| Academia Sinica Patent applications |
| Patent application number | Title | Published |
|---|
| 20120129869 | PHOSPHORYLATION AND MUTATIONS OF ANAPLASTIC LYMPHOMA KINASE AS A DIAGNOSTIC AND THERAPEUTIC TARGET IN LUNG CANCER - The invention related to the use of high-density loss of heterozygosity (LOH) mapping in lung adenocarcinoma to identify intragenic LOH and driver mutations in different domains of ALK resulted in enhanced tumor growth in xenografted mouse. Mutant (H694R and E1384K) ALKs showed activation of Y1604 ALK and downstream AKT, STAT3 and ERK signaling pathways. Increases of oncogenic signalings resulted in enhanced cell proliferation, colony-formation, cell-migration and tumor-growth in xenografted mouse. Western blot and immunohistochemistry analysis using antibody against phospho-Y1604 ALK on 11 lung cancer cell-lines and 263 cancer specimens indicated ALK activation in all lung cancers regardless of tumor stages. Treating mutant-bearing mice with ALK inhibitor WHI-P 154 resulted in tumor shrinkage, metastasis suppression, and improved survival. Hyperphosphorylation of Y1604 ALK occurred early and continuously throughout tumor progression and could be used as a biomarker to detect lung cancer. Oncogenic ALK point mutations could be treatment targets for lung cancer. | 05-24-2012 |
| 20120129707 | Glycopeptide-Functionalized Nanoparticles Arrays for Capturing and Detecting Biomolecules - A surface-enhanced Raman spectroscopic (SERS) system for detecting a biomolecule. The system includes a substrate, an array of nanoparticles disposed on the substrate, each being partially embedded in the substrate and having a non-embedded surface, and a linking agent disposed on the non-embedded surface of each of the nanoparticles. The array of nanoparticles has a uniform interparticle gap of 1-50 nm and the linking agent is capable of binding to the biomolecule. | 05-24-2012 |
| 20120126112 | MOLECULAR ION ACCELERATOR - A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte. | 05-24-2012 |
| 20120108498 | STRUCTURAL AND MECHANISTIC BASIS FOR NOVEL COMPOUND BIOSYNTHESIS USING THE 4-ELECTRON HEXOSE OXIDASE - A novel pharmaceutical composition comprising a compound of formula (I) is disclosed. The novel compound can include a pharmaceutically acceptable carrier. The invention further comprises methods for making compounds of formula (I) using Dbv29, and to the use of compound of formula (I) to treat bacterial infections. | 05-03-2012 |
| 20120093721 | USES OF CANCER-TARGETING PEPTIDES IN CANCER DIAGNOSIS - Cancer-targeting peptides and uses thereof in cancer diagnosis. | 04-19-2012 |
| 20120083012 | Expression System for Producing Multi-Enzyme Complexes and Uses Thereof - An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex. | 04-05-2012 |
| 20120077192 | Risk Assessment For Adverse Drug Reactions - The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test. | 03-29-2012 |
| 20120045519 | USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA - Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of deoxyelephantopin or an analogue thereof; and a pharmaceutically acceptable carrier. Methods of inhibiting proliferation, migration and/or metastasis of melanoma cells in a subject in need thereof are also disclosed. Also disclosed are methods for reducing side effects of an anti-cancer agent in a subject in need thereof. | 02-23-2012 |
| 20120040420 | Flavor Compound-Producing Yeast Strains - Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds. | 02-16-2012 |
| 20120040164 | LARGE-AREA PARTICLE-MONOLAYER AND METHOD FOR FABRICATING THE SAME - The present invention provides a particle monolayer and a method for fabricating the same. The method comprises the following steps: providing a container; adding a solvent into said container; adding a mixture of a particle-suspension and a spreading agent into said solvent; and adding a solvent-soluble polymer to said mixture to form a particle-monolayer. By using a solvent-soluble polymer, the particle monolayer fabricated by the method is a large-area particle monolayer with ordered structure, and the method can be used for any kind of substrates. | 02-16-2012 |
| 20120039988 | CANCER-TARGETING PEPTIDES AND USES THEREOF IN CANCER THERAPY - Cancer-targeting peptides and uses thereof in cancer therapy. | 02-16-2012 |
| 20120036597 | Cold-Tolerant Plants - Disclosed are chill- or cold-tolerant plants and methods of making the plants. Also disclosed are methods for identifying a plant that is tolerant to chill. | 02-09-2012 |
| 20120023625 | CHEMICAL INHIBITORS OF ETHYLENE BIOSYNTHESIS - The present invention provides methods for improving the quality of harvested plants. The present invention also provides novel ACC synthase inhibitors useful for improving the quality of harvested plants. | 01-26-2012 |
| 20120023549 | CAPTCHA AND reCAPTCHA WITH SINOGRAPHS - A method for inviting a challenged entity to provide input concerning a sinograph includes displaying, to the challenged entity, a first region having an image of a challenge sinograph; displaying at least a first event-sensitive region, the first event-sensitive region having an image of a real root of the challenge sinograph; and displaying at least a second event-sensitive region. The second event sensitive region has an image of a faux root of the challenge sinograph. | 01-26-2012 |
| 20120014945 | Anti-Dengue Virus Antibodies - Provided herein are monoclonal antibodies specific to dengue virus as well as their antigen-binding fragments, and functional variants. Also disclosed are uses thereof for treating or diagnosing dengue virus infection. | 01-19-2012 |
