Biomet Biologics, LLC Patent applications |
Patent application number | Title | Published |
20150320938 | Single Step Desiccating Bead-in-Syringe Concentrating Device - A device for processing a biological material is disclosed. The device includes a syringe barrel comprising beads, a filter positioned at a close end of the barrel, a plunger insertable into the barrel through an open end, and a needle. The plunger includes a paddle assembly that is configured to mix a biological material with the beads after the biological material has been harvested from a patient. | 11-12-2015 |
20150290369 | Inertial Cell Washing Device - A device for separating a component out of a multicomponent mixture. The device has a housing that extends along a central longitudinal axis. The housing has a top end and a bottom end, and defines a channel that extends from the top end of the housing around the central axis to the bottom end of the housing to define a helical flow path. The device also includes an inlet port at the top end of the housing that communicates with the channel, and a first outlet port. | 10-15-2015 |
20150273360 | System and Method for Separating a Fraction - A material separation system and method is disclosed. The system may include a buoy having a volume that includes or houses a reacting component. The buoy may be placed in a container to hold the material to be separated during a separation procedure. The separated material may be used to various procedures following separation. | 10-01-2015 |
20150265423 | Method For Rinsing And Delivering Bone Graft - A method for rinsing and delivering a bone graft. The method includes selecting a delivery syringe containing bone graft material wherein the syringe is coupled to a filter assembly, determining a bone graft:fluid ratio, washing the bone graft material, reconstituting the bone graft material to generate the bone graft with the predetermined bone graft:fluid ratio, and delivering the bone graft to a surgical site. | 09-24-2015 |
20150264917 | Cell Washing Device Using Non-Mechanical Fluid Vortex Flow - A device for washing a suspension of cells. The device includes a bowl-shaped basin having a top end and a bottom end and an axis extending from the top end to the bottom end, and an inlet port formed in the basin. The inlet port is positioned at an angle to allow for a wash solution to be injected or delivered into the basin and circulate around the basin about the central axis. A suspension of cells can be washed in the circulating wash solution. The circulating wash solution forces the cells to settle at the bottom of the basin, where they can be extracted. | 09-24-2015 |
20150141332 | METHODS FOR DIAGNOSING OSTEOARTHRITIS - Methods for managing osteoarthritis, in a human or other mammalian subject, comprising the measurement of certain cytokines and growth factors in a tissue sample of a subject, including one or more of platelet-derived growth factor AB (PDGF-AB), platelet-derived growth factor BB (PDGF-BB), and epidermal growth factor (EGF). Tissue samples may be whole blood, blood fractions, urine, saliva, and synovial fluid. Methods include diagnosing osteoarthritis, and methods for assessing the severity of osteoarthritis, such as in subject that have been diagnosed with osteoarthritis using radiographic or other methods. Methods may also include comparison of measured cytokine levels to a reference level. Methods of managing the clinical progression of osteoarthritis include initiating a clinical action based on the difference between the measured cytokine level and a reference level. | 05-21-2015 |
20140275497 | Methods for Making Cytokine Compositions From Tissues Using Non-Centrifugal Methods - Apparatus and methods for generating a solution rich in interleukin-1 receptor antagonist from a tissue comprising cytokine-producing cells. The apparatus can include a filter used with a separation system. The separation system can include a float. | 09-18-2014 |
20140274895 | Methods And Non-Immunogenic Compositions For Treating Inflammatory Disorders - Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets. | 09-18-2014 |
20140274894 | METHODS FOR MAKING CYTOKINE COMPOSITIONS FROM TISSUES USING NON-CENTRIFUGAL METHODS - Non-centrifugal methods for generating a solution rich in interleukin-1 receptor antagonist from a tissue comprising cytokine-producing cells. The solution rich in IL-1ra can also include at least one of sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1 RII. | 09-18-2014 |
20140271870 | TREATMENT OF PAIN USING PROTEIN SOLUTIONS - Methods for treating pain using a protein solution comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets. | 09-18-2014 |
20140271589 | TREATMENT OF COLLAGEN DEFECTS USING PROTEIN SOLUTIONS - Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. | 09-18-2014 |
20140271587 | TREATMENT OF INFLAMMATORY RESPIRATORY DISEASE USING BIOLOGICAL SOLUTIONS - Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cBMA), optionally combining the protein solution and cBMA to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof. The present methods, compositions and devices are useful for treating COPD and the progression of COPD. | 09-18-2014 |
20140257133 | Bone Marrow Aspiration Needle - A bone marrow aspiration assembly including a cannulated introducer needle and an aspiration needle. The cannulated introducer needle is curved to approximate a natural curvature of an iliac crest. The aspiration needle includes apertures for aspirating bone marrow. The aspiration needle is configured to be received in, and extend from, the cannulated introducer needle to reach a bone marrow aspiration site in the iliac crest. | 09-11-2014 |
