LTS Lohmann Therapie-Systeme AG Patent applications |
Patent application number | Title | Published |
20160067405 | DUAL-CHAMBER CYLINDER-PISTON UNIT FOR THE LYOPHILISATION, STORAGE, RECONSTITUTION AND APPLICATION OF INJECTION SOLUTIONS FOR AN INJECTOR, AND METHOD FOR FILLING THE CYLINDER-PISTON UNIT - A method for filling a cylinder/piston unit ( | 03-10-2016 |
20150321438 | CHILDPROOF, HIGHLY INERT INDIVIDUAL PACKAGING - A method for producing childproof, highly inert individual dose packagings for transdermal therapeutic systems or film-like forms of administration in the form of a sealing edge bag that can be peeled back with a complete surrounding and continuous sealing surface, comprising two packaging elements, that are arranged on top of each other and form the upper side and the bottom side of a bag containing the product, wherein at least one layer of the packaging material elements is a metal layer and at least one packaging material element a film laminate with at least three-layer design; and the outer layer of the at least three-layer film laminate comprises at least one line-shaped weakening that is not touching the edge of the packaging on the upper and bottom side and the line-shaped weakening has a reduced resistance to tear for opening the packaging. | 11-12-2015 |
20150320676 | TOPICAL DRUG FOR TREATING APHTHAE - Topical drugs for treating aphthae, wherein the topical drugs are in the form of a film-shaped dosage form. The topical drugs include a film made of a water-swellable or water-soluble polymer or polymer mixture, and at least one active ingredient selected from the group of tanning agents and essential oils. | 11-12-2015 |
20150272904 | PREPARATION IN FILM FORM FOR BIPHASIC RELEASE OF PHARMACOLOGICALLY ACTIVE OR OTHER SUBSTANCES - A polymer-based preparation in film form for biphasic release of substances present therein to liquid surroundings, is characterized in that the preparation comprises at least two polymer matrix layers which differ in terms of their construction from polymers, with release taking place rapidly from one of the layers, and release taking place slowly from at least one other layer. | 10-01-2015 |
20150238437 | TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY - A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m | 08-27-2015 |
20150064231 | Oral film containing opiate enteric-release beads - A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines. | 03-05-2015 |
20140363103 | STACKABLE BAG PACKAGING - A method for producing a tightly sealed bag packaging and to a tightly sealed bag packaging having at least one perforation and a receiving area surrounded by a plate-shaped edge region for the inert packaging of a product containing active ingredients, wherein the bag packaging comprises cover films or cover film segments bounding the receiving area and forming the edge region. The cover films or cover film segments are each provided with a channel system having at least one channel. The channel system crosses the part of the cover film or the cover film segment covering the receiving area. At one end, each channel is provided with a branching into two channel branches, Furthermore, a slit is arranged between the two channel branches, interrupting a peripheral edge of the bag packaging. | 12-11-2014 |
20140323994 | TRANSDERMAL THERAPEUTIC SYSTEM FOR 5-AMINOLEVULINIC ACID HYDROCHLORIDE - The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases. | 10-30-2014 |
20140316354 | MULTILAYERED TRANSMUCOSAL THERAPEUTIC SYSTEM - A film-shaped therapeutic system comprising at least two layers connected with each other, for transmucosal administration of active substances. The system has a layer which is mucoadhesive in an aqueous environment and a mono-layered or multi-layered backing layer. At least one of these layers contains an active substance. The mucoadhesive layer is capable of swelling in an aqueous media, but is insoluble or only poorly soluble in an aqueous media. A process for treating a patient by medicinal therapy or prophylaxis by the film-shaped therapeutic system is also provided. | 10-23-2014 |
20140272069 | Edible film-shaped preparation with cola taste - The invention relates to edible film-shaped cola-flavored preparations which disintegrate quickly and without leaving a residue when coming in contact with moisture. In advantageous embodiments, edible, water-soluble, film-shaped preparations containing cola flavoring are provided that contain hydroxypropylated pea starch and hydroxypropylated tapioca starch as a film-forming polymer, or contains such a polymer in combination with further film-forming polymers. | 09-18-2014 |
20140249471 | CYLINDER-PISTON UNIT WITH ADHESIVE DISC II - A cylinder-piston unit, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. On its end face directed away from the bottom portion, the adhesive disc has an adhesive coating. In the storage position, the adhesive disc has at least one sealing element or a sealing area for closing the discharge tube, the effect of which sealing element or sealing area is no longer present in the application position. In the application position, the front edge of the end face of the discharge tube protrudes at least 0.5 mm beyond the adhesive coating of the adhesive disc. A cylinder-piston unit of an injector is developed whose discharge system is suitable for safely penetrating the outer layers of skin, covered by the term “dermis”, in order to convey the injection solution into or under the skin and keep it there for a definable period of time. | 09-04-2014 |
