AEGIS THERAPEUTICS LLC Patent applications |
Patent application number | Title | Published |
20140128479 | Absorption Enhancers for Drug Administration - A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and non-irritating, while stabilizing and increasing the bioavailability of the drug. The invention also provides compositions that enhance absorption of drugs via the oral, ocular, nasal, nasolacrimal, inhalation or pulmonary, oral cavity (sublingual or Buccal cell) or CSF delivery route of a patient, including but not limited to insulin, glucagon and exendin-4. | 05-08-2014 |
20130253009 | Compositions for Drug Administration - The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms. | 09-26-2013 |
20130089595 | Controlled Release Formulations - The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or controlled release of the incorporated compounds as the hydrogel is degraded in the body. | 04-11-2013 |
20130034597 | ORALLY BIOAVAILABLE PEPTIDE DRUG COMPOSITIONS AND METHODS THEREOF - The present invention provides orally bioavailable peptide drug compositions including a cyclic peptide and an orally compatible absorption enhancer, as well as methods for providing increased oral bioavailability of peptide drugs. | 02-07-2013 |
20120070487 | ALKYLSACCHARIDE COMPOSITIONS WITH NUTRACEUTICALS - The present invention provides nutraceutical compositions with enhanced oral bioavailability. The compositions of the present invention include one or more alkylsaccharides admixed with one or more nutraceutical. | 03-22-2012 |
20110129462 | INTRANASAL ADMINISTRATION OF ACTIVE AGENTS TO THE CENTRAL NERVOUS SYSTEM - Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The polypeptide can be a catalytically active protein or an antibody, antibody fragment or antibody fragment fusion protein. The polypeptides are formulated with one or more specific agents. | 06-02-2011 |
20110046058 | COMPOSITIONS FOR ENTERAL ABSORPTION AND SUSTAINED ACTION OF LEPTIN-RELATED PEPTIDES USEFUL IN THE TREATMENT OF OBESITY AND LEPTIN-MODULATED DISEASE - The invention relates generally to enterally absorbed peptide compositions and more specifically to leptin-related peptide compositions, methods of administration, and methods of modulating the speed and sustained action of systemic absorption of such peptides useful in the treatment of obesity and other leptin modulated diseases. | 02-24-2011 |
20110020435 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of insulin or an analog thereof. | 01-27-2011 |
20100209485 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof. | 08-19-2010 |
20100203014 | ZWITTERIONIC BUFFERED ACIDIC PEPTIDE AND PROTEIN FORMULATIONS - The present invention provides glycine buffered pharmaceutical compositions suitable for nasal administration and methods for nasal delivery of such compositions. The pharmaceutical compositions described herein include a therapeutically active peptide and/or protein admixed with an aqueous solution buffered with glycine and having a pH in the ranging from about 3.0 to 4.5. The compositions are formulated to maintain stability of the peptide for an extended period of time, but do not significantly change the normal pH of nasal mucosal secretions avoiding irritation and burning sensation in the nose upon administration. | 08-12-2010 |
20100160378 | COMPOSITIONS FOR DRUG ADMINISTRATION - The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain relief. The compositions include at least one alkyl glycoside and at least one therapeutic agent, such as a 5-HT receptor agonist, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms. | 06-24-2010 |
20100124567 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example parathyroid hormone (PTH) or PTH analogs, amylin, a monoclonal antibody, insulin, Peptide T or analog thereof, gastrin, gastrin releasing peptides, gastrin releasing peptide-like (GRP) proteins, epidermal growth factor or analog thereof. | 05-20-2010 |
20090326193 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for preventing loss of a parathyroid hormone (PTH) analog or octreotide via denaturation due to adherence upon contact with glass. | 12-31-2009 |
20090305958 | STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or analog thereof, for example parathyroid hormone (PTH) or PTH analogs, amylin, insulin, Peptide T or analog thereof, gastrin, gastrin releasing peptides, gastrin releasing peptide-like (GRP) proteins, epidermal growth factor or analog thereof. | 12-10-2009 |
20080268032 | Stabilizing Alkylglycoside Compositions and Methods Thereof - The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example amylin, a monoclonal antibody, insulin, Peptide T or analog thereof, gastrin, gastrin releasing peptides, gastrin releasing peptide-like (GRP) proteins, epidermal growth factor or analog thereof. | 10-30-2008 |