| 20120013640 | GRAPHICAL REPRESENTATION OF EVENTS - Some general aspects of the invention relate to approaches for generating a graphical representation of scenes related to an event. Information representing an event is first obtained. The information includes, for example, a set of images of physical scenes related to an event, and additional data associated with the images (for example, geo coordinates and audio files). Images are assigned a degree of significance determined from at least the obtained information representing the event. Based on the degree of significance, a set of images is selected for use in the graphical representation, and partitioned into subsets of images each subset to be presented in a respective one of one or more successive presentation units of the graphical representation. In some examples, the graphical representation can be enhanced by introducing textual annotations to the images. A user can then refine the generated graphical representation by modifying the layout and content of the images and annotations | 01-19-2012 |
| 20110321179 | NON-HUMAN ANIMAL MODEL FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) WITH LOSS-OF-TDP-43 FUNCTION - A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The animal model comprises a rodent whose spinal cord motor neurons have a loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. A method for identifying a candidate agent for treating, preventing and/or inhibiting ALS associated with a loss-of-function of TDP-43 is also disclosed. | 12-29-2011 |
| 20110307200 | RECOGNIZING MULTIPLE APPLIANCE OPERATING STATES USING CIRCUIT-LEVEL ELECTRICAL INFORMATION - An approach to measuring power consumption of multiple appliances adopts a transition probability to model the correlation and causality of appliance events caused by human behavior. The sequential order and relevance of using appliances can be taken into account. For instance, correlation between the use of (e.g., states of) different electrical appliances may be used. | 12-15-2011 |
| 20110301058 | MICROFLUIDIC DEVICE - A novel approach for fabricating Monolithic Internal micro Pillars (MIPi) made of SU-8 photoresist is described. A microfluidic chip with the internal pillars (a MIPi chip) was used for cell capturing study. The surface of MIPi was coated with specific antibody and then used for capturing cells by affinity binding. An antibody, anti-EGFR, which has high affinity to lung cancer cells, CL1-5, was coated on the micro pillars. The coated MIPi chip specifically captured the cancer cells that were pumped through the MIPi chip. Simulation and experiment was carried out to compare the effect of different geometry of the micro pillars on the cell capturing rate. | 12-08-2011 |
| 20110284733 | MASS SPECTROMETER AND METHODS FOR DETECTING LARGE BIOMOLECULES - A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP. | 11-24-2011 |
| 20110284466 | ROBUST AND LOW BACKPRESSURE ON-COLUMN TUNNELED FRIT FOR NANO-UPLC-MS APPLICATIONS - A durable on-column tunneled frit was developed for use in nanoflow UPLC systems. The frit was tunneled during sol-gel reaction. The tunneled-frit fabrication process is easy and reproducible in terms of back pressure and durability. This design creates low backpressure with high liquid flow, which is suitable for the nanoflowUPLC application. A short packing (2 cm C18 particle) tunneled-frit column was demonstrated to sustain 10,000 psi continuous liquid flow for over one week without any particle leakage or pressure instability. The tunneled-frit was also successfully applied to the fabrication of nanoUPLC trapping and analytical column system. It was demonstrated to have high separation efficiency and sensitivity for the analysis of tryptic peptides as well as improved detection sensitivity for phosphopeptide analysis. | 11-24-2011 |
| 20110281323 | Novel Fungal Laccases and Uses Thereof - Novel laccases from | 11-17-2011 |
| 20110281288 | Reusable Nanowire Field Effect Transistor System for Detecting Biomolecular Interactions - A reusable nanowire field effect transistor for detecting biomolecular interactions. The field effect transistor contains nanowire covalently linked to a docking molecule, which is capable of binding to an anchor molecule in a reversible manner, i.e., at an association constant of 10 | 11-17-2011 |
| 20110280809 | PDIA4, TARGET OF CYTOPILOYNE DERIVATIVES, FOR TUMOR DIAGNOSIS AND TREATMENT - Methods of diagnosing cancer that are based in part on the findings that Pdia4 promotes cell growth, cell proliferation, and cell cycle are disclosed herein. Methods of using microvessel density as a surrogate marker and reducing tumor microvessel density in a subject are also enclosed herein. | 11-17-2011 |
| 20110269702 | POLYACETYLENIC COMPOUNDS FOR PROTECTING AGAINST PANCREATIC ISLET ATROPHY - Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a mammal with metabolic syndrome, prediabetes or diabetes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: | 11-03-2011 |
| 20110263828 | METHODS FOR MODIFYING HUMAN ANTIBODIES BY GLYCAN ENGINEERING - Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided. | 10-27-2011 |
| 20110257376 | GLYCOPROTEOMIC PROBES FOR FLUORESCENT IMAGING OF FUCOSYLATED GLYCANS IN VIVO - Methods are provided for labeling cellular glycans bearing azide groups via fluorescent labeling comprising Cu(I)-catalyzed [3+2] cycloaddition of a probe comprising alkynyl group. Generation of fluorescent probes from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2] cycloaddition of the alkyne group of the probe to an azido-modified sugar are provided. Incorporation of azido-containing fucose analog into glycoconjugates via the fucose salvage pathway are disclosed. Fluorescent visualization of fucosylated cells by flow cytometry of cells treated with 6-azidofucose labeled with click-activated fluorogenic probe or biotinylated alkyne is disclosed. Visualization of intracellular location of fucosylated glycoconjugates by fluorescence microscopy are disclosed. | 10-20-2011 |
| 20110251074 | METHOD FOR IDENTIFYING HLA COMPLEXES ASSOCIATED WITH ADVERSE DRUG REACTIONS - A method for identifying from an HLA library an HLA complex that specifically binds to a compound. This method can be relied on to assess whether a compound is likely to induce an adverse drug reaction and, if so, in which human population. | 10-13-2011 |
