| BECTON, DICKINSON AND COMPANY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120125126 | FLUIDICS WITH THERMAL COMPENSATION FOR A FLOW-TYPE PARTICLE ANALYZER - The present invention provides an improved fluidic system for a flow-type particle analyzer, such as a flow cytometer or hematology analyzer, that enables adjustment of the system to compensate for changes in fluid viscosity resulting from changes in temperature. | 05-24-2012 |
| 20120103112 | DUAL FEEDBACK VACUUM FLUIDICS FOR A FLOW-TYPE PARTICLE ANALYZER - The present invention relates to a vacuum-driven fluidic system for a flow-type particle analyzer. The system includes a vacuum pump which creates a pressure drop downstream of the flow cell, which pulls sheath fluid and sample fluid through the flow cell. A variable-resistance fluidic resistor is configured to control the ratio of sample fluid flow to sheath fluid flow. Dual feedback circuits, one configured to modulate the vacuum pump power in response to the pressure drop across the flow cell, referred to as the dynamic pressure drop, and a second configured to modulate the vacuum pump power in response to the pressure drop created by the vacuum pump relative to ambient pressure, referred to as the static pressure drop, are used to automatically control the system. The present invention enables adjustment of the sample fluid flow rate while maintaining a constant total fluid flow through the flow cell, and further, enables pausing the system without significant fluctuations in the vacuum. | 05-03-2012 |
| 20120100557 | SAMPLE PREPARATION DEVICE AND ASSOCIATED METHOD - A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device. | 04-26-2012 |
| 20120078225 | Dual Chamber Syringe With Retractable Needle - Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided. | 03-29-2012 |
| 20120078172 | AUTOMATIC RECONSTITUTION INJECTOR DEVICE - The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device. | 03-29-2012 |
| 20120077215 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BETA-LACTAMASES - Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes. | 03-29-2012 |
| 20120071827 | Dual Chamber Syringe With Retractable Needle - Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided. | 03-22-2012 |
| 20120071642 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF A CARBAPENEMASE GENE - Compositions and methods for the rapid and sensitive detection of a carbapenemase in a sample are provided. The compositions include novel primer and probe compositions for use in detecting the presence of this enzyme in a sample, particularly using PCR methods. These primers and probe sets can be used in amplification methods (such as PCR, particularly quantitative PCR) and packaged into kits for use in amplification methods for the purpose of detecting carbapenemase in a test sample, particularly a patient sample, particularly a direct sample. Thus, in one embodiment, the present invention provides for novel oligonucleotide primers set forth in SEQ ID NOs:1, 2, 4, 5, 7, 8, 14, 15, 17, 18, and 20, and the novel oligonucleotide probe sequences set forth in SEQ ID NOs:3, 6, 9, 16, and 19. These sequences can be used in a method of detecting carbapenemase in a sample. | 03-22-2012 |
| 20120070879 | REDUCTION OF ANTIBIOTIC ACTIVITY OR CONCENTRATION IN BIOLOGICAL SAMPLES USINGMOLECULARLY IMPRINTED POLYMERS - Methods of removing undesired compounds such as antibiotics from a biological sample are provided. The methods use Molecularly Imprinted Polymers (“MIPs”) to remove or inactivate antibiotics in a sample. The methods use MIPS to remove or inactivate compounds such as antibiotics in a cell culture. | 03-22-2012 |
| 20120065612 | CATHETER ASSEMBLY - A catheter assembly is disclosed having a catheter adapter and a needle hub. The catheter adapter has an inner lumen with a septum located within the inner lumen. An introducer needle is inserted through the inner lumen. A septum activator also located within the inner lumen, such that a distal end of the septum activator contacts the septum. The septum activator has an internal cavity and a cavity seal forming a surface of the internal cavity. | 03-15-2012 |
| 20120059325 | ASSEMBLY METHOD FOR CATHETER WITH BLOOD CONTROL - A system and method for assembling a catheter device, wherein a septum actuator is positioned within the lumen of a catheter adapter to provide a pathway through a septum component, an introducer needle being inserted through the septum via the septum actuator thereby preventing damage to the septum, the septum actuator thereafter being withdrawn from the septum and positioned within a rearward chamber of the catheter adapter lumen. | 03-08-2012 |
| 20120058553 | Apparatus for Transporting Biological Samples - A container assembly for storing, treating, transporting and stabilizing a biological sample includes a container, a cap and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. In another embodiment, the sample holder has a closure member for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container. | 03-08-2012 |
| 20120058351 | Coating System, Articles and Assembly Using the Same and Methods of Reducing Sticktion - The present invention provides a coating system for an article including a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with a coating prepared from a composition including a first, curable organopolysiloxane comprising at least two alkenyl groups; and a second, curable organopolysiloxane comprising at least two polar groups, the second organopolysiloxane being different from the first organopolysiloxane, which can provide low breakloose force when used in syringe assemblies. | 03-08-2012 |
| 20120046614 | SKIN ENGAGEMENT MEMBER FOR USE WITH NEEDLE ASSEMBLY OR MEDICAL INJECTOR - A skin engagement member is provided herein for use with a needle assembly or a medical injector to minimize irritation of a patient's skin surrounding an injection site during injection by a needle of the needle assembly or medical injector. The skin engagement member includes: a body; a surface defined on the body for engaging the patient's skin during injection by the needle; an aperture formed through the body configured to permit passage therethrough of the needle; and, rotatable mounting features for rotatably mounting the body to the needle assembly or medical injector such that the surface, while engaging the patient's skin, is rotatable about the aperture. Advantageously, with the subject invention, a skin engagement member may be located in engagement with a patient's skin which, due to pressure applied during injection, may be held in a generally fixed position against the skin with rotation of the injector about the skin engagement member being permitted. Accordingly, irritation of the patient's skin about the injection site may be minimized. | 02-23-2012 |
| 20120046411 | Recycled Resin Compositions And Disposable Medical Devices Made Therefrom - Compositions including recycled resin components and medical devices and components made from such compositions are disclosed. The compositions and medical devices are characterized as biocompatible and sterilization stable. In one or more embodiments, the compositions include a recycled resin component and may include one or more of an anti-oxidant component, slip additive component, anti-static component, impact modifier component, colorant component, acid scavenger component, X-ray fluorescence agent component, radio opaque filler component, surface modifier component, melt stabilizer component, clarifier component, processing aid component and reinforcing agent component. Methods of forming medical articles and components are also disclosed. | 02-23-2012 |
| 20120041417 | User-Actuated Storage Assembly For Injection Device - A storage assembly is removably connectable to a drug delivery device. A first chamber is disposed in the housing. A plurality of penetrating members are stored in the first chamber. A second chamber is disposed in the housing for storing the plurality of penetrating members after being used in an injection. A transfer drum disposed in the housing transfers one of the penetrating members from the first chamber to an injection position and from the injection position to the second chamber following an injection. | 02-16-2012 |
| 20120041394 | OPTIMIZED INTRACRANIAL CATHETERS FOR CONVECTION-ENHANCED DELIVERY OF THERAPEUTICS - A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter. | 02-16-2012 |
| 20120041381 | Sterility Barrier For Pen Needle And Storage Container Therefor - A pen needle includes a hub having a first opening at a first end and a second opening at a second end. A needle is connected to the hub and extends through the first opening at the first end. Access to the needle through the second opening is prevented by a sterility barrier, which has a movable portion that is moved along a longitudinal axis of the needle to provide access to the needle. A storage container includes a housing having a plurality of cavities to receive a plurality of pen needles. A cover is rotatably connected to the housing and is rotated such that an access portion thereof is aligned with one of the cavities, thereby providing access to the pen needle in the cavity. | 02-16-2012 |
| 20120041367 | MEDICAL INJECTOR WITH POST-AUTORECONSTITUTION DOSE SETTING AND AUTOPLUNGER DRIVE - A medical injector is provided herein having a body; a reservoir containing first and second mixable components, a stopper associated with the reservoir, a predetermined extent of advancement of the stopper causing mixing of the first and second mixable components; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; a first releasable retainer for releasably retaining the plunger in a first state against force of the spring; a first trigger for causing the first releasable retainer to release the plunger; a second releasable retainer for releasably retaining the plunger in a second state against force of the spring; and, a second trigger for causing the second releasable retainer to release the plunger. The spring causes the plunger to advance from the first state to the second state. The plunger engages the stopper during the advancement from the first state to the second state so that the stopper traverses at least the predetermined extent of advancement thereby causing mixing of the first and second mixable components. Advantageously, with the subject invention, a medical injector is provided which allows for autoreconstitution with subsequent dose setting and autoplunger activation, the autoreconstitution and the autoplunger activations being activated by separate triggers. | 02-16-2012 |
| 20120041366 | MEDICAL INJECTOR WITH DOSE KNOB ACTIVATION FOR AUTOMATED RECONSTITUTION - A medical injector is provided herein having a body and a reservoir disposed in the body, the reservoir including at least first and second mixable components. At least one stopper is associated with the reservoir where distal advancement of the stopper over a predetermined distance causes mixing of the mixable components. A plunger is disposed in the body, along with a knob stem and a knob fixed to the knob stem so as to be rotatable therewith. A sleeve is telescopingly disposed over the knob stem, wherein the knob stem and the sleeve have cooperating elements formed thereon which selectively permit rotation of the knob stem to be transmitted to the sleeve so that the knob stem and the sleeve may rotate together. A spring is also provided for urging the sleeve distally. A releasable retainer releasably retains the sleeve against force of the spring. Rotation of the knob releases the sleeve and allows the spring to displace the sleeve distally. Distal movement of the sleeve causes distal movement of the plunger which causes distal movement of the stopper thus causing mixing of the mixable components. Advantageously, with the subject invention, a medical injector may be provided where autoreconstitution can be achieved by the turning of a knob. | 02-16-2012 |
| 20120036175 | DETERMINING POPULATION BOUNDARIES USING RADIAL DENSITY HISTOGRAMS - Apparatuses and methods for determining population boundaries are described. In one embodiment, population boundaries are determined using radial density histograms. | 02-09-2012 |
| 20120031203 | DEVICE FOR AUTOMATICALLY ADJUSTING THE BACTERIAL INOCULUM LEVEL OF A SAMPLE - Various embodiments of the present invention provide, for example, a system and method for automatically adjusting the inoculum level of a sample. Certain embodiments of the present invention may measure a concentration of particles present in a preliminary sample using a sensor device and determine an amount of diluent to be added to or removed from a sample container to prepare a sample having a selected concentration of particles, corresponding to a selected inoculum level. Embodiments of the present invention may also automatically add or remove the diluent using an automated fluidics system so as to prepare a sample having the selected particle concentration. Once the selected particle concentration is achieved and verified, some embodiments may also remove at least a portion of the sample from the sample container such that the container contains a selected volume of the sample. | 02-09-2012 |
| 20120029465 | Blunt Needle Safety Drug Delivery System - Drug delivery devices having non-luer connections and adapters and adaption connectors for providing non-luer connections to drug delivery devices are provided. An exemplary drug delivery device for use with a catheter connection includes a blunt needle component with a non-luer connection and a filter component with a non-luer connection, wherein the non-luer connections of the blunt needle component and filter component are incompatible with standard luer fitting and intravenous route-accessing devices. In one or more embodiments, an adapter having a non-luer connection at one end and a luer connector is provided for use with blunt needle components and filter components wherein one of the blunt needle component and the filter component includes a luer connection and the other of the blunt needle component and the filter component includes a non-luer connection. Methods of delivering liquid medication to a catheter are also provided. | 02-02-2012 |
| 20120029427 | Dual Chamber Syringe With Retractable Needle - Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided. | 02-02-2012 |
| 20120022566 | Lancet Device - A lancet device generally includes a housing having opposing lateral sides extending between a forward end and a rearward end, and a shield coaxially and movably associated with the housing. The housing includes a plurality of longitudinal ribs extending along a portion of at least one of the opposing lateral sides. The plurality of longitudinal ribs form a finger grip on at least one of, and typically both of the opposing lateral sides. The shield is generally movable from a first position in which the shield extends outwardly from the forward end of the housing to a second position in which the shield is at least partially moved within the housing, based on axial pressure applied by the user against the finger grip formed by the longitudinal ribs. | 01-26-2012 |
