| ASAHI KASEI MEDICAL CO., LTD. Patent applications |
| Patent application number | Title | Published |
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| 20120123002 | METHOD FOR PURIFICATION OF ANTIBODY USING POROUS MEMBRANE HAVING AMINO GROUP AND ALKYL GROUP BOTH BOUND TO GRAFT CHAIN IMMOBILIZED ON POROUS SUBSTRATE - A method is disclosed for purifying an antibody monomer, comprising providing a porous membrane comprising a hydrophobic porous substrate, a hydrophilic molecular chain of a different material from that of the porous substrate, immobilized on the surface of pores of the porous substrate, and a side chain of the molecular chain, containing a nitrogen atom to which one to three alkyl groups each having two or three carbon atoms are bonded; passing an antibody solution containing antibody aggregates of dimers or higher-order multimers through the porous membrane to adsorb the antibody aggregates to the porous membrane; and recovering the purified antibody monomer in the passed solution. | 05-17-2012 |
| 20120077963 | METHOD FOR REMOVING VIRUSES FROM HIGH CONCENTRATION MONOCLONAL ANTIBODY SOLUTION - An object of the present invention is to provide a method for removing even small viruses from a high concentration monoclonal antibody solution using a membrane, and thus for recovering the antibody within a short time at high yield in the form of a filtrate. The present invention provides a method for producing a preparation containing a monoclonal antibody, which comprises a step of removing viruses by filtering viruses in a monoclonal antibody solution using a virus-removing membrane, wherein
| 03-29-2012 |
| 20120067811 | BLOOD PROCESSING FILTER AND THE METHOD FOR MANUFACTURING THE SAME - This invention relates to a blood processing filter including a band-shaped first seal part that seals an inlet-side flexible container of the blood processing filter and a filter element of the blood processing filter so as to surround an inlet port, and an annular second seal part that seals at least the inlet-side flexible container and an outlet-side flexible container and is formed surrounding the first seal part at a position that is closer to an outer edge than the first seal part. A valley part corresponding to the first seal part is provided on an outlet side of the filter element. An outlet opening that communicates with an inside of the outlet-side flexible container is formed in the outlet port. At least one portion of the outlet opening is arranged so as to overlap with the valley part. | 03-22-2012 |
| 20120067810 | BLOOD PROCESSING FILTER AND THE METHOD FOR MANUFACTURING THE SAME - This invention relates to a blood processing filter comprising a sheet-like filter element, an inlet-side flexible container and an outlet-side flexible container that sandwich the filter element and are sealed thereto, an inlet port provided in the inlet-side flexible container for accepting blood before being processed by the filter element, and an outlet port provided in the outlet-side flexible container for discharging blood after being processed by the filter element. The blood processing filter also includes a flow channel securing sheet arranged between the filter element and the outlet-side flexible container. A flow channel hole through which blood processed by the filter element passes is formed in the flow channel securing sheet. The outlet port is provided so as to be capable of communicating with the flow channel hole. | 03-22-2012 |
| 20110240549 | FILTER FOR PROCESSING BLOOD - A filter for processing blood that comprises a flexible container having an inlet and an outlet for blood, and a sheet-like blood processing filter material situated in such a manner so as to partition the inside of the container into an inlet side and an outlet side, wherein the flexible container comprises a container body which houses the blood processing filter material and an outlet port that forms the outlet, and the outlet port has a protrusion that protrudes from the container body into the inside of the container body, the protrusion having a plurality of fluid channel inlets formed at locations that are not in contact with the blood processing filter material. | 10-06-2011 |
| 20110210067 | USE OF POROUS HOLLOW-FIBER MEMBRANE FOR PRODUCING CLARIFIED BIOMEDICAL CULTURE MEDIUM - Use of a porous hollow fiber membrane for producing a clarified biomedical culture medium by a method including a filtration step of distributing a biomedical culture medium over the porous hollow fiber membrane, a tube wall of the hollow fiber membrane being constituted of a blend of a hydrophobic polymer and polyvinylpyrrolidone. A content of the polyvinylpyrrolidone is not lower than 0.2% by mass and not higher than 3% by mass relative to a total mass of the porous hollow fiber membrane, and, when the tube wall is divided in a membrane-thickness direction equally into three regions, a content of the polyvinylpyrrolidone in an outer circumferential region including an outer face is higher than a content of the polyvinylpyrrolidone in an inner circumferential region including an inner face, and an average pore size in the inner face is larger than an average pore size in the outer face. | 09-01-2011 |
| 20110166326 | FILTRATION METHOD - Provided is a filtration method for the step of removing viruses in a process of producing a protein preparation during which an intermediate protein preparation with a high protein concentration flows at high pressure to a virus removal filter. The filtration method employs a virus removal filter which has a close fitting nozzle of which the inlet at least has a pressure resistance of 600 kPa or more, and an effective area of the virus removal membrane of at least 0.0001 m | 07-07-2011 |
| 20110031191 | FILTER MATERIAL FOR REMOVING AGGREGATES AND METHOD OF FILTERING BLOOD PRODUCT - An aggregate-removing filter material efficiently removes aggregates that are contained in a blood product for transfusion and may cause transfusion reactions without clogging, and exhibits excellent quality stability, and a blood product filtration method uses a filter apparatus that includes the aggregate-removing filter material and a leukocyte-removing filter material. The aggregate-removing filter material includes short fibers having a fineness of 0.7 to 4.0 dtex and a fiber length of 1 to 80 mm, and a ground fabric that includes long fibers, a fiber axis of the long fibers being oriented in a planar direction of the ground fabric, the short fibers being entangled with the ground fabric so that the aggregate-removing filter material has a total weight per unit area of 10 to 80 g/m | 02-10-2011 |
| 20100096328 | METHOD OF TESTING INTEGRITY OF MICROPOROUS MEMBRANE - [Problem] An object of the present invention is to provide a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution. | 04-22-2010 |
| 20100062412 | METHOD OF REMOVING ABNORMAL PRION PROTEIN FROM BLOOD PRODUCTS - Provided are a method of conveniently and efficiently removing abnormal prion protein from a blood product and a method of removing leukocyte simultaneously with abnormal prion protein. The method of removing an abnormal prion protein from a blood product includes filtering the blood product through a filter filled with a carrier coated with a polymer, which is composed of three units including 20 mol % or more and 40 mol % or less of a unit originating from a hydrophobic polymerizable monomer, 5 mol % or more and 13 mol % or less of a unit originating from a polymerizable monomer containing a basic nitrogen-containing part, and a unit originating from a polymerizable monomer containing a protonic neutral hydrophilic part as the balance, and then recovering the filtered blood product. | 03-11-2010 |
| 20080260710 | Method for Suppressing Surgical Site Infection and Column to be Used for the Method - An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject. The present invention also provides a column for blood circulation which is filled with a carrier having affinity for leukocytes comprising neutrophils, which is used for suppressing a surgical site infection during or within 24 hours after surgical operation on a digestive system organ. | 10-23-2008 |
| 20080237127 | Polysulfone Hemodialyzer - An object of the present invention is to provide a polysulfone hemodialyzer with large membrane area that exhibits an unprecedented high dialytic performance over a wide molecular weight range from urea to β | 10-02-2008 |
