Actelion Pharmaceuticals Ltd. Patent applications |
Patent application number | Title | Published |
20160052891 | PREPARATION OF PYRIMIDINE INTERMEDIATES USEFUL FOR THE MANUFACTURE OF MACITENTAN - The present invention relates to a new synthetic intermediate, namely the compound of formula I-2 I or a salt thereof. Said compound of formula I-2 or its salt can be used to prepare the compound of formula I-3 I which is an important synthetic intermediate used in the preparation of macitentan. | 02-25-2016 |
20160031866 | PYRIDIN-4-YL DERIVATIVES - The invention relates to compounds of the Formula (I), Formula (I) wherein R | 02-04-2016 |
20160024050 | NOVEL ACRYLAMIDE DERIVATIVES AS ANTIMALARIAL AGENTS - The invention relates to novel acrylamide derivatives of the formula (I) wherein R | 01-28-2016 |
20160022678 | THERAPEUTIC COMPOSITIONS CONTAINING MACITENTAN - The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having prostacyclin receptor (IP) agonist properties, or a pharmaceutically acceptable salt thereof. | 01-28-2016 |
20150344425 | INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS - The invention relates to indole carboxamide derivatives of formula (I), | 12-03-2015 |
20150322008 | INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST - The invention relates to indole carboxamide derivatives of formula (I), | 11-12-2015 |
20150203459 | PROCESS FOR THE PREPARATION OF [(2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIM- INO)-3-](O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS - The present invention relates to a new process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and to the new intermediate (R)-3-chloro-4-(2,3-dihydroxypropoxy)-benzaldehyde used in this process. (2Z,5Z)-5-(3-Chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one is described in WO 2005/054215 to act as an immunosuppressive agent. The present invention further also relates to a new process for the preparation of (R)-3-chloro-4-(2,3-dihydroxypropoxy)-benzaldehyde. | 07-23-2015 |
20150158855 | 2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives of formula (I) | 06-11-2015 |
20150133669 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID - The present invention relates to new processes for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid, which is a useful intermediate for the synthesis of pyridine-4-yl derivatives as immunomodulating agent. Moreover, the present invention also relates to new intermediates used in those processes. | 05-14-2015 |
20150025075 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS - The invention relates to heterocyclic amide derivatives of formula (I), | 01-22-2015 |
20140303208 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES - Compounds of formula (I): | 10-09-2014 |
20140194526 | STABILIZED COMPOSITIONS OF VOLATILE ALKYLATING AGENTS AND METHODS OF USING THEREOF - A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol. | 07-10-2014 |
20140187810 | STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME - Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions. | 07-03-2014 |
20140171425 | QUINAZOLINE-2,4-DIONE DERIVATIVES - The invention relates to antibacterial compounds of formula (I), wherein R | 06-19-2014 |
20140163035 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS - The invention relates to heterocyclic amide derivatives of formula (I), wherein R | 06-12-2014 |
20140148460 | THERAPEUTIC COMPOSITIONS - The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having PDE5-inhibitory properties, or a pharmaceutically acceptable salt thereof, for therapeutic use, simultaneously, separately or over a period of time, in the treatment of a disease wherein vasoconstriction is involved. | 05-29-2014 |
20140142193 | Stabilized Compositions Of Alkylating Agents And Methods Of Using Same - A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: an alkylating agent such as, for example, a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol. | 05-22-2014 |
20140142093 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS - The present invention relates to antibacterial compounds of formula (I) wherein “----” is a bond or is absent, V is CH, CR | 05-22-2014 |
20140073651 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS - The invention relates to benzamide derivatives of formula (I), | 03-13-2014 |
20140045870 | 7-(Heteroaryl-Amino)-6,7,8,9-Tetrahydropyrido[1,2-A]Indol Acetic Acid Derivatives and Their Use as Prostaglandin D2 Receptor Modulators - The present invention relates to 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives of the formula (I), | 02-13-2014 |
20140038961 | 3-UREIDOISOQUINOLIN-8-YL DERIVATIVES - The invention relates to 3-ureidoisoquinolin-8-yl derivatives of formula I | 02-06-2014 |
