| BIOVATOR TECHNOLOGIES AB Patent applications |
| Patent application number | Title | Published |
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| 20120088688 | IN VITRO ASSAY FOR IDENTIFICATION OF ALLERGENIC PROTEINS - In vitro evaluation of a potentially allergenic or tissue irritating substance is conducted by cultivating test cells in the presence of the substance and the presence of up regulated genes chosen from G1P2, OASL, IFIT1, TRIM22, IFI44L, MXI, RSAD2, IFIT3, IFITM1, IFIT2, SPR, GNB2, XK, IFITM3, C 33.28 HERV-H protein mRNA, GPR15, MT1G, MT1B, MT1A, ADFP, IL8, MT1E, MT1F, MT1H, SLC30A1, SERPINB2, CD83, and TncRNA, or expression products from them, are measured. The expression products from one or more of the genes may be used for in vitro analysis of allergy or tissue irritation. A probe comprising at least three nucleic acids, preferably 3-40, especially 5-15, chosen from RNA complementary to the RNA corresponding to any of the genes may be used for in vitro analysis of allergy or tissue irritation. Further, a reagent kit comprising one or more probes that recognize products produced during the expression of any the genes is disclosed. | 04-12-2012 |
| 20110053163 | Biomarker - The invention relates to a process for in vitro prediction of a potentially allergenic substance wherein monocytes and/or macrophages and/or myelomonocytic cell lines are cultivated in the presence of the substance and interferon-γ, whereby productions of cytokines and/or neopterin are increased and measured. | 03-03-2011 |
| 20100311068 | ASSAY - The invention relates to process for in vitro prediction of a potentially allergenic substance wherein monocytes and/or macrophages and/or myelomonocytic cell lines are cultivated in the presence of the substance and interferon-γ, whereby productions of cytokines and/or neopterin are increased and measured. The allergic reaction may be estimated by measuring up regulated or down-regulated genes chosen from G1P2, OASL, IFIT1, TRIM22, IFI44L, MXI, RSAD2, IFIT3, IFITM1, IFIT2, C 33.28 HERV-H protein mRNA, IFITM3, XK, GPR15, MT1G, MT1B; MT1A, ADFP, IL8, MT1E, MT1F, MT1H, SLC30A1, SERPINB2, CD83, TncRNA or expression products from them are measured. The invention also relates to a reagent kit for use in the process comprising interferon-γ and reagents which recognise cytokines preferably each of IL-8 and neopterin and/or reagents such as probes recognising up-regulated or down-regulated genes. | 12-09-2010 |
| 20090098545 | IN VITRO ASSAY FOR IDENTIFICATION OF ALLERGENIC PROTEINS - The present invention relates to a process for in vitro evaluation, of a potentially allergenic or tissue irritating sub-stance whereby test cells are cultivated in the presence of the substance, and the presence of up regulated genes chosen from G1P2, OASL, IFIT1, TRIM22, IFI44L, MXI, RSAD2, IFIT3, IFITM1, IFIT2, SPR, GNB2, XK, IFITM3, C 33.28 HERV-H protein mRNA, IFITM3, XK, GPR15, MT1G, MT1B; MT1A, ADFP, JL8, MT1E, MT1F, MT1H, SLC30A1, SERPINB2, CD83, TncRNA or expression products from them are measured. The invention also regards use of the expression products from one or more of the genes for in vitro analysis of allergy or tissue irritation. It also relates to a probe comprising at least three nucleic acids, preferably 3-40, especially 5-15 chosen from RNA complementary to the RNA corresponding to any of the genes and the use thereof for in vitro analysis of allergy or tissue irritation. Further it regards a reagent kit comprising one or more probes that recognize products produced during the expression of any the genes. | 04-16-2009 |