20140242045 | Methods And Compositions For Delivering Interleukin-1 Receptor Antagonist - Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating adipose tissue and/or adipocytes with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist. | 08-28-2014 |
20140212400 | METHODS FOR REJUVINATING RED BLOOD CELLS - Methods and a system for transfusing blood to a mammalian subject. The method includes obtaining a volume of donated red blood cells (RBCs), adding an enhancement composition to the RBCs to form a treated blood composition, incubating the treated blood composition to form an incubated blood composition, and administering the incubated blood composition to a patient. The system includes a functionally-closed, sterile Y-type tube set. | 07-31-2014 |
20140155680 | ANGIOGENESIS INITIATION AND GROWTH - Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site. | 06-05-2014 |
20140154234 | METHOD FOR GENERATING THROMBIN - Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen. | 06-05-2014 |
20140097135 | Apparatus And Method For Separating and Concentrating Fluids Containing Multiple Components - Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture. | 04-10-2014 |
20140091048 | Buoy Fractionation System - A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 04-03-2014 |
20140088492 | Method And Apparatus For Separating A Material - A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side. | 03-27-2014 |
20140071787 | Method And Apparatus To Create Autologous Clotting Serum - A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device. | 03-13-2014 |
20140054246 | Apparatus And Method For Separating And Concentrating Fluids Containing Multiple Components - A buoy or float can be positioned within a separation container to assist in a physical separation of components of a whole material positioned in the separation container. The buoy can be positioned within the container to move from between and separation a first end and a second end of the container substantially unaffected by a portion of the whole material, including a clotted portion thereof. A first port can be provided near the first end of the container for introduction of the whole material and a second port can be provided near the second end of the container for removal of at least a portion of a separated material. | 02-27-2014 |
20140051061 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture. | 02-20-2014 |
20140034567 | Method And Apparatus For Producing Autologous Clotting Components - A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient. | 02-06-2014 |
20140021147 | Liquid Separation From Adipose Tissue - Extracting or removing at least a portion of liquid phase from a whole sample using a centrifugal force is disclosed. Centrifugal forces are used to apply pressure to a whole sample and drive a liquid phase through a passage region that can be perforated and/or porous and maintain a drier portion within a separation container. The whole sample can be dried, which includes a remaining sample where excess or a selected amount of liquid is removed. Direct access to the separation container or area can then be made to provide for an efficient withdrawal of the drier material from the separation container. | 01-23-2014 |
20140012315 | Method and Apparatus for Containing, Transporting, and Providing a Material - A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site. | 01-09-2014 |
20130345038 | Sterile Blood Separating System - A system for separating components of a composition according to density. The system includes a torque generating device, a separation device, and a housing. The separation device separates the composition into different components according to density. The housing accommodates the separation device. The housing includes a base having an interface that transfers torque from the torque generating device to the separation device, a cover, and a conduit for introducing the composition into the separation device without opening the cover. | 12-26-2013 |
20130324913 | Method and Apparatus for Application of a Fluid - A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site. | 12-05-2013 |
20130259951 | Apparatus and Method for Separating and Concentrating a Component of a Fluid - A system for separating and concentrating a component of a whole material is disclosed. The whole material can include a material that has more than one component, such as whole blood that can include at least red blood cells, monocytes, and plasma. The system can include a substantially single container including a separation section and a concentration section wherein a component can be moved from the separation section, after a separation, to the concentration section to be concentrated. The concentrated component can then be withdrawn from the separation and concentration container for a selected procedure. | 10-03-2013 |
20130255197 | Clean Transportation System - A method of transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container. A first portion with a first end of the container is inserted into an inner cavity of a first member of a housing assembly. A second member of the housing assembly is coupled to the first member such that a second portion of the biological material container is covered by the second member. A second end of the biological material container opposite to the first end is covered with a cap member of the housing assembly such that the biological material container is full encapsulated within the housing assembly to maintain sterility in the nonsterile field. A container port of the biological material container is coupled to a cap port extending through the housing assembly. | 10-03-2013 |