| 20120022502 | SYSTEMS AND METHODS FOR IMPROVING CATHETER HOLE ARRAY EFFICIENCY - Systems and methods for manufacturing a peripheral catheter having a plurality of diffusion holes. | 01-26-2012 |
| 20120022464 | Dual Chamber Passive Retraction Needle Syringe - Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. In one or more embodiments, the assemblies include a fluid barrel for retaining fluid and a retraction barrel for housing the retraction feature and the needle hub assembly. The assemblies include a trigger element that moves with the plunger rod to activate the retraction feature within the retraction mechanism. | 01-26-2012 |
| 20120016345 | LUER CONNECTOR - A luer lock connector is disclosed. The luer lock connector includes a connector body having a distal end, a proximal end, and a gripping portion between the distal end and the proximal end. A substantially flexible material is disposed on at least the outer surface of the gripping portion of the connector body. An intravenous line is coupled to the distal end of the connector body. A luer connector fitting is disposed on the proximal end of the body, the luer connector having an outer diameter less than a maximum exterior thickness of the gripping portion of the connector body. | 01-19-2012 |
| 20120016318 | ANTIMICROBIAL IV ACCESS CAP - An antimicrobial IV access cap having an inner surface for retaining an antimicrobial agent, and further configured to receive a portion of an access port of an intravascular device. | 01-19-2012 |
| 20120016307 | REMOVABLE FLASH CHAMBER - A needle hub and catheter assembly are disclosed herein. The needle hub includes an introducer needle having a lumen extending therethrough. A needle hub is coupled to a proximal end of the introducer needle. A flash chamber is removably coupled to the needle hub or the introducer needle. An interior of the flash chamber is in fluid communication with the lumen of the introducer needle when the flash chamber is coupled to the needle hub or the introducer needle. As such, the flash chamber can collect a sample of blood that can be accessed when the flash chamber is removed. In some instances, the blood can also be dispensed from the flash chamber into a test strip or other testing device. | 01-19-2012 |
| 20120016302 | CATHETER ASSEMBLY AND PIERCED SEPTUM VALVE - A septum activator is disclosed herein. The septum activator has an outer tubular body and an inner tubular body. The outer tubular body and the inner tubular body each have a plurality of openings therein. The inner tubular body has a first position relative to the outer tubular body and a second position relative to outer tubular body. In the first position, the plurality of openings of the inner tubular body do not overlap with the plurality of openings in the outer tubular body. In the second position, the plurality of openings of the inner tubular body overlap with the plurality of openings of the inner tubular body. | 01-19-2012 |
| 20120016301 | CATHETER ASSEMBLY AND PIERCED SEPTUM VALVE - A pierced septum valve is disclosed herein. The pierced septum valve includes a septum that is located within a lumen of a body. A septum activator is positioned proximal the septum within the lumen of the body. A seal is disposed between an outer surface of the septum activator and the body to seal the portion of the septum activator distal the lumen from the portion of the septum activator proximal the lumen. One or more vents are disposed between the seal and the lumen of the body to permits the passage of air but not blood past the seal. | 01-19-2012 |
| 20120016266 | VENTED BLOOD SAMPLING DEVICE - An extravascular system is disclosed. The system includes a body, a septum, a septum activator, and a blood sampling device. The body has and inner lumen extending therethrough. The septum is disposed within the inner lumen. The septum activator is disposed within the inner lumen proximal the septum. The septum activator has an inner passage extending therethrough. The blood sampling device has a tube that is longer than a length of the septum activator and has a width less than or equal to a width of the inner passage of the septum activator. An interior of the tube is in fluid communication with a reservoir within the blood sampling device. A vent is in fluid communication with the reservoir. The vent passes air but not blood therethrough. | 01-19-2012 |
| 20120016265 | DEVICE AND METHOD FOR COLLECTING A BLOOD SAMPLE - A vent plug is disclosed that includes a body having a distal end, a proximal end, and a lumen extending through the distal and proximal ends. A membrane is disposed across the lumen, the membrane being hydrophobic and air permeable. A fluid chamber is formed within the lumen distal the membrane. A distal lumen opening being shaped and sized to retain blood within the lumen until the internal pressure of the lumen increases in response the a finger pressing against a proximal lumen opening. | 01-19-2012 |
| 20120016213 | BLOOD TEST STRIP AND AN INTRAVENOUS CATHETER SYSTEM - A blood test strip useful for venting a closed intravenous system and collecting a blood sample is described herein. The blood test strip includes a blood test strip, one or more vents, and a gripping member coupled to the proximal end of the blood test strip. The one or more vents are disposed between the distal and the proximal portions of the blood test strip. | 01-19-2012 |
| 20120009558 | METHOD AND APPARATUS FOR IDENTIFICATION OF BACTERIA - An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained. | 01-12-2012 |
| 20110313363 | Medical Components Having Coated Surfaces Exhibiting Low Friction and Low Reactivity - This invention relates to medical articles, such as a syringe assemblies, including a substrate having a coating on a surface thereof, the coating including: (1) at least one organopolysiloxane and (2) a deposition product applied to the at least one organopolysiloxane by plasma-enhanced chemical vapor deposition of a composition including at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof, and methods of making and using the same. | 12-22-2011 |
| 20110311416 | Container Assembly and System for Detection Thereof - A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light. | 12-22-2011 |
| 20110307117 | SYSTEM AND METHOD FOR HEATING AND INSULATING CONTRAST MEDIA - A system for heating and insulating contrast media is disclosed herein. A thermal insulating cover sized to cover at least a portion of a contrast media container is provided with a heating element. A temperature sensor measures the temperature of the contrast media and communicates this temperature to a temperature controller, which controls the heating element in order to maintain the contrast media near a predetermined temperature. Temperature data is transmitted to a computer system by a data communicator. | 12-15-2011 |
| 20110306937 | MAGNETIC SAFETY NEEDLE ASSEMBLY - A safety needle assembly is provided herein which includes a hub; a needle fixed to the hub, the needle having a distal end formed for insertion into a patient; a shield moveable relative to the hub from a first position, where the shield covers the distal end of the needle, to a second position, where the distal end of the needle is exposed and not covered by the shield; a first magnetic element fixed to the hub; and, a second magnetic element fixed to the shield. The first and second magnetic elements are configured so as to define a repulsive force therebetween which urges the first and second magnetic elements apart. The repulsive force urges the shield towards the first position. Advantageously, with the subject invention, a safety needle assembly may be provided which includes a minimal number of parts, without sacrificing reliability. | 12-15-2011 |
| 20110306934 | SYSTEMS AND METHODS FOR PROVIDING A CONVECTION-ENHANCED DELIVERY DEVICE - A delivery device system is provided for assisting a patient and physician in maintaining a depth and position of an inserted catheter within a target tissue. The delivery device includes a base member that is secured to an external surface of the patient. The base member includes an aperture through which a catheter is inserted to access the target tissue. The base member further includes a hinged clip that selectively locks into a closed position to secure the catheter within the delivery device and maintain a desired insertion depth of the catheter within the target tissue. The base member further includes a receiving channel for compatibly and adjustably securing an adapter portion of the catheter in a horizontal orientation. | 12-15-2011 |
| 20110288491 | SAFETY NEEDLE ASSEMBLY - A safety needle assembly is provided herein which includes a hub; a needle fixed to the hub, the needle having a distal end, formed for insertion into a patient, and a proximal end; a first shield having a tubular body at least partially encircling a portion of the needle, wherein in an initial state, the first shield extends from the hub; a second shield having a tubular body at least partially encircling a portion of the needle; a biasing element disposed to urge the second shield distally towards the distal end of the needle; and, a releasable retaining arrangement for releasably retaining the second shield in a first state. Upon a predetermined extent of proximal movement of the first shield relative to the hub, the second shield is released thereby allowing the biasing element to urge the second shield to a second state in which the distal end of the needle is covered. Advantageously, with the arrangement of the subject invention, two shields are provided for at least partially covering a needle with one of the shields acting as a trigger. | 11-24-2011 |
| 20110282279 | Passive Reuse Prevention Syringe That Uses a Flange Lock - A syringe assembly includes a syringe barrel having an inside surface defining a chamber, an open proximal end, a distal end, and an outlet; a plunger assembly disposed at least partially within the syringe barrel, including an elongate plunger rod having a locking flange formed thereon; and a plunger head having a distal sealing surface, the plunger rod being engageable with the plunger head such that the plunger rod is adapted to move the plunger head within the chamber of the syringe barrel through an injection cycle; and a flange lock disposed at the open proximal end of the barrel. The flange lock is integral with the open proximal end of the syringe barrel. During the injection cycle, the flange lock engages the locking flange of the plunger rod so as to prevent removal of the plunger rod from the syringe barrel. | 11-17-2011 |
| 20110276031 | SYSTEMS AND METHODS FOR PROVIDING A CLOSED VENTING HAZARDOUS DRUG IV SET - A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure. | 11-10-2011 |
| 20110276010 | SYSTEMS AND METHODS FOR PROVIDING A CLOSED VENTING HAZARDOUS DRUG IV SET - A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure. | 11-10-2011 |
| 20110275988 | SYSTEMS AND METHODS FOR PROVIDING A CLOSED VENTING HAZARDOUS DRUG IV SET - A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure. | 11-10-2011 |
| 20110275090 | USE OF ACHROMOPEPTIDASE FOR LYSIS AT ROOM TEMPERATURE - A process for detecting the presence or absence of gram-positive bacteria in a biological sample. The biological sample can be obtained from any mammal and contains, at a minimum, cellular components. The sample is combined with an enzymatic lysing agent such as achromopeptidase, and lysed at room temperature. Ferric oxide is then added to the sample containing achromopeptidase. A magnetic field is applied to the sample and nucleic acids are extracted from the cellular components. Target nucleic acids, if present, are amplified using techniques such as Polymerase Chain Reaction (PCR) and then used to detect the presence or absence of gram-positive bacteria. | 11-10-2011 |
| 20110269224 | Tissue Container for Molecular and Histology Diagnostics Incorporating a Breakable Membrane - A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container and separates the two chambers. When the breakable membrane is broken, fluid can pass between the first and second chambers. The membrane may be broken through an activator on the closure, such as a depressible member or a rotatable carrier, causing the sample holder to break through the membrane. | 11-03-2011 |
| 20110264051 | Syringe With Adjustable Two Piece Plunger Rod - Medical devices comprising a syringe barrel and a two-piece plunger rod are provided. According to one or more embodiments, the two-piece plunger rod includes a distal portion and proximal portion slidably mounted to the distal portion. The distal and proximal portions include a tab and plurality of grooves which engage to adjust the overall length of the plunger rod to a plurality of locked lengths. The locked lengths of the plunger rod permit varying amount of fluid to be expelled from the barrel. | 10-27-2011 |
| 20110257603 | SAFETY PEN NEEDLE ASSEMBLY HAVING SHIELDING FOR PATIENT AND NON-PATIENT ENDS - A safety pen needle assembly is provided herein which includes a hub and a needle fixed to the hub. Further, a first shield is provided, along with a second shield which has a biasing element disposed to urge the second shield proximally towards a proximal end of the needle. The assembly further includes a releasable retaining assembly for releasably retaining the second shield in an initial position against the force of the biasing element. A predetermined extent of movement of the first shield causes the retaining assembly to release the second shield, and, wherein, with the second shield being released, the second shield is urged proximally by the biasing element to a second position where the second shield covers the proximal end of the needle. Advantageously, with the subject invention, an assembly is provided which allows for passive activation of a shield on a non-patient end of a pen needle assembly by a patient-end shield. | 10-20-2011 |
| 20110250634 | Tissue Container for Molecular and Histology Diagnostics Incorporating a Breakable Membrane - A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container and separates the two chambers. When the breakable membrane is broken, fluid can pass between the first and second chambers. The membrane may be broken through an activator on the closure, such as a depressible member or a rotatable carrier, causing the sample holder to break through the membrane. | 10-13-2011 |
| 20110244457 | IMMUNO-AMPLIFICATION - A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. | 10-06-2011 |
| 20110236883 | DETECTION OF HERPES SIMPLEX VIRUS TYPES 1 AND 2 BY NUCLEIC ACID AMPLIFICATION - The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G(US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers as described herewith. The method of the invention further identifies the type of HSV, either HSV-1 or HSV-2, in a sample. Also encompassed by the invention is a kit comprising the primers and detector primers which may be used with the amplification method described herewith. | 09-29-2011 |
