AUTOGENOMICS, INC. Patent applications |
Patent application number | Title | Published |
20110086771 | Biochip - Improved biochips comprise a matrix layer coupled to a substrate, wherein the matrix layer includes a plurality of ligands in a plurality of predetermined positions and wherein ligands bind to an anti-ligand disposed in a sample fluid. Preferred matrix layers are multi-functional matrix layers that reduce autofluorescence, incident-light-absorption, charge-effects, and/or surface unevenness of the substrate, and contemplated biochips may comprise additional matrix layers. Contemplated biochips may be useful in detection and/or quantification of various anti-ligands, including polypeptides, polynucleotides, carbohydrates, pharmacologically active molecules, bacterial or eukaryotic cells, and/or viruses. | 04-14-2011 |
20110046001 | Multiplex Assay for Respiratory Viruses - A method of detecting the presence of a plurality of respiratory viruses using a multiplexed diagnostic assay is disclosed. The method provides a plurality of oligonucleotides that each is specific for a specific respiratory virus. A multiplex PCR is run using the oligonucleotides, which produces double-stranded products. The method also provides a plurality of extension oligonucleotides that each is specific for a specific double-stranded product. Each extension oligonucleotide also has a distinct second portion having a unique sequence. A primer extension reaction is run using the extension oligonucleotides, which produces single-stranded products. The single-stranded products are hybridized to a solid carrier. | 02-24-2011 |
20090233272 | Multiplexed Nucleic Acid Analysis with High Specificity - A test kit and method includes amplification and extension primers that are selected to allow multiplex PCR and extension at increased specificity. Preferably, the extension primers include a tag that hybridizes with a capture probe on a biochip, wherein the tag is distinct from the target nucleic acid sequence to be analyzed. Further preferred kits include a biochip and various instructions. | 09-17-2009 |
20080311568 | Compositions and Methods for Nucleic Acid Analysis of Sequences with Insertions or Deletions - Contemplated methods and kits include a plurality of single stranded oligonucleotides that comprise a discriminating sequence that is encompassed on one end by a label and on the other end by a unique tag sequence. In one preferred aspect, the discriminating sequence is an RNA repeat unit, forms a heteroduplex with a complementary DNA repeat unit of the target nucleic acid, and the discriminating agent is RNaseH. Using such systems, the number of repeat units can be simply identified by hydrolysis of the discriminating sequence where such sequence is adjacent to a predetermined number of DNA repeat units in the single stranded oligonucleotide. | 12-18-2008 |