| ABBOTT CARDIOVASCULAR SYSTEMS INC. Patent applications |
| Patent application number | Title | Published |
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| 20120035630 | CLOSURE DEVICE WITH LONG TINES - A device for engaging tissue may include a generally annular-shaped body defining a plane and disposed about a central axis extending substantially normal to the plane. The body may be movable from a substantially planar configuration lying generally in the plane towards a transverse configuration extending out of the plane. The body may include a plurality of looped elements including alternating inner and outer curved regions. The inner curved regions may define an inner periphery of the body and the outer curved regions may define an outer periphery of the body in the planar configuration. A plurality of tines may extend from the outer curved regions. The tines may be oriented generally towards the central axis in the planar configuration and generally parallel to the central axis in the transverse configuration. The tines may extend beyond the central axis without passing through the central axis so as to collectively form a central lumen about the central axis in the planar configuration. | 02-09-2012 |
| 20120034222 | Nitric Oxide Generating Medical Devices - Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided. | 02-09-2012 |
| 20120029615 | BIOABSORBABLE STENT WTIH LAYERS HAVING DIFFERENT DEGRADATION RATES - A bioabsorbable stent and method of forming the same including a stent scaffolding formed from polymer layers with different degradation rates is disclosed. The polymer layers include an abluminal layer, a luminal layer, and optionally one or more middle layers. A degradation rate of the layers increases from the luminal layer to the abluminal layer. | 02-02-2012 |
| 20120029555 | EXPANDABLE BIOABSORBABLE PLUG APPARATUS AND METHOD - An apparatus for occluding a venous or arterial puncture site is disclosed including a plug insertable within, or adjacent to, a puncture site in a wall of a body lumen. An insert is forced into an aperture within the plug to cause expansion thereof. The insert may be drawn into the aperture by applying tension to a line passing therethrough and secured to the insert. Barbs may secure to the plug to engage the wall of the body lumen or adjacent tissue tract. Elongate members passing through the wall of the plug may be forced outwardly into the wall of the body lumen or adjacent tissue as the insert is forced into the aperture. | 02-02-2012 |
| 20120024474 | METHODS FOR IMPROVED STENT RETENTION - Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a retention layer over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery. | 02-02-2012 |
| 20120024460 | METHODS FOR IMPROVED STENT RETENTION - Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a degradable or water soluble sheath over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery. | 02-02-2012 |
| 20120017416 | Method For Stent Retention On A Balloon Catheter - A balloon is inflated from a collapsed configuration, then deflated. A polymeric stem is then disposed over the deflated balloon and the stent crimped to the balloon. | 01-26-2012 |
| 20120016458 | ENDOPROSTHESIS HAVING IMPROVED STRAIN DISTRIBUTION - An endoprosthesis for delivery in a body lumen can be configured to inhibit structural fatigue, crack formation, and elastic recoil while providing improved crimping and expansion uniformity and radial strength. As such, the endoprosthesis can include at least one multi-stage crest element connecting adjacent bar arms. The multi-stage crest element and, optionally, the connection or transition between the multi-stage crest element and the bar arms can form a plurality of undulations or curves to improve the distribution of the strains experienced by the endoprosthesis. The improved strain distribution can improve the structural integrity and prevent failure of the endoprosthesis. | 01-19-2012 |
| 20120015019 | Drug Coated Balloon With In-Situ Formed Drug Containing Microspheres - The current invention relates to methods of forming a coating that involves the in-situ formation of drug microspheres. The coating may be applied to a medical device, such as a catheter balloon or a stent. Coated devices and methods of treatment therewith are also encompassed within the embodiments of the present invention. | 01-19-2012 |
| 20120010693 | Mounting Stents On Stent Delivery Systems - A system for mounting a stent on a balloon catheter includes two positioning and alignment stations, which are used to prepare a stent and catheter for crimping using the same crimping head. The system is configured for automated assembly of the stent and catheter prior to crimping. A catheter and stent are placed on a computer-controlled carriage that delivers the stent and catheter to the crimper head. Before placing the stent and catheter into the crimper head, an automated alignment system locates the stent between balloon markers. | 01-12-2012 |
| 20120010565 | BALLOON CATHETER WITH IMPROVED TAPER SUPPORT - A catheter balloon having improved steerability is disclosed having a transition between a soft distal tip and a relatively stiffer working portion of a balloon carrying a stent, in the form of a support sleeve on the inner member. The support sleeve provides stiffness to the taper portion of the balloon and also allows precise location of a radio opaque marker. The support sleeve can have a varying thickness or be made of a combination of materials to yield an increasing or decreasing stiffness along the support sleeve to provide an even smoother transition along the balloon's length. | 01-12-2012 |
| 20120009084 | Method For Radiation Sterilization Of Medical Devices - Methods and systems for selection radiation exposure in sterilization of medical devices are disclosed. | 01-12-2012 |
| 20120009083 | Method For Radiation Sterilization Of Medical Devices Using A Package Having Modifier Sections - Methods and systems for selection radiation exposure in sterilization of medical devices are disclosed. | 01-12-2012 |
| 20120007003 | System For Radiation Sterilization Of Medical Devices Using A Package Having Modifier Sections - Methods and systems for selection radiation exposure in sterilization of medical devices are disclosed. | 01-12-2012 |
| 20120006999 | System For Radiation Sterilization Of Medical Devices - Methods and systems for selection radiation exposure in sterilization of medical devices are disclosed. | 01-12-2012 |
| 20120003291 | NANOBEAD RELEASING MEDICAL DEVICES - Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided. | 01-05-2012 |
| 20110315301 | BALLOON CATHETER HAVING A SHAFT WITH A VARIABLE STIFFNESS INNER TUBULAR MEMBER - A catheter having an elongated shaft and a balloon on a distal shaft section, the elongated shaft comprising an outer tubular member, and an inner tubular member which has a bonded portion along which an outer surface of the inner tubular member is bonded to an inner surface of the outer tubular member. The inner tubular member has a proximal portion proximal to the bonded portion, and a distal portion distal to the bonded portion with higher axial compression stiffness and column strength than the proximal portion thereof. The catheter has improved trackability, axial collapse resistance, pushability, and crossability, for improved ability to position the balloon at a desired location in a patient's body lumen. | 12-29-2011 |
| 20110313510 | Polymer Metal and Composite Implantable Medical Devices - A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles. | 12-22-2011 |
| 20110313509 | STENT WITH COMPACT CRIMP CONFIGURATION - A stent having a compacted configuration in which adjacent crowns of its undulating rings overlap one another. The overlapping compacted configuration provides for a relatively low profile in view of the coverage that is achieved by the stent upon expansion. | 12-22-2011 |
| 20110311713 | SYSTEMS AND METHODS FOR ROTATING AND COATING AN IMPLANTABLE DEVICE - A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member. | 12-22-2011 |
| 20110311605 | Coating Designs For The Tailored Release Of Dual Drugs From Polymeric Coatings - Provided herein are coating designs for the tailored release of two therapeutic agents from polymer coatings and methods of making and using the same. | 12-22-2011 |
| 20110311596 | POLY(AMIDE) AND POLY(ESTER-AMIDE) POLYMERS AND DRUG DELIVERY PARTICLES AND COATINGS CONTAINING SAME - The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers. | 12-22-2011 |
| 20110307053 | POLYMER METAL AND COMPOSITE IMPLANTABLE MEDICAL DEVICES - A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. | 12-15-2011 |