| 20110224617 | CATHETER DEVICE WITH HOODING FEATURE - An intravenous catheter device having features to aid a user in hooding the beveled portion of an introducer needle during the catheterization process. An intravenous catheter device is modified to include a biasing arm capable of advancing a portion of the catheter device to cause a beveled portion of an introducer needle to be hooded within an interior lumen of the catheter tube. The dimensions of the biasing arm and various other interacting surfaces of the catheter device are configured to achieve effective hooding of the needle tip while avoiding overhooding or underhooding inaccuracies. | 09-15-2011 |
| 20110224612 | MEDICAL DEVICE INCLUDING AN AIR EVACUATION SYSTEM - Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided. | 09-15-2011 |
| 20110224611 | MEDICAL DEVICE INCLUDING AN AIR EVACUATION SYSTEM - Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided. | 09-15-2011 |
| 20110224610 | Medical Device Including an Air Evacuation System - Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided. | 09-15-2011 |
| 20110213315 | MEDICAL INJECTOR WITH SLIDABLE SLEEVE ACTIVATION - In one aspect, a medical injector is provided herein which includes a body; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; a releasable retainer for retaining the plunger in a first state against force of the spring; and, a sleeve disposed on the body, the sleeve being slidable relative to the body. Sliding movement of the sleeve over a predetermined extent relative to the body results in the releasable retainer releasing the plunger thereby allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon sliding movement of the sleeve, thereby minimizing premature or failed activations. | 09-01-2011 |
| 20110213299 | MEDICAL INJECTOR WITH BUTTON ACTIVATION - A medical injector is provided herein which includes a body; a slidable button at least partially disposed in the body; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first state against force of the spring. Upon a predetermined extent of sliding movement of the button, the button engages the releasable retainer so as to cause the releasable retainer to release the plunger thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon button activation, thereby minimizing premature or failed activations. | 09-01-2011 |
| 20110208160 | Safety Drug Delivery System - Drug delivery systems are provided that include an actuator assembly permanently attached to a filter for connection of a container containing medications such as epidural anesthesia, to a delivery site. In one or more embodiments, the actuator assembly includes a projection with an opening extending from a distal end of the actuator assembly in a proximal direction and the filter includes an inlet and an outlet in fluid communication with the opening. The filter includes a housing including two plates joined together or a cylindrical body defining a cavity containing filter materials. A conduit may be attached to the outlet of the filter to allow connection of the drug delivery systems described to a delivery site, such as a catheter. Methods of administering a medication to a delivery site are also provided. | 08-25-2011 |
| 20110208128 | Safety Drug Delivery Connectors - Drug delivery connectors are provided for permitting and blocking fluid flow between a container and a catheter connector or other drug delivery site. Embodiments of the drug delivery connectors include a ball valve for forming a releasable seal within the drug delivery connectors. In one or more embodiments, the ball valve prevents fluid flow between an open proximal end and an open distal end of the drug delivery connector and is movable in a proximal direction to release the releasable seal to permit fluid flow from the open proximal direction to the open distal direction. Methods of delivering medication to a catheter connector that includes an actuator are also provided | 08-25-2011 |
| 20110202013 | MEDICAL INJECTOR WITH COUPLED BODY PORTIONS - A medical injector is provided herein which includes first and second body portions each having a longitudinal axis and configured to couple at a coupling. The first and second body portions are complementarily formed so as to be movable about the coupling. The medical injector also includes an axially-displaceable plunger; biasing element for advancing the plunger a predetermined distance; and, a releasable retainer for releasably retaining the plunger in a first state against the force of the biasing element. In an initial state, the axes of the first and second body portions are not aligned and the plunger is in the first state. In a coupled state, the axes of the first and second body portions are axially aligned, and the releasable retainer releases the plunger, thereby allowing the biasing element to advance the plunger the predetermined distance. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon assembly of the pen injector, thereby minimizing premature or failed activations. | 08-18-2011 |
| 20110201999 | NEEDLE MOUNTING FEATURE FOR ENSURING PROPER RECONSTITUTION SEQUENCE - A medical injector is provided herein having a body and a needle mounting surface movable relative to the body, the needle mounting surface having features for mounting a needle thereto. In an initial state, the needle mounting surface is disposed within the body with no needle mounted thereto. With relative movement between the body and the needle mounting surface, the needle mounting surface is urged out of the body. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered. | 08-18-2011 |
| 20110201516 | ASSAY FOR DETECTING CLOSELY-RELATED SEROTYPES OF HUMAN PAPILLOMAVIRUS (HPV) - A real time Taq-Man PCR assay for detecting multiple serotypes of human papillomavirus (HPV) wherein the number of serotypes detected exceeds the number of colorimetric channels for detection. A biological sample is combined with three oligonucleotide primer/probe sets such that the probes and primers anneal to a target sequence. Each primer/probe set is at least preferential for a specific serotype of an organism. The first and second primer/probe sets are degenerate with respect to each other. The third primer/probe set is not degenerate with respect to the first and second primer/probe sets and discriminates for a third serotype. The third primer/probe set has a signal moiety that emits signal at a wavelength that is the same or different from the wavelength emitted by the signal moiety of the degenerate primer/probe set probes. The target sequences, if present, are amplified and detected. | 08-18-2011 |
| 20110196310 | MEDICAL INJECTOR WITH RATCHETING PLUNGER - A medical injector is provided herein having a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided formed to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally towards a distal end of the body but not proximally towards a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger thereby allowing the engagement portion to by-pass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector. The displacement from the ready state causes distal displacement of the engagement portion with the engagement portion engaging one or more of the ratchet teeth and causing distal displacement of the plunger with the engagement portion. Advantageously, the subject invention provides a plunger for a medical injector which may be controllably advanced with a minimum number of cooperating parts. | 08-11-2011 |
| 20110187021 | Device For Separating Components of a Fluid Sample - A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends. | 08-04-2011 |
| 20110186537 | Systems, Apparatus and Methods for Coating the Interior of a Container Using a Photolysis and/or Thermal Chemical Vapor Deposition Process - Systems, apparatus and methods are provided to apply barrier and/or lubricant materials onto the interior surface of a container, such systems including a container having a chamber; a gas supply source for supplying monomer gas through a gas inlet duct having a portion extending into the chamber; a photolysis source and/or pyrolyzing surface for photolyzing and/or pyrolyzing at least a portion of the monomer gas to form a reactive gas comprising at least one reactive moiety; optionally a temperature controller for maintaining the interior surface of the container at a temperature which is less than the temperature of the pyrolyzing surface to facilitate deposition and polymerization of the reactive moiety on the interior surface of the container; and an outlet duct at the open end or a second end of the container for removing excess reactive gas from the chamber. | 08-04-2011 |
| 20110184168 | LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES - Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus. | 07-28-2011 |
| 20110178433 | SENSOR STRIP POSITIONING MECHANISM - A blood sample test device has a continuous strip sensor which is advanced through the device so that multiple blood sample tests can be conducted on a single strip. The device is provided with a sprocket having an encoder which engages sprocket holes on the strip to precisely control the advancement of the strip through the device. | 07-21-2011 |
| 20110178427 | Flashback Blood Collection Needle - A needle assembly includes a transparent or translucent housing with a fluid inlet and outlet end, a flashback chamber, and a venting mechanism therebetween. The venting mechanism includes a blocking member to control the fluid flow in the venting mechanism so that it flows along the longest path through the vent. Substantially axially aligned inlet and outlet cannulas extend from the housing and communicate with the chamber. A sealable sleeve covers the external end of the outlet cannula. Relative volumes of the cannulas, the chamber, and the sleeve are selected to provide rapid reliable flashback indicative of venous entry with an internal vent positioned within the housing to divide the interior into first and second chambers, with the second chamber being adapted to maintain a negative pressure therein relative to the external environment so as to inhibit leakage of blood from the needle tip on withdrawal from the patient. | 07-21-2011 |
| 20110178424 | Specimen Collection Container Having a Transitional Fill-Volume Indicator Indicating Extraction Method - A specimen collection container having a transitional fill-volume indicator is disclosed. The specimen collection container includes an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior. The specimen collection container includes a transitional fill-volume indicator adjacent the sidewall, such that the container defines a first volumetric interior defined by the sidewall between the closed bottom end and the transitional indicator. The specimen collection container also defines a second volumetric interior defined by the sidewall between the closed bottom end and a portion of the sidewall disposed above the transitional indicator. The first volumetric interior is adapted to allow extraction of a specimen therefrom by a first extraction process, and the second volumetric interior is adapted to allow extraction of a specimen therefrom by either the first extraction process or a second extraction process, the second extraction process being different than the first extraction process. | 07-21-2011 |
| 20110177537 | Method and System for Measuring a Sample to Determine the Presence of and Optionally Treat a Pathologic Condition - The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone analog(s) thereof involved in diabetes or metabolic syndrome. The methods comprise a quantitative separation of at least those analytes of interest whose common presence interferes with measuring the presence/absence or concentration of one of the analytes of interest by a subsequent analytical method. | 07-21-2011 |
| 20110174820 | Container Assembly - A container assembly such as a petri dish or a contact plate for use as a sampling device for microorganisms includes a base member, a lid and a locking mechanism that provides a secure locking engagement between the lid and the base member. The locking mechanism is designed such that does not lock except upon application of a specific intentionally applied compressive force, and which may be readily disengaged from locking engagement without the need for a rotational movement or torsional force. | 07-21-2011 |
| 20110174637 | ELECTRODE LAYOUT FOR BLOOD TEST SENSOR STRIP - An improved electrode layout for a continuous strip sensor is provided which reduces misalignment of the electrodes with the contacts which read the position of the strip. Better contact with the electrodes reduces or eliminates transient signals between stop positions of the sensor strip. | 07-21-2011 |
| 20110174624 | Methods and Apparatus for Carrier-Free Deflection Electrophoresis - The invention relates to a method and apparatus for carrier-free deflection electrophoresis, in which a separating media and a sample to be examined flow through a separating chamber between a pair of electrodes in a series of reversing bulk fluid flow along the direction of the electrodes, thereby separating the sample into zones which are to be collected into fractions for analysis or further processing. Among other things, the apparatus and method enable high-resolution separation of particles that can be performed in miniaturized chambers in electrophoresis modes including isoelectric focusing, zone electrophoresis, and isotachophoresis. | 07-21-2011 |
| 20110166476 | Safety Blood Collection Assembly with Indicator - A needle assembly is disclosed. The needle assembly includes a housing having a flash chamber, and having a distal end and a proximal end engageable with a specimen collection container. The assembly includes a cannula having a patient end, a non-patient end, and a sidewall extending therebetween defining a cannula interior. The patient end of the cannula projects at least partially from the distal end of the housing, and the cannula interior is in fluid communication with the flash chamber. The assembly further includes a shield restrainably engaged with a portion of the housing and axially transitionable over the patient cannula from a retracted position in which the patient end is exposed, to an extended position in which the patient end is shielded by at least a portion of the shield, wherein at least a portion of the flash chamber is visible in the retracted position. | 07-07-2011 |
| 20110166475 | Safety Blood Collection Assembly with Indicator - A needle assembly is disclosed. The needle assembly includes a housing having a flash chamber, and having a distal end and a proximal end engageable with a specimen collection container. The assembly includes a cannula having a patient end, a non-patient end, and a sidewall extending therebetween defining a cannula interior. The patient end of the cannula projects at least partially from the distal end of the housing, and the cannula interior is in fluid communication with the flash chamber. The assembly further includes a shield restrainably engaged with a portion of the housing and axially transitionable over the patient cannula from a retracted position in which the patient end is exposed, to an extended position in which the patient end is shielded by at least a portion of the shield, wherein at least a portion of the flash chamber is visible in the retracted position. | 07-07-2011 |