20130345199 | 1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES - The present invention relates to 1-[m-Carboxamido(hetero)aryl-methyl]-piperidine-4-carboxamide derivatives of formula (I) | 12-26-2013 |
20130324579 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS - The present invention relates to pyrazole and imidazole derivatives of formula (I) wherein U, V, L, X, Y, R | 12-05-2013 |
20130317048 | COMBINATION COMPRISING PACLITAXEL FOR TREATING OVARIAN CANCER - The invention relates to the combination of an endothelin receptor antagonist of formula (I) | 11-28-2013 |
20130310432 | NOVEL THIAZOLIDIN-4-ONE-DERIVATIVES - The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents. | 11-21-2013 |
20130310407 | COMBINATIONS COMPRISING MACITENTAN FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME - The invention relates to the use of macitentan in combination with a cytotoxic therapy agent (such as temozolomide or paclitaxel), with radiotherapy or with both a cytotoxic therapy agent and radiotherapy, in the treatment of malignant glioma, in particular glioblastoma multiforme. | 11-21-2013 |
20130303514 | 2-METHOXY-PYRIDIN-4-YL-DERIVATIVES - The invention relates to pyridine derivatives of Formula (I) | 11-14-2013 |
20130289295 | DIASTEREOSELECTIVE PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS - The present invention relates to a new process for the diastereoselective preparation of (1R*,4R*,5S*,6S*)-6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds, the compounds of the formula (II), which may subsequently be further transformed to 5-aryl-bicyclo[2.2.2]oct-5-en-2-one compounds of the formula (I): | 10-31-2013 |
20130281406 | THIAZOLE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS - The present invention relates to thiazole derivatives of Formula (I) and their use as P2Y | 10-24-2013 |
20130261159 | OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS - The invention relates to oxazolyl-methylether derivatives of formula (I), | 10-03-2013 |
20130237525 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS - The present invention relates to lactam derivatives of formula (I) | 09-12-2013 |
20130231319 | Bridged Spiro[2.4]heptane Ester Derivatives - The invention relates to a method for preparing linear polymers having an amide end or having a star architecture comprising an amide core, by means of a ring opening using lactide and glycolide monomers or a lactide monomer ring in the presence of a catalyst, wherein the method includes the steps of: (i) reacting the excess monomer(s) with an initiator in a solvent, said initiator being selected from among an amine and an amino alcohol, given that the initiator has at least one primary or secondary amine function; (ii) adding a catalyst, said catalyst being a non-nucleophilic base and including at least one neutral sp2 nitrogen atom; and (iii) neutralizing the reaction mixture. Said novel method is particularly advantageous in that it can be easily monitored and enables better modulation of the polymers, and thus of the properties thereof, than the methods of the prior art. The invention also relates to novel polymers that are obtainable by means of said method. | 09-05-2013 |
20130211104 | PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS - The present invention relates to a new process for the preparation of 6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): | 08-15-2013 |
20130210830 | THERAPEUTIC COMPOSITIONS - The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having PDE5-inhibitory properties, or a pharmaceutically acceptable salt thereof, for therapeutic use, simultaneously, separately or over a period of time, in the treatment of a disease wherein vasoconstriction is involved. | 08-15-2013 |
20130196348 | NEUROPEPTIDE Q AS MODULATOR OF GPCR GALR2 AND USES THEREOF - The invention relates to the identification of Neuropeptide Q as ligand of the GALR2 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GALR2 polypeptides and Neuropeptide Q polypeptides as the basis of screening assays for agents that modulate the activity of the GALR2 receptor. The invention also encompasses diagnostic assays based upon the GALR2/Neuropeptide Q polypeptide interaction, as well as kits for performing diagnostic and screening assays. | 08-01-2013 |
20130190336 | STABLE PHARMACEUTICAL COMPOSITIONS COMPRISING A PYRIMIDINE-SULFAMIDE - The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof | 07-25-2013 |
20130150424 | PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - The present invention relates to (S)-proline sulfonamide compounds of formula (I) | 06-13-2013 |
20130109685 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | 05-02-2013 |
20130065902 | 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS - The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), | 03-14-2013 |