| 20110305819 | METHOD OF COATING STENTS - A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer. | 12-15-2011 |
| 20110295356 | STENT HAVING OPTIMIZED EXPANSION RATIO - An intravascular stent has an elongated tubular member that has a manufactured inner diameter and a manufactured outer diameter. The nominal expansion outer diameter (implanted diameter) is approximately 1.618 times larger than the manufactured outer diameter, which is referred to the Golden Ratio. The Golden Ratio provides for optimal crimping and expansion aesthetics, stent expansion uniformity, and uniform coatability for stent receiving a drug coating. | 12-01-2011 |
| 20110295155 | GUIDE WIRE WITH CORE HAVING WELDED WIRE SEGMENTS - An intravascular guide wire having two core materials joined together without the use of a connector tube or sleeve, the core materials being stainless steel and psuedoelastic metal alloy, nitinol. The core materials are joined to each other through an intermediate transition piece made essentially of nickel, which is welded on either side to the two core materials. In a multi-segment intravascular guide wire, discrete, high modulus and medium modulus core portions of different materials are welded to a shapeable, low modulus distal core portion made of a third material having a flattened, shapeable section at a most distal end that is not welded to but made from the distal core portion, so the flattened, shapeable section can be deformed to create a steerable tip. Processes such as simultaneous resistance and friction welding can be used to join the core portions. | 12-01-2011 |
| 20110288622 | EXPANDABLE ENDOPROSTHESES, SYSTEMS, AND METHODS FOR TREATING A BIFURCATED LUMEN - An endoprosthesis for treating a bifurcated lumen. The distal end of the endoprosthesis can include at least two wings and at least two troughs so the endoprosthesis can adequately scaffold the ostium of a bifurcated lumen by at least partially straddling the carina of the lumen bifurcation. The distal end of the endoprosthesis can also be configured to have increased expandability to help allow conformity to the anatomy of a bifurcated lumen. | 11-24-2011 |
| 20110288577 | APPARATUS AND METHOD FOR JOINING ADJACENT TISSUE - Apparatuses and methods are disclosed for reducing the size of openings within a heart valve or other opening in the wall of a body lumen by implanting an elastically expanded member around the opening and then permitting the expandable member to contract. The expandable member may encircle a portion of an inflatable member, the distal end of which is inserted through the opening along with the expandable member. The inflatable member is inflated to expand the expandable member and then drawn proximally form the opening to drive projections formed on the expandable member into the valve or wall. The inflatable member is then withdrawn, allowing the expandable member to elastically contract. The inflatable member may have first and second stages, where the second stage is distal of the first stage and has a larger inflated diameter. | 11-24-2011 |
| 20110283501 | CRIMPING APPARATUS - An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the deliver device. | 11-24-2011 |
| 20110281022 | Methods For Controlling The Release Rate And Improving The Mechanical Properties Of A Stent Coating - Methods for controlling the release rate and improving the mechanical properties of a stent coating are disclosed. | 11-17-2011 |
| 20110281020 | Maintaining A Fixed Distance During Coating Of Drug Coated Balloon - A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet. | 11-17-2011 |
| 20110281019 | Direct Fluid Coating Of Drug Eluting Balloon - A system and method for coating an expandable member of a medical device comprises providing a dispenser in fluid communication with a fluid source with the dispenser having at least one outlet to dispense fluid of the fluid source therefrom. The outlet(s) of the dispenser is positioned proximate a surface of an expandable member, with relative movement between the outlet(s) and the surface of the expandable member established along a coating path, and fluid is dispensed from the dispenser to form a substantially continuous bead of fluid between the at least one outlet and the surface of the expandable member along the coating path, and simultaneously drying the fluid while dispensing the fluid from the dispenser to control flow of fluid on the surface of the expandable member. The fluid source can include a variety of therapeutic agents. | 11-17-2011 |
| 20110278771 | TUBE EXPANSION PROCESSES AND SYSTEMS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods of and systems for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein. | 11-17-2011 |
| 20110277305 | STENTS WITH HIGH RADIAL STRENGTH AND METHODS OF MANUFACTURING SAME - Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The desired orientation of polymer molecules may be achieved by one or any combination of extruding polymers into hollow tubes to induce axially oriented polymer chains, applying a tensile load to polymer tubes to induce axially oriented polymer chains, and radially expanding polymer tubes to induce circumferentially oriented polymer chains. Stent patterns include struts defining diamond shaped cells and/or W-shaped cells. | 11-17-2011 |
| 20110271513 | Methods for Crimping a Polymeric Stent Scaffold Onto a Delivery Balloon - A medical device includes a polymer stent scaffold crimped to a catheter having an expansion balloon. A process for forming the medical device includes placing the scaffold on a support supported by an alignment carriage, and deionizing the scaffold to remove any static charge buildup on the scaffold before placing the scaffold within a crimper to reduce the scaffold's diameter. The polymer scaffold is heated to a temperature below the polymer's glass transition temperature to improve scaffold retention without adversely affecting the mechanical characteristics of the scaffold when deployed to support a body lumen. | 11-10-2011 |
| 20110270387 | Implantable Medical Devices Comprising Poly[L-Lactide-Co-(3,6-Dialkyl-1,4-Dioxane-2,5-Dione)] - This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione). | 11-03-2011 |
| 20110270383 | Methods for Crimping a Polymeric Stent Onto a Delivery Balloon - A medical device-includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. | 11-03-2011 |
| 20110270382 | Drug Delivery After Biodegradation Of The Stent Scaffolding - Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots. | 11-03-2011 |
| 20110270228 | APPARATUS AND METHOD OF MAKING A VARIABLE STIFFNESS MULTILAYER CATHETER TUBING - A catheter body having a variable stiffness along its longitudinal length and a method for manufacturing same is disclosed wherein an inner layer having an uninterrupted length serves as a backbone for segments of coextrusion of, e.g., Pebax or nylon and a tie layer which are then bonded to the backbone to create a multi-stiffness catheter body. | 11-03-2011 |
| 20110264193 | OPTIMAL RATIO OF POLAR AND BENDING MOMENT OF INERTIA FOR STENT STRUT DESIGN - An intravascular stent is provided to be implanted in coronary arteries and other body lumens. The transverse cross-section of at least some of the stent struts have a ratio of polar and bending moments of inertia, which results in optimal resistance to stent twisting. This resistance to twisting ratio for the stent struts minimizes out of plane twisting of the struts or projecting edges of the struts when the stent is expanded from a compressed diameter to an expanded diameter in a coronary artery. | 10-27-2011 |
| 20110263497 | APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I. | 10-27-2011 |
| 20110262530 | SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I. | 10-27-2011 |
| 20110257722 | STENT AND CATHETER ASSEMBLY AND METHOD FOR TREATING BIFURCATIONS - An apparatus and method is provided for stenting bifurcated vessels. A proximal angled stent is configured for implanting in a side-branch vessel wherein the proximal angled stent has an angulated portion that corresponds to the angle formed by the intersection of the side-branch vessel and the main vessel so that all portions of the side-branch vessel at the bifurcation are covered by the proximal angled stent. A main-vessel stent is provided for implanting in the main vessel, wherein the main-vessel stent has an aperture or stent cell that aligns with the opening to the side-branch vessel to permit unobstructed blood flow between the main vessel and the side-branch vessel. Side-branch and main-vessel catheter assemblies are advanced over a pair of guide wires for delivering, appropriately orienting, and implanting the proximal angled stent and the apertured stent. | 10-20-2011 |