| 20110250192 | USE OF MICRORNA SIGNATURES FOR ASSESSING RISK LEVELS OF NEUROBLASTOMA PATIENTS - Methods for assessing the risk level or survival/death probability of a neuroblastoma patient based on a number of microRNA signatures, optionally in combination with Dicer, Drosha, and age at diagnosis. Also disclosed herein is use of Dicer, Drosha, or both in suppressing neuroblastoma cell growth | 10-13-2011 |
| 20110236885 | Genetic Variants Predicting Warfarin Sensitivity - We discovered that a polymorphism in the promoter of the VKORC1 gene is associated with warfarin sensitivity. This polymorphism can explain both the inter-individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORC1 gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided. | 09-29-2011 |
| 20110236882 | QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY - Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided. | 09-29-2011 |
| 20110233519 | Fabrication of GaN Substrate by Defect Selective Passivation - Defect selective passivation in semiconductor fabrication for reducing defects. | 09-29-2011 |
| 20110212439 | HLA ALLELES ASSOCIATED WITH ADVERSE DRUG REACTIONS AND METHODS FOR DETECTING SUCH - This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B*4601). | 09-01-2011 |
| 20110195463 | NOVEL THERMOPHILIC ENDO-GLUCANASE AND USES THEREOF - A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting ligocellulosic material to fermentable sugars. | 08-11-2011 |
| 20110195133 | DERMCIDIN-DERIVED PEPTIDES FOR LUNG CANCER DIAGNOSTICS - Methods for diagnosis of non-small cell lung cancers by detection of endogenous peptides in exhaled breath condensate (EBC) are provided. Diagnostic peptides derived from dermcidin (DCD) are provided. A specific dermcidin-derived peptide E-R11, having the sequence ENAGEDPGLAR, is provided. E-R11 peptide levels in EBC, as measured by mass spectrometry (MS), are highly diagnostic of non-small cell lung cancers. A method for inhibiting growth of lung cancer cells by inhibiting DCD expression by RNA interference also is provided. | 08-11-2011 |
| 20110177033 | RAS RESPONSIVE ELEMENT BINDING PROTEIN 1 (RREB1) AS A THERAPEUTIC TARGET FOR THALASSEMIAS AND SICKLE CELL ANEMIA - A method of screening compounds capable of activating ζ and/or ε globin gene promoter activity in an erythroid cell is disclosed. The methods comprises contacting in a medium a compound to be screened with RREB1; wherein the medium comprises a polynucleotide comprising the nucleotide sequence of 5′-M-C-M-C-A-M-M-H-M-M-M-3′, wherein M is the nucleotide adenine or cytosine, and H is the nucleotide adenine, cytosine or thymine; the RREB1 bindable to the polynucleotide; determining binding of the compound to the RREB1; and determining change in binding of the RREB1 to the polynucleotide; wherein detection of binding of the compound to the RREB1 and change in binding of the RREB1 to the polynucleotide is indicative that the compound is capable of activating ζ and/or ε globin gene promoter activity. Also disclosed is a method of activating ζ and/or ε globin gene promoter activity in an erythroid cell. | 07-21-2011 |
| 20110157177 | AUTOMATIC TRACING ALGORITHM FOR QUANTITATIVE ANALYSIS OF CONTINUOUS STRUCTURES - This invention provides an automatic tracing algorithm for quantitative analysis of continuous structures, such as the images of tree-like or network-like structures. The algorithm includes the steps of encoding 3-D image voxels by using a source field encoding methodology followed by a defined image threshold, tracing the codelets along encoded voxels such that the characteristic element of a 3-D image such as the center line of fiber, fiber branch, loop, and end point can be determined systematically, and achieving the automatic analysis without manual intervention. In addition, quantitative measurements are exquisitely calculated by the location and distance of these characteristic elements between coded voxels. The algorithm is more suitable to automatically analyze the 2D/3D images of complex neurons, blood vessels, collagens in skin tissue, and fibril morphology in polymeric materials. | 06-30-2011 |
| 20110147581 | APPARATUSES AND METHODS FOR PORTABLE MASS SPECTROMETRY - Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 10 | 06-23-2011 |
| 20110143829 | METHOD AND SYSTEM FOR PROPHESYING BEHAVIOR OF ONLINE GAMER, AND COMPUTER PROGRAM PRODUCT THEREOF - A method and a system for prophesying a behavior of an online gamer, and a computer program product thereof are provided. In the present method, a gamer descriptor of a specific gamer of an online game accumulated before a time point is obtained firstly. Then, the gamer descriptor is divided into a plurality of sub-traces according to the time. Thereafter, at least one feature is derived from each of the sub-traces, and all features derived from the sub-traces are used for determining a possibility that the specific gamer quits the online game within a specific time period in the future. | 06-16-2011 |
| 20110141483 | OPTICAL PROFILOMETRY - A method for imaging an object using a microscope includes obtaining axial response data, the axial response data representative of a relationship between a separation between a top surface of the object and an objective lens of the microscope and an intensity of light reflected by the top surface of the object; positioning the object at a distance from the objective lens that is within a linear region of the axial response data; sequentially illuminating the object with a plurality of periodic patterns; obtaining a plurality of images of the object, each image resulting from the illumination of the object with a corresponding one of the plurality of periodic patterns; determining a reconstructed image of the object based on the plurality of images of the object; and, based on variations in the intensity of the reconstructed image, determining a topographic profile of the top surface of the object. | 06-16-2011 |
