in mass spectrometric analysis of a sample may contain one or more MPA or metabolites from saliva samples, comprising: (a) reagents for deproteinating of the saliva sample, including internal standards; (b) reagents for separating the one or more MPA or metabolites from the saliva sample; (c) reagents for analyzing the one or MPA or metabolites using a mass spectrometer; (d) a solution of one or more MPA or metabolites in saliva samples; and (e) instructions for analyzing the one or more MPA or saliva using a mass spectrometer. The kit includes (a) mobile phase solutions; (b) a chromatography column; and (c) a quality control specimen. | 11-17-2011 |
20110264635 | SYSTEMS AND METHODS FOR PROVIDING CONTINUOUS FILE PROTECTION AT BLOCK LEVEL - A system and method are disclosed for providing continuous file protection in a computer processing system. In accordance with an embodiment, the system includes a configuration module, a filter driver, and a storage module. The configuration module permits a user to elect certain files or folders for protection. The configuration module runs at an application layer without involving the computer processing system's operating system. The filter driver intercepts and splits write input and outputs addressed at protected files or folders. The storage module is also run without involving the computer processing system's operating system. The storage module is for performing functions including data logging, version managements, and data recovery. | 10-27-2011 |
20110034670 | BISUBSTRATE INHIBITORS OF PROTEIN KINASES AS THERAPEUTIC AGENTS - A bisubstrate inhibitor of Src kinases, having a nucleotide or N-heteroaromatic moiety; and a peptide/phosphopeptide, peptidomimetic, or phosphopeptide mimic moiety. The moieties are linked by a rigid or a flexible linker. The nucleotide or N-heteroaromatic moiety is ATP, ATP-mimics, N-heteroaromatics including purine-based derivatives, pyrimidine-based derivatives such as 2,4-diamino-5-substituted pyrimidine derivatives, pyrazole[3,4-d]pyrimidine derivatives, pyrrolo[2,3-d]pyrimidine derivatives, pyrido[2,3-d]pyrimidine derivatives, amino-substituted dihydropyrimido[4,5-d]pyrimidinone derivatives, thieno- and furo-substituted derivatives, quinazoline derivatives, and quinoline derivatives, and several natural products such as aminogenistein. The phosphopeptide mimics comprise phosphonate-based phosphotyrosine mimetics such as phosphonomethylphenylalanine (Pmp) and its analogues, carboxylic acid-based phosphotyrosine mimetics such as malonyltyrosine or phenylalanine analogues and their derivatives such as carboxymethyl phenylalanine, uncharged pTyr mimetics, and conformationally constrained peptides. The phosphopeptide or phosphopeptide mimics inhibits the Src kinases SH2 domain. | 02-10-2011 |
20100148758 | SYSTEMS AND METHODS FOR ON-CHIP POWER MANAGEMENT - A power measurement system is disclosed for use on an integrated circuit for measuring the power used by the integrated circuit. The power measurement system includes a low-dropout voltage regulator and a signal input unit. The low-dropout voltage regulator includes a power transistor that couples a supply voltage to a circuit to be powered by the supply voltage, and the low-dropout voltage regulator provides an internal adjustment signal (V | 06-17-2010 |
20100116379 | COMPOSITE USED FOR THERMAL SPRAY INSTRUMENTATION AND METHOD FOR MAKING THE SAME - A superalloy article which comprises a substrate comprised of a superalloy, a bond coat comprised of MCrAlY wherein M is a metal selected from the group consisting of cobalt, nickel and mixtures thereof applied onto at least a portion of the substrate and a ceramic top coat applied over at least a portion of the bond coat. The bond coat is exposed to a temperature of within the range of between about 1600-1800° F. subsequent to its application onto the substrate. | 05-13-2010 |
20100113305 | OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES - This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds. | 05-06-2010 |