| 20110251677 | Coating Designs For The Tailored Release Of Dual Drugs From Polymeric Coatings - Provided herein are coating designs for the tailored release of two therapeutic agents from polymer coatings and methods of making and using the same. | 10-13-2011 |
| 20110251672 | ASPECT RATIO FOR STENT STRUT DESIGN - An intravascular stent is provided to be implanted in coronary arteries and other body lumens. The stent includes stent struts that have a transverse cross-section that is substantially rectangular and an aspect ratio in the range of 0.9 to 1.0 to 1.4 to 1.0. This range of aspect ratios for the stent struts minimizes out of plane twisting of the struts or projecting edges of the struts when the stent is expanded from a compressed diameter to an expanded diameter in a coronary artery. | 10-13-2011 |
| 20110247943 | SYSTEM AND METHOD FOR ELECTROPOLISING DEVICES - A system and method is described for electropolising tubular metallic prostheses. In one aspect, the system provides a continuously changing set of points of contact between anode and prosthesis. In another aspect, the cathode is given a conical shape to correct for current concentrations that would otherwise exist and unevenly affect the amount of electropolishing over the length of the prosthesis. | 10-13-2011 |
| 20110245908 | Mandrels Supporting Medical Devices During Processing of the Medical Devices - An apparatus and method for applying a coating composition to a stent. A mandrel for supporting the stent has one or more drive pins and other supporting structure that loosely supports the stent, in an unstable position. The support permits freedom of movement of the stent relative to the mandrel to cause the stent to frequently re-position itself over the mandrel during a spraying process. When a coating composition is applied, the stent randomly or periodically moves about relative to the mandrel due to intermittent contact between the stent and the rotating mandrel and fluidic forces applied through the sprayed coating composition. | 10-06-2011 |
| 20110245766 | Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members. | 10-06-2011 |
| 20110244112 | STENT COATING METHOD - A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir. | 10-06-2011 |
| 20110244017 | Absorbable Coating For Implantable Device - The present invention provides an absorbable coating for an implantable device and the methods of making and using the same. | 10-06-2011 |
| 20110240882 | Radiation Sterilization of Implantable Medical Devices - A system and method for sterilization of medical devices includes methods for reducing the variance in dose levels over the medical device by either varying the dose levels for each pass before a radiation source, such as an electron beam, or by increasing the number of passes before a radiation source. | 10-06-2011 |
| 20110239939 | STENT COATING APPARATUS USING FOCUSED ACOUSTIC ENERGY - An apparatus for coating a stent includes an optical feedback system used to align a transducer with a stent strut. Once alignment is achieved, the transducer causes a coating to be ejected onto the stent strut and the transducer is moved along the stent strut to coat the stent strut. | 10-06-2011 |
| 20110238155 | STENT FORMED FROM BIOERODIBLE METAL-BIOCERAMIC COMPOSITE - Medical devices and methods of fabricating such medical devices, such as stents, formed at least in part from a metal matrix composite including bioceramic particles dispersed within an erodible metal are disclosed. | 09-29-2011 |
| 20110238039 | Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members. | 09-29-2011 |
| 20110230959 | INTRAVASCULAR STENT WITH INVERTED END RINGS - The invention is directed to an expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The invention provides for an intravascular stent having a plurality of cylindrical rings connected by undulating links. A plurality of inverted cylindrical end rings can be coupled at least in part to a plurality of adjacent cylindrical rings in the form of mirror images such that a symmetrical configuration is present on at least one of a proximal end and a distal end of the stent. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. The inverted end ring configuration of the stent aims at reducing the stent-to-shoulder distance as well as delivering therapeutic drug to the peri-stent area while maintaining a pristine stent deployment. | 09-22-2011 |
| 20110230948 | STENT DELIVERY SYSTEM HAVING A FIBROUS MATRIX COVERING WITH IMPROVED STENT RETENTION - The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment. | 09-22-2011 |
| 20110230840 | GUIDEWIRE HAVING LINEAR CHANGE IN STIFFNESS - The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device. | 09-22-2011 |
| 20110229548 | Implantable Medical Device With Poly(Vinylidene Fluoride-Co-Hexafluoropropylene)/Zotarolimus Drug Layer - This invention relates to an implantable medical device for and method of treating a vascular disease where the device is preferably a stent comprising a drug reservoir layer comprising poly(vinylidene fluoride-co-hexafluoropropylene) and zotarolimus. | 09-22-2011 |
| 20110224719 | BIOABSORBABLE PLUG - In one example implementation, a device for closing an opening in tissue includes a proximal end and a distal end. The device further includes a port that extends from the proximal end of the device towards the distal end of the device. In addition to extending from the proximal end of the device towards the distal end of the device, the port includes a restriction zone and a storage region. The device further includes a blocking element that is configured to move between a neutral position, located in the storage region of the port, and a blocking position, located in the restriction zone of the port. When the blocking element is in the blocking position, the blocking element cooperates with the restriction zone in the port to assist in blocking fluid flow through the port. | 09-15-2011 |
| 20110224713 | SLOTTED INTRODUCER NEEDLE AND METHOD FOR ACCESSING A BODY LUMEN - An introducer needle for accessing a body lumen includes an annular-shaped body having a distal end and a proximal end, a leading edge formed on the distal end, and a slot defined in the leading edge and extending proximally from the distal end. In at least one example, the slot can be include a first edge and a second edge, the first edge and the second edge each extending proximally from the leading edge and being separated by a central angle greater than 90 degrees and less than 360 degrees. The first end and the second edge are in continuous communication with the leading edge. | 09-15-2011 |
| 20110213458 | INTRAVASCULAR STENT - The invention is directed to an expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. | 09-01-2011 |
| 20110213451 | MEDICAL DEVICE SHIELD AND METHODS FOR DELIVERING A MEDICAL DEVICE - Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the housing, and a limit element having a first constraining position and a second open position. | 09-01-2011 |
| 20110210108 | METHOD FOR LASER CUTTING TUBING USING INERT GAS AND A DISPOSABLE MASK - A method for making a device includes providing a tubular member which will be formed into the device, masking at least a portion of the inner surface of the tubular member with a removable sacrificial material, selectively removing a portion of the tubular member and sacrificial material using a laser device, and mechanically removing the sacrificial material from the inner surface of the tubular member. The method may also include applying a chemical solution to the tubular member and sacrificial material which primarily attacks the either the tubular member or sacrificial material. | 09-01-2011 |
| 20110209442 | Sterilization Methods For Medical Devices - Methods of sterilizing medical devices, including implantable medical devices like stents, chemically and with radiation are disclosed. Methods of preparing a sterile, packaged medical device, including a sterile, packaged implantable medical device or stent are disclosed. | 09-01-2011 |