| 20110166474 | Safety Blood Collection Assembly with Indicator - A needle assembly is disclosed. The needle assembly includes a housing having a flash chamber, and having a distal end and a proximal end engageable with a specimen collection container. The assembly includes a cannula having a patient end, a non-patient end, and a sidewall extending therebetween defining a cannula interior. The patient end of the cannula projects at least partially from the distal end of the housing, and the cannula interior is in fluid communication with the flash chamber. The assembly further includes a shield restrainably engaged with a portion of the housing and axially transitionable over the patient cannula from a retracted position in which the patient end is exposed, to an extended position in which the patient end is shielded by at least a portion of the shield, wherein at least a portion of the flash chamber is visible in the retracted position. | 07-07-2011 |
| 20110160675 | SAFETY PEN NEEDLE ASSEMBLY - In one aspect, a safety pen needle assembly is provided herein which includes a hub with a needle fixed to the hub, the needle having a distal end, formed for insertion into a patient, and a proximal end. The assembly further includes a shield and a biasing member disposed between the hub and the shield configured to urge the shield distally. A protrusion extends from at least one of the hub and the shield with a channel being formed in at least the other of the hub and the shield. The channel is formed to accommodate the protrusion. The shield is movable from a first position to a second position. In the first position, the shield is spaced from the distal end of the needle such that the distal end of the needle is exposed. In the second position, the shield covers the distal end of the needle. The channel guides the protrusion as the shield moves from the first position to the second position. With this arrangement, a shield may be directed to move in a desired path with stability. In addition, the distal end of the needle may be initially exposed to permit visual confirmation of priming, while allowing the shield to cover a majority of the needle to minimize any needle-related anxiety. | 06-30-2011 |
| 20110160663 | SYSTEMS AND METHODS FOR PROVIDING A CATHETER ASSEMBLY - A system for controlling fluid flow in a catheter assembly is disclosed herein. An intravenous catheter assembly has a catheter adapter and a needle hub, and the catheter adapter has an inner lumen. A septum is disposed within a portion of the inner lumen, and a slit is formed through the septum. A Parylene coating is disposed within the slit of the septum, the Parylene coating has a thickness of between approximately 0.00005 to 0.0005 millimeters. An introducer needle has a first end coupled to the needle hub and the second end extending through the inner lumen of the catheter adapter. A middle portion of the introducer needle is positioned within a portion of the septum. | 06-30-2011 |
| 20110160662 | SYSTEMS AND METHODS FOR PROVIDING A FLUSHABLE CATHETER ASSEMBLY - A flushable catheter assembly having features to enable selective activation of fluid flow through the catheter assembly is disclosed herein. A septum is placed within the catheter adapter of the catheter assembly and includes a pathway that is closed prior to being biased open via a septum activator also positioned within the catheter adapter. A plurality of air vent channels is interposed between the septum and the inner surface of the catheter adapter to permit “flashback” of blood during insertion of the catheter into a patient. The septum activator is advanced through the pathway of the septum as a coupler is attached to a proximal opening of the catheter adapter. | 06-30-2011 |
| 20110159047 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 06-30-2011 |
| 20110150958 | CHLORHEXIDINE ACETATE ANTISEPTIC CLEANING AGENT - An antiseptic cleaning agent, generally, comprising chlorhexidine acetate and a solvent, such as an alcohol and/or water. The chlorhexidine acetate acts as a highly effective biocide. Additionally, the chlorhexidine acetate allows the cleaning agent to dry without leaving a tacky residue. Where the cleaning agent comprises one or more alcohols, the alcohols may comprise any suitable alcohols, including lower alcohols having from 1 to 6 carbon atoms, such as ethanol and isopropanol. Where the ratio of ethanol to isopropanol may be from between about 1:1000 to about 1000:1. In addition to chlorhexidine acetate, the cleaning agent optionally comprises another non-alcohol biocide, such as triclosan. The cleaning agent can be used in any suitable manner. For instance, the cleaning agent may be impregnated in an absorbent material, such as a towelette, swabstick, or gauze. Additionally, the absorbent material may comprise a positively charged or a non-ionic substance, such as polypropylene or polyester. | 06-23-2011 |
| 20110130745 | CATHETER HOLE HAVING AN INCLINED TRAILING EDGE - A catheter having a catheter body with a lumen and a distal lumen opening. The catheter's lumen extends through the catheter body along a longitudinal axis of the catheter body. A hole is formed through a wall of a distal portion of the catheter body. A portion of the proximal surface of the hole is inclined at an acute angle with respect to the longitudinal axis of the catheter body. The acute angle of the proximal hole surface opens proximally with respect to the catheter body. | 06-02-2011 |
| 20110130728 | VASCULAR ACCESS DEVICE TIME SENSITIVE STATUS INDICATION - A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device. | 06-02-2011 |
| 20110130727 | VASCULAR ACCESS DEVICE TIME SENSITIVE STATUS INDICATION - A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device. | 06-02-2011 |
| 20110130726 | VASCULAR ACCESS DEVICE TIME SENSITIVE STATUS INDICATION - A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device. | 06-02-2011 |
| 20110125102 | Flashback Blood Collection Needle with Needle Shield - A needle assembly is provided with the housing, and IV cannula for accessing a blood vessel and a non-patient cannula for communication with an evacuated tube. A flashback chamber is provided in the housing at or near the distal end of the housing. A shield is hinged to a portion of the assembly proximally of the entrance to the flashback chamber. As a result, good visibility of the flashback chamber is achieved. After use, the shield can be rotated into a closed portion for surrounding the IV cannula and avoiding accidental needle sticks. | 05-26-2011 |
| 20110124117 | SERS NANOTAG ASSAYS WITH ENHANCED ASSAY KINETICS - Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods. | 05-26-2011 |
| 20110123414 | MULTILAYER CONTAINERS - A multilayer evacuated blood collection tube is provided having a first tube layer, and a second tube layer formed on the first tube layer and a closure, the second tube layer being a nanocomposite barrier layer. Such containers include but are not limited to blood collection tubes, evacuated blood collection tubes, centrifuge tubes, culture bottles, and syringe barrels. | 05-26-2011 |
| 20110118667 | Hub Assembly Having A Hidden Needle For A Drug Delivery Pen - A hub assembly for a pen injection device allows a needle to be disposed in at least one of a plurality of positions prior to an injection. A hub of the hub assembly is connected to the pen injection device, and the needle is received by the hub. A shield is movably connected to the hub and allows the needle to be disposed in at least one of several positions prior to an injection, such as a position in which the needle is visible for priming and a position that prevents the needle from being visible. A tab connected to the hub is received by a channel formed in the shield to control movement of the shield. | 05-19-2011 |
| 20110112438 | Squeeze Activated Medical Puncturing Device - The medical puncturing device ( | 05-12-2011 |
| 20110106044 | METHODS FOR EVALUATING THE AGGREGATION OF A PROTEIN IN A SUSPENSION INCLUDING ORGANOPOLYSILOXANE AND MEDICAL ARTICLES COATED WITH ORGANOPOLYSILOXANE CONTAINING A PROTEIN SOLUTION - This invention relates to methods for evaluating or inhibiting the aggregation of a protein in an aqueous suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution including sugar and a non-ionic surfactant. | 05-05-2011 |
| 20110106016 | PEN NEEDLE ASSEMBLY - A pen needle assembly is provided herein for use with a medical injector containing an injector body and a reservoir sealed by a septum encased in the injector body. The pen needle assembly includes a hub and a needle fixed to the hub. The hub is formed to be telescopingly mounted onto the distal end of the injector body using a track that accommodates a guide key. When mounting the pen needle assembly onto the injector body, a first portion of the track is configured to receive the guide key and to guide the guide key in a straight line across sufficient distance to permit the proximal end of the needle to fully pierce through the septum, without rotation of the needle. A second portion of the track is configured to permit the pen needle assembly to be turned with the proximal end of the needle being located proximally of the septum. | 05-05-2011 |
| 20110098641 | DISPOSABLE INJECTION DEVICE - An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position. | 04-28-2011 |
| 20110097718 | MS-COMPATIBLE NONIONIC OR ZWITTERIONIC SURFACTANTS IN FREE-FLOW ELECTROPHORESIS - The invention relates to the use of MS compatible surfactants in free-flow electrophoretic methods, which allow the separation of analytes with differentiated electrophoretic mobility. The surfactant is preferably a cleavable surfactant, such as PPS. | 04-28-2011 |
| 20110097334 | Novel Marker Genes for Regulatory T Cells from Human Blood - The present invention provides novel marker genes for the specific identification and characterization of human suppressive and/or regulatory T cells including natural, adaptive, and expanded CD4 | 04-28-2011 |
| 20110092917 | DRUG DELIVERY DEVICE HAVING CARTRIDGE WITH ENLARGED DISTAL END - A drug delivery device is provided herein which includes a tubular body having a proximal end and a distal end, the tubular body defining an opening at or in proximity to the distal end, the opening defining an inner diameter. A drug cartridge is also provided having a proximal end, a distal end and a barrel portion disposed therebetween. The distal end of the drug cartridge is larger in diameter than the inner diameter of the opening. The drug cartridge is inserted into the tubular body to a use position by first inserting the proximal end of the drug cartridge into the opening. The distal end of the drug cartridge limits insertion of the drug cartridge into the tubular body due to the interengagement of the distal end of the drug cartridge and the tubular body. With the drug cartridge being in the use position, the distal end of the drug cartridge is located at least partially externally of the tubular body. The medical pen injector of the subject invention further includes an adaptor engageable with the body. The adaptor encompasses the distal end of the drug cartridge with the drug cartridge being in the use position. The adaptor includes features for mounting a needle assembly thereto. Advantageously, with the subject invention, a drug cartridge having a large distal end may be accommodated with a drug delivery device, e.g., a pen injector type device. | 04-21-2011 |
| 20110092903 | Syringe With Disabling Mechanism - Syringe assemblies having a passive disabling system to prevent reuse are provided. According to one or more embodiments, the syringe assembly comprises a barrel, plunger rod and stopper wherein the plunger rod further comprises a flexible protrusion that locks the plunger rod within the barrel. Certain embodiments further include a frangible portion on the plunger rod that breaks when reuse is attempted. | 04-21-2011 |
| 20110091990 | DEVICE AND METHODS FOR COLLECTION OF BIOLOGICAL FLUID SAMPLE AND TREATMENT OF SELECTED COMPONENTS - A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood. | 04-21-2011 |
| 20110071492 | HUB ASSEMBLY HAVING A HIDDEN NEEDLE FOR A DRUG DELIVERY PEN - A hub assembly for a pen injection device prevents a patient from seeing a needle of a hub assembly during an injection. A hub is connected to the pen injection device. A needle is received by the hub. A compressible member is connected to the hub and is compressible between a first position that entirely covers said needle and a second position that exposes the needle for an injection. | 03-24-2011 |
| 20110071475 | OUTER COVER OF A PEN NEEDLE FOR A DRUG DELIVERY PEN - A connecting member removably connects a plurality of pen needles together, thereby providing a convenient way for a patient to carry multiple pen needles. The connecting member may be integrally formed with the outer cover of the pen needle or may be a separate member that removably receives the pen needle. An outer cover of a pen needle is provided with gripping means to facilitate gripping and handling of the outer cover. A lid connects to the outer cover to seal the outer cover. The lid also has gripping means to facilitate gripping and handling the lid. A cap is provided that has a first opening for receiving a first end of the outer cover and a second opening for receiving a second end of the outer cover. | 03-24-2011 |
| 20110071471 | Reversible Cap For Pen Needle Outer Cover - A pen needle assembly includes a cap for covering the non-injection end of a needle of a pen needle. The needle is received by a hub, which is disposed in an outer cover. The cap is adapted to be connected to the outer cover in a first or second position. The cap is removable in the first position and the cap is locked to the outer cover in the second position. | 03-24-2011 |
| 20110071230 | Medical Devices Formed From Recycled Medical Waste and Methods of Manufacture - Methods of reclaiming plastic from plastic medical waste containers containing medical waste and manufacturing recycled medical devices are described. Recycled medical devices made from plastic medical waste containers containing medical waste are also described. | 03-24-2011 |
| 20110070599 | Method for Screening of Active Tuberculosis - The present invention provides an improved and simplified assay for use in diagnosing active Tuberculosis infections. The present assay is carried out using a sample of whole blood, does not require separating the blood into components, such as the isolation of peripheral blood mononucleocytes (PBMC), and is carried out using only cell-surface staining of T-cells. | 03-24-2011 |
| 20110069492 | LENS POSITIONING APPARATUS - The present invention provides an optical analyzer having illumination optics that include a light source, such as a laser or other source, adapted to emit a collimated, or approximately collimated, light beam, and a focusing lens that focuses the beam onto a focus spot within a detection region, wherein the focusing lens is mounted in a lens positioning apparatus that allows for precise positioning of the focus spot within the detection region. The lens positioning apparatus comprises a lens holder adapted to rotate through a small angle around a pivot axis parallel to the optical path, such that the lens holder rotates in a plane perpendicular to the optical path, and an actuator adapted to provide an angular displacement of the lens holder around the pivot axis. The lens holder holds the focusing lens at a first distance from the pivot axis, and is coupled to the actuator at a second distance from the pivot axis, wherein the second distance is larger than the first distance. | 03-24-2011 |
