| APLAGEN GMBH Patent applications |
| Patent application number | Title | Published |
|---|
| 20100203001 | PROCESS FOR FORMING DISULFIDE BRIDGES - The present invention relates to an improved method of formation of disulfide bridges in substances bearing SH groups, in particular peptides, for example by formation of intramolecular disulfide bridges, in which a heterocyclic compound having at least one nitrogen atom (e.g. caffeine or a caffeine-like substance) is used for catalysis of the reaction. It was found, surprisingly, that addition of the heterocyclic substance increases both the yield and the purity of the product bearing disulfide bridges. | 08-12-2010 |
| 20100029911 | Method For Solid-Phase Peptide Synthesis And Purification - Use of an activated solid phase and a peptide-conjugated anchoring part for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. | 02-04-2010 |
| 20090081145 | PROCESS FOR FORMING DISULPHIDE BRIDGES - The present invention relates to an improved method of formation of disulfide bridges in substances bearing SH groups, in particular peptides, for example by formation of intramolecular disulfide bridges, in which a heterocyclic compound having at least one nitrogen atom (e.g. caffeine or a caffeine-like substance) is used for catalysis of the reaction. It was found, surprisingly, that addition of the heterocyclic substance increases both the yield and the purity of the product bearing disulfide bridges. | 03-26-2009 |