| 20110208286 | CATHETER ASSEMBLY AND METHOD FOR TREATING BIFURCATIONS - An improved stent design and stent delivery catheter assembly for repairing a main vessel and a side branch vessel forming a bifurcation. The stent includes rings aligned along a common longitudinal axis and connected by links, where the stent has one or more portals for aligning with and partially expanding into the opening to the side branch vessel. The stent is implanted at a bifurcation so that the main stent section is in the main vessel, and the portal section covers at least a portion of the opening to the side branch vessel. A second stent can be implanted in the side branch vessel and abut the expanded central section to provide full coverage of the bifurcated area in the main vessel and the side branch vessel. Radiopaque markers on the stent and on the tip of the delivery catheter assist in aligning the portal section with the opening to the side branch vessel. | 08-25-2011 |
| 20110203739 | METHOD FOR RETAINING A VASCULAR STENT ON A CATHETER - A method of securely mounting a stent on a balloon of a catheter. The method generally includes crimping a stent on a balloon of a catheter at least one time, and positioning the balloon with the stent thereon within a polished bore of a mold formed at least in part of a metallic material. The balloon is pressurized and heated within the mold, or within a sheath, in two stages as the stent is restrained from radially expanding. The method may include crimping the stent onto the balloon one or two times during processing. The method increases retention of the stent on the balloon catheter following sterilization. | 08-25-2011 |
| 20110198327 | HYBRID STENT AND METHOD OF MAKING - A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduce the likelihood of the development of restenosis in the coronary arteries. The inner and outer polymeric materials can be of the same polymer or different polymer to achieve different results, such as enhancing flexibility and providing a stent that is visible under MRI, computer tomography and x-ray fluoroscopy. | 08-18-2011 |
| 20110196474 | MAGNETICALLY SENSITIVE DRUG CARRIERS FOR TREATMENT OR TARGETED DELIVERY - Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described. | 08-11-2011 |
| 20110196187 | MAGNETICALLY SENSITIVE DRUG CARRIERS AND DELIVERY DEVICES - Apparatuses for delivering compositions of matter comprising a magnetically sensitive drug carrier and a related drug and methods for causing the drug carriers to localize within the patient using an internal or external magnetic field are described. | 08-11-2011 |
| 20110190872 | Crush Recoverable Polymer Scaffolds Having a Low Crossing Profile - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile. | 08-04-2011 |
| 20110190871 | Crush Recoverable Polymer Scaffolds - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 08-04-2011 |
| 20110190698 | Method and Apparatus for Delivering an Agent to a Kidney - Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices. | 08-04-2011 |
| 20110184384 | Blood Vessel Permeability-Enhancement For The Treatment Of Vascular Diseases - This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents. | 07-28-2011 |
| 20110166479 | COMPOSITE RADIOPAQUE INTRACORPOREAL PRODUCT - The invention is directed to a guidewire having a distal flexible member, such as a helical coil, which is formed with at least one highly radiopaque component and at least one high strength component. In a presently preferred embodiment, the highly radiopaque component is at least 10% and less than about 60% of the transverse cross-section of the flexible member, preferably at least 20% but less than 40%. The highly radiopaque component may be formed of radiopaque material such as platinum, gold, iridium and the like and the high strength component may be formed of a material such as tantalum, stainless steel, NiTi alloys, Co—Cr—Mo alloys and the like. | 07-07-2011 |
| 20110144736 | FLEXIBLE STENT - The present invention is directed to a flexible expandable stent for implantation in a body lumen, such as a coronary artery. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of links which be polymeric or metallic. Varying configurations and patterns of the links provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness. | 06-16-2011 |
| 20110137243 | Coating On A Balloon Device - The present invention provides a hygroscopic coating on a balloon for an implantable device and methods of making and using the same. | 06-09-2011 |
| 20110077731 | MULTIPLE STENT DELIVERY SYSTEM - A stent delivery system having multiple stents in a single delivery catheter, configured for delivering and deploying at least some of the stents in a patient's anatomy. A reversibly collapsible stent stop secured to the inner tubular member abuts a proximal end of a first distal stent prior to deployment of the first stent, and is configured to radially collapse as the inner tubular member is proximally withdrawn into the outer tubular member through the second collapsed stent, and radially self expand along at least a section thereof at a location proximally adjacent to a proximal end of a second collapsed stent prior to deployment of the second stent after deployment of the first stent. One or two stent retainer are attached to the shaft of a stent delivery catheter to prevent longitudinal shifting of the stent along the longitudinal axis of the catheter. | 03-31-2011 |
| 20110059228 | Drug-Eluting Coatings Applied To Medical Devices By Spraying And Drying To Remove Solvent - A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns. | 03-10-2011 |
| 20110049751 | Method Of Fabricating A Low Crystallinity Poly(L-Lactide) Tube - Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device. | 03-03-2011 |
| 20110046709 | METHODS FOR IMPLANTING A STENT USING A GUIDE CATHETER - Various methods for implanting a stent into an ostium or a proximal portion of a body vessel utilizing a guide catheter, rather than a convention balloon angioplasty balloon catheter, as the primary delivery device are disclosed. The guide catheter can be used as the primary stent delivery catheter for the ostium region of the body vessel and can be anchored to the vessel to allow secondary treatment devices to be advanced to distal locations in the body vessel. | 02-24-2011 |
| 20110022163 | Implantable Medical Device Comprising Copolymer Of L-Lactide With Improved Fracture Toughness - The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt % percent crystallinity of 40% or less. | 01-27-2011 |
| 20110020427 | Method Of Treating Malignant Solid Tumors Using Transcatheter Arterial Chemoembolization (TACE) - This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor. | 01-27-2011 |
| 20100331951 | STENT DELIVERY CATHETER SYSTEM AND METHOD OF IMPLANTING A SELF-EXPANDING STENT WITH EMBOLIC PROTECTION - A catheter system and method for implanting an endoprosthesis such as a stent at a treatment site in a patient's body lumen. The catheter provides a complete system for stent delivery, dilatation, and delivery and/or recovery of an expandable device, such as an embolic protection device, adjacent to the treatment site in the body lumen. | 12-30-2010 |
| 20100331819 | Drug Delivery System and Method of Treatment of Vascular Diseases Using Photodynamic Therapy - This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site. | 12-30-2010 |
| 20100330147 | Drug Delivery Compositions Including Nanoshells For Triggered Drug Release - The current invention is directed to compositions comprising a plurality of particles including nanoshells or a medical device with a coating including nanoshells allowing for triggered drug release. Methods of treatment with such compositions are also included. | 12-30-2010 |
| 20100323091 | Methods To Increase Fracture Resistance Of A Drug-Eluting Medical Device - Methods for increasing the fracture resistance of a polymer stent's drug-polymer coating and scaffolding including applying a coating and crimping using techniques that increase the resistance to fracture in the coating layer and scaffolding and scaffolding. | 12-23-2010 |
| 20100323019 | Microparticles for the treatment of disease - Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed. | 12-23-2010 |
| 20100299911 | METHODS FOR MANUFACTURING AN ENDOPROSTHESIS - Method for manufacturing an endoprosthesis are described. The method may include selecting an indication range based on a range of inner diameters of a body lumen. A nominal diameter of the endoprosthesis may be selected. A range of chronic outward force, a range of radial force, a range of safety factors, or combinations thereof may be selected. A design characteristic may be determined based on the indication range, the nominal diameter, and at least one of the range of chronic outward force, the range of radial force, and the range of safety factors. The endoprosthesis may be manufactured based on the determined design characteristic. | 12-02-2010 |
| 20100291175 | POLYMERS COMPRISING AMORPHOUS TERPOLYMERS AND SEMICRYSTALLINE BLOCKS - The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer. | 11-18-2010 |