| 20110068036 | Plastic Reclaimed From Infectious Medical Waste and Medical Devices Manufactured Therefrom - Methods of reclaiming plastic from infectious medical waste and manufacturing medical devices from reclaimed plastic are described. Medical devices made from plastic reclaimed from infectious medical waste are also described. | 03-24-2011 |
| 20110068034 | Shipping Container Integrating A Sharps Disposal Container With A New Product Storage Container - A shipping container integrates a sharps disposal container with a new product storage container for shipping. The storage container stores new product. A sharps disposal container receives used sharps. One of the storage container and the sharps disposal container is disposed within the other of the storage container and the sharps disposal container for shipping. A lid is adapted to be connected to the outermost container of the sharps disposal container and the storage container for shipping and to a top of the sharps disposal container for receiving used sharps. | 03-24-2011 |
| 20110066121 | SYSTEMS AND METHODS FOR PROVIDING AN ANTISEPTIC APPLICATOR - An antiseptic applicator device having a reservoir for storing an antiseptic agent, the reservoir being coupled to an applicator pad, and a defeatable membrane being interposed between the reservoir and the applicator pad. Embodiments of the device further include opposing handles, wherein an interior lumen of each handle houses a breakable phial containing a desired solution, and wherein upon moving the handles to a closed position, the phials are broken to release the desired solutions which are then absorbed by the applicator pad. | 03-17-2011 |
| 20110065798 | ANTI-INFECTIVE LUBRICANT FOR MEDICAL DEVICES AND METHODS FOR PREPARING THE SAME - A lubricious antiseptic coating material containing various solvents to achieve mutual miscibility and provide a generally homogenous product. A coating material is provided having an antipathogenic agent and a solvent for dissolving the same. The coating further includes a lubricious agent and a solvent for dissolving the same. Thus, the coating material contains antiseptic and lubricious properties suitable for application to a desired surface to kill or inhibit the growth of pathogens known to cause catheter related bloodstream infections. | 03-17-2011 |
| 20110059455 | METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS - A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated. | 03-10-2011 |
| 20110059017 | POLYMER COATED SERS NANOTAG - An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer. | 03-10-2011 |
| 20110054406 | VASCULATURE ENTRY CONFIRMATION MECHANISM - A vascular entry confirmation mechanism that produces a signal when a cannula and/or catheter is properly placed in a blood vessel is described herein. Generally, the confirmation mechanism comprises a cannula (such as a venapuncture needle), a signaling element, a power source, electrical components to electrically connect the signaling element to the power source, and a switching mechanism, which is configured to close a circuit between the signaling element and power source when a fluid (e.g., blood), flows into the cannula. Accordingly, the confirmation mechanism is configured to produce a signal (e.g., an audible or a visual signal) when a patient's vasculature is punctured. | 03-03-2011 |
| 20110046570 | SYSTEMS AND METHODS FOR PROVIDING A FLUSHABLE CATHETER ASSEMBLY - A flushable catheter assembly having features to enable selective activation of fluid flow through the catheter assembly is disclosed herein. A septum is placed within the catheter adapter of the catheter assembly and includes a pathway that is closed prior to being biased open via a septum activator also positioned within the catheter adapter. A plurality of air vent channels is interposed between the septum and the inner surface of the catheter adapter to permit “flashback” of blood during insertion of the catheter into a patient. The septum activator is advanced through the pathway of the septum as a coupler is attached to a proximal opening of the catheter adapter. | 02-24-2011 |
| 20110034882 | Stoppers Used in Pre-filled Syringes - A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel. | 02-10-2011 |
| 20110028909 | Medical Device Assembly - Medical device assemblies having a connection mechanism for securely connecting a hub to fluid storage containers in a luer slip relationship are described. An exemplary medical device includes a hub forming a cavity, a second indicating element disposed within the cavity that engages the hub. Additional features of the medical device include a second indicating element contoured to form a line contact with the hub. In a specific configuration, the hub includes a first indicating element attached to the hub and extending proximally into the cavity having a protrusion. In a more specific configuration, the medical device includes a fluid storage container that has an indication system for visually indicating optimal fluid-tight engagement of the hub and the fluid storage container. | 02-03-2011 |
| 20110022001 | PEN NEEDLE ASSEMBLY - A pen needle assembly is provided herein having a hub with a distal end and a proximal end; a needle fixed to the hub and having a distal end, for insertion into a patient, and a proximal end; an inner shield disposed proximally of the hub; a spring disposed between the inner shield and the hub and configured to bias the hub distally; an outer shield with a distal end, a proximal end, and a tubular body at least partially encircling a portion of the needle with at least portions located radially outward further from the needle than the inner shield such that the outer shield at least partially encases the hub, the needle, the inner shield, and the spring; and a releasable retaining assembly configured to releasably retain the hub in a first locked state against the biasing of the spring. The distal end of the needle is covered by the outer shield with the hub being in a first locked state. Upon release of the releasable retaining assembly, the hub moves under force of the spring to an unlocked second state. In the unlocked second state, the distal end of the needle extends distally from the distal end of the outer shield. Advantageously, with the arrangement of the subject invention, an injection may be conducted properly by a person apprehensive of seeing a needle during a medical injection and may also help a person insert the needle at the proper angle. | 01-27-2011 |
| 20110020923 | MULTILAYER TISSUE CULTURE VESSEL - The present invention discloses a vessel for culturing cells which includes: a bottom including a base with an upwardly extending wall at least partially bounding the base of the bottom; a top including a base with a downwardly extending wall at least partially bounding the base of the top; a tubular neck with an opening defined therein; and, one or more shelves, wherein, each shelf includes a base with an upwardly extending wall at least partially bounding the base of the shelf. The upwardly extending wall of a first shelf adjoins the downwardly extending wall of the top with the first shelf being located intermediate the bottom and the top. The base of each of the shelves having at least one aperture formed therein. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells. The tubular neck extends from the vessel with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells. | 01-27-2011 |
| 20110015583 | SYSTEMS AND METHODS FOR PROVIDING AN IV ADMINISTRATION SET INCORPORATING DRIP MONITORING CIRCUITRY - A circuitry for counting drips and monitoring a rate of infusion is incorporated into an IV administration set. The circuitry includes a pair of leads that are positioned in the pathway of fluid droplets, such that each droplet simultaneously contacts both leads. As such, the leads act as a virtual switch that is closed by the presence of a droplet. This event is then displayed on a drip signaling device to aid a user in adjusting the infusion rate of the IV administration set. | 01-20-2011 |
| 20110015546 | BLOOD GLUCOSE SENSOR - The invention is directed to an apparatus and method for blood sample acquisition and testing. The apparatus incorporates a test strip having a blood sample volume detection area in which a blood sample is accumulated and a minimum blood sample volume is detected. Once a minimum blood sample volume is detected, the test strip is moved with respect to the blood sample extraction site so that a bending surface of the test strip is presented to the blood sample, utilizing the surface tension of the blood sample droplet to facilitate movement of the blood sample to a measurement site on the strip where blood glucose in the sample is measured. | 01-20-2011 |
| 20110015545 | DIAGNOSTIC TEST STRIP HAVING FLUID TRANSPORT FEATURES - A test strip for testing a blood sample is provided with a fluid transport feature to facilitate transport of a blood sample obtained from a lancing operation through a capillary channel to a measurement site. A fluid transport path is defined on the major face of the strip terminating at the mouth of the capillary channel. The fluid transport path includes a depending portion at one end opposite the mouth of the channel. The depending portion extends away from the strip on the side facing the fluid sample, such that a droplet of fluid sample contacting the depending portion is directed toward the mouth of the capillary channel. Thereafter the sample moves by capillary action to the measurement site. | 01-20-2011 |
| 20110011149 | METHODS TO PROVIDE A FEATURE ON A NEEDLE - A gripping surface is provided on an outer surface of a needle shield as incorporated into an intravenous catheter assembly. The gripping surface provides a gripping position nearer the catheter adapter, catheter and needle tip for improved balance and control of the catheter assembly during insertion of the catheter. Additionally, the gripping surfaces include a guard feature to prevent a user's unintended contact with various components of the catheter assembly whereby the contact may result in an undesirable “over the bevel” condition. | 01-20-2011 |
| 20110009831 | ANTIMICROBIAL COATING FOR DERMALLY INVASIVE DEVICES - An antimicrobial coating applied to a transdermal surface of a catheter device. An antimicrobial coating applied to catheter device such that when the catheter device is fully inserted, the antimicrobial coating is interposed between the catheter device and the dermal layers of the patient. | 01-13-2011 |
| 20110009830 | Flush Syringe Assembly with Controlled Pulsatile Flushing - Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the cathether are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element. | 01-13-2011 |
| 20110009829 | Flush Syringe Assembly - Syringe assemblies for use in flush applications are provided. Syringe assemblies according to one aspect of the present invention include a plunger rod and a syringe barrel that incorporate one or more pulsing elements on the plunger rod or barrel that are rotatable to create pulsatile movement or continuous and unimpeded movement a plunger rod within a syringe barrel. One or more embodiments pertain to syringe assemblies permit both pulsatile movement of the plunger rod within the barrel and continuous and unimpeded movement of the plunger rod in the distal direction along substantially the entire length of the syringe barrel upon application of force to the plunger rod in only the distal direction. Methods of flushing a catheter are also provided. | 01-13-2011 |
| 20110009738 | SYSTEM AND METHOD FOR VISUALIZING NEEDLE ENTRY INTO A BODY - A system for visualizing needle entry into a body is presented. The system includes a needle for entering a body. The needle is coated with a radiation scattering coating on at least a portion of the needle. The system additionally includes a radiation visualization device which detects reflected radiation directed at a target body and enables medical personnel to view anatomical structures such as a blood vessel along with the inserted needle within a body. | 01-13-2011 |
| 20110009717 | BLOOD SAMPLING DEVICE - A blood sampling device useful for collecting a blood sample from a separate vascular access device is described herein. The blood sampling device includes a body shaped and sized for partial insertion into a separate vascular access device. The body includes a reservoir defined within the body, which has an internal volume sufficient to contain enough blood for use in a diagnostic blood test. The body also includes a gas permeable vent disposed on the body, in which the gas permeable vent is in gaseous communication with the reservoir. When connected to a separate vascular access device the blood sampling device collects a blood sample as blood flows into the reservoir from the separate vascular access device and as gases pass out the reservoir via the gas permeable vent. | 01-13-2011 |
| 20100331778 | Passive Reuse Prevention Syringe That Uses A Flange Lock - A syringe assembly includes a syringe barrel having an inside surface defining a chamber, an open proximal end, a distal end, and an outlet; a plunger assembly disposed at least partially within the syringe barrel, including an elongate plunger rod having a locking flange formed thereon; and a plunger head having a distal sealing surface, the plunger rod being engageable with the plunger head such that the plunger rod is adapted to move the plunger head within the chamber of the syringe barrel through an injection cycle; and a flange lock disposed at the open proximal end of the barrel. The flange lock is integral with the open proximal end of the syringe barrel. During the injection cycle, the flange lock engages the locking flange of the plunger rod so as to prevent removal of the plunger rod from the syringe barrel. | 12-30-2010 |
| 20100324503 | CATHETER HOLE HAVING A FLOW BREAKING FEATURE - A peripheral catheter having a catheter tip diffuser for reducing an exit velocity of an infusant within the catheter. Pluralities of diffusion side holes are provided on the tip portion of the catheter. Some examples further include pluralities of annularly arranged, staggered diffusion holes provided on the tip portion of an intravenous catheter to streamline infusant issued from the diffusion holes. An inner surface of each diffusion hole is further angled relative to the inner surface of the catheter lumen such that an infusant within the lumen exits the catheter though the diffusion holes at an angle less than 90°. | 12-23-2010 |
| 20100318040 | Catheter Locking Solution Having Antimicrobial and Anticoagulation Properties - The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine. | 12-16-2010 |