| 20110136100 | NON-HUMAN ANIMAL DISEASE MODEL FOR HEPATITIS B VIRUS-ASSOCIATED DISEASE - A non-human animal disease model for hepatitis B virus-associated liver disease is disclosed. The animal disease model is transduced with a hepatitis B virus genome in the liver cells thereof and exhibits the following symptoms: hepatitis B viral particles and hepatitis B viral DNA in the serum, hepatitis B virus (HBV) envelope and HBV e proteins in the serum, expression of HBV core and HBV envelope proteins in the liver but not in the kidney, heart, lung, brain, pancreas, spleen, stomach or intestine tissues. The animal disease model may develop hepatocellular carcinoma, exhibiting an elevated level of alanine aminotransferase as compared to a control animal without the hepatitis B virus genome in the liver cells thereof, and liver pathological symptoms such as tumor nodules, dysplasia, inflammatory infiltrates, necrosis and fibrosis. | 06-09-2011 |
| 20110126316 | USE OF RICE POLYPEPTIDES/NUCLEIC ACIDS FOR PLANT IMPROVEMENT - A method of making a transgenic plant by transforming into a host plant a recombinant DNA construct that expresses in the transgenic plant a rice polypeptide and the transgenic plant thus produced. | 05-26-2011 |
| 20110117630 | Method for Producing Extracellular Multi-Enzyme Complexes in Host Cells - A polycistronic expression cassette encoding proteins necessary for constructing a multi-enzyme complex was developed. Also disclosed herein is a host cell containing this polycistronic expression cassette and uses thereof in degrading biomass. | 05-19-2011 |
| 20110111429 | FLUORESCENT CARBAZOLE COMPOUNDS FOR CANCER DIAGNOSIS - A compound of formula (I): | 05-12-2011 |
| 20110098926 | ALIGNMENT AND ANTI-DRIFT MECHANISM - A system includes a displacement sensor, an actuator connected to the displacement sensor, and a feedback unit. The displacement sensor is configured to measure at least one of a relative position and a relative orientation between the displacement sensor and the target object. The feedback unit receives a signal from the displacement sensor related to the measured relative position or relative orientation and controls the actuator to move the displacement sensor on the basis of variations in the received signal arising due to a change in environmental conditions. | 04-28-2011 |
| 20110095210 | OPTICAL IMAGING SYSTEM - A system includes an objective lens, an imaging module, and a measurement module. The objective lens is configured to receive light emitted by a light source, focus the emitted light onto a target object, and receive light reflected by the target object. The imaging module is configured to receive a first portion of the reflected light. The measurement module is configured to receive a second portion of the reflected light and includes a photo detector and an astigmatic lens configured to direct the second beam onto the photo detector. | 04-28-2011 |
| 20110091972 | Fabricating Scaffolds and Other Cell-Growth Structures Using Microfluidics to Culture Biological Samples - Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell. | 04-21-2011 |
| 20110082052 | PHAGE DISPLAYING SYSTEM EXPRESSING SINGLE CHAIN ANTIBODY - Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof. | 04-07-2011 |
| 20110076598 | CORRIN COMPOUND FUEL CELL CATALYSTS - The invention provides metal-containing corrin compounds as catalysts for oxygen reduction in electrochemical devices, such as in fuel cells. The catalysts provide more efficient reduction at lower cost than conventional noble metal catalyst. Methods for preparing the catalysts are also provided. | 03-31-2011 |
| 20110072542 | PLANT TUBBY-LIKE PROTEINS - An isolated polypeptide containing an amino acid sequence at least 70% identical to a Tubby-like protein (SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11), and an isolated nucleic acid encoding the polypeptide. Disclosed is an isolated nucleic acid that, under stringent conditions, hybridizes to a probe containing one of SEQ ID NOs:1-11; or its complementary sequence. Also disclosed are (1) a transformed cell or a transgenic plant containing such a nucleic acid and (2) a transformed cell or a transgenic plant having a reduced level(s) of one or more of the Tubby-like proteins. Also within the scope of the invention are methods for making the transformed cells or transgenic plants. | 03-24-2011 |
| 20110055547 | PERSONAL INFORMATION MANAGEMENT AND DELIVERY MECHANISM - Some general aspects relate to secured means for managing and delivering personal information, for example, in the context of electronic commerce. A request from a first entity to encrypt personal information includes a first specification of the personal information to be encrypted. An encrypted specification of the personal information is then generated according to an encoding strategy. The encrypted specification of the personal information is provided to the first entity for subsequent use by a personal information user. A second entity sends a request to decrypt the encrypting specification of the personal information. Upon determining that the second entity is an authorized personal information receiver, a decrypted specification of the personal information is formed according to a decoding strategy determined based on an analysis of the encrypted specification. This decrypted specification of the personal information is then provided to the second entity. | 03-03-2011 |
| 20110046003 | ALPHA-SELECTIVE SIALYL PHOSPHATE DONORS FOR PREPARATION OF SIALOSIDES AND SIALOSIDE ARRAYS FOR INFLUENZA VIRUS DETECTION - A novel N-acetyl-5-N,4-O-carbonyl-protected dibutyl sialyl phosphate donor for sialylation of both primary and sterically hindered secondary acceptors to prepare sialosides with high yield and α-selectivity is disclosed. Methods for making disaccharide building blocks comprising α(2→3), α(2→6), α(2→8), α(2→8)/α(2→9) alternate, and α(2→9) sialosides are provided. methods for one-pot synthesis of complex sialosides are disclosed. Libraries of sialosides and methods for using the libraries for detection and receptor binding analysis of surface glycoproteins or pathogens and cancer cells are disclosed. Methods for distinguishing between hemagglutinin (HA) from various strains of influenza are provided. | 02-24-2011 |