| 20100286664 | CATHETER PUSH DEVICE - A clamping device for gripping a catheter shaft to facilitate advancement in a patient's body lumen. The clamping device is preferably configured to be releasably secured to the catheter shaft and longitudinally slidable along the catheter shaft. The clamping device comprises a body portion that couples to a portion of the catheter adapter on a proximal end, and an axially directed internal lumen sized to receive the catheter shaft. Extending longitudinally from the body portion are opposed, resilient cantilevered fingers that flex inwardly against the catheter shaft upon application of digital pressure from the practitioner's thumb and forefinger to grip and capture the catheter shaft, thereby increasing the surface area of the interaction between the practitioner and the catheter and enhancing pushability. | 11-11-2010 |
| 20100278956 | METHOD FOR RETAINING A VASCULAR STENT ON A CATHETER - A method of securely mounting a stent on a balloon of a balloon catheter. The method generally includes crimping a stent on a balloon of a balloon catheter, and positioning the balloon with the drug delivery stent thereon within a polished bore of a mold formed at least in part of a metallic material. The balloon is pressurized and heated within the mold as the mold radially restrains the stent from expanding. The stent is recrimped on the balloon after removal from the mold to increase retention of the stent on the balloon. | 11-04-2010 |
| 20100251838 | Fixture for Mechanical Analysis of a Hollow Tube - A test fixture for use with a Dynamic Mechanical Analyzer (DMA) restrains a hollow cylindrical tube for purposes of performing either a tensile or transverse/bending load test. The fixture includes a clamp that is configured to restrain the tube without imparting a preload or changing a mechanical property of the tube. | 10-07-2010 |
| 20100249702 | POROUS CATHETER BALLOON AND METHOD OF MAKING SAME - A porous balloon or other catheter structure is formed by creating specific size pores for delivering an agent to a body lumen. The pores can be created by passing matter or energy through the surface of the catheter structure, as by a laser or a projectile. In the case of a laser, the catheter structure can be reversed so that the inner surface becomes the outer surface to convert diverging pores into converging pores. In the case of projectiles, a pore size can be achieved by selecting an appropriate size and shaped projectile to obtain the desired characteristic. Alternatively, a material to make the catheter structure can include impurities that can be removed once the catheter structure is set, leaving pores where the material formed around the impurities. | 09-30-2010 |
| 20100244293 | Method For The Manufacture Of Stable, Nano-Sized Particles - The current invention relates to methods of making nano-particles of a material with a narrow polydispersity. The particle materials are active agents, organic compounds, polymers, and combinations thereof. | 09-30-2010 |
| 20100241069 | OSTIAL LESION STENT DELIVERY SYSTEM - A method and apparatus for repairing a vessel at a bifurcation, such as an aorto-ostium, without obstructing blood flow through the bifurcation. Delivery system having an anchor mechanism for positioning an expandable ostial stent within a diseased portion of a bifurcation so that the tubular body of the stent is seated within a side branch to the bifurcation, thereby repairing the vessel at the bifurcation without occluding blood flow. The anchor mechanism includes a plurality of wing-like members for holding the stent at a desired location in the side-branch of the main vessel. The stent delivery system may be used with a dilation catheter prior to deploying the anchor mechanism and stent. | 09-23-2010 |
| 20100222876 | APPARATUSES AND METHODS FOR HEART VALVE REPAIR - A medical device for treating a heart having a faulty heart valve is disclosed. The medical device comprises a ligature including a first anchoring member and a second anchoring member is used. The ligature is percutaneously deployable into a patient with a faulty heart valve wherein the first anchoring member to anchor to a first tissue area of the heart and the second anchoring member to anchor to a second tissue area of the heart. | 09-02-2010 |
| 20100222875 | METHOD FOR FORMING A POROUS STENT COATING - Methods for forming porous stent coatings are disclosed. | 09-02-2010 |
| 20100211009 | PERFUSION CATHETER HAVING ARRAY OF FUNNEL SHAPED MEMBRANES - An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure. | 08-19-2010 |
| 20100209476 | COATING COMPRISING A TERPOLYMER COMPRISING CAPROLACTONE AND GLYCOLIDE - The present invention provides a coating comprising a reservoir layer comprising a terpolymer comprising caprolactone and glycolide and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same. | 08-19-2010 |
| 20100196314 | Modified Two-Component Gelation Systems, Methods of Use and Methods of Manufacture - Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region. | 08-05-2010 |
| 20100196313 | Modified Two-Component Gelation Systems, Methods of Use and Methods of Manufacture - Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region. | 08-05-2010 |
| 20100193485 | METHODS AND SYSTEMS FOR LASER CUTTING AND PROCESSING TUBING TO MAKE MEDICAL DEVICES - Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A doping material can be added to the melted portion of the tubular member to promote the formation of brittle slag. A fixture can be used to hold a cut workpiece in order to ream sacrificial material from the surface of the workpiece. Pressurized gas can be supplied to the inner lumen of the tubular member to cause slag to form on the outside surface, rather than the inner surface, of the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A rotating mandrel can be placed within the lumen of the tubular member during laser cutting. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to “blast” islands from the workpiece. | 08-05-2010 |
| 20100193484 | MULTIPLE BEAM LASER SYSTEM FOR FORMING STENTS - A system and method for precision cutting using multiple laser beams is described, The system and method includes a combination of optical components that split the output of a single laser into multiple beams, with the power, polarization status and spot size of each split beam being individually controllable, while providing a circularly polarized beam at the surface of a work piece to be cut by the laser beam. A system and method for tracking manufacture of individual stents is also provided. | 08-05-2010 |
| 20100193483 | LASER CUTTING PROCESS FOR FORMING STENTS - Systems and methods for improving the cutting efficiency and cut profile of stent strut is provided. A means for altering the energy distribution of a laser beam is provided, along with various ways of controlling a laser to provide for improved strut configurations are provided. A method for improved cutting speeds using a combination of laser sources is also provided. | 08-05-2010 |
| 20100193482 | LASER CUTTING SYSTEM - A laser cutting system including a chamber configured to provide a controlled environment while the laser is being used to cut a pattern into a material to reduce or eliminate heat and oxygen related changes to the mechanical characteristics of the material. A system for providing a gas to the controlled environment within the chamber, as well as a means for exhausting gas and cutting debris from the chamber is also described. A cutting mandrel that provides for flow of a shielding gas and also provides a means for dispersing a laser beam before it can produce unwanted damage to a section of tubing is also described. | 08-05-2010 |
| 20100189876 | Balloon Catheter for Delivering Therapeutic Agents - A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit desirable delivery of a substance from the micropores of the coating and into the tissue of a patient's lumen. | 07-29-2010 |
| 20100185179 | NEEDLED CANNULA WITH FILTER DEVICE - An apparatus may include a cannula. The cannula may be operable to be percutaneously advanced through a blood vessel. The cannula may have a proximal end and a distal end. At least one needle may be coupled to the distal end of the cannula. A filter device may be coupled at a position proximal to the at least one needle. The filter device may have a distal portion that is operable to have a first diameter under a first condition and a second, different diameter under a second condition. Methods of using such an apparatus are also disclosed. | 07-22-2010 |
