Technische Universität München Patent applications |
Patent application number | Title | Published |
20160137698 | BIOSYNTHETIC PROLINE/ALANINE RANDOM COIL POLYPEPTIDES AND THEIR USES - The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, wherein said biosynthetic random coil polypeptide, said biosynthetic random coil polypeptide segment or said biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. Said at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituents) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or said conjugates are described. | 05-19-2016 |
20160114441 | DEVICE FOR GENERATING A ROTATORY ULTRASONIC VIBRATION ON A TOOL - A device adapted for generating a rotatory ultrasonic vibration on a tool that includes a first part which is adapted for the rotationally fixed connection of the device to a spindle of a machine tool that rotates about an axis of rotation, and a second part which is adapted for the rotationally fixed connection of the device to a tool. The device also includes a claw coupling which is configured to connect the first and second parts for rotation with one another and has a form fit of at least one first flank on the first part and at least one second flank, lying opposite the first flank, on the second part. The device also includes at least one piezoelectric oscillation element arranged between first and second flanks of the claw coupling configured for generating a rotatory ultrasonic vibration about the axis of rotation. | 04-28-2016 |
20150069114 | FRICTION STIR WELDING APPARATUS AND METHOD FOR JOINING WORKPIECES BY MEANS OF A FRICTION STIR WELDING PROCESS - The invention relates to a friction stir welding apparatus for joining workpieces | 03-12-2015 |
20140193625 | METHOD FOR PRODUCING A COMPONENT FROM A COMPOSITE FIBER MATERIAL AND COMPOSITE FIBER MATERIAL COMPONENT - A process for the production of a component ( | 07-10-2014 |
20140170197 | POLYMERIC DELIVERY SYSTEMS FOR ACTIVE AGENTS - The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates. | 06-19-2014 |
20140116892 | Apparatus and Method for Evaluating Characteristics of Target Molecules - Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined. | 05-01-2014 |
20140050693 | BIOLOGICAL ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY - Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which consist essentially of Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention. | 02-20-2014 |
20140039153 | CANCER IMAGING AND TREATMENT - A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: | 02-06-2014 |
20130316962 | Muteins of hNGAL and related proteins with affinity for a given target - The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein. | 11-28-2013 |
20130302575 | METHOD AND MATERIAL SYSTEM FOR BUILDING MODELS IN LAYERS - The present invention describes a method for building models in layers, wherein a first material and subsequent thereto selectively a second material are applied in layers in a build space, and these two application steps are repeated until a desired model is obtained. The two materials form a solid object in a suitable mixing ratio, the first material including a particulate material and the second material being applied with the aid of a print head. The first material, the second material and/or the particulate material include one or more diamines and/or one or more dicarbonyl compounds as the binder. | 11-14-2013 |
20130288702 | Visual Localization Method - There is provided a visual localization method comprising: (a) transmitting data representative of one or more detected visual features from a mobile device to a server; (b) estimating the location of the mobile device at the server based on the visual features | 10-31-2013 |
20130209411 | Lactocepins For Use in the Treatment of IP-10-Mediated Inflammatory Diseases - The invention relates to lactocepins and/or a functionally active fragment thereof for use in the prophylaxis and/or the treatment of a disease and to one or more lactocepin(s) and/or one or more functionally active fragment(s) thereof for use in the prophylaxis and/or treatment of IP-10-mediated inflammatory diseases. | 08-15-2013 |
20130189745 | ARTIFICIAL CELLULOSOME AND THE USE OF THE SAME FOR ENZYMATIC BREAKDOWN OF RESILIENT SUBSTRATES - The present invention relates to an in vitro produced, artificial cellulosome for enzymatic breakdown of resilient substrates. In particular, the present invention provides a complex having an increased activity on resilient substrates, such as crystalline cellulose. The in vitro formed complex comprises a backbone scaffold having at least four binding sites capable of binding the enzyme components, whereby at least two of the binding sites have essentially the same binding specificity; and at least three different enzyme components being randomly bound to the at least four binding sites. Method for preparing the complex and uses of the same for enzymatic breakdown of resilient substrates are also provided. | 07-25-2013 |
