Alza Corporation Patent applications |
Patent application number | Title | Published |
20160106686 | MULTILAMINATE BACKING CONSTRUCTION - A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing. | 04-21-2016 |
20160058747 | TRANSPARENT TRANSDERMAL NICOTINE DELIVERY DEVICES - A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%. | 03-03-2016 |
20150265548 | MULTILAMINATE BACKING CONSTRUCTION - A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing. | 09-24-2015 |
20150246007 | TRANSDERMAL NICOTINE SALT DELIVERY SYSTEM - A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. | 09-03-2015 |
20150196754 | CURRENT CONTROL FOR ELECTROTRANSPORT DRUG DELIVERY - Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode). | 07-16-2015 |
20150125493 | METHODS AND DEVICES FOR PROVIDING PROLONGED DRUG THERAPY - Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug. | 05-07-2015 |
20140271799 | TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF - A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed. | 09-18-2014 |
20140260096 | Stable Therapeutic Formulations - Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents. | 09-18-2014 |
20140249125 | HIGH ENHANCER-LOADING POLYACRYLATE FORMULATION FOR TRANSDERMAL APPLICATIONS - A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives. | 09-04-2014 |
20140180223 | TRANSPARENT TRANSDERMAL NICOTINE DELIVERY DEVICES - A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%. | 06-26-2014 |
20140130973 | MULTILAYER DRUG DELIVERY SYSTEM WITH BARRIER AGAINST RESERVOIR MATERIAL FLOW - A multilayered drug delivery system with a barrier suitable for delivery of drug through an individual's body surface. By placing a barrier between two adjacent layers, unintended drug flow due to migration of a drug matrix between the adjacent matrix layers in the system to a patient is avoided. | 05-15-2014 |
20140030316 | TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF - A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed. | 01-30-2014 |
20130209562 | METHODS AND DEVICES FOR PROVIDING PROLONGED DRUG THERAPY - Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug. | 08-15-2013 |
20130195934 | METHODS AND DEVICES FOR PROVIDING PROLONGED DRUG THERAPY - Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug. | 08-01-2013 |
20130172428 | HIGH ENHANCER-LOADING POLYACRYLATE FORMULATION FOR TRANSDERMAL APPLICATIONS - A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives. | 07-04-2013 |
20120310187 | TRANSPARENT TRANSDERMAL NICOTINE DELIVERY DEVICES - A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%. | 12-06-2012 |
20120070496 | ANTIDEPRESSANT DOSAGE FORM - A dosage form having sustained-release or controlled-release properties for delivering 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol from the dosage form over an extended period of time in a therapeutically responsive dose to produce antidepressant therapy. | 03-22-2012 |
20110229533 | EXTENDED RELEASE DOSAGE FORM - A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed. | 09-22-2011 |
20100221305 | Formulations for coated microprojections containing non-volatile counterions - The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation. | 09-02-2010 |
20100160895 | Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents - An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member. | 06-24-2010 |
20100152649 | Apparatus and method for transdermal delivery of parathyroid hormone agents - An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member. | 06-17-2010 |
20100152242 | Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition - A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided. | 06-17-2010 |
20100119568 | Apparatus and method for transdermal delivery of parathyroid hormone agents - An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member. | 05-13-2010 |
20100076368 | Electrotransport Delivery Device Having Improved Safety and Reduced Abuse Potential - An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (I | 03-25-2010 |
20100004583 | Hydrophobic Circuit Board Coating of Electrotransport Drug Delivery Devices - The present invention encompasses an improved electrotransport drug delivery device utilizing a hydrophobic modifier to prevent moisture condensation. Use of a hydrophobic modifier increases the hydrophobicity of coated parts of the device, reducing the amount of moisture uptake of the device during storage in a high humidity environment. In a further embodiment, a package of the improved electrotransport drug delivery device is provided. In addition, a method of reducing moisture condensation to an electrical device and a method of preserving an electrical device for an electrotransport drug delivery device are provided. | 01-07-2010 |
20090312689 | Adjustable Current Electrotransport Fentanyl Delivery Device - A transdermal electrotransport fentanyl delivery system having relatively stable fentanyl flux. The system has a controller that controls a current through a donor reservoir wherein the current is generally changed nonlinearly with time with conductance or resistance as a factor to result in a relatively stable fentanyl flux. | 12-17-2009 |
20090275877 | Method of Enhancing Electrotransport Polypeptide Flux By Amino Acid Substitution with Histidine - Methods of modifying polypeptide drugs in order to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by substituting a histidine residue (His) for one or more glutamine (Gln), threonine (Thr) and/or asparagine (Asn) residue(s). The His for Gln substitution is particularly preferred from the standpoint of retaining biological activity of the parent polypeptide. Compositions containing the modified polypeptide, which are useful for transdermal electrotransport delivery, are also provided. | 11-05-2009 |
20090264855 | Method and Device for Transdermal Electrotransport Delivery of Fentanyl and Sufentanil - The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device ( | 10-22-2009 |
20090186147 | Transdermal drug delivery devices having coated microprotrusions - Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent. | 07-23-2009 |
20090183673 | Method and apparatus for coating skin piercing microprojections - An Apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections ( | 07-23-2009 |
20090143724 | Microprojection Array Immunization Patch and Method - Skin patches ( | 06-04-2009 |
20090136554 | Transdermal sustained release drug delivery - Provided herein are microprojections and microprojection arrays for delivering biologically active agents. Also provided herein are compositions suitable for coating such microprojections and microprojection arrays. | 05-28-2009 |
20090105634 | Anodic Reservoir for Electrotransport of Cationic Drug - An electrotransport system for delivery of a cationic drug. The system has a donor anodic reservoir having an insoluble biocompatible polymeric anion source embedded in the reservoir. The anion source has precipitating anions that can precipitate out metal ions generated from sacrificial metal of the anode during electrotransport. | 04-23-2009 |
20090087484 | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules - A formulation and dosage form for enhancing the bioavailability of orally administered hydrophilic macromolecules includes a permeation enhancer, a hydrophilic macromolecule, and a carrier such as a nonionic surfactant that exhibits in-situ gelling properties. The formulation is delivered within the GI tract as a liquid having at least some affinity for the surface of the GI mucosal membrane. Once released, it is believed that the liquid formulation spreads across one or more areas of the surface of the GI mucosal membrane, where the carrier of the formulation then transitions into a bioadhesive gel in-situ. As a bioadhesive gel, the formulation presents the hydrophilic macromolecule and the permeation enhancer at the surface of the GI mucosal membrane at concentrations sufficient to increase absorption of the hydrophilic macromolecule through the GI mucosal membrane over a period of time. A dosage form incorporates the formulation and may be designed to provide the controlled release of the formulation within the GI tract over a desired period of time. | 04-02-2009 |
20090075323 | Static Diffusion Cell for Diffusion Sampling Systems - A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system. | 03-19-2009 |
20090036822 | Electrotransport Agent Delivery Method and Apparatus - An electrotransport device for delivering or sampling an agent through a body surface by electrotransport, the device having a housing including an upper, exterior housing portion and a lower housing portion, the housing enclosing electronic components, and at least one hydratable or hydrated reservoir containing water or an at least partially aqueous solution of the agent. At least a portion of the housing is composed of an ethylene-octene copolymer. | 02-05-2009 |
20080226687 | Drug delivery and method having coated microprojections incorporating vasoconstrictors - A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal. | 09-18-2008 |