| 20100168786 | SUPPORT FRAME FOR AN EMBOLIC PROTECTION DEVICE - An embolic filtering device includes a filter support frame which provides a freely articulating structure for deploying and maintaining a filter body in a deployed configuration. A filter body having an inlet end and an outlet end is coupled to the filter support frame. The filter support frame includes a plurality of arms, each arm having a first end and a second end. The first ends of the arms are generally coupled together, with each of the second ends of the arms having a support element coupled thereto. Each arm can articulate independently from another. Each support element can freely articulate on each arm. The free ends of each support element can be biased to an outwardly extending position so that a suitable force will be created to maintain the filter body firmly pressed against a vessel wall when deployed. | 07-01-2010 |
| 20100145433 | ENDOPROSTHESES FOR DEPLOYMENT IN A BODY LUMEN - Example embodiments include an endoprosthesis that has a first annular segment that is radially expandable and a second annular segment that is also radially expandable. An axial segment, which includes one or more struts, is operatively associated with the first annular segment and the second annular segment to maintain a specified distance between the first annular segment and the second annular segment. | 06-10-2010 |
| 20100145278 | AGENT DELIVERY CATHETER HAVING ARTICULATING ARMS - An agent delivery catheter which has a support member comprising at least one articulating arm having an end fixedly secured relative to the shaft and having an anchor end section opposite to the fixed end. The articulating arm is biased to pivot at the fixed end away from the shaft, to transform from a low profile configuration to a high profile configuration in which the arm extends laterally away from the shaft and the anchor end section contacts the patient's body lumen wall, to support the shaft in the body lumen during delivery of an agent, for example by injection from a needle extended from the catheter into the wall of the body lumen. | 06-10-2010 |
| 20100145265 | AGENT DELIVERY CATHETER HAVING A RADIALLY EXPANDABLE CENTERING SUPPORT MEMBERS - A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member. | 06-10-2010 |
| 20100144635 | METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS - Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents. | 06-10-2010 |
| 20100130927 | LOW COMPLIANT CATHETER TUBING - combination of at least two polyamides. The catheter component can be made from a blend of the two polyamides, or a co-extrusion of the two polyamides with an inner layer and an outer layer. The first polyamide has a Shore D durometer hardness of more than seventy seven (77), and can be selected from various transparent amorphous nylons having an amorphous segment such as an aliphatic segment, an aromatic segment, or a cycloaliphatic segment. The second polyamide has a lower durometer hardness than the first polyamide, and preferably less than 73, and can be a block copolymer of nylon and polytetramethylene glycol. Both polyamides have the same amide block or segment, e.g. nylon 12. Adding small amounts of the high hardness polyamide can reinforce the low polyamide at the amorphous segments, thereby increasing the overall strength of the material. | 05-27-2010 |
| 20100130926 | ROBUST CATHETER TUBING - A multilayer balloon catheter is formed to have an inner layer and an outer layer, where the outer layer is adapted to resist shredding and premature rupture. The outer layer is formed of a material having a glass transition temperature that is lower than the transition or melting temperature of the inner layer. By forming the balloon on a mold at a temperature between the glass transition temperature of the outer layer and the glass transition or melting temperature of the inner layer, the outer layer will undergo a thermal relaxation that will alleviate some of the axial orientation of the polymer chains that develop during the formation of the multilayer balloon. This relaxation leads to a resistance to shredding when the balloon is expanded during operation. | 05-27-2010 |
| 20100130925 | ROBUST CATHETER TUBING - A balloon catheter having a multilayer catheter shaft is formed to have an inner layer and an outer layer, where the inner layer and outer layer are selected from materials that enhance the pushability of the catheter while preserving the flexibility. Using a combination of a high Shore D duromater value material and a lower Shore D duromater value material, various combinations of multilayer catheter shafts are disclosed utilizing different glass transition temperatures and block copolyamides to obtain the desired characteristics. | 05-27-2010 |
| 20100126414 | Mounting Assembly For A Stent And A Method Of Using The Same To Coat A Stent - A mounting assembly for a stent and a method of coating a stent using the assembly are provided. | 05-27-2010 |
| 20100125322 | STENT DELIVERY CATHETER SYSTEM WITH HIGH TENSILE STENGTH - A stent delivery catheter system having a reinforcing tether member secured to the catheter such that the catheter is provided with an improved combination of an enhanced tensile strength together with other catheter performance characteristics such as low profile and high flexibility. | 05-20-2010 |
| 20100125280 | DELIVERY SYSTEM HAVING ONE PIECE INNER MEMBER WITH FLAT DISTAL END PORTION - A delivery system has reduced profile in the catheter portion of the delivery system without compromising the pushability of the delivery system. The present invention also provides a structure which improves and simplifies the attachment of small catheter components to other structures forming the catheter portion the delivery system. | 05-20-2010 |
| 20100114295 | THERMOELASTIC AND SUPERELASTIC NI-TI-W ALLOY - A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility. | 05-06-2010 |
| 20100106242 | STENT AND METHOD FOR MAKING A STENT - A stent includes a body, a layer of therapeutic agent over at least a section of the body, and a sealant layer over the layer of therapeutic agent. The sealant layer includes a through hole that allows release of the therapeutic agent of the therapeutic agent layer through the through hole when the stent is deployed in a blood vessel. | 04-29-2010 |
| 20100104653 | Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The method for treating a vascular disease includes providing a formulation comprising a plurality of nanoparticles having a density different from that of blood and further comprising one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles; and administering a therapeutically effective amount of the formulation to a vascular disease locale in a patient. | 04-29-2010 |
| 20100104506 | Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The medical device includes a coating that comprises a plurality of nanoparticles, wherein the nanoparticles comprise one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles and further comprise one or more contrast enhancing agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles. | 04-29-2010 |
| 20100096781 | Method Of Fabricating An Implantable Medical Device Using Gel Extrusion And Charge Induced Orientation - The invention provides a method of manufacturing a polymeric implantable medical device using gel extrusion of high molecular weight polymers or charge-induced orientation to avoid heat degradation of the polymer that might occur during conventional heat extrusion. | 04-22-2010 |
| 20100082095 | Coatings Including Dexamethasone Derivatives And Analogs And Olimus Drugs - The present invention encompasses a coating on the surface of a substrate and the coated substrates. The coating includes a polymer, an olimus drug (sirolimus, everolimus, zotarolimus, etc.), and a dexamethasone derivative. The polymer may be a hydrophobic polymer, preferably a fluoropolymer, and more preferably a fluoropolymer with at least 25% vinylidene fluoride by weight. | 04-01-2010 |
| 20100057050 | CATHETER CONFIGURED FOR INCREMENTAL ROTATION - A catheter which allows the rotational orientation of the distal end of the catheter to be adjusted in discrete intervals as the physician rotates the proximal end of the catheter. The catheter is designed to intentionally induce whipping but to limit the amount of whipping to a desired rotational interval. | 03-04-2010 |
| 20100057037 | Agent Delivery Catheters - An agent delivery catheter that includes an anti-whipping feature, improved assembly of distal parts and/or accuracy/repeatability of needle delivery to a target tissue. Additional features include fitting a catheter with a pneumatic delivery device for delivery of a therapeutic agent without using a needle. | 03-04-2010 |