20130005734 | THERAPEUTIC COMPOSITIONS - The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having PDE5-inhibitory properties, or a pharmaceutically acceptable salt thereof, for therapeutic use, simultaneously, separately or over a period of time, in the treatment of a disease wherein vasoconstriction is involved. | 01-03-2013 |
20120202221 | NATURAL PEPTIDE AND DERIVATIVES AS MODULATORS OF GPCR GPR1 AND USES THEREOF - The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GPR1 polypeptides and Humanin polypeptides as the basis of screening assays for agents that modulate the activity of the GPR1 receptor. The invention also encompasses diagnostic assays based upon the GPR1/Humanin polypeptide interaction, as well as kits for performing diagnostic and screening assays. | 08-09-2012 |
20120115916 | OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS - The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R | 05-10-2012 |
20120115841 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS - The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R | 05-10-2012 |
20120040989 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY - The invention relates to antibacterial compounds of formula I | 02-16-2012 |
20110245259 | 5-Amino-2-(1-Hydroxy-Ethyl)-Tetrahydropyran Derivatives - The invention relates to antibacterial compounds of formula I | 10-06-2011 |
20110201595 | OXAZOLIDINYL ANTIBIOTICS - The invention relates to antibacterial compounds of formula I | 08-18-2011 |
20110195961 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS - The invention relates to antibacterial compounds of formula I | 08-11-2011 |
20110195949 | 2-BENZOTHIOPHENYL- AND 2-NAPHTHYL-OXAZOLIDINONES AND THEIR AZAISOSTERE ANALOGUES AS ANTIBACTERIAL AGENTS - The invention relates to antibacterial compounds of formula (I) | 08-11-2011 |
20110124636 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R | 05-26-2011 |
20110082132 | [4-(1-AMINO-EHTYL) - CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-EHTYL) -TETRAHYDRO-PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS - The invention relates to antibacterial compounds of formula I | 04-07-2011 |
20110039836 | TRICYCLIC ANTIBIOTICS - The invention relates to antibacterial compounds of formula (I) | 02-17-2011 |
20110039823 | OXAZOLIDINONE ANTIBIOTICS - The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m, and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. Certain compounds of formula (I) are new and are also part of this invention. | 02-17-2011 |
20110021581 | DOSING REGIMEN FOR A SELECTIVE S1P1 RECEPTOR AGONIST - The present invention relates to a dosing regimen for a selective S1P | 01-27-2011 |
20100331318 | AZATRICYCLIC ANTIBIOTIC COMPOUNDS - The invention relates to antibacterial compounds of formula I | 12-30-2010 |
20100331308 | OXAZOLIDINONE DERIVATIVES - The invention relates to compounds of Formula (I) | 12-30-2010 |
20100240717 | NOVEL THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS - The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH | 09-23-2010 |
20100234396 | Tetrhydropyridoindole Derivatives - The invention relates to tetrahydropyridoindole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and methods of treatment comprising administration of said compounds. | 09-16-2010 |
20100222600 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to novel azetidine compounds of formula (I), wherein R | 09-02-2010 |
20100190830 | (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives - The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R | 07-29-2010 |
20100179135 | 3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRAN DERIVATIVES - Antibacterial compounds including 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives are provided, and methods of treatment or prevention of bacterial infection with such compounds are provided. | 07-15-2010 |
20100168005 | Pyridin-3-yl derivatives as immunomodulating agents - The invention relates to pyridin-3-yl derivatives of Formula (I) wherein R | 07-01-2010 |
20100137290 | OXAZOLIDINONE ANTIBIOTIC DERIVATIVES - The invention relates to antibacterial compounds of formula I | 06-03-2010 |
20100087495 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS - The invention relates to phenyl derivatives of formula (I), their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. | 04-08-2010 |
20100075946 | NOVEL THIOPHENE DERIVATIVES - The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents. | 03-25-2010 |
20100069376 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE ANTIBACTERIALS - The invention relates to novel chimeric antibiotics of formula I | 03-18-2010 |
20100063108 | Pyridin-4-yl derivatives as immunomodulating agents - The invention relates to pyridine derivatives of Formula (I) wherein A, R | 03-11-2010 |
