| 20090304777 | AGENT ADMINISTRATION - An intra-ruminal bolus and method of manufacture is described that releases a therapeutically effective amount of at least one beneficial agent to a ruminant animal over a time period of less than approximately 21 days. The bolus includes at least one beneficial agent, at least one densifier material, at least one binding agent, and at least one releasing agent. The bolus is manufactured using a ratio of binding agent to releasing agent that is tailored to achieve the desired rate of release and timing of delivery. This ratio is in the order of approximately 1 part binding agent to between approximately 0.01 and approximately 2 parts releasing agent and may be varied within this range in order to obtain the preferred release length of time. The bolus is particularly useful for delivery of anti-parasitic compounds but may also be used for delivery of other active agents such as trace elements including selenium and cobalt. | 12-10-2009 |