| 20110015096 | MULTIPLEX BARCODED PAIRED-END DITAG (mbPED) LIBRARY CONSTRUCTION FOR ULTRA HIGH THROUGHPUT SEQUENCING - Multiplex barcoded Paired-End Ditag (mbPED) library construction for ultra high throughput sequencing is disclosed. The mbPED library comprises multiple types of barcoded Paired-End Ditag (bPED) nucleic acid fragment constructs, each of which comprises a unique barcoded adaptor, a first tag, and a second tag linked to the first tag via the barcoded adaptor. The two tags are the 5′- and 3′-ends of a nucleic acid molecule from which they originate. The barcoded adaptor comprises a barcode, a first polynucleotide sequence comprising a first restriction enzyme (RE) recognition site, and a second polynucleotide sequence comprising a second RE recognition site and covalently linked to the first polynucleotide sequence via the barcode. The two REs lead to cleavage of a nucleic acid at a defined distance from their recognition sites. The length of the adaptor is set so that the bPED nucleic acid fragment fits one-step sequencing. | 01-20-2011 |
| 20110014215 | GRANULYSIN AND USES THEREOF - Disclosed are uses of granulysin in methods of diagnosing or treating autoimmune disorders. | 01-20-2011 |
| 20110010797 | Method for changing nitrogen utilization efficiency in plants - The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of | 01-13-2011 |
| 20100317603 | Treatment of Cancer and Inflammatory Disorder - Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders. | 12-16-2010 |
| 20100310587 | IMMUNOMODULATORY COMPOSITIONS - Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN γ or IL-2 transcription. | 12-09-2010 |
| 20100308303 | QUANTUM DOT MEMORY - A method of making a quantum dot memory cell, the quantum dot memory cell including an array of quantum dots disposed between a first electrode and a second electrode, includes obtaining values for a tunneling current through the quantum dot memory cell as a function of a voltage applied to the quantum dot memory cell and selecting parameters of the quantum dot memory cell such that the tunneling current through the quantum dot memory cell exhibits a bistable current for at least some values of the voltage applied to the quantum dot memory cell. The values for the tunneling current are determined on the basis of a density of states of the array of quantum dots. | 12-09-2010 |
| 20100306862 | NON-HUMAN ANIMAL MODEL FOR FRONTOTEMPORAL LOBAR DEGENERATION WITH UBIQUITIN-POSITIVE INCLUSIONS (FTLD-U) - Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed. | 12-02-2010 |
| 20100275986 | ORGANIC DYE AND DYE-SENSITIZED SOLAR CELL USING THE SAME - An organic dye used in a dye-sensitized solar cell is described, having general formula (1): | 11-04-2010 |
| 20100272312 | INFORMATION HIDING WITH SIMILAR STRUCTURES - In some aspects, message data is generated from a first representation of a message and a reference image. The message data is generated to hide the message such that generating a second representation of the message from the message data requires processing of a second image that is perceptually similar to the first image. In some examples, a degree to which the second representation of the message is perceptually similar to the first representation of the message is related to a degree to which the second image is perceptually similar to the first image. | 10-28-2010 |
| 20100247571 | METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS - Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41. | 09-30-2010 |
| 20100212039 | INFERTILITY CONTROL OF GENETICALLY MODIFIED FISH - A method of inducing male and/or female infertility in a genetically modified (GM) fish is disclosed. Also disclosed is a method of generating an infertile GM fish with a phenotype and/or genotype of interest. The method involves generation of a GM fish whose genome comprises a foreign transgene operably linked to a fish gonad-specific promoter selected from the group consisting of an ovary-specific promoter and a testis-specific promoter. The transgene comprises a suicide gene selected from the group consisting of a reductase and a photosensitizer, in which the reductase is operably linked to a reporter gene. Infertility of the GM fish is induced if the GM fish expressing the reductase is treated with an effective amount of a reductase-activated cytotoxic prodrug or if the GM fish expressing the photosensitizer is treated with light irradiation. | 08-19-2010 |
| 20100204166 | POLYACETYLENIC COMPOUNDS FOR STIMULATING INSULIN GENE EXRESSION, PRODUCTION AND SECRETION - This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: | 08-12-2010 |
| 20100203582 | Protein Expression System Involving Mutated Severe Respiratory Syndrome-Associated Coronavirus 3C-Like Protease - A mutated severe acute respiratory syndrome-associated coronavirus 3C-like protease and use thereof for cleaving a protein that includes a cleavage site recognizable by the mutated protease to yield a polypeptide fragment of interest. | 08-12-2010 |
| 20100184647 | Use of Epinecidin-1 Peptides and Anti-lipopolysaccharide Factor Peptides for Treating Microbial Infection - Treatments of trichomonas, propionibacterium, or yeast infection using an epinecidin-1 peptide or an anti-lipopolysaccharide factor peptide. | 07-22-2010 |
| 20100184617 | CHARACTERIZATION OF MICROARRAYS BY NANOGOLD STAINING - Methods for determining the quality of a biomolecular microarray to determine suitability of the microarray for performing specific binding reactions, such as hybridization, are provided. Methods are based on staining a microarray with a solution of detectable nanoparticles that reversibly stain the biomolecules through an electrostatic interaction to select microarrays that meet quality standards for hybridization reactions. A gold nanoparticle solution based staining method for DNA microarrays is provided. Destaining methods allowing multiple rounds of hybridization of nanogold stained microarrays are provided. Microarrays selected by methods of the invention are provided. | 07-22-2010 |
| 20100184186 | NOVEL RIGIDOPORUS MICROPORUS LACCASE - An isolated | 07-22-2010 |
