ARIAD Pharmaceuticals, Inc. Patent applications |
Patent application number | Title | Published |
20150315194 | CRYSTALLINE FORMS OF 3-(IMIDAZO[1,2-B] PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-BENZAMIDE AND ITS MONO HYDROCHLORIDE SALT - Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyljbenzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methyl piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein. The instant application is directed to novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl}phenyl}benzamide and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, compositions comprising such crystalline forms, and to methods of their preparation and use. | 11-05-2015 |
20150225436 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS - The invention features compounds of the general formula: | 08-13-2015 |
20140349968 | Compositions and Methods for Treating Cancer - The instant invention provides a method of treating a cancer selected from the group consisting of non-small cell lung cancer and breast cancer with an mTOR inhibitor and an αv62 3 integrin antagonist, wherein the mTOR inhibitor is ridaforolimus, everolimus, temsirolimus or a combination thereof. | 11-27-2014 |
20140171649 | Methods and Compositions for the Synthesis of Multimerizing Agents - The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof. | 06-19-2014 |
20140066434 | Methods and Compositions for Treating Parkinson's Disease - The invention discloses methods and compositions for treating or preventing Parkinson's disease by administering a compound of Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein. | 03-06-2014 |
20140066406 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 03-06-2014 |
20140045826 | METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES - The invention discloses methods and compositions for treating or preventing neurodegenerative disease by administering a compound of Formula I: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein. | 02-13-2014 |
20140024620 | Methods for Inhibiting Cell Proliferation in EGFR-Driven Cancers - The invention features a method for treating patients who have an EGFR-driven cancer, which is, or has become, refractory to a tyrosine kinase inhibitor, such as eriotinib and gefitinib, by administering a compound of formula (I) to the patient. The invention also features treating EGFR-driven cancers having an EGFR mutation identified herein. | 01-23-2014 |
20130231337 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 09-05-2013 |
20130225528 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 08-29-2013 |
20130225527 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 08-29-2013 |
20130202702 | ORAL FORMULATIONS - A solid pharmaceutical composition containing AP23573 suitable for oral administration is disclosed. | 08-08-2013 |
20130196979 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 08-01-2013 |
20130178622 | Methods and Compositions for Treating Cancer - The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)-methyl)-3-(trifluoromethyl)phenyl)benzamide. | 07-11-2013 |
20130018046 | Acetylenic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 01-17-2013 |
20130005738 | Monocyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 01-03-2013 |
20120316137 | Methods and Compositions for Treating Cancer - The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)-methyl)-3-(trifluoromethyl)phenyl)benzamide. | 12-13-2012 |
20120316135 | Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers - The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula I: | 12-13-2012 |
20120202776 | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS - The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use. | 08-09-2012 |
20120178716 | Unsaturated Heterocyclic Derivatives - This invention relates to compounds of the general formula: | 07-12-2012 |
20120178714 | Phosphorus-containing Compounds & Uses Thereof - This disclosure concerns a new family of phosphorus-containing compounds of Formula (I): | 07-12-2012 |
20120135986 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 05-31-2012 |
20120130076 | Synthetic Multimerizing Agents - New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula | 05-24-2012 |
20110294806 | AZAINDOLE DERIVATIVES AS KINASE INHIBITORS - This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use. | 12-01-2011 |
20110288078 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS - This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. | 11-24-2011 |
20100247643 | Oral formulations - A solid pharmaceutical composition containing AP23573 suitable for oral administration is disclosed. | 09-30-2010 |
20100197907 | Phosphorus-containing compounds & uses thereof - This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: | 08-05-2010 |
20100151523 | REGULATED EXPRESSION OF RECOMBINANT PROTEINS FROM ADENO-ASSOCIATED VIRAL VECTORS - Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo. | 06-17-2010 |