20130226149 | APPARATUS AND METHOD FOR SEPARATING AND CONCENTRATING FLUIDS CONTAINING MULTIPLE COMPONENTS - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 08-29-2013 |
20130196425 | System and Process for Separating a Material - Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations. | 08-01-2013 |
20130189668 | BLOOD SEPARATION AND CONCENTRATION SYSTEM - This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator. | 07-25-2013 |
20130178425 | METHODS AND COMPOSITIONS FOR DELIVERING INTERLEUKIN-1 RECEPTOR ANTAGONIST - Methods, systems, and compositions related to generating and using a solution rich in interleukin-1 receptor antagonist are provided. Methods include contacting a liquid comprising white blood cells with a solid extraction material and stimulating with an electromagnetic field to activate production of interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist can be separated from the solid extraction material. Methods for treating a site of inflammation in a patient include administering the solution rich in interleukin-1 receptor antagonist to the site of inflammation. | 07-11-2013 |
20130123724 | Bone Marrow Aspiration Needle - Disclosed is an aspiration assembly including an outer cannulated needle having a tip, a threaded collar, and an inner aspiration needle. A material can be aspirated through at least the inner aspiration needle. The distance that the tip of the inner aspiration needle extends from the tip of the outer cannulated needle changes when the inner aspiration needle is rotated relative to the outer cannulated needle. | 05-16-2013 |
20130102452 | Buoy Suspension Fractionation System - A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 04-25-2013 |
20130068676 | All-In-One Means Of Separating Blood Components - A separation device including a first buoy, a second buoy, a first valve, and a second valve. The first buoy is mounted to a buoy guide post and slidably mounted within a separation chamber. The second buoy is slidably mounted to the guide post and movable between a first position and a second position. The second buoy closes the first valve and opens the second valve when in the first position. The second buoy opens the first valve and closes the second valve when in the second position. The second buoy has a density such that after spinning the device for a suitable period of time a first component of the composition is isolated between the first buoy and the second buoy and a second component of the composition is isolated between the second buoy and the end of the separation chamber that is opposite to a port. | 03-21-2013 |
20130045523 | Method and Apparatus to Create Autologous Clotting Serum - A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device. | 02-21-2013 |
20130040042 | Surgical Mesh Spray and Delivery System - A device for spraying a biological substance onto a biocompatible implant. The device includes a housing that defines a sterile chamber. A spray head is within the chamber and proximate to a first end. A first conduit is configured to direct the biological substance into the chamber through a first spray tip of the spray head. A second conduit is configured to direct an activator into the chamber through a second spray tip of the spray head. A third conduit is configured to direct compressed air to the chamber through a third spray tip of the spay head. The spray head is configured to direct a coating of the biological substance as activated by the activator to the implant seated within the chamber at a second end that is opposite to the first end. | 02-14-2013 |
20130026255 | Multi-Fluid Blending Spray Tip for Coaxial Syringe - A coaxial syringe spray assembly that includes a first receptacle defined by the assembly, a second receptacle defined by the assembly and in coaxial alignment with the first receptacle, and a spray tip assembly configured to be in fluid communication with both the first receptacle and the second receptacle. The spray tip defines a first fluid chamber in fluid communication with the first receptacle, a second fluid chamber in fluid communication with the first receptacle, and an outlet port that defines a blending chamber that is in fluid communication with the second receptacle, the first fluid chamber, and the second fluid chamber such that a first fluid introduced into the first fluid chamber and a second fluid introduced into the second fluid chamber are mixed in the blending chamber to provide a mixture having a helical flow pattern. | 01-31-2013 |
20120301957 | Method and Apparatus for Collecting Biological Materials - A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube. | 11-29-2012 |
20120282240 | THROMBIN ISOLATED FROM BLOOD AND BLOOD FRACTIONS - Methods, apparatus, and compositions related to generating and using thrombin. Methods include preparing a solution comprising thrombin by precipitating fibrinogen from a liquid comprising whole blood or a blood fraction. Precipitated fibrinogen is removed from the liquid to form a post-precipitation liquid that is incubated with calcium and a plurality of beads to form a clot. A solution comprising thrombin is separated from the clot. Thrombin prepared thereby can be used as a tissue sealant and in methods of applying a tissue sealant to subject, including application of an autologous tissue sealant. | 11-08-2012 |
