| Bio-Ker S.r.l Patent applications |
| Patent application number | Title | Published |
|---|
| 20110281797 | SITE-SPECIFIC MONOCONJUGATED INSULINOTROPIC GLP-1 PEPTIDES - The present invention is related to glucagon-like peptide-1 (GLP-1) and analogues insulinotropic peptides, monoconjugated to biocompatible polymeric molecules by enzymatic direct and site-specific transglutamination reaction as well as their pharmaceutical formulations and delivery systems for therapeutical application in dismetabolic pathologies such as type 2 diabetes. | 11-17-2011 |
| 20100029555 | G-CSF SITE-SPECIFIC MONO-CONJUGATES - Novel site-specific mono-conjugates of Granulocyte Colony Stimulating Factor (G-CSF) are hereby described, with analogues and derivatives thereof, which stimulate proliferation and differentiation of progenitor cells to mature neutrophiles. These conjugates have been obtained using transglutaminase to covalently and site-specifically bind a hydrophilic, non-immunogenic polymer to a single glutamine residue of the human G-CSF native sequence and analogues thereof. These novel site-specific mono-conjugated derivatives are recommended for therapeutic use since they are stable in solution and exhibit significant biological activity in vitro and a longer bloodstream half-life, as compared to the non-conjugated protein, with a consequent prolonged pharmacological activity. | 02-04-2010 |
| 20090042277 | NUCLEIC ACIDS ENCODING RECOMBINANT SOLUBLE ENDOPROTEASES - The present invention relates to the expression and secretion in | 02-12-2009 |