20130168570 | DEVICE AND METHOD FOR COMBINED OPTICAL AND NUCLEAR IMAGE ACQUISITION - A device for combined optical and nuclear image comprises a nuclear image acquisition module and a reference image acquisition module. The reference image acquisition module has: an optical image sensor and an optical imaging system for deflecting the optical radiation from a reference field of view to the image sensor, wherein the optical imaging system comprises a mirror for the optical radiation, which mirror is arranged between the reference field of view and the optical image sensor. On the image sensor, a respective image area is assigned to at least one of nuclear partial fields of view. The optical imaging system is arranged such that the optical radiation coming from the at least one nuclear partial field of view is deflected substantially exactly to the respectively assigned of the image areas. | 07-04-2013 |
20130157057 | METHOD FOR PRODUCING A COMPONENT FROM A FIBRE COMPOSITE, PREFORM THEREFOR, AND COMPONENT - A method for producing a component from a fibre composite. A number of layers of a dry fibrous material are stacked to form a pile, the pile is covered by a thermoplastic film in a gas-tight manner, the inner space occupied by the pile within the film is pumped dry and the layers are fixed to form a preform that is stable during transport, the preform is reshaped, a liquid thermosetting material is inserted into the inner space by infiltration of the fibrous material, and the preform is hardened with the infiltrated fibrous material to form the finished component, the film binding permanently as the surface. The invention also relates to a component produced in such a way, and to a corresponding preform. The production method provides a process-integrated surface finishing of the fibre composite. The surface properties are created by the bound thermoplastic film. | 06-20-2013 |
20130129622 | CYCLOPENTAPEPTIDE DERIVATIVES AND USES THEREOF - The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa | 05-23-2013 |
20130073513 | Hybrid OLTP and OLAP High Performance Database System - There is provided a method of maintaining a hybrid OLTP and OLAP database, the method comprising: executing one or more OLTP transactions; creating a virtual memory snapshot; and executing one or more OLAP queries using the virtual memory snapshot. Preferably, the method further comprises replicating a virtual memory page on which a data object is stored in response to an update to the data object, whereby the updated data object is accessible for OLTP transactions, while the non-updated data object remains accessible for OLAP queries. Accordingly, the present invention provides a hybrid system that can handle both OLTP and OLAP simultaneously by using hardware-assisted replication mechanisms to maintain consistent snapshots of the transactional data. | 03-21-2013 |
20130072420 | BIOSYNTHETIC PROLINE/ALANINE RANDOM COIL POLYPEPTIDES AND THEIR USES - The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, wherein said biosynthetic random coil polypeptide, said biosynthetic random coil polypeptide segment or said biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. Said at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or said conjugates are described. | 03-21-2013 |
20130071367 | ANIMAL FEED FOR CALVES FOR CONDITIONING THE INTESTINAL FLORA - The present invention is directed to a animal feed for calves comprising calf-specific bacteria, optionally lipids, proteins, vitamins and/or mineral materials for conditioning of the intestinal flora in calves, and thus, for prophylaxis and/or treatment of diarrhea in calves. | 03-21-2013 |
20120235416 | SHAFT POWER PLANT - A shaft power plant ( | 09-20-2012 |
20120222744 | CAVITATION REACTOR - Cavitation reactor for hydrodynamic generation of homogeneous, oscillating cavitation bubbles in a fluid, including, while forming a flow duct and arranged one behind the other in the direction of flow of the fluid, an acceleration section designed to increase a flow velocity, a diaphragm arranged transversely to the direction of flow with a plurality of micro-passages designed for generating cavitation bubbles, where at least 10 micro-passages per cm | 09-06-2012 |
20120084392 | METHOD AND SYSTEM FOR PROVIDING MEDIA CONTENTS FOR A PLURALITY OF NODES IN A DATA NETWORK - A method for providing media contents for a plurality of addressable nodes in a data network, said media contents comprising at least one media file. For each media file to be provided, a decentralized structure managed via a first node is formed so the respective media file is divided into a plurality of sections and an identity value is allocated to the sections, the first node(s) respectively responsible for a sub-interval and for a sub-quantity of sections from the respective media file. In a respective first node, a number of second nodes and corresponding addresses are deposited, the second node(s) specified for providing said sections according to said sub-interval, for which the respective first node is responsible. A receiving node retrieves the addresses of second nodes having sections of said media file by a request to said first node, and downloads the sections from said retrieved addressed second nodes. | 04-05-2012 |