| 20100049240 | CAGE AND SLEEVE ASSEMBLY FOR A FILTERING DEVICE - A cage and sleeve assembly for an embolic filtering device used to filter embolic particles from a body vessel has a strut assembly that is movable between an unexpanded position and an expanded position. Struts having strut ends at the respective ends form a cage. The strut ends are initially made from linear elastic nitinol, and a series of spot or laser or other types of welds then secure the strut ends in the sleeve assembly. In one approach, the ends of the strut ends are welded to form a tube. In another approach, the strut ends are welded onto a sleeve. The strut ends may optionally have ends that are partial cylinders, and the partial cylinders are welded onto a cylindrical sleeve. Effects from the welding, such as changing linear elastic nitinol to superelastic nitinol, are contained within a heat-effected zone, and do not extend into areas of the structure that typically bend during use. | 02-25-2010 |
| 20100036472 | DELIVERY SYSTEM WITH VARIABLE DELIVERY RATE FOR DEPLOYING A MEDICAL DEVICE - A delivery system utilizes a handle assembly including an actuating mechanism capable of initially providing sufficient mechanical advantage to overcome static friction when initiating deployment of the medical device. The actuating mechanism includes components which help to increase the speed of deployment as the physician continues to manipulate the actuating mechanism. | 02-11-2010 |
| 20100004627 | NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN - A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site. | 01-07-2010 |
| 20100000328 | METHOD FOR MEASURING STENT DISLODGEMENT FORCE - A method for measuring the force necessary to dislodge a stent from a balloon catheter to which it is mounted. The balloon catheter with a stent mounted thereon is encased in a mass of gel material. The force necessary to pull the catheter from the gel is measured. | 01-07-2010 |
| 20090324670 | Polyester Implantable Medical Device With Controlled In Vivo Biodegradability - This invention relates to blends of high, optionally medium, and low molecular weight polyesters where at least the low molecular weight polyester is substituted with an acidic moiety, the biodegradation of the blends being controllable by selection of the mean molecular weigh of each fraction, the quantity of each fraction in the blend and the amount and pKa of the acidic moiety(ies). | 12-31-2009 |
| 20090318855 | DEVICES AND METHODS FOR IMPROVING INTRAVASCULAR UPTAKE OF AGENTS - This invention is generally related to therapeutic treatment of a coronary vessel wall, and more particularly, to systems and methods for improving uptake of therapeutic agents within the endothelium for enhanced delivery of therapeutic agents to a treatment site. A medical device is provided that is capable of reducing the pressure applied to a vessel wall and delivering a therapeutic agent into the vessel wall. Also, methods are described for using the device to facilitate delivery and uptake of a therapeutic agent into the vessel wall. | 12-24-2009 |
| 20090297621 | Microparticles For The Treatment Of Disease - Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed. | 12-03-2009 |
| 20090297575 | Implantable Drug Delivery Devices Having Alternating Hyrdrophilic And Amphiphilic Polymer Layers - An implantable drug delivery medical device with alternating hydrophilic and amphiphilic polymer layers and methods of using for the treatment of vascular disease are disclosed. | 12-03-2009 |
| 20090285873 | IMPLANTABLE MEDICAL DEVICES AND COATINGS THEREFOR COMPRISING BLOCK COPOLYMERS OF POLY(ETHYLENE GLYCOL) AND A POLY(LACTIDE-GLYCOLIDE) - The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same. | 11-19-2009 |
| 20090270787 | SYSTEMS AND METHODS FOR CREATING ENLARGED MIGRATION CHANNELS FOR THERAPEUTIC AGENTS WITHIN THE ENDOTHELIUM - A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent. | 10-29-2009 |
| 20090270721 | INTRA-VENTRICULAR SUBSTANCE DELIVERY CATHETHER SYSTEM - A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration. | 10-29-2009 |
| 20090269479 | Method For Biostable Inclusion Of A Biobeneficial Agent On An Outermost Surface Of An Implantable Medical Device - The current invention is directed to a method of protecting UV or visible light sensitive drugs from the effects of UV or visible radiation used to form covalent bonds between a biobeneficial material and the outermost surface of an implantable medical device in order to lessen the foreign body response to the device. | 10-29-2009 |
| 20090264818 | CONTROLLING SHAFT BENDING MOMENT AND WHIPPING IN A TENDON DEFLECTION OR OTHER TENDON SYSTEM - A tendon deflection system including a shaft, a plurality of tendons movably disposed within the shaft, and a force-balancing element coupled to the tendons. In a first section, the plurality of tendons are arranged around the shaft at equal angles to each other and at an equal distance from the center of the shaft. The tendons operating in concert with the force-balancing element minimize the moment expressed in the first section. The second section is deflectable and includes at least one tendon, extending from the plurality of tendons in the first section, which is arranged along one side of the shaft such that the bending moment expressed in the second section is greater than the first section. | 10-22-2009 |
| 20090258047 | Heparin Prodrugs and Drug Delivery Stents Formed Therefrom - A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. | 10-15-2009 |
| 20090258029 | Heparin Prodrugs and Drug Delivery Stents Formed Therefrom - A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. | 10-15-2009 |
| 20090258028 | Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug - This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention. | 10-15-2009 |
| 20090255827 | AUTOMATED ELECTROPOLISHING PROCESS - An electropolishing system including an anode, a cathode, a rolling block and a motion controller. The anode is configured to removably retain a metal device to be electropolished, and may be formed as a bar made from a solid cylindrical piece of metal or other configurations, such as wires with hooks. The anode transfers the electricity to the metal device while grooming the surface of the metal device as it contacts the rolling block. The cathode may be configured as a mesh and completes the electrical circuit. The rolling block is formed from a relatively smooth, solid material and positioned so as to allow the metal device to roll against the surface of the block. The motion controller is configured to provide vertical and horizontal movement of the anode and metal device, using force transducers to control the compression of the metal device against the rolling block. | 10-15-2009 |
| 20090248130 | NITINOL ALLOY DESIGN AND COMPOSITION FOR VASCULAR STENTS - A stent and a delivery system for implanting the stent in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element in order to minimize the stress hysteresis of the superelastic material. The stress hysteresis is defined by the difference between the loading plateau stress and the unloading plateau stress of the superelastic material. The resulting delivery system has a small profile and includes a sheath covering the stent that has a thin wall. | 10-01-2009 |
| 20090246253 | Methods Of Providing Antioxidants To Implantable Medical Devices - Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices. | 10-01-2009 |
| 20090240325 | Implantable Medical Device Coatings With Improved Mechanical Stability - Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed. | 09-24-2009 |
| 20090232865 | End-Capped Poly(Ester Amide) Copolymers - This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases. | 09-17-2009 |
| 20090204068 | AGENT DELIVERY CATHETER HAVING AN INFLATION BRIDGE BETWEEN TWO AXIALLY SPACED BALLOONS - An agent delivery catheter having two or more axially spaced balloons and an inflation bridge providing fluid communication between the two balloons. The catheter generally has a proximal balloon, a distal balloon, and a tube defining an inflation bridge lumen which is located in part within the inflatable interiors of the balloons, and which extends therebetween, and which has a proximal port within the proximal balloon interior and a distal port within the distal balloon interior to thereby provide for inflation of the distal balloon by placing the distal balloon interior in fluid communication with the proximal balloon interior of the shaft. | 08-13-2009 |
