Bio-Rad Laboratories Patent applications |
Patent application number | Title | Published |
20150152475 | SYSTEMS AND METHODS FOR FLUORESCENCE DETECTION WITH A MOVABLE DETECTION MODULE - A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement. | 06-04-2015 |
20130145204 | SUPERVISING AND RECOVERING SOFTWARE COMPONENTS ASSOCIATED WITH MEDICAL DIAGNOSTICS INSTRUMENTS - A system for applying a recovery mechanism to a network of medical diagnostics instruments is provided herein. The system includes the following: a plurality of medical diagnostics instruments, each associated with a network connected component; a plurality of communication modules, each associated with a corresponding one of the plurality of network connected components, wherein each one of the plurality of communication modules is arranged to report on malfunctioning components that are network connected with the corresponding component, and a recovery module, configured to: (i) obtain reports from the communication modules; (ii) re-establish the malfunctioning components; and (iii) notify all communication modules of the re-establishment of the malfunctioning components, wherein the communication modules are further configured to re-establish connection between the corresponding components and the re-established components. | 06-06-2013 |
20130143308 | SYSTEMS AND METHODS FOR FLUORESCENCE DETECTION WITH A MOVABLE DETECTION MODULE - A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement. | 06-06-2013 |
20130098456 | COMMON MODE PULSE DAMPER FOR RECIPROCATING PUMP SYSTEMS - Pulses in a pumping system resulting from paired reciprocating pumps are dampened by a pressure vessel that includes two compartments separated by a flexible membrane and otherwise isolated from each other. | 04-25-2013 |
20130035239 | FILTERING SMALL NUCLEIC ACIDS USING PERMEABILIZED CELLS - Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described. | 02-07-2013 |
20120322058 | Analysis of nucleic acids - Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles. | 12-20-2012 |
20120285830 | HYDROLYSIS-RESISTANT POLYACRYLAMIDE GELS - Polyacrylamide gels that offer high resolution in protein separations and are more stable relative to hydrolysis than conventional polyacrylamide gels that rely on Tris or Tris-Bis as buffering agents are made by incorporating triethanolamine in place of most or all of the Tris or Tris-Bis. | 11-15-2012 |
20120252015 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). | 10-04-2012 |
20110160073 | SYSTEMS AND METHODS FOR FLUORESCENCE DETECTION WITH A MOVABLE DETECTION MODULE - A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement. | 06-30-2011 |
20100133427 | EXTENDED DYNAMIC RANGE LIGHT DETECTION SYSTEMS AND METHODS - Systems and methods for detecting and measuring light emitted from a sample and having a large dynamic range, e.g., a range of luminous intensity covering six or more orders of magnitude, that may be difficult to fully detect using a single detector with a limited detection range. Simultaneous measurements of the emitted light in two intensity ranges are performed using two detectors, e.g., one including a photomultiplier tube (PMT) and the other including a solid state detector such as a photodiode. A beam splitting element directs light emitted from a sample under investigation to both detectors simultaneously such that a portion of the light impinges on the first detector and a second portion of the light impinges on the second detector. A processor receives output signals from the two detectors and provides an output representing the luminous intensity of the sample over a detection range greater than the detection range of each individual detector, thereby providing a detection system having an enhanced dynamic range. | 06-03-2010 |
20090014630 | EXTENDED DYNAMIC RANGE SYSTEM DESIGN - Systems and method for detecting and measuring light emitted from a sample and having a large dynamic range, e.g., a range of luminous intensity covering six or more orders of magnitude, that may be difficult to fully detect using a single detector with a limited detection range. Simultaneous measurement of the emitted light in two intensity ranges is performed using two detectors, e.g., one including a photomultiplier tube (PMT) and the other including a solid state detector such as a photodiode. A beam splitting element directs light emitted from a sample under investigation to both detectors simultaneously such that a portion of the light impinges on the first detector and a second portion of the light impinges on the second detector. A processor receives output signals from the two detectors and provides an output representing the luminous intensity of the sample over a detection range greater than the detection range of each individual detector, thereby providing a detection system having an enhanced dynamic range. | 01-15-2009 |