| APOTEX PHARMACHEM INC. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120095249 | METHODS OF MAKING EFAVIRENS AND INTERMEDIATES THEREOF - The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: | 04-19-2012 |
| 20120065409 | METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF - There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I) | 03-15-2012 |
| 20110065931 | ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES - Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications. | 03-17-2011 |
| 20110040120 | PREPARATION OF OSELTAMIVIR PHOSPHATE (TAMIFLU.RTM.) AND INTERMEDIATES STARTING FROM D-GLUCOSE OR D-XYLOSE - Novel processes for the preparation of the anti-viral agent, Oseltamivir Phosphate and novel intermediates prepared in such processes. The novel processes use as starting materials D-glucose or D-xylose in the preparation of Oseltamivir Phosphate. | 02-17-2011 |
| 20110034465 | PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF - Provided are process for the preparation of (R)- and/or (S)-Rivaroxaban, and compounds which are intermediate compounds used in the processes for the preparation of (R)- and/or (S)-Rivaroxaban. | 02-10-2011 |
| 20110015189 | METHODS OF MAKING EFAVIRENZ AND INTERMEDIATES THEREOF - The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1 may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes. | 01-20-2011 |
| 20100324298 | Novel Process for the Preparation of Esomeprazole and Salts Thereof - A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art. | 12-23-2010 |
| 20100273798 | PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF - This invention provides a process for the preparation of S-Rivaroxaban and/or R-Rivaroxaban comprising reacting, in the presence of a first base, a compound of Formula 9: | 10-28-2010 |
| 20100273790 | PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF - This invention provides a process for the preparation of S-Rivaroxaban and/or R-Rivaroxaban comprising reacting, in the presence of a first base, a compound of Formula 9: | 10-28-2010 |
| 20100168111 | POLYMORPHIC FORM OF 5 CHLORO N {[(5S) 2 OXO 3 [4 (3 OXOMORPHOLIN 4 YL)PHENYL]OXA-ZOLIDIN 5 YL]-METHYL}THIOPHENE 2 CARBOXAMIDE - A polymorphic form of rivaroxaban, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]-methyl}thiophene-2-carboxamide (termed form APO-A), processes for the preparation thereof, and compositions and formulations comprising form APO-A are provided. Also provided are compositions comprising a crystalline form of rivaroxaban and solvents selected from C3 to C6 ketones, C3 to C4 amides and mixtures thereof. | 07-01-2010 |
| 20100056802 | AMORPHOUS FORM OF AN L-ARGININE SALT OF PERINDOPRIL AND PROCESSES FOR PREPARATION THEREOF - In illustrative embodiments, there is provided an amorphous form of L-arginine salt of perindopril which may be particularly suitable for pharmaceutical applications, and processes for preparing said form. | 03-04-2010 |