| 20100183649 | METHOD OF PRODUCING VIRUS-LIKE PARTICLES OF PICORNAVIRUS USING A SMALL-UBIQUITIN-RELATED FUSION PROTEIN EXPRESSION SYSTEM - A method for producing picornaviral capsid protein complexes (e.g., picornavirus like particles) in | 07-22-2010 |
| 20100166769 | High-yield Transgenic Mammalian Expression System for Generating Virus-like Particles - Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described. | 07-01-2010 |
| 20100136678 | METHODS OF DIAGNOSIS OF SPINAL MUSCULAR ATROPHY AND TREATMENTS THEREOF - Methods for treating SMA in a subject comprise administering to the subject a recombinant genetic vector comprising at least one copy of a Stathmin inhibitor. The inhibitor can be a Stathmin expression inhibitor. The inhibitor can be or can encode an antisense or RNAi nucleic acid, such as a siRNA or a shRNA. The copy can be a copy of a host-expressible Stathmin inhibitor or a copy of a host-expressible Stathmin expression inhibitor. Screening methods can comprise the following steps: providing a Stathmin binding agent and a cellular sample from a human subject at least suspected of either having SMA or having a low SMN protein-based condition; contacting the Stathmin binding agent with the cellular sample under conditions in which the agent can specifically bind to Stathmin present in the sample to form complexes, and removing non-specifically bound agent therefrom to leave remaining complexes, and detecting remaining complexes and comparing the level of complexes detected or of the corresponding Stathmin concentration that is present in the sample, to a control level determined from a healthy cellular sample. The detection of an elevated level of complexes or of Stathmin concentration provides a positive screening result. | 06-03-2010 |
| 20100135547 | OPTICAL SECTIONING MICROSCOPY - Systems and methods for optical sectioning microscopy with structured illumination are provided. A light source generates a light beam with a spatial pattern for successively illuminating a sample at each phase of a plurality of phases. A detector detects a first set of images of the sample at a first axial resolution and a first lateral resolution, each image being associated with a respective phase of the plurality of phases of the illumination. A processor processes the first set of images to generate an enhanced sectioned image of the sample. More specifically, the processor generates data representing a second set of images at a second axial resolution greater than the first axial resolution; and subsequently, performs spectral analysis on the data representing the second set of images to form data representing the enhanced sectioned image of the sample at a second lateral resolution greater than the first lateral resolution. | 06-03-2010 |
| 20100129367 | HUMAN BETA-GLUCURONIDASE MUTANTS WITH ELEVATED ENZYMATIC ACTIVITY UNDER PHYSIOLOGICAL CONDITIONS AND METHOD FOR IDENTIFYING SUCH - A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system. | 05-27-2010 |
| 20100129294 | NATTOKINASE FOR DEGRADING AND REDUCING AMYLOID FIBRILS ASSOICATED WITH ALZHEIMER'S DISEASE, PRION DISEASES AND OTHER AMYLOIDOSES - A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence in Alzheimer's disease, prion diseases and/or other amyloidoses in a mammalian subject is disclosed. In the method a therapeutically effective amount of nattokinase is administered. | 05-27-2010 |
| 20100119444 | Tumor-Targeting Peptides and Uses Thereof - Tumor targeting peptides and uses thereof in tumor diagnosis and treatment. | 05-13-2010 |
| 20100117060 | Quantum dot infrared photodetector apparatus - The present invention is disclosed that a device capable of normal incident detection of infrared light to efficiently convert infrared light into electric signals. The device comprises a substrate, a first contact layer formed on the substrate, an active layer formed on the first contact layer, a barrier layer formed on the active layer and a second contact layer formed on the barrier layer, wherein the active layer comprises multiple quantum dot layers. | 05-13-2010 |
| 20100113519 | 1,5-Dideoxy-1,5-imino-D-glucitol Compounds - 1,5-Dideoxy-1,5-imino-D-glucitol compounds as shown in the specification. Also disclosed is a method of treating a hexosaminidase-associated disease. | 05-06-2010 |
| 20100095406 | Method of Controlling Plant Growth and Architecture by Controlling Expression of Gibberellin 2-Oxidase - Novel gibberellin 2-oxidase (GA2ox) genes were identified. Differential expression of GA2ox genes correlated with flower development, seed germination, tiller growth and other developmental processes. In addition, the early and increased growth of tiller and adventitious root and altered root architecture caused by overexpression of GA2oxs further suggest the pleiotropic role of GA2oxs in controlling growth and architecture in plants such as rice. GA2ox5, GA2ox6 and GA2ox9 were three genes encoding class C20 GA2oxs in rice. Mutants or transgenic rice overexpressing class C20 GA2oxs exhibited a broad range of mutant phenotypes, including semi-dwarfism, increased root system and higher tiller numbers that may favor grain yield. Mutations in the conserved domain III were found to affect the physiological activity of class C20 GA2oxs. Methods are described for controlling plant growth and architecture by controlling gene expression of gibberellin 2-oxidase in the plant. | 04-15-2010 |
| 20100084081 | Method for Fabricating Organic Optoelectronic Multi-Layer Devices - A method for fabricating organic optoelectronics multi-layer devices is disclosed. A polydimethylsiloxane (PDMS) surface is pretreated with an organic solvent and used to directly form a uniform optoelectrical thin-film from organic solution by spin coating. The optoelectrical thin-film films that are formed on the PDMS surface are easily transferable to any substrate by a slight, externally applied force for providing conformal contact with a target substrate and thermal annealing, depending on the polymers to be transferred. Pretreatment of the PDMS surface with the organic solvent combined with a dry transfer process provides an easier way to cascade polymer architecture fabrication. In addition, the method increases the performance of various types of organic photo electronics, and permits an extension of the types of research that can be performed in the field of photo electronics. | 04-08-2010 |