20120228291 | Clean Transportation System - A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed. | 09-13-2012 |
20120228203 | Method and Apparatus for Producing Autologous Thrombin - A device for isolating a component of a multi-component composition. The device includes a housing, a chamber, and a withdrawal port. The chamber is rotatably mounted within the housing. The chamber includes a chamber base and a sidewall. The side wall extends from the chamber base. At least a portion of the sidewall is defined by a filter that permits passage of a first component of the multi-component composition out of the chamber through the filter and to the housing base. The filter restricts passage of a second component of the multi-component composition through the filter. The withdrawal port extends from a position proximate to the housing base to an exterior of the device. The withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device. | 09-13-2012 |
20120172836 | IMPLANTABLE DEVICE FOR PRODUCTION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST - Treatments and devices for generating and using interleukin-1 receptor antagonist (IL-1ra). An implantable device is loaded with adipose tissue and/or white blood cells and inserted into an inflammation site in a patient to produce interleukin-1 receptor antagonist in vivo. The implantable device has an enclosed or substantially enclosed body that defines an internal space. At least a portion of the body comprises a first bioresorbable material and a second bioresorbable material is within the internal space along with one or more voids. The second bioresorbable material includes an activation surface to activate adipose tissue and/or white blood cells loaded into the device to produce IL-1ra. | 07-05-2012 |
20120145652 | Method of Separating a Selected Component from a Multiple Component Material - A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 06-14-2012 |
20120045823 | Method and Apparatus for Collecting Biological Materials - A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube. | 02-23-2012 |
20120035501 | Bone Marrow Aspiration Needle - A bone marrow aspiration assembly including an outer cannula and an inner cannula. The inner cannula is moved only radially about a longitudinal axis thereof with respect to the outer cannula to selectively align inner openings of only one of distal, intermediate, and proximal opening groups of the inner cannula with outer openings of only one of distal, intermediate, and proximal opening groups of the outer cannula to permit aspiration therethrough. | 02-09-2012 |
20120027746 | METHOD FOR GENERATING THROMBIN - Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen. | 02-02-2012 |
20120015796 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture. | 01-19-2012 |
20120010559 | ANGIOGENESIS INITIATION AND GROWTH - Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site. | 01-12-2012 |
20110319249 | Blood Separating Device - A device for separating components of a composition according to density. The device includes a rotatable chamber and a plurality of buoys. The rotatable chamber has an axis of rotation. The plurality of buoys are positioned within the rotatable chamber and about the axis of rotation. The buoys are radially movable between an expanded position in which the buoys are at a first location relative to the axis of rotation and a contracted position in which the buoys are at a second location relative to the axis of rotation. The first location is further from the axis of rotation than the second location is. The buoys are movable in response to force generated during rotation of the rotatable chamber. | 12-29-2011 |
20110284460 | Buoy Suspension Fractionation System - A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 11-24-2011 |
20110281714 | Method and Apparatus for Preparing Platelet Rich Plasma and Concentrates Thereof - The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP. | 11-17-2011 |
20110251041 | Method and Apparatus for Separating a Material - A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side. | 10-13-2011 |
20110192804 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture. | 08-11-2011 |
20110168193 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 07-14-2011 |
20110100919 | Method for Preparing Platelet Rich Plasma and Concentrates Thereof - A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder. | 05-05-2011 |
20110082441 | Bone Marrow Aspiration Needle - Disclosed is an aspiration assembly including an outer cannulated needle having a tip, a threaded collar, and an inner aspiration needle. A material can be aspirated through at least the inner aspiration needle. The distance that the tip of the inner aspiration needle extends from the tip of the outer cannulated needle changes when the inner aspiration needle is rotated relative to the outer cannulated needle. | 04-07-2011 |
20110077596 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture. | 03-31-2011 |
20110056893 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 03-10-2011 |
20110021334 | Buoy Suspension Fractionation System - A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 01-27-2011 |