| 20100314796 | Syringe and Removable Needle Assembly Having Binary Attachment Features - A syringe and detachable needle assembly having binary attachment features include an elongate syringe barrel having a longitudinal axis, an open proximal end and an open distal end including a collar. The collar includes the cylindrically shaped sidewall having an inside surface and an outside surface. A needle assembly includes the hub having a body portion including a proximal end, a distal end and a conduit therethrough. A cannula having a distal end, a proximal end and a lumen therethrough is attached to the distal end of the hub so that the lumen is in fluid communication with the chamber. A lug is provided on one of the collar and the hub and a ramp and a rest surface is provided on the other of the collar and the hub. The ramp is oriented at an acute angle with respect to longitudinal axis for guiding the lug during needle assembly attachment, to the rest surface forcing the hub to contact the barrel to form a seal the hub and the barrel. | 12-16-2010 |
| 20100311607 | METHOD FOR RAPID IDENTIFICATION OF MICROORGANISMS - The present invention relates, in general, to probes, methods, and kits used to determine the presence or absence of a microorganism in a sample. The probes, methods, and kits comprise at least one capture probe and/or at least one detector probe. | 12-09-2010 |
| 20100305601 | Contact Activated Lancet Device - A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure. | 12-02-2010 |
| 20100305600 | Contact Activated Lancet Device - A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure. | 12-02-2010 |
| 20100305599 | Contact Activated Lancet Device - A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure. | 12-02-2010 |
| 20100305544 | Intradermal Syringe and Needle Assembly - A device and method for making an injection with a short needle, which includes a needle cannula and a limiter surrounding the needle cannula and includes a skin engaging surface on the limiter. The limiter is moveable from a first position in which an elongate portion of the needle cannula is exposed for access to a medication vial, to a locked second position in which the limiter is not movable from the second position to the first position. In the second position, the needle tip extends beyond the skin engaging surface a distance which is ordinarily unable to access the vial. | 12-02-2010 |
| 20100305519 | CANNULA HAVING AN OVERLAPPING CANNULA FEATURE AND NOTCH FEATURE - A cannula having a notch feature and a cannula feature that at least partially overlap each other is described herein. Generally, the cannula comprises a tubular shaft with a substantially constant outer diameter. The cannula feature comprises at least one surface that extends laterally past the cannula's outer diameter. For instance, the cannula feature may comprise a crimp feature or a welded ferrule feature. The cannula feature further comprises a distal end and a proximal end. Accordingly, a portion, if not all, of the notch feature is disposed between the cannula feature's distal end and proximal end. The cannula may be used in any suitable assembly, including a catheter assembly comprising a needle capture mechanism. | 12-02-2010 |
| 20100298779 | LOW EXTRACTABLE, THERMOPLASTIC SYRINGE AND TIP CAP - A prefilled syringe and syringe assembly having a syringe and a tip cap are produced from materials that do not interfere with the substance contained in the syringe and enable long term storage. The tip cap is made from a blend of a cyclic olefin polymer or copolymer and a thermoplastic elastomer. The thermoplastic elastomer is blended with the cyclic olefin copolymer in an amount so that the normally stiff and hard cyclic olefin copolymer is flexible and resilient to effectively seal and couple to the tip of a prefilled syringe. | 11-25-2010 |
| 20100294663 | METHODS AND DEVICES FOR ISOTACHOPHORESIS APPLICATIONS - The invention relates to an operation mode of electrophoresis, which separates and/or fractionates particles of differentiated electrophoretic mobility. More specifically, the invention relates to isotachophoresis (ITP), including free-flow and capillary isotachophoresis, and provides novel electrophoresis methods, as well as kits and devices for carrying out such methods. | 11-25-2010 |
| 20100292656 | DRUG DELIVERY DEVICE FOR DRUG SUSPENSIONS - A drug delivery device is provided herein, the device including a reservoir for containing a medicament. The medicament includes a suspension of solids in a liquid carrier. The device also includes a needle having a distal end for injection into a patient, a proximal end in communication with the reservoir, and a lumen extending between the distal and proximal ends. A path is defined from the reservoir to the distal end of the needle through the lumen, the path having an inner diameter that decreases in the proximal to distal direction along at least a portion thereof. Advantageously, with the subject invention, a flow path may be defined which provides a more gradual transition in diameter from the reservoir to the distal tip of a needle. In this manner, changes in velocity of the suspension may be less abrupt than in the prior art, thus better maintaining solid particles in the suspension. | 11-18-2010 |
| 20100288694 | Density Phase Separation Device - A mechanical separator for separating a fluid sample into first and second phases within a collection container is disclosed. The mechanical separator may have a separator body having a through-hole defined therein, with the through-hole adapted for allowing fluid to pass therethrough. The separator body includes a float, having a first density, and a ballast, having a second density greater than the first density. A portion of the float is connected to a portion of the ballast. Optionally, the float may include a first extended tab adjacent a first opening of the through-hole and a second extended tab adjacent the second opening of the through-hole. In certain configurations, the separator body also includes an extended tab band disposed about an outer surface of the float. The separator body may also include an engagement band circumferentially disposed about at least a portion of the separator body. | 11-18-2010 |
| 20100288663 | Syringe Assembly - A syringe assembly comprises a syringe barrel having an elongated body defining a chamber for retaining fluid, an open proximal end, a distal end and a frusto-conically shaped tip extending from the distal end and having a passageway therethrough in fluid communication with the chamber. The chamber has an inside diameter of at least 13.5 mm. A stopper is in fluid-tight engagement inside the barrel. An elongated plunger rod extends proximally from the stopper through the open proximal end of the barrel. A flange is positioned at the proximal end of the plunger rod. The flange is shaped and positioned to limit the distal motion of the plunger rod in the barrel by contacting the proximal end of the barrel. A tip cap is releasably connected to the tip for sealing the passageway and the chamber contains injectable liquid. | 11-18-2010 |
| 20100286605 | VALVE FOR MIXING OF SUBSTANCES - A valve is provided herein for permitting mixing of at least two components, the valve including a body configured for slidable liquid tight engagement with an injector or drug cartridge barrel. The body includes a proximal end, a distal end, and a channel extending therebetween, the channel having a proximal portion and a distal portion. A poppet is sealingly and slidably disposed in the channel to selectively move between first and second positions. The poppet includes a proximal end, a distal end, and a fluid channel, the fluid channel being defined in the poppet and extending from an outlet opening located distally of the distal end of the body. With the poppet being in the first position, the poppet defines a liquid tight seal in the channel such that liquid flow through the channel is prevented. With the poppet being in the second position, the fluid channel is in communication with the proximal portion of the channel so as to define a liquid flow path from the proximal portion of the channel to the outlet opening. Advantageously, with the subject invention, a valve is provided which permits controlled separation and mixing of substances in a standard injector or drug cartridge barrel, without any modification required thereto. | 11-11-2010 |
| 20100286380 | PRETREATMENT METHOD FOR EXTRACTION OF NUCLEIC ACID FROM BIOLOGICAL SAMPLES AND KITS THEREFOR - The present invention relates to methods for pretreating biological samples for extraction of nucleic acid therefrom. The present invention employs a combination of at least one protein denaturant with one or more of the following elements to form a reaction mixture for extraction of nucleic acid: (1) at least one aprotic solvent, (2) stepwise heating, and (3) sample dilution. | 11-11-2010 |
| 20100280462 | Luer Slip Connector with Roughened Tip - Medical devices with male luer slip fittings with either a male conical tip having a roughened outer surface or a female luer fitting with a roughened surface and methods for manufacture and use are disclosed. The outer surface of the male conical tip or a surface of the female luer fitting is roughened to increase the force required to remove the male luer fitting from the female luer fitting without causing leakage of the connection. | 11-04-2010 |
| 20100280414 | Protease Inhibitor Sample Collection System - A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent comprises or consists of one or more protease inhibitors. | 11-04-2010 |
| 20100279397 | BIOLOGICAL SPECIMEN COLLECTION AND STORAGE DEVICES - A biological sample containment system and method are provided that include a container for storing the biological sample and an indicator affixed to the container for displaying at least one measured characteristics of the container or sample, wherein measurement of the characteristic is commenced by activation of the indicator. In another embodiment of the invention, a biological sample containment system and method are provided that include a container for storing the biological sample and a colored scale affixed to the container, wherein the colored scale facilitates identification of at least one characteristic of the biological sample. In yet another embodiment of the invention, a biological sample containment system and method are provided that include a container for collecting a biological sample and a label affixed to the container, wherein information relating to the biological sample or container is situated on the label. | 11-04-2010 |
| 20100274190 | Passive Reuse Prevention Syringe That Uses A Tip Lock - Various embodiments of syringe assemblies include a syringe barrel and a substantially conical tip or outlet disposed on the distal end of the barrel. The substantially conical tip includes a locking mechanism that engages an extension of a plunger assembly extending from a distal end of the plunger assembly so as to retain the extension within the substantially conical tip or outlet upon full injection of the contents of the syringe to a patient. According to one embodiment, a plunger head of the plunger assembly is slidably disposed on the extension. According to another embodiment, a separate hub, which holds a needle cannula, is disposed on an outlet at the distal end of the syringe barrel, which contains the locking mechanism. According to a further embodiment, the locking mechanism includes a locking clip disposed within the substantially conical tip of the syringe assembly. | 10-28-2010 |
| 20100273261 | METHODS FOR PRODUCING SYNTHETIC SURFACES THAT MIMIC COLLAGEN COATED SURFACES FOR CELL CULTUE - The present invention discloses methods for producing synthetic surfaces that mimic collagen coated surfaces for cell culture comprising: providing a monomer source comprising one or more organic compounds which are capable of polymerization, wherein at least one organic compound is prolinol; creating a plasma of said monomer source; and contacting at least a portion of a surface with the plasma to provide a plasma polymer coated surface. Advantageously, such methods provide an animal-free, synthetic, chemically defined surface that mimics a collagen coated surface for cell culture. Advantageously, such methods not only reduce the cost and/or issues associated with animal-derived collagen but are also amenable to large scale manufacturing. | 10-28-2010 |
| 20100273156 | SEQUENCES AND METHODS FOR DETECTING INFLUENZA A AND INFLUENZA B VIRUS - Nucleic acid amplification primers and methods for specific detection of influenza A and influenza B nucleic acid targets are disclosed. The primer-target binding sequences are useful for detection of influenza A and influenza B targets in a variety of amplification and hybridization reactions. The oligonucleotide sequences are able to differentiate between influenza A and influenza B strains through specific hybridization to one or the other virus strain, enabling specific detection of the presence of influenza A and/or influenza B in a specimen. | 10-28-2010 |
| 20100262120 | METHOD AND DEVICE FOR CONTROLLING DRUG PHARMACOKINETICS - Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling. | 10-14-2010 |
| 20100262038 | Flashback Blood Collection Needle - A needle assembly includes a transparent or translucent housing with a fluid inlet end, a fluid outlet end, a flashback chamber, and a venting mechanism therebetween. Substantially axially aligned inlet and outlet cannulas extend from the housing and communicate with the chamber. A sealable sleeve covers the external end of the outlet cannula. Relative volumes of the cannulas, the chamber, and the sleeve are selected to provide rapid reliable flashback indicative of venous entry with an internal vent positioned within the housing so as to divide the interior into first and second chambers, with the second chamber being adapted to maintain a negative pressure therein relative to the external environment so as to inhibit leakage of blood from the needle on withdrawal from the patient. | 10-14-2010 |
| 20100255504 | Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates - Chemically-reactive, water-soluble, heterocycle-substituted 7-hydroxycoumarin dyes, their bioconjugates and uses are described. The conjugates derived from reactive heterocycle-substituted 7-hydroxycoumarin dyes are used for analyzing biological compounds. These heterocycle-substituted 7-hydroxycoumarin dyes are particularly useful as fluorescent labels for biopolymer detection reagents, such as antibodies or nucleic acid probes. The dye-antibody conjugates of the invention are particularly useful for analyzing analytes using a flow cytometer equipped with a violet laser as an excitation source due to their strong absorption at 405 nm and high fluorescence quantum yield. | 10-07-2010 |
| 20100252467 | PACKAGING FOR SURGICAL BLADE TIPS - A package for a surgical blade tip is provided herein. The package cooperates with the surgical blade tip to properly retain it and facilitate mounting onto a surgical blade handle. In one aspect, the invention includes a package having a body with a side wall and at least two detents extending inwardly from the side wall. In addition, a surgical blade tip is provided having an adaptor with a blade extending therefrom. The adaptor includes at least two recesses formed therein. The surgical blade tip is disposed in the package with the detents being at least partially inserted into the recesses. Also, the detents are configured to apply a retentive force to the adaptor to retain the adaptor in a first position and configured to deflect with a predetermined amount of torque being applied to the surgical blade tip so as to permit the adaptor to rotate from the first position to a second position where the detents are not inserted into the recesses. Advantageously, with the subject invention, a package may be provided which maintains a blade of a surgical blade tip in spaced relationship so as to minimize contamination thereof. In addition, the interengagement of the detents and the recesses allows for proper retention of the surgical blade tip during mounting onto a surgical blade handle. | 10-07-2010 |
