| ART ADVANCED RESEARCH TECHNOLOGIES INC. Patent applications |
| Patent application number | Title | Published |
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| 20120025101 | METHOD OF DECOMPOSING CONSTITUENTS OF A TEST SAMPLE AND ESTIMATING FLUORESCENCE LIFETIME - The present invention relates to a method of decomposition of a test sample into constituents thereof. The method proceeds by optically imaging the test sample to obtain a corresponding unknown time-domain resolved signal and decomposes the unknown time-domain resolved signal by comparing the unknown time-domain resolved signal with time-domain resolved reference signals. Furthermore, the method allows the determination of the presence or absence of constituents. Relative quantities may also be determined if sample material properties are known or taken into account. Lifetime decay of the constituents may also be estimated by handling effect of light diffusion in the test sample as time decay. | 02-02-2012 |
| 20110133064 | TIME-DOMAIN METHOD AND APPARATUS FOR DETERMINING THE DEPTH AND CONCENTRATION OF A FLUOROPHORE IN A TURBID MEDIUM - Methods and apparatuses for determining the depth and concentration of fluorophores in a turbid medium are disclosed. The method advantageously provides for a rapid estimation of the depth of the flurophore using characteristics of a temporal point spread function. The concentration of the flurophore can be determined using the method of the present invention by combining a calculated depth of the flurophore with a measurement of the intensity of the emitted fluorescence. The intensity can be accurately measured by the apparatus disclosed herein which combine back-reflection and trans-illumination geometries for the source of light injecting and detection. | 06-09-2011 |
| 20100310181 | REGISTRATION OF OPTICAL IMAGES OF TURBID MEDIA - A co-registration system provides a means for spatially warping an optical image of an object with another images of a similar object. The optical image may be a scatter image, and the second image may be the same type of image modality, or may be different. The co-registration may use landmarks selected by a user, or may make use of contour information derived from the images. The system may also include processing of three-dimensional volume data in the form of sets of two-dimensional slices for co-registration. | 12-09-2010 |
| 20090216457 | METHOD FOR IMPROVING FLUORESCENCE IMAGE CONTRAST - There is provided an improved method for enhancing fluorescence images of an object, such as a biological tissue, by selectively eliminating or reducing unwanted fluorescence from fluorophores other than the fluorophore of interest. The method is based on the measurement of the lifetime of fluorophores while preserving information related to the fluorescence intensity of the fluorophore of interest. | 08-27-2009 |
| 20090184259 | METHOD OF DECOMPOSING CONSTITUENTS OF A TEST SAMPLE AND ESTIMATING FLUORESCENCE LIFETIME - The present invention relates to a method of decomposition of a test sample into constituents thereof. The method proceeds by optically imaging the test sample to obtain a corresponding unknown time-domain resolved signal and decomposes the unknown time-domain resolved signal by comparing the unknown time-domain resolved signal with time-domain resolved reference signals. Furthermore, the method allows the determination of the presence or absence of constituents. Relative quantities may also be determined if sample material properties are known or taken into account. Lifetime decay of the constituents may also be estimated by handling effect of light diffusion in the test sample as time decay. | 07-23-2009 |
| 20090103096 | METHOD FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA - There is provided a method for improving contrast and resolution of an optical image of an object obtained by time-resolved techniques such as Time Domain (TD) and Frequency Domain (FD). The method comprises obtaining a Temporal Point Spread Function (TPSF), and determining optical properties of volumes of interest (VOI), each volume being defined by an ensemble of equiprobable effective photon paths corresponding to a time point or time gate of the TPSF. | 04-23-2009 |
| 20090080723 | DIFFUSE OPTICAL IMAGING CORRECTED FOR BOUNDARY EFFECTS - A method of optically imaging an object includes the determination of a source point and a destination point within the object. Planar boundaries are selected that approximate a geometrical shape of the object, and virtual sources are found using a reflection of the original source through the boundaries. Subsequent reflections of the added sources may be used to find higher order sources. Contributions to an optical transfer function from each of the added sources are added to determine a cumulative optical transfer function until a convergence limit is reached. The resulting optical transfer function is more accurate than the original in that it takes boundary phenomena into consideration. | 03-26-2009 |
| 20090005692 | Optical Imaging Method For Tissue Characterization - There is provided a method for detecting and characterizing abnormalities within biological tissues. The method involves the characterization of the optical properties of the tissue to derive relative values of physiological properties between normal and suspicious regions of the tissue. In some aspects of the invention optical imaging and other imaging modalities are combined to detect and identify a disease state of the tissue. | 01-01-2009 |
| 20080312879 | FLUORESCENCE TOMOGRAPHY USING LINE-BY-LINE FORWARD MODEL - A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in which a time resolved detector detects the excitation wavelength and generates temporal point spread functions from which the coefficient values are found. Alternatively, the coefficient values may be determined by calculating them from a dataset containing a spatial distribution of absorption and reduced scattering coefficients in a volume of interest. The fluorescence detection may be continuous wave, time resolved, or a combination of the two. An estimator uses a detected fluorescence signal and an estimated fluorescence signal to estimate the image values. | 12-18-2008 |
| 20080260647 | Method for Fluorescence Tomographic Imaging - There is provided a method for determining the concentration of a fluorophore in a medium using moments of order k of the fluorescence signal. The method allows higher fidelity 3-dimensional reconstructions of the fluorophore in the medium. The method can be applied in imaging of fluorophores in biological tissues. | 10-23-2008 |
| 20080260220 | REGISTRATION OF OPTICAL IMAGES OF SMALL ANIMALS - A method for registering a first imaging dataset of a small animal with a second imaging dataset of the animal includes defining a contour of the animal body and dividing it into subregions using skeleton lines. The subregions of the first dataset, once defined, are morphed individually into corresponding subregions of the second dataset. A set of lines may be found for defining each of the subregions, and an index determined which relates the lines of a subregion of the first dataset to those of a corresponding subregion of the second dataset. A pixel index may thereafter be determined for each of the lines, and used to map each pixel of a line to a corresponding list of pixels for the corresponding line of the other dataset. | 10-23-2008 |
| 20080218727 | METHOD AND APPARATUS FOR OPTICAL IMAGE RECONSTRUCTION USING CONTOUR DETERMINATION - The present invention relates to a method and a system for optical imaging of an object in transmission configuration. The method and system obtain contour coordinates of the object using source/detector configurations references and acquire optical data from a region of interest (ROI) of the object. Then, the method and system apply a weighting factor to said optical data as a function of the contour coordinates, and reconstruct an image of the ROI using the weighted optical data and photon diffusion equation. | 09-11-2008 |