| 20090157043 | LOW PROFILE AGENT DELIVERY PERFUSION CATHETER HAVING A FUNNEL SHAPED MEMBRANE - An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 06-18-2009 |
| 20090156998 | CATHETER HAVING TRANSITIONING SHAFT SEGMENTS - A catheter having shaft segments which are joined together by a strong bond providing a low profile shaft section with a flexibility transition and/or a compositional transition. A balloon catheter embodying features of the invention has a distal tip member and a coupling band member surrounding a junction of an inner tubular member of the shaft, and has a gradual change in bending stiffness along a distal end section of the shaft which extends distally from a location within the balloon interior. Another catheter embodying features of the invention has shaft segments joined together by a diagonal seam. | 06-18-2009 |
| 20090149568 | Biodegradable Coatings For Implantable Medical Devices - Biodegradable coatings for implantable medical devices are disclosed. | 06-11-2009 |
| 20090148491 | Dual-Targeted Drug Carriers - The present invention relates to implantable medical devices containing surface-treated, dual-targeted drug carriers for treating vascular diseases. | 06-11-2009 |
| 20090131910 | VISUALIZATION OF A CATHETER VIEWED UNDER ULTRASOUND IMAGING - A catheter for use in a patient's body lumen, having a shaft section configured to minimize ultrasonic image artifacts and the direct ultrasonic image brightness of the shaft surface and its internal components, and to produce its image at a wide range of imaging angles, preferably with an intensity not substantially different than surrounding tissue of the body lumen under ultrasound visualization. The shaft section is operative for the desired use of the catheter, yet is also configured to facilitate accurately imaging the shape and location of the shaft section, and easily differentiate it from the surrounding anatomy without unduly obscuring the images of the adjacent anatomy using an ultrasound imaging system. | 05-21-2009 |
| 20090105644 | INTRAVASCULAR MEDICAL DEVICE HAVING A READILY COLLAPSIBLE COVERED FRAME - An elongated intravascular device having a frame configured for reversibly expanding in a patient's body lumen, which has a sleeve secured to the frame, and at least one sleeve-folding strut configured to fold the sleeve inwardly as the frame radially collapses in the patient's body lumen. Additional aspects of the invention are directed to methods of recovering such expanded frame type devices, and a recovery catheter configured for collapsing an expanded frame. The devices and methods of the invention facilitate the collapse of expanded frame devices, for repositioning or removal from the patient's body lumen. | 04-23-2009 |
| 20090105642 | LOW PROFILE AGENT DELIVERY PERFUSION CATHETER HAVING REVERSIBLY EXPANDING FRAMES - An agent delivery catheter and method, configured to deliver an agent to an inner surface of a patient's body lumen by forming an agent containment pocket along the inner surface of the patient's body lumen wall between a proximal expandable frame and a distal expandable frame, while minimizing ischemic conditions during the procedure. | 04-23-2009 |
| 20090104240 | Dual Drug Formulations For Implantable Medical Devices For Treatment of Vascular Diseases - The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases. | 04-23-2009 |
| 20090075933 | CYTOCOMPATIBLE ALGINATE GELS - The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy. | 03-19-2009 |
| 20090053392 | Implantable medical devices for local and regional treatment - Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed. | 02-26-2009 |
| 20090047324 | Medical Devices Containing Rapamycin Analogs - A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs. | 02-19-2009 |
| 20090047323 | Medical Devices Containing Rapamycin Analogs - A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs. | 02-19-2009 |
| 20090047318 | NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. | 02-19-2009 |
| 20090041923 | MEDICAL DEVICE HAVING A LUBRICIOUS COATING WITH A HYDROPHILIC COMPOUND IN AN INTERLOCKING NETWORK - A medical device having a lubricious coating on at least a section of the medical device, and a method of coating a medical device, the lubricious coating being a network of a hydrophilic compound cross-linked to itself and interlocked with a network of a cross-linked polymerized multifunctional monomer or polymer. The coating can include one or more agents which provide enhanced adhesion of the coating on the device, or which provide faster hydration of the coating and/or improved lubricity. Additionally, the lubricious coating can be provided with one or more therapeutic or diagnostic agents, and in one embodiment the agent elutes relatively quickly in a concentrated release from the lubricious coating upon hydration of the coating. | 02-12-2009 |
| 20090012601 | STENT AND CATHETER ASSEMBLY AND METHOD FOR TREATING BIFURCATIONS - An improved stent system for treating a bifurcation. Up to three stents are mounted on two parallel balloon catheters wherein a proximal stent is disposed about both balloons while two distal stents are each disposed about one of the balloons. Such configuration enhances the flexibility of the assembly to facilitate its advancement through tortuous vasculature, while the structural independence of the stents maximizes the systems ability to spread into a wide range of bifurcation angles. A single link between each distal stent and the proximal stent may be relied upon to maintain relative stent position during deployment. | 01-08-2009 |
| 20080296274 | METHOD FOR LASER CUTTING TUBING USING INERT GAS AND A DISPOSABLE MASK - A method for making a device includes providing a tubular member which will be formed into the device, masking at least a portion of the inner surface of the tubular member with a removable sacrificial material, selectively removing a portion of the tubular member and sacrificial material using a laser device, and mechanically removing the sacrificial material from the inner surface of the tubular member. The method may also include applying a chemical solution to the tubular member and sacrificial material which primarily attacks the either the tubular member or sacrificial material. | 12-04-2008 |
| 20080287911 | CATHETER WITH LAMINAR FLOW DRUG DELIVERY PROPERTIES - Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed. | 11-20-2008 |
| 20080286372 | THERAPEUTIC COMPOSITIONS FOR TARGETED VESSEL DELIVERY - Methods for treating a vascular disease by delivering therapeutic compositions with enhanced endothelium targeting are disclosed. | 11-20-2008 |
| 20080269868 | STENT DELIVERY CATHETER SYSTEM AND METHOD OF IMPLANTING A SELF-EXPANDING STENT WITH EMBOLIC PROTECTION - A catheter system and method for implanting an i such as a stent at a treatment site in a patient's body lumen. The catheter provides a complete system for stent delivery, dilatation, and delivery and/or recovery of an expandable device, such as an embolic protection device, adjacent to the treatment site in the body lumen. | 10-30-2008 |
| 20080234812 | Stent spin coating method - A method is disclosed for spin coating a stent. The method comprises conducting the following acts at the same time: applying a coating substance to the stent; rotating the stent about a first axis of rotation; and rotating the stent about a second axis of rotation. | 09-25-2008 |
| 20080234810 | Amorphous Glass-Coated Drug Delivery Medical Device - An implantable medical device that can include an amorphous glass primer layer, an amorphous glass drug-containing layer and a nanoporous amorphous glass top-coat layer is disclosed. | 09-25-2008 |
| 20080221552 | AGENT DELIVERY PERFUSION CATHETER - An agent delivery catheter and method, configured to deliver an agent to an inner surface of a patient's body lumen by forming an agent containment pocket along the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 09-11-2008 |
| 20080221550 | RAPID EXCHANGE INFUSION CATHETER - An infusion catheter and method, with an elongated shaft having a guidewire lumen which has a proximal section and a common distal section extending to a distal port at a distal end of the shaft, and an infusion lumen which is in fluid communication with the distal port of the guidewire lumen and which joins the common distal section of the guidewire lumen at a location distal to the guidewire proximal port. A restricted passage from the infusion lumen to the common distal section of the guidewire lumen has a smaller transverse dimension than the guidewire lumen and a guidewire slidably disposed in the guidewire lumen. | 09-11-2008 |