| 20100249821 | Contact Activated Lancet Device - A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure. | 09-30-2010 |
| 20100249714 | SYSTEMS AND METHODS FOR PROVIDING A CONVENTIONAL INTEGRATED CATHETER WITH UNIVERSAL GRIP - A universal gripping surface is provided on an intravenous catheter assembly. The universal gripping surface provides a plurality of surfaces whereby a user may grip the catheter assembly in a desired gripping configuration for improved balance and control of the catheter assembly during insertion of the catheter. Additionally, the universal gripping surface includes a guard feature to prevent a user's unintended contact with various components of the catheter assembly whereby the contact may result in an undesirable “over the bevel” condition. | 09-30-2010 |
| 20100249713 | SYSTEMS AND METHODS FOR PROVIDING A SAFETY INTEGRATED CATHETER WITH UNIVERSAL GRIP - A universal gripping surface is provided on an intravenous catheter assembly. The universal gripping surface provides a plurality of surfaces whereby a user may grip the catheter assembly in a desired gripping configuration for improved balance and control of the catheter assembly during insertion of the catheter. Additionally, the universal gripping surface includes a guard feature to prevent a user's unintended contact with various components of the catheter assembly whereby the contact may result in an undesirable “over the bevel” condition. | 09-30-2010 |
| 20100242993 | Patient fluid line access valve antimicrobial cap/cleaner - Cap and cleaning devices antiseptically maintain patient fluid line access valves to minimize the risk of infection via catheters. The devices have a cap that may contain a dry pad impregnated with an antimicrobial agent. The cap covers the access portion of the access valve when not in use. The devices have a hood that contains a wet pad impregnated with a cleaning solution and, optionally, an antimicrobial agent. The wet pad cleans the access portion of the access valve prior to and optionally, after the access valve is utilized to access the patient fluid line. | 09-30-2010 |
| 20100241087 | CANNULA-TIP SHIELDING MECHANISM - A needle tip shielding mechanism is described herein. The shielding mechanism comprises an outer housing, an inner housing, and a needle having a needle feature. Generally, the outer housing comprises at least one adapter-interlock feature. Moreover, the inner housing comprises a needle-feature capture mechanism, such as a washer feature, and a needle-tip capture mechanism, such as duckbilled tip barrier. In some cases, the inner housing is slidably moveable within the outer housing. In such cases, the inner housing is movable between a first position that biases the adapter-interlock feature into an engaged position and a second position that allows the adapter-interlock feature to move to an unengaged position. This ability to bias the interlock feature in the engaged position and to allow the interlock feature to move to the unengaged position allows the shielding mechanism to be selectively coupled to and released from an interlock-feature mating component within a catheter adapter. | 09-23-2010 |
| 20100240021 | METHOD AND APPARATUS FOR AUTOMATED STAINING OF BIOLOGICAL MATERIALS - Various embodiments of the present invention provide methods and systems for optimally staining biological samples for analysis. In one embodiment, images of a sample are recorded before and after the application of a staining reagent and a decolorization reagent. A difference image is then generated based at least in part on a comparison of the images of the sample recorded before and after the application of the staining and decolorization reagents. Application parameters of the staining and decolorization reagents are then corrected based at least in part on the difference image such that the reagents may be optimally reapplied to generate a final image of the sample that may enable a user to better differentiate at least one target of interest in the sample. In one example, embodiments of the present invention allow for the generation of images that show only Gram-positive bacteria or only Gram-negative bacteria. | 09-23-2010 |
| 20100227343 | GLYCODELIN MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER - Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention. | 09-09-2010 |
| 20100227335 | MATRIX METALLOPROTEINASE-7 (MMP-7) MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER - Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MMP-7. Monoclonal antibodies having the binding characteristics of an MMP-7 antibody of the invention and monoclonal antibodies that bind to an MMP-7 epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce an MMP-7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed MMP-7 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MMP-7 epitope of a disclosed monoclonal MMP-7 antibody and methods of using these polypeptides in the production of MMP-7 antibodies are also encompassed by the present invention. | 09-09-2010 |
| 20100222746 | BI-DIRECTIONAL CANNULA FEATURE CAPTURE MECHANISM - A bi-directional cannula feature capture mechanism is described herein. Generally, the capture mechanism comprises an inner housing, an outer housing, and a cannula. The inner housing comprises a proximal and a distal cannula feature mating component. The outer housing is adapted to slidably receive the inner housing in a proximal direction. Additionally, the cannula extends through the inner housing and the cannula's feature has a proximal engagement and a distal engagement. The proximal and distal engagements are respectively configured to irreversibly engage the proximal and distal cannula feature mating components when the cannula tip is moved into a shielded position. | 09-02-2010 |
| 20100222745 | BI-DIRECTIONALLY ENGAGEABLE CANNULA CRIMP FEATURE - A cannula, such as an IV catheter introducer needle, that has a bi-directionally engageable crimp feature is described herein. The feature comprises a maximum outer diameter that is greater than an outer diameter of the cannula. Additionally, the feature comprises a proximal side and a distal side. The larger outer diameter of the proximal side can act as a proximal engagement that prevents the cannula from being entirely extracted in a proximal direction from a cannula shield. The distal side of the feature can comprise a notch that acts a distal engagement, which prevents the cannula from reemerging distally from the shield, once the cannula has been pulled into the shield. The notch can include an engagement surface that extends laterally past the cannula's outer diameter. The engagement surface can be configured to run substantially perpendicular to the cannula's longitudinal axis. | 09-02-2010 |
| 20100221751 | METHOD OF SCREENING ENDOTHELIAL CELLS FOR ANGIOGENIC CAPABILITY - Provided is a method of screening a primary endothelial cell population for angiogenesis capability comprising: (a) measuring the percentage of cells that are positive for VEGF R2 and CD34, the level of VEGF R2, or measuring the VEGF R2 to VEGF R1 ratio in the population; and (b) selecting those populations where the measured percentage or the measured ratio is over a threshold value. | 09-02-2010 |
| 20100217229 | BUBBLE FREE-SELF PRIMED IV SET - A bubble free, self-priming IV set for use in the administration of liquids that includes a drip chamber comprising a chamber inlet and a chamber outlet, a bubble isolation device disposed within the drip chamber that prevents air bubbles from exiting the chamber outlet, a tube having an inlet end coupled to the chamber outlet of the drip chamber and an outlet end, and an end plug that includes an air vent. The end plug may be coupled to the outlet end of the tube and is a flow restrictor so that when a liquid is moving through the tube, the velocity of the liquid flow is controlled such that the front of the liquid does not trap bubbles in the tube. | 08-26-2010 |
| 20100217206 | Luer-Snap Connection and Luer-Snap Syringe - Syringes having a snap-fit mechanism for attaching a needle hub to a syringe barrel in a snap-fit relationship and packaged medical device comprising a syringe with a snap-fit mechanism and a needle hub mare provided. An exemplary syringe includes a barrel with a collar and a rotatable arm which allows connection of a needle hub to the barrel in a snap-fit relationship. Additional features of the collar and rotatable arm may also permit disconnection of the needle hub from the barrel without the use of relative rotation of the needle hub and barrel. In a specific configuration, the syringe utilizes a torsional snap-fit element to connect the needle hub to the barrel in a snap-fit rotation. In a more specific configuration, the syringe utilizes a collar with differing interior surfaces which permit snap-fit assembly and disassembly of the needle and the barrel. | 08-26-2010 |
| 20100204660 | SYSTEMS AND METHODS FOR PROVIDING A FLOW CONTROL VALVE FOR A MEDICAL DEVICE - The present invention relates generally to a vascular access device having a septum positioned within a lumen of the device, the device further having a pusher for providing a fluid pathway through the septum. In particular, the present invention relates to systems and methods for improving flow of a fluid through the access device, while minimizing stagnation of fluids within the device. These systems and methods include various modified fluid pathways and interactions between the vascular access device body, the septum and the pusher. | 08-12-2010 |
| 20100204648 | SYSTEMS AND METHODS FOR PROVIDING A FLUSHABLE CATHETER ASSEMBLY - A flushable catheter assembly having features to enable selective activation of fluid flow through the catheter assembly is disclosed herein. A septum is placed within the catheter adapter of the catheter assembly and includes a pathway that is closed prior to being biased open via a septum activator also positioned within the catheter adapter. A plurality of air vent channels is interposed between the septum and the inner surface of the catheter adapter to permit “flashback” of blood during insertion of the catheter into a patient. The septum activator is advanced through the pathway of the septum as a coupler is attached to a proximal opening of the catheter adapter. | 08-12-2010 |
| 20100204553 | ARTERIAL FLASHBACK CONFIRMATION CHAMBER - The present invention relates to an arterial flashback confirmation chamber. Generally, the confirmation chamber is used with a vascular access device to allow an operator to see active arterial flashback confirmation for a period of time that is long enough to permit the operator to properly place the cannula of the vascular access device within a patient's artery. In some instances, the confirmation chamber comprises a flashback compartment, means for prolonging active arterial flashback confirmation, and a vent. Some examples of suitable prolonging means comprise a flashback compartment with a relatively large internal volume, circuitous tubing, an absorbent material, an orifice and/or tubing with a smaller inner diameter than the inner diameter of the cannula, and the like. Where the vascular access device comprises a catheter assembly, the catheter assembly and confirmation camber are optionally used with a guide wire and/or a blood sensor. | 08-12-2010 |
| 20100200706 | SYSTEMS AND METHODS FOR ORGANIZING AND PRIMING AN IV ADMINISTRATION SET - A device having a surface on which an intravenous administration set is organized and temporarily retained in a desired configuration to prevent undesirable tangling during setup of the set. The device further includes a plurality of clips to retain various components of the intravenous administration set in a desired orientation to improve priming of the components. The intravenous administration set is released from the device by pulling a terminal end of the set in a direction away from the device. | 08-12-2010 |
| 20100191189 | Catheter and Introducer Needle Assembly with Needle Shield - A catheter and introducer needle assembly with a needle shield is provided. The needle shield includes a means for preventing unwanted distal movement of the needle once the needle has been withdrawn into the needle shield. The needle shield also includes a means for connecting the needle shield to the catheter hub until the sharp distal tip of the introducer needle has been withdrawn into the needle shield. Thus, when the distal end of the introducer needle extends from the distal portion of the needle shield, the needle shield is connected to the catheter hub and when the sharp distal end of the introducer needle is withdrawn into the needle shield, the needle shield is disconnected from the catheter hub. At that point, the sharp needle tip is secured within the needle shield. | 07-29-2010 |
| 20100191188 | Catheter and Introducer Needle Assembly with Needle Shield - A catheter and introducer needle assembly with a needle shield is provided. The needle shield includes a means for preventing unwanted distal movement of the needle once the needle has been withdrawn into the needle shield. The needle shield also includes a means for connecting the needle shield to the catheter hub until the sharp distal tip of the introducer needle has been withdrawn into the needle shield. Thus, when the distal end of the introducer needle extends from the distal portion of the needle shield, the needle shield is connected to the catheter hub and when the sharp distal end of the introducer needle is withdrawn into the needle shield, the needle shield is disconnected from the catheter hub. At that point, the sharp needle tip is secured within the needle shield. | 07-29-2010 |
| 20100184066 | ASSAY FOR TRICHOMONAS VAGINALIS BY AMPLIFICATION AND DETECTION OF TRICHOMONAS VAGINALIS AP65-1 GENE - A region of the | 07-22-2010 |
| 20100179489 | Needleless luer access connector - A needleless luer access connector is disclosed having a septum disposed in a housing. The septum has a proximal portion with a cross section, a medial portion with a cross section smaller than the cross section of the proximal portion, and a distal portion. A longitudinal slit extends through the septum from the proximal portion to the distal portion. The septum and housing are designed so that septum will not be rotated or removed from the housing when the connector is accessed by a male luer taper. In addition, the septum and housing are designed to bias the slit at the distal portion closed and so a male luer connector does not have to extend completely through the distal portion to open the slit at the distal portion. Finally, the septum and housing are designed to minimize the amount of dead space in the connector when accessed with a male luer taper. | 07-15-2010 |
