Arizona Board of Regents on behalf of The University of Arizona Patent applications |
Patent application number | Title | Published |
20150132297 | SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA - The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients. | 05-14-2015 |
20150126563 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME - Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. | 05-07-2015 |
20140318886 | ACOUSTIC AND ELASTIC FLATBAND FORMATION IN PHONONIC CRYSTALS:METHODS AND DEVICES FORMED THEREFROM - A phononic device is provided suitable for attenuating mechanical vibration, as well as acoustic vibration that propagate through a medium. Through the periodic inclusion of domains of a material in a matrix that vary in the ratio of the longitudinal speed of sound (CL) and the transverse speed of sound (CT) between the domains and the matrix of equal to or greater than 2.0 and 40, respectively; improved significant attenuation of vibration is achieved. | 10-30-2014 |
20140308297 | Stem Cell Fusion Model of Carcinogenesis - Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation of new therapeutic targets to inhibit metastasis and other markers of carcinogenesis. | 10-16-2014 |
20140161725 | Molecular Imaging of Cancer Cells In Vivo - Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods. | 06-12-2014 |
20140112873 | MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE - The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell. | 04-24-2014 |
20130230516 | TARGETED CRYPTOSPORIDIUM BIOCIDES - The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields. | 09-05-2013 |
20130224709 | Portable Low Cost Computer Assisted Surgical Trainer and Assessment System - A system is provided for evaluating MIS procedures. The system includes a sensor configured to receive task-performance data, block components, and actuating components. The sensor, block components, and actuating components are configured to simulate a training task. The system also includes a processor. The processor is configured to determine, based on the received task-performance data, a trial task-performance metric corresponding to a trial performance of the training task. The processor is also configured to select a reference task-performance metric from a plurality of reference task-performance metrics. Each reference task-performance metric in the plurality corresponds to a respective reference performance of the training task. The processor is additionally configured to determine, based on a comparison of the trial task-performance metric to the reference task-performance metric, a task-performance classification level. The processor is further configured to cause a graphical display to provide an indication of the task-performance classification level. | 08-29-2013 |
20130184317 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME - Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. | 07-18-2013 |
20130143414 | NANOSTRUCTURED ELECTRODES AND ACTIVE POLYMER LAYERS - Embodiments of methods for fabricating polymer nanostructures and nanostructured electrodes are disclosed. Material layers are deposited onto polymer nanostructures to form nanostructured electrodes and devices including the nanostructured electrodes, such as photovoltaic cells, light-emitting diodes, and field-effect transistors. Embodiments of the disclosed methods are suitable for commercial-scale production of large-area nanostructured polymer scaffolds and large-area nanostructured electrodes. | 06-06-2013 |
20130027713 | WHITE LIGHT ACHROMATIC GRATING IMAGING POLARIMETER - White-light snapshot channeled linear imaging (CLI) polarimeters include polarization gratings (PGs) configured to produce a compensated shear between portions of an input light flux in first and second polarization states. The disclosed CLI polarimeters can measure a 2-dimensional distribution of linear Stokes polarization parameters by incorporating two identical PGs placed in series along an optical axis. In some examples, CLI polarimeters are configured to produce linear (S | 01-31-2013 |
20120318317 | MOLECULAR THERMOELECTRIC DEVICE - An enormous order-dependent quantum enhancement of thermoelectric effects in the vicinity of higher-order interferences has been discovered in the transmission spectrum of nanoscale junctions. Significant enhancements due to both transmission nodes and resonances across such junctions are exemplified by single-molecule junctions (SMJs) based on 3,3′-biphenyl and polyphenyl ether (PPE). Thermoelectric devices employing such SMJs offer superior efficiency and performance. Moreover, the enhanced thermoelectric response is not limited to only SMJs, but may be obtained from any junction exhibiting transmission nodes or resonances arising from coherent electronic transport. | 12-20-2012 |
20120295344 | Stem Cell Fusion Model of Carcinogenesis - Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation of new therapeutic targets to inhibit metastasis and other markers of carcinogenesis. | 11-22-2012 |
20120293808 | SYSTEM AND METHOD FOR NON-CONTACT METROLOGY OF SURFACES - A non-contact metrology system utilizes a display that can be programmed with a plurality of targets. The display targets shine on a specular surface and the reflected targets are detected by an imaging device. Based on the display pattern and the expected location of the reflected pattern, it is possible to characterize the reflective surface. The displayed pattern can be a regular array of targets and the reflected pattern detected by the imaging device is an irregular display of targets whose locations are based on the particular display pattern, the location of the display system and imaging device and the nature of the surface. Deviations of the actual location of targets from the expected location of targets is indicative of unexpected variations in the surface. Alternatively, the display has an irregular pattern of targets such that the reflected signals result in a regularly spaced array detected by the imaging device. | 11-22-2012 |
20120276741 | BENIGN, LIQUID CHEMICAL SYSTEM-BASED BACK END OF LINE (BEOL) CLEANING - A back end of line cleaning process is performed using a liquid mixture containing at least two benign chemicals that can form a eutectic. In one embodiment, liquid mixtures of urea and choline chloride, at a molar ratio of 2:1, in the temperature range of 40° C. to 70° C. are used to remove etch residues on copper interconnects and dielectric layers created by g-line and DUV resists. In certain embodiments, eutectic, hypereutectic, and hypoeutectic compositions of the at least two benign chemicals are used. | 11-01-2012 |
20120225793 | METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS - Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject. | 09-06-2012 |
20120152725 | FABRICATION OF PILLARED GRAPHENE - A method of fabricating pillared graphene assembles alternate layers of graphene sheets and fullerenes to form a stable protostructure. Energy is added to the protostructure to break the carbon-carbon bonds at the fullerene-to-graphene attachment points of the protostructure and allow the bonds to reorganize and reform into a stable lower energy unitary pillared graphene nanostructure in which open nanotubes are conjoined between graphene sheets. The attachment points may be functionalized using tether molecules to aid in attachment, and add chemical energy to the system. The arrangement and attachment spacing of the fullerenes may be determined using spacer molecules or an electric potential. | 06-21-2012 |
20120128637 | Cellular Seeding and Co-Culture of a Three Dimensional Fibroblast Construct - The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore. | 05-24-2012 |
20110263672 | Metabolites of Wortmannin Analogs and Methods of Using the Same - Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein. | 10-27-2011 |
20110144066 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME - Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. | 06-16-2011 |
20110110941 | Wortmannin Analogs and Methods of Using Same in Combination with Chemotherapeutic Agents - Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer. | 05-12-2011 |
20110031104 | CARBON ION BEAM GROWTH OF ISOTOPICALLY-ENRICHED GRAPHENE AND ISOTOPE-JUNCTIONS - Isotopically-enriched graphene and isotope junctions are epitaxially grown on a catalyst substrate using a focused carbon ion beam technique. The focused carbon ion beam is filtered to pass substantially a single ion species including a single desired carbon isotope. The ion beam and filtering together provide a means to selectively isotopically-enrich the epitaxially-grown graphene from given carbon precursor and to selectively deposit graphene enriched with different carbon isotopes in different regions. | 02-10-2011 |
20100279105 | Coated Magnetic Particles, Composite Magnetic Materials and Magnetic Tapes Using Them - The invention relates to polymer coated magnetic particles for magnetic tape storage. The invention also describes methods for making the particles and magnetic tape compositions comprising the coated particles. | 11-04-2010 |
20100183611 | TARGETED CRYPTOSPORIDIUM BIOCIDES - The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields. | 07-22-2010 |
20090143399 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 06-04-2009 |
20090099165 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 04-16-2009 |