| 20100076205 | DYE COMPOUND AND DYE-SENSITIZED SOLAR CELL - A dye compound is described, which is expressed by formula (I): | 03-25-2010 |
| 20100073056 | ORGANIC TRANSISTOR INVERTER - A transistor includes a first semiconductor layer associated with a first electrode; a second semiconductor layer associated with a second electrode; and a discontinuous layer between the first and second semiconductor layer. The discontinuous layer has a plurality of openings being formed on a nonuniform organic surface. Applications of the transistor include an inverter that operates at low supply voltage and high frequency. | 03-25-2010 |
| 20100055096 | METHODS AND REAGENTS FOR THE ANALYSIS AND PURIFICATION OF POLYSACCHARIDES - The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions. Polysaccharide compositions include those isolated from | 03-04-2010 |
| 20100047869 | Novel Thermophilic Endo-Glucanase and Uses Thereof - A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting lignocellulosic material to fermentable sugars. | 02-25-2010 |
| 20100008904 | Treatment Of Insulin Resistance - Disclosed are a method of for treating insulin resistance and a method identifying a compound for treating insulin resistance. | 01-14-2010 |
| 20090324619 | Immunogenic Protein Carrier Containing An Antigen Presenting Cell Binding Domain and A Cysteine-Rich Domain - A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen conjugated to multiple cysteine residues in the cysteine-rich domain, and an immune composition containing the immunoconjugate and an adjuvant, as well as their uses in eliciting immune responses. | 12-31-2009 |
| 20090317837 | CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS - A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4. | 12-24-2009 |
| 20090317411 | COMPOSITIONS FOR INDUCING IMMUNE RESPONSES SPECIFIC TO GLOBO H AND SSEA3 AND USES THEREOF IN CANCER TREATMENT - An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., α-GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis. | 12-24-2009 |
| 20090317366 | METHOD FOR TREATING PROGRESSIVE NEURODEGENERATIVE DISORDERS - A method for treating a progressive neurodegenerative disorder with bone marrow stem cells and a G-CSF receptor agonist. | 12-24-2009 |
| 20090313725 | Gibberellin 2-Oxidase Genes And Uses Thereof - Novel gibberellin 2-oxidase (GA2ox) genes were identified. Differential expression of GA2ox genes correlated with flower development, seed germination, tiller growth and other developmental processes. In addition, the early and increased growth of tiller and adventitious root and altered root architecture caused by overexpression of GA2oxs further suggest the pleiotropic role of GA2oxs in controlling growth and architecture in plants such as rice. GA2ox5, GA2ox6 and GA2ox9 were three genes encoding class C20 GA2oxs in rice. Mutants or transgenic rice overexpressing class C20 GA2oxs exhibited a broad range of mutant phenotypes, including semi-dwarfism, increased root system and higher tiller numbers that may favor grain yield. Mutations in the conserved domain III were found to affect the physiological activity of class C20 GA2oxs. | 12-17-2009 |
| 20090311284 | Recombinant Viral Proteins And Particles - Disclosed are nucleic acids encoding fusion polypeptides containing the sequence of a Bamboo mosaic virus coat protein or a segment thereof; and an immunogenic heterologous fragment that is fused to the carrier fragment. Also disclosed are related chimeric bamboo mosaic virus particle, related expression vectors, related host cells, and related compositions. Methods of producing and using the fusion polypeptide or chimeric Bamboo mosaic virus particle are also disclosed. | 12-17-2009 |
| 20090306174 | Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics - Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human β-hexosaminidase, a new target for development of osteoarthritis therapeutics. | 12-10-2009 |
| 20090298945 | Aqueous Extracts from Monocotyledon Plants and Their Use in Cardioprotection - Method of treating hypertension with a trans-aconitic acid containing composition (e.g., a water extract derived from a monocotyledon plant). | 12-03-2009 |
| 20090280535 | SUMO Fusion Protein Expression System for Producing Native Proteins - A simple and efficient SUMO fusion protein expression system for producing native proteins. | 11-12-2009 |
| 20090280531 | Preparation of Soluble Capsid Proteins of Picornaviruses Using SUMO Fusion Technology - A method of producing a soluble capsid protein of a picornavirus using a novel and efficient SUMO fusion protein expression system. | 11-12-2009 |
| 20090274352 | THREE-DIMENSIONAL MICROSCOPIC MAGNETIC RESONANCE ANGIOGRAPHY - A method comprises performing a first T2-weighted imaging (T2WI) on a subject; injecting the subject with a contrast agent after performing the first T2WI; and waiting a predetermined period of time before performing a second T2WI on the subject. The first T2WI and second T2WI are then co-registered. The co-registered first T2WI and co-registered second T2WI are then trimmed. A ΔR | 11-05-2009 |
| 20090246887 | Diamond Crystallites For Biotechnological Applications - A diamond-based composition that contains (1) a diamond crystallite having chemically derivatized surface groups, and (2) a polymer having functional groups, in which a portion of the functional groups bind to the chemically derivatized surface groups non-covalently. Also disclosed are methods of using such composition for analyzing a biological sample by determining the identity of biomolecules bound to the composition. | 10-01-2009 |
| 20090203539 | Avian Sex Identification Oligonucleotides - This invention relates to a number of bird sex-identification oligonucleotides and their use in determining the sex of birds in various families. | 08-13-2009 |