| 20100177305 | CUVETTE FOR FLOW-TYPE PARTICLE ANALYZER - The present invention provides an optical cuvette for use in a flow-type particle analyzer, wherein the cuvette includes a removable flow tube containing a flow channel oriented coaxially. | 07-15-2010 |
| 20100168675 | ONE PIECE LOW DRAG SEPTUM - A one-piece low drag septum is provided for preventing escape of fluid from an introducer needle during removal of such a needle from a catheter and introducer needle assembly. The septum generally includes a distal portion, a proximal portion, a cavity portion, and a longitudinal axis. The distal portion acts as a primary seal to prevent escape of blood from the catheter into the assembly and is generally positioned furthest away from the user of the apparatus and nearest the patient. The cavity portion reduces friction placed on the introducer needle. The proximal portion of the septum acts as a secondary seal to prevent escape of material from the cavity, seals the cavity, and wipes the needle as it is being withdrawn from the catheter assembly. | 07-01-2010 |
| 20100168614 | Needle Assembly - A blood collection set including a non-patient needle assembly interconnected with an intravenous needle assembly through tubing is provided. The non-patient needle assembly includes a hub assembly adapted for mounting with a blood collection set, and an internal blunting member including a blunted tip. The non-patient needle assembly further includes an external cannula concentric with the internal blunting member and including a non-patient puncture tip adjacent the blunted tip. The external cannula is axially displaceable with respect to the hub assembly between a first retracted position in which the non-patient puncture tip extends beyond the blunted tip and a second activated position in which blunted tip extends beyond the non-patient puncture tip. | 07-01-2010 |
| 20100167417 | LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES - Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus. | 07-01-2010 |
| 20100160135 | Density Phase Separation Device - A mechanical separator for separating a fluid sample into first and second phases is disclosed. The mechanical separator includes a float, a ballast assembly longitudinally moveable with respect to the float, and a bellows structure. The bellows structure includes a first end, a second end, and a deformable bellows therebetween. The float is attached to a portion of the first end of the bellows structure, and the ballast is attached to a portion of the second end of the bellows structure. The attached float and bellows structure includes a releaseable interference engagement therebetween. The float has a first density, and the ballast has a second density that is greater than the first density of the float. | 06-24-2010 |
| 20100155343 | Density Phase Separation Device - A mechanical separator for separating a fluid sample into first and second phases is disclosed. The mechanical separator includes a float having a first portion and a second portion, a ballast circumferentially disposed about a section of the float, and a deformable bellows defining an open passageway extending between a first end and a second end. The ballast is longitudinally moveable with respect to the float and engaged with the deformable bellows between the first end and the second end. At least a portion of the float is transitionable from a restraint position to a sealed position through the first end of the bellows. The first portion of the float can be positioned within the interior of the deformable bellows in the restraint position, and the first portion of the float can be positioned at an exterior location longitudinally displaced from the deformable bellows in the sealed position. | 06-24-2010 |
| 20100155319 | Density Phase Separation Device - A mechanical separator for separating a fluid sample into first and second phases is disclosed. The mechanical separator includes a float having a passageway extending between first and second ends thereof with a pierceable head enclosing the first end of the float, a ballast longitudinally moveable with respect to the float, and a bellows extending between a portion of the float and a portion of the ballast. The bellows is adapted for deformation upon longitudinal movement of the float and the ballast, with the bellows isolated from the pierceable head. The float has a first density and the ballast has a second density greater than the first density. The bellows is structured for sealing engagement with a cylindrical wall of a tube, and the pierceable head is structured for application of a puncture tip therethrough. The separation device is suitable for use with a standard medical collection tube. | 06-24-2010 |
| 20100147843 | CONTAINER ASSEMBLY AND METHOD FOR MAKING ASSEMBLY - The present invention is directed to a method of assembling a container including an inner tube contained within an outer tube. The method includes providing an outer tube, providing a spacing element adjacent the open top of the outer tube and inserting an inner tube within the outer tube. The spacing element provides for venting of air from between the inner and outer tubes through the top of the container during assembly thereof. | 06-17-2010 |
| 20100145226 | Flashback Blood Collection Needle - A needle assembly includes a transparent or translucent housing with a fluid inlet end, a fluid outlet end, a flashback chamber and a venting mechanism therebetween. Substantially axially aligned inlet and outlet cannulas extend from the housing and communicate with the chamber. A sealable sleeve covers the external end of the outlet cannula. Relative volumes of the cannulas, the chamber and the sleeve are selected to provide rapid reliable flashback indicative of venous entry with an internal vent plug over the outlet of the flashback chamber to inhibit leakage of blood, from the needle on withdrawal from the patient. | 06-10-2010 |
| 20100137834 | SYRINGE ASSEMBLY - A syringe assembly comprises a syringe barrel having an elongated body defining a chamber for retaining fluid, an open proximal end, a distal end and a frusto-conically shaped tip extending from the distal end and having a passageway therethrough in fluid communication with the chamber. The chamber has an inside diameter of at least 13.5 mm. A stopper is in fluid-tight engagement inside the barrel. An elongated plunger rod extends proximally from the stopper through the open proximal end of the barrel. A flange is positioned at the proximal end of the plunger rod. The flange is shaped and positioned to limit the distal motion of the plunger rod in the barrel by contacting the proximal end of the barrel. A tip cap is releasably connected to the tip for sealing the passageway and the chamber contains injectable liquid. | 06-03-2010 |
| 20100137472 | ANTIMICROBIAL COATING COMPOSITIONS - Antimicrobial compositions and methods are disclosed. The antimicrobial compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. In one aspect, the invention relates to a mild solvent coating using acrylate-type mild solution coating. These compositions include rheological modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include cetyl pyridium chloride, cetrimide, alexidine, chlorexidine diacetate, benzalkonium chloride, and o-phthalaldehyde. Additionally, the compositions comprise one or more suitable mild solvents, such as a low molecular weight alcohol, alkane, ketone, and combinations thereof. | 06-03-2010 |
| 20100137379 | ANTIMICROBIAL LUBRICANT COMPOSITIONS - Antimicrobial lubricant compositions are disclosed. The antimicrobial lubricant compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. The compositions include an oil lubricant. Representative lubricants may include polydimethyl siloxane, trifluoropropyl copolymer polysiloxane, and a copolymer of dimethylsiloxane and trifluoropropylmethylsiloxane. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include of aldehydes, anilides, biguanides, bis-phenols, quaternary ammonium compounds, cetyl pyridium chloride, cetrimide, alexidine, chlorhexidine diacetate, benzalkonium chloride, and o-phthalaldehyde. | 06-03-2010 |
| 20100136604 | IN VITRO TUMOR ANGIOGENESIS MODEL - Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells. | 06-03-2010 |
| 20100136209 | SYSTEMS AND METHODS FOR APPLYING AN ANTIMICROBIAL COATING TO A MEDICAL DEVICE - Methods for applying an antimicrobial coating to a medical device is disclosed. Generally, the methods comprise providing a medical device, dispensing an antimicrobial coating onto the device, flushing excess coating from the device, and curing the coating onto the device. In one aspect, the coating includes a UV-curable, antimicrobial composition. In this aspect, the medical device can be coated and the coating can be cured with UV light in a manner of seconds. In another aspect, the coating includes an antimicrobial solution that contains an acrylate-type polymer or copolymer. In this aspect, the medical device can be coated and the coating can be heat-cured in a manner of minutes. Both the UV-curable composition and the antimicrobial solution can also include rheological modifiers, as necessary. Additionally, the compositions include one or more antimicrobial agents, which may be selected from a wide array of agents. | 06-03-2010 |
| 20100135949 | ANTIMICROBIAL COMPOSITIONS - Antimicrobial compositions and methods are disclosed. The antimicrobial compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. In one aspect the invention relates a UV curable antimicrobial coating comprising a UV curable composition comprising an oligomer, a momoner, and a photoinitiator which are together capable of forming a UV curable polymer composition. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include cetyl pyridium chloride, cetrimide, alexidine, chlorexidine diacetate, benzalkonium chloride, and o-phthalaldehyde. | 06-03-2010 |
| 20100120059 | INSTRUMENT SETUP SYSTEM FOR A FLUORESCENCE ANALYZER - The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry. | 05-13-2010 |
| 20100105059 | ASSAY FOR CHLAMYDIA TRACHOMATIS BY AMPLIFICATION AND DETECTION OF CHLAMYDIA TRACHOMATIS PMPA GENE - A region of the | 04-29-2010 |
| 20100094171 | BLOOD COLLECTION SET WITH VENTING MECHANISM - The blood collection set includes an IV needle assembly, a length of flexible plastic tubing extending from the IV needle assembly and a non-patient needle assembly. The set is formed with a venting mechanism that permits an outflow of air, while blocking an outflow of blood or other fluids. Thus, the venting mechanism enables air that had existed in interior portions of the blood collection set to be vented allowing for greater flash visualization on venous entry, and avoids the need to employ a discard tube. | 04-15-2010 |
| 20100082055 | LANCER - A lancer device that enables a user to draw blood from a patient and discard the used lancet without touching it. The device also has an adjustable tip for selecting the depth of stylet penetration into the patient and a triggering mechanism that utilizes a yoke latch and a leaf spring to discharge the lancet. The lancer also has a dampening feature to reduce vibrations when the lancet is moving. | 04-01-2010 |
| 20100069840 | Syringe Assembly Having Disabling Mechanism - A syringe assembly having passive disabling structure includes a barrel and a plunger rod assembly. The plunger rod assembly includes a plunger rod and a stopper connected by an indexing locking element. The number of strokes of the syringe plunger before the stopper is locked into the barrel rendering the syringe assembly unusable is determined by the number of detents on the plunger rod and stopper which engage the locking mechanism. Upon completion of the final delivery stroke, any attempt to withdraw the plunger rod from the barrel will cause the locking element to engage the barrel and trap the stopper in the barrel preventing further use of the syringe. | 03-18-2010 |
| 20100067024 | LABEL PROCESSOR AND METHOD RELATING THERETO - A system and method are provided for providing information on at least one container for storing a biological sample, including: a holder configured to hold at least one biological sample container and a receiver configured to receive information relating to at least one of the container or the biological sample as well as data relating to at least one instruction for printing the information. The system and method further include a printer configured to print the information in accordance with the at least one instruction. In one embodiment, the printer is configured to print the information directly on the container. In another embodiment, the system and method further include an applicator configured to apply a label on the container and the printer is configured to print the information on the label. In another embodiment, the system and method include a detector configured to detect whether the container contains the biological sample and a processor configured to determine the manner for printing the information. In this embodiment, the determination is based, at least in part, on whether container contains the biological sample. | 03-18-2010 |
| 20100057004 | Extravascular System In-Line Venting - An extravascular system may include a fluid path and a gas vent in communication with the fluid path. A method of venting a medical device may include providing a closed extravascular system having a fluid path, providing a gas vent in communication with the fluid path, venting gas from the extravascular system through the gas vent, and maintaining closure of the extravascular system during and after venting. | 03-04-2010 |
| 20100055708 | Assay for Chlamydia trachomatis by amplification and detection of Chlamydia trachomatis cytotoxin gene - A region of the | 03-04-2010 |
| 20100049143 | Detachable Needle Syringe Having Reduced Dead Space - A syringe and detachable needle assembly having reduced dead space features includes an elongate syringe barrel having open distal end including a collar and a distally facing annular surface projecting inwardly from the collar. A needle assembly includes a hub having a proximally facing annular surface and an outwardly projecting annular sealing ring positioned distally from the surface. The needle assembly also includes a cannula having a lumen therethrough connected to the distal end of the hub. Structure is provided for engaging the hub to the barrel resulting in the annular surface of the barrel contacting the annular surface of the hub to form a primary seal between said barrel and said hub and the annular sealing ring contacting the collar to form a secondary seal between the barrel and the hub. | 02-25-2010 |
| 20100042048 | Luer Integrated Air Venting System - A vascular access device incorporating a luer integrated air venting system, including a female luer fitting having a venting mechanism located within the female luer fitting and a fluid diverter located within the vent mechanism. The venting mechanism providing communication between said vascular access device and ambient surroundings until contact with a fluid. | 02-18-2010 |