20110243699 | DAMPING OR PREVENTION OF VIBRATIONS IN INDUSTRIAL TRUCKS - An industrial truck is shown with a lifting frame, on which a load-receiving section is arranged so as to be movable vertically. The load-receiving section has at least one degree of movement freedom with respect to the lifting frame, which lies in a plane perpendicular to the main direction of travel of the industrial truck and has at least one horizontal component. In addition, a vibration control system is provided for damping or preventing vibrations in the relative position of load-receiving section and lifting frame. | 10-06-2011 |
20110165258 | POLYMERIC DELIVERY SYSTEMS FOR ACTIVE AGENTS - The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates. | 07-07-2011 |
20110104695 | METHODS OF PREDICTING THERAPEUTIC EFFICACY OF CANCER THERAPY - The present invention relates to novel methods and kits for predicting, prognosing, and/or monitoring therapeutic efficacy of cancer therapy on a subject having malignant tumor or cell proliferative disorder. | 05-05-2011 |
20110027175 | CANCER IMAGING AND TREATMENT - A compound, or a pharmaceutically acceptable salt or ester thereof, comprises a ligand for the chemokine receptor CXCR4 and a detectable label, the ligand having a binding affinity for the CXCR4 receptor, measured as IC | 02-03-2011 |
20100280368 | Trocar tube, Trocar, Obturator and/or Rectoscope for the Transluminal Endoscopic Surgery Via Natural Body Orifices - A trocar tube, trocar, obturator, rectoscope is suitable for transluminal endoscopic surgery via natural body cavities. A trocar tube ( | 11-04-2010 |
20090215025 | SMALL PEPTIDIC AND PEPTIDO-MIMETIC AFFINITY LIGANDS FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS - The present invention pertains to compounds that show a high affinity to Factor VIII and Factor VIII-like proteins, and their uses. The compounds are characterized by the general Formula B-Q-X, wherein B represents a dipeptide, tripeptide, or a peptidomimetic; Q represents a spacer and X represents an anchoring molecule; Q and X are optional. These compounds can be used for coating a solid support material. The resulting coated solid support material can be used for purifying Factor VIII by means of affinity chromatography methods. In addition, the compounds of the present invention may be used for stabilizing Factor VIII and for enhancing its activity. The present invention thus pertains also to methods for manufacturing a stabilized Factor VIII containing medicament of increased activity. The inventive compounds can furthermore be used in diagnostic kits and as research tools. | 08-27-2009 |
20090038419 | Sample System For Fluid Samples - The present invention relates to a sampling system for fluid samples having sample receiving vessel for receiving the sample, which is sealed by a septum and holder for the sample receiving vessel for receiving and holding the sample receiving vessel and also a sample probe for dipping into a fluid volume and for taking a fluid sample from the fluid volume, the sample probe being configured as a hollow volume which, at one end, has a first opening for introducing the holder and the sample receiving vessel and, at another end, is sealed by a first valve which is provided with a hollow needle which projects into the interior of the sample probe said valve being able to be opened by contact with the holder and/or with the sample receiving vessel and then connecting the exterior of the sample probe to the inner volume of the hollow needle. | 02-12-2009 |
20090014283 | DEVICE FOR NON-CONTACT CONVEYING, HANDLING AND STORAGE OF STRUCTURAL ELEMENTS AND MATERIALS - A device for generating a floating state of an object by sound waves includes a rigid support structure having a top surface for absorbing forces generated by the gravitation or acceleration of the levitating object and perpendicularly acting on the top surface. A thin oscillatory element is arranged in parallel to the top surface. Further provided is a vibration generator for making the thin oscillatory element vibrating and levitating above the top surface so that the object is levitating above the thin oscillatory element without contacting it. | 01-15-2009 |
20080305038 | Transport of Nano-and Macromolecular Structures Into Cytoplasm and Nucleus of Cells - The present invention refers to novel conjugate molecules and their use or the transport of nano- and macromolecular structures into cells and/or the nucleus. More particularly, the present invention refers to conjugate molecules containing a carrier, preferably thiopyridyl moieties, and a cargo moiety. Thereby, the thiopyridyl moiety is bound to the cargo moiety to act as a carrier, particularly for efficient intracellular and/or intranuclear delivery of drugs, nano-or macromolecular structures, etc. The novel conjugate molecules are provided for the manufacture of a medicament for gene therapy, apoptosis, or for the treatment of diseases such as cancer, autoimmune diseases or infectious diseases. | 12-11-2008 |