RHODE ISLAND HOSPITAL Patent applications |
Patent application number | Title | Published |
20160139149 | CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS - Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from nonalcoholic fatty liver disease. CHI3L1 levels can also be used to monitor treatment progress in patients having NASH. Also disclosed herein are compositions and methods for treating NASH by targeting CHI3L1. | 05-19-2016 |
20150352131 | Compositions and Methods for the Prevention and Treatment of Osteolysis and Osteoporosis - This application discloses compositions, devices, and methods for the prevention and treatment of osteolysis and osteoporosis. Treatment or prevention of osteolysis or osteoporosis is carried out by targeting the enzyme, Shp2 (a Src homology 2 (SH2) domain containing non-transmembrane Protein Tyrosine Phosphatase (PTP)), or proteins involved in the Shp2 signaling pathway by administering a Shp2 pathway inhibitor that inhibits fusion of pre-osteoclasts. | 12-10-2015 |
20150258213 | Nanotubes as Carriers of Nucleic Acids into Cells - The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids. | 09-17-2015 |
20140369984 | BIOMATERIAL FOR ARTICULAR CARTILAGE MAINTENANCE AND TREATMENT OF ARTHRITIS - The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery. | 12-18-2014 |
20140206629 | Stromal Derived Factor Inhibition And CXCR4 Blockade - The invention relates to inhibition of SDF-1α expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-α stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder. | 07-24-2014 |
20140179611 | TRIBONECTINS - The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. | 06-26-2014 |
20140171482 | Nanotubes as Carriers of Nucleic Acids into Cells - The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids. | 06-19-2014 |
20140088191 | Inhibition of Renal Fibrosis - The invention provides compositions and methods for inhibiting renal fibrosis. | 03-27-2014 |
20140081432 | Method and Apparatus for Rehabilitation Using Adapted Video Games - A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game commands. These commands are coupled with other inputs to control the video game that will be used to ensure adherence to a prescribed rehabilitation regimen. Information is gathered on the participant, in order to aid in rehabilitation. | 03-20-2014 |
20130288972 | Compositions and Methods For The Treatment of Orthopedic Disease or Injury - Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment. | 10-31-2013 |
20130217948 | Advanced Radiotherapy Treatment Planning Optimization - A method of radiotherapy treatment planning is described. A planned target volume is identified for radiotherapy treatment and at least one volume of interest is identified. The mass, density, and total deposited energy contained in the planned target volume and the volumes of interest are identified and dose objectives are determined. At least one of the objectives is a function of the identified mass, density, or deposited energy. A composite objective function is determined using the dose objectives for the planned target volume and the volumes of interest. A near optimal solution to the composite objective function is determined to produce a radiotherapy treatment plan. | 08-22-2013 |
20130072435 | TRIBONECTINS - The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. | 03-21-2013 |
20130066394 | Pain Management - A system including a processor configured to be coupled to an electrical lead that is configured to sense electrical activity in a patient, a memory coupled to the processor, the memory containing computer readable instructions that, when executed by the processor, cause the processor to detect a pain signature in the sensed electrical activity, determine a treatment protocol in response to the detected pain signature, and cause the treatment protocol to be delivered to the patient via the electrical lead. | 03-14-2013 |
20120270655 | DEVICE CONTROLLER WITH CONFORMABLE FITTING SYSTEM - A controller with a conformable fitting system is configured for controlling a device, such as a toy or game, is pliable, flexible and cushioning to provide a custom fit of the device controller to the body part of the patient or user. The device controller spans across a joint, such as a wrist, and includes a pivot between preferably two main portions. The rotation axis of the device controller is aligned with the pivot axis of the joint to receive the physical therapy. A sensor, such as a digital encoder, is located proximal thereto to determine the relative positioning of the main portions to each other. The sensor electronically communicates with the device, such as a toy or game, to serve as a controller therefor. | 10-25-2012 |
20100204087 | TRIBONECTINS - The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. | 08-12-2010 |
20100190199 | GPR30 ESTROGEN RECEPTOR IN BREAST AND OVARIAN CANCERS - A method of prognosis for ovarian or breast cancer patients is carried out by detecting GPR30 in a sample of tissue. An elevation in the level of GPR30 compared to a normal control level indicates presentation of late stage disease and indicates responsiveness of the tumor to hormonal therapy. | 07-29-2010 |
20100172832 | DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS - The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention. | 07-08-2010 |
20100144837 | DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS - The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH. | 06-10-2010 |
20100136581 | DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS - The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH. | 06-03-2010 |
20100048458 | TRIBONECTINS - The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. | 02-25-2010 |
20100021400 | Active Sunscreen Composition - The invention relates to topical compositions comprising a fluorescent dye that absorbs UVA and UVB radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to UV light. | 01-28-2010 |
20090216333 | WRIST IMPLANTS - An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion. | 08-27-2009 |
20090204223 | KINEMATIC TOTAL WRIST ARTHROPLASTY - An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion. | 08-13-2009 |