| 20090203045 | Crystal Structure Of Soluble Glutaminyl Cyclase - A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat QC-associated disorders is also described. | 08-13-2009 |
| 20090137793 | DISACCHARIDE COMPOUNDS - Disaccharide compounds used as building blocks for making heparin and heparan sulfate oligosaccharides. Also disclosed are methods for making these disaccharide compounds. | 05-28-2009 |
| 20090110951 | Atomically Sharp Iridium Tip - A method for preparing an iridium tip with atomic sharpness. The method includes tapering an iridium wire to a needle shape and heating the iridium needle in an oxygen atmosphere. Also disclosed is an iridium needle having a pyramidal structure which terminates with a small number of atoms prepared by the methods. | 04-30-2009 |
| 20090092703 | Phytase-Expressing Transgenic Plants - Disclosed are a transgenic plant and a transformed plant cell containing a heterologous nucleic acid that includes a sweet potato sporamin SPO promoter operably linked to a sequence encoding a polypeptide. Also disclosed are uses of the plant or cell. | 04-09-2009 |
| 20090087895 | EXPRESSION VECTORS FOR PRODUCING TAG-CLEAVABLE FUSION PROTEINS IN MULTIPLE EXPRESSION SYSTEMS - This invention features a kit containing multiple expression vectors for producing tag-cleavable fusion proteins in various expression systems, or for producing fusion proteins in | 04-02-2009 |
| 20090082574 | Metallacycles and methods of making the same - The present invention provides for novel metallacycles and processes for making the same. | 03-26-2009 |
| 20090075397 | Method for characterizing sugar-binding interactions of biomolecules - This invention provides a donor bead for use in an assay, wherein the bead (a) is coated with a layer of hydrogel having directly or indirectly bound thereto a polyacrylamide-supported sugar or a polyacrylamide-supported glycan, and (b) comprises a photosensitizer which, upon excitation by laser light of a suitable wavelength, converts ambient oxygen to singlet state oxygen. This invention also provides an acceptor bead for use in an assay, wherein the bead (a) is coated with a layer of hydrogel having directly or indirectly bound thereto a polyacrylamide-supported sugar or a polyacrylamide-supported glycan, and (b) comprises a chemiluminescer and a fluorophore, whereby when the bead is contacted with singlet state oxygen, the singlet state oxygen reacts with the chemiluminescer which in turn activates the fluorophore so as to cause the emission of light of a predetermined wavelength. This invention further provides related kits, detection methods and characterization methods. | 03-19-2009 |
| 20090063376 | RECONSTRUCTION OF GENE NETWORKS FROM TIME-SERIES MICROARRAY DATA - Gene regulation network is reconstructed using time series microarray data under the method of the Bayesian network. Particular power-law function is used to calculate the joint probabilities among genes across time points. This invention discloses the use of the downhill simplex algorithm to find global maxima of interrelational likelihood. Arcs with higher frequencies are selected to establish the gene regulation network. Prior knowledge may be included into candidate gene networks to accelerate search for best networks. | 03-05-2009 |
| 20090062216 | BUTANOL EXTRACT OF BIDENS PILOSA - A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: | 03-05-2009 |
| 20090053795 | RECOMBINANT CANDIDA RUGOSA LIPASES - The present invention features an isolated nucleic acid that includes a mutant DNA encoding a | 02-26-2009 |
| 20090053727 | Risk Assessment For Adverse Drug Reactions - The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test. | 02-26-2009 |
| 20090053425 | Assembly of nano-particles using DNA-mediated charge trapping - A method for producing single-dimensioned gold-nano-particle patterns having a single-particle resolution in which the line-width is only limited by the particle size. Initially, a focused electron beam is used to generate a positive charge layer on an SiO | 02-26-2009 |
| 20090041803 | Dioscorea Extracts - An extract from a tuber of a | 02-12-2009 |
| 20080266548 | Method for characterizing transparent thin-films using differential optical sectioning interference microscopy - An imaging, differential optical sectioning interference microscopy (DOSIM) system and method for measuring refractive indices and thicknesses of transparent thin-films. The refractive index and thickness are calculated from two interferometric images of the sample transparent thin-film having a vertical offset that falls within the linear region of an axial response curve of optically sectioning microscopy. Here, the images are formed by a microscope objective in the normal direction, i.e., in the direction perpendicular to the latitudinal surface of the thin-film. As a result, the lateral resolution of the transparent thin-film is estimated based on the Rayleigh criterion, 0.61λ/NA. | 10-30-2008 |
| 20080250528 | Rice Glutelin Gene Promoters - A nucleic acid containing a glutelin gene promoter. Disclosed are transformed plant cells and transgenic plants containing a nucleic acid that includes the promoter operably linked to a sequence encoding heterologous protein. Also disclosed are methods of making the transformed plant cells and transgenic plants and methods for expressing a polypeptide. | 10-09-2008 |
| 20080227109 | Risk assessment for adverse drug reactions - The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB 1 and HLA-A region of the specific HLA-B haplotype can also be used for the test. | 09-18-2008 |
| 20080199911 | VP1 OF FOOT-AND-MOUTH DISEASE VIRUS - A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1 protein of a foot-and-mouth disease virus. Also disclosed are a vaccine containing the polypeptide, a method of producing the polypeptide, and a method of inducing an immune response in a subject by administering to the subject an effective amount of the polypeptide. | 08-21-2008 |