20100048648 | Thiophene derivatives as S1P1/EDGE1 receptor agonists - The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. | 02-25-2010 |
20100035895 | 2-AMINOCARBONYL-PYRIDINE DERIVATIVES - The present invention relates to 2-aminocarbonyl-pyridine derivatives of Formula (I) and their use as P2Y | 02-11-2010 |
20100029623 | 4-(1-AMINO-ETHYL)-CYCLOHEXYLAMINE DERIVATIVES - The invention relates to compounds of formula (I) wherein R | 02-04-2010 |
20100029617 | 1,4,5,6,7,8-HEXAHYDRO-1,2,5-TRIAZA-AZULENE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives and their use as orexin receptor antagonists. | 02-04-2010 |
20100004274 | Stable pharmaceutical compositions comprising a pyrimidine-sulfamide - Stable pharmaceutical compositions include the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof: | 01-07-2010 |
20090318459 | Therapeutic Compositions Comprising a Specific Endothelin Receptor Antagonist and a PDE5 Inhibitor - The invention relates to a product containing the compound of formula (I) below | 12-24-2009 |
20090291962 | 2-PHENYL-6-AMINOCARBONYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR - The invention relates to 2-phenyl-6-aminbcarbonyl-pyrimidinc derivatives and their use as P2Y | 11-26-2009 |
20090275588 | NOVEL SULFONAMIDE COMPOUNDS - The invention relates to novel sulfonamide compounds and their use as orexin receptor antagonists. | 11-05-2009 |
20090270414 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS - The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients. | 10-29-2009 |
20090270375 | SPIRO ANTIBIOTIC DERIVATIVES - The invention relates to compounds of formula (I) wherein R | 10-29-2009 |
20090247578 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE-DERIVATIVES AND THEIR USES AS ANTIBACTERIALS - The invention relates to novel chimeric antibiotics of formula I | 10-01-2009 |
20090105232 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES - The invention relates to antibiotic cyclohexyl or piperidinyl carboximide derivatives of formula (I) | 04-23-2009 |
20090099228 | PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists. | 04-16-2009 |
20090088457 | Primary Amines as Renin Inhibitors - The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. | 04-02-2009 |
20090082394 | Tetrahydroisoquinoline Derivatives to Enhance Memory Function - The invention relates to the use of tetrahydroisoquinoline derivatives for the preparation of a medicament to enhance, maintain and/or restore all stages and/or types of short-, middle- and/or long-term memory. | 03-26-2009 |
20090062342 | AMINES - The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. | 03-05-2009 |
20090023775 | 1-[2-(4-BENZYL-4-HYDROXY-PIPERIDIN-1 -YL )-ETHYL]-3-(2-METHYL-QUINOLIN- 4-YL)- UREA AS CRYSTALLINE SULFATE SALT - The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt and a process for its preparation. Further, the present invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt alone or in combination with other compounds. Further, the present invention relates to formulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt in the preparation of pharmaceutical compositions. The invention also relates to the use of such sulfate salts in formulations as neurohormonal antagonists. | 01-22-2009 |
20090005421 | Novel Pyridine Derivatives - The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents. | 01-01-2009 |
20090005368 | Ethanol or 1,2-Ethanediol Cyclohexyl Antibiotic Derivatives - The invention relates to antibiotic ethanol or 1,2-ethanediol cyclohexyl derivatives of formula (I) wherein R1 represents (C | 01-01-2009 |
20080318955 | Novel Thiophene Derivatives as Sphingosine-1-Phosphate-1 Receptor Agonists - The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents. | 12-25-2008 |
20080312242 | 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES - The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin. | 12-18-2008 |
20080300294 | Novel Thiophene Derivatives - The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents. | 12-04-2008 |
20080280962 | NOVEL THIAZOLIDIN-4-ONE DERIVATIVES - The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents. | 11-13-2008 |
20080280888 | Antibiotics Derivatives - The invention relates to antibiotic derivatives of formula I | 11-13-2008 |
20080234272 | Novel Piperazines as Antimalarial Agents - The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria. | 09-25-2008 |
20080233188 | Stable Pharmaceutical Compositions Comprising a Pyrimidine - Sulfamide - The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof. | 09-25-2008 |
20080214598 | Novel Piperidine Carboxylic Acid Amide Derivatives - The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin. | 09-04-2008 |