20110014705 | METHOD AND APPARATUS FOR SEPARATING BIOLOGICAL MATERIALS - According to various embodiments, a system can be provided to separate undifferentiated cells and/or stromal cells from a whole tissue sample. The whole tissue sample can be any appropriate tissue sample obtained directly from a patient. The tissue sample can be obtained during a selected operating procedure for immediate or quick application or re-application to the patient. Accordingly, autologous cells can be obtained intraoperatively for application to a patient substantially soon after obtaining a whole tissue sample. | 01-20-2011 |
20110003276 | BLOOD SEPARATION AND CONCENTRATION SYSTEM - This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator. | 01-06-2011 |
20100324450 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 12-23-2010 |
20100323870 | Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components - An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. | 12-23-2010 |
20100317099 | Liquid Separation from Adipose Tissue - Extracting or removing at least a portion of liquid phase from a whole sample using a centrifugal force is disclosed. Centrifugal forces are used to apply pressure to a whole sample and drive a liquid phase through a passage region that can be perforated and/or porous and maintain a drier portion within a separation container. The whole sample can be dried, which includes a remaining sample where excess or a selected amount of liquid is removed. Direct access to the separation container or area can then be made to provide for an efficient withdrawal of the drier material from the separation container. | 12-16-2010 |
20100226909 | Method And Apparatus For Producing Autologous Thrombin - A device for isolating a component of a multi-component composition. The device includes a housing, a chamber, and a withdrawal port. The chamber is rotatably mounted within the housing. The chamber includes a chamber base and a sidewall. The side wall extends from the chamber base. At least a portion of the sidewall is defined by a filter that permits passage of a first component of the multi-component composition out of the chamber through the filter and to the housing base. The filter restricts passage of a second component of the multi-component composition through the filter. The withdrawal port extends from a position proximate to the housing base to an exterior of the device. The withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device. | 09-09-2010 |
20100206798 | Method And Apparatus For Preparing Platelet Rich Plasma And Concentrates Thereof - The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP. | 08-19-2010 |
20100106138 | METHOD AND APPARATUS FOR CONTAINING, TRANSPORTING, AND PROVIDING A MATERIAL - A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site. | 04-29-2010 |
20100055087 | METHODS AND COMPOSITIONS FOR DELIVERING INTERLEUKIN-1 RECEPTOR ANTAGONIST - Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating adipose tissue and/or adipocytes with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist. | 03-04-2010 |
20090289014 | Blood Separating Device - A device for separating components of a composition according to density. The device includes a rotatable chamber and a plurality of buoys. The rotatable chamber has an axis of rotation. The plurality of buoys are positioned within the rotatable chamber and about the axis of rotation. The buoys are radially movable between an expanded position in which the buoys are at a first location relative to the axis of rotation and a contracted position in which the buoys are at a second location relative to the axis of rotation. The first location is further from the axis of rotation than the second location is. The buoys are movable in response to force generated during rotation of the rotatable chamber. | 11-26-2009 |
20090253566 | Clean Transportation System - A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed. | 10-08-2009 |
20090250413 | Sterile Blood Separating System - A system for separating components of a composition according to density. The system includes a torque generating device, a separation device, and a housing. The separation device separates the composition into different components according to density. The housing accommodates the separation device. The housing includes a base having an interface that transfers torque from the torque generating device to the separation device, a cover, and a conduit for introducing the composition into the separation device without opening the cover. | 10-08-2009 |
20090220482 | METHODS AND COMPOSITIONS FOR DELIVERING INTERLEUKIN-1 RECEPTOR ANTAGONIST - Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist. | 09-03-2009 |
20090014391 | Buoy Suspension Fractionation System - A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 01-15-2009 |
20080306431 | METHODS OF REDUCING SURGICAL COMPLICATIONS IN CANCER PATIENTS - A method of treating irradiated tissue, such as for revascularizing and preventing or reducing wound healing complications in a human or other animal subject having cancer. The method comprises administering to the irradiated tissue a therapeutic composition comprising one or more of platelet rich plasma, platelet poor plasma or platelet concentrate. In some embodiments the complications sought to be prevented and/or reduced can include: fibrotic tissue, prolonged would drainage, hematomas, seromas, fistula formation infection, pain, poor coloration, deficient vascularity, and desensitization in or around the irradiated site. | 12-11-2008 |
20080283474 | BUOY SUSPENSION FRACTIONATION SYSTEM - A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal. | 11-20-2008 |