20140249470 | CYLINDER-PISTON UNIT WITH MULTI-PART PISTON - A cylinder-piston unit, of a needle-free injector, with at least one cylinder accommodating an injection solution, and with at least one piston. The piston is composed of a drive body and of a sealing body. The sealing body is at least one elastic disc, which bears under a radial clamping action against the inner wall of the cylinder. The drive body is a pot-shaped body with a peripheral elastic skirt. At least one area of the skirt bears under a radial clamping action against the inner wall of the cylinder. The cylinder chamber areas located in front of and behind the drive body communicate with each other via at least one recess. The drive body is arranged behind the sealing body in the cylinder, and the skirt faces towards the sealing body. A piston is developed which, at ambient pressure, can be set down on the liquid level of a filled cylinder in a bubble-free, sterile and gas-tight manner and which nevertheless withstands a high compression pressure without leakage during the targeted emptying of the cylinder-piston unit. | 09-04-2014 |
20140245882 | CYLINDER-PISTON UNIT WITH SHORT CANNULA - A cylinder-piston unit, with at least one cylinder accommodating an injection solution and having an outlet opening, and with at least one piston. The cylinder, or a component mounted upstream of the cylinder, has an end face from which, during correct emptying of the cylinder-piston unit, a short cannula protrudes, which has an outlet opening at its free end. The outlet opening has a surface with a border which has a point near the bottom or an edge near the bottom. The point near the bottom or the edge near the bottom lies 0.15-0.3 mm away from the end face or the front-most point or edge thereof. A cylinder-piston unit is developed which is intended for a disposable injector and which is suitable for virtually painless penetration of the human skin, among other reasons for the administration of highly viscous injection solutions. | 09-04-2014 |
20140243740 | CYLINDER-PISTON UNIT WITH ADHESIVE DISC I - A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm. A needle-free cylinder-piston unit of an injector whose discharge system is suitable for safely penetrating the outer layers of skin, covered by the term “dermis”, in order to convey the injection solution into or under the skin. | 08-28-2014 |
20140242168 | SWELLABLE COATED TABLET - The present invention provides perorally administrable drug release systems and processes for producing perorally administrable systems having a drug-containing core and a sheath which surrounds the core and comprises a swellable shell and an elastic coating which surrounds at least the shell, the sheath having at least one orifice. | 08-28-2014 |
20140234444 | METHOD OF USING A FILM-SHAPED PREPARATION COMPRISING OILY SUBSTANCES FOR ORAL ADMINISTRATION - Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided. | 08-21-2014 |
20140234395 | PLASTER HAVING ADJUSTABLE OCCLUSION - Transdermal or topical plasters containing active ingredient are provided that include a non-occlusive back layer, a matrix formed from of one or more polymer layers having at least one pharmaceutical active ingredient in one or more of the layers, in which the structure-forming base polymers of the layer(s) are non-occlusive or only slightly occlusive and a second polymer that has a low water-vapor permeability and that is immiscible or only very slightly miscible with the base polymer is dispersed in at least one of the polymer layers. | 08-21-2014 |
20140155483 | Edible Oral Strip or Wafer Dosage Form Containing Ion Exchange Resin for Taste Masking - An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration. | 06-05-2014 |
20140096865 | CYLINDER-PISTON UNIT SUITABLE FOR STORING INJECTION SOLUTIONS FOR A NEEDLE-FREE INJECTOR AND METHOD FOR THE BUBBLE-FREE AUTOMATIC OR MANUAL FILLING OF THE CYLINDER-PISTON UNIT, ALSO UNDER ATMOSPHERIC PRESSURE - A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed. | 04-10-2014 |
20140086978 | Transdermal Therapeutic System Provided With Improved Long-Term Carrying Comfort - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 03-27-2014 |
20140046279 | Method for preventing the crystallisation of pharmaceuticals in a polymer film - The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step. | 02-13-2014 |
20140021269 | Dispenser for the Controlled Release of Volatile Substances - A dispenser for a volatile substance, which contains a reservoir and two control elements. The first control element exerts a control function that is dependent on the substance characteristics of the volatile substance and the material characteristics of the constituents of said first control element. However, the second control element exerts a control function that is independent of the substance characteristics of the volatile substance and the material characteristics of the constituents of said first control element. The first control element is located between the reservoir and the second control element and is permeable to at least one volatile substance. The second control element consists of a material that is impermeable to the volatile substance and contains defined material cavities. Perfumes, crop protection agents, pheromones and repellents, which can be released in a controlled manner, constitute the volatile substances. | 01-23-2014 |
20140005611 | DISPOSABLE INJECTOR WITH A FLEXURALLY ELASTIC PISTON-ACTUATING RAM | 01-02-2014 |
20130341237 | TIGHTLY SEALING SINGLE DOSE PACKAGING - A single-dose package for transdermal therapeutic systems or film-shaped administration forms, in the form of a tear-open sealed-edge pouch with a completely surrounding and continuous non-peelable sealing surface. The single-dose packages comprise two packaging material elements, which are arranged one lying an top of the other and form the upper side and underside of a pouch that contains the product. At least one packaging material element is a tear-resistant film laminate with an at least three-layer structure, wherein at least one layer of the packaging material elements is a metal layer. The single-dose package also has a linear weakening, which lies in the sealing area, does not touch the edge of the package and extends in the direction of the weaker tear resistance of the upper side and underside and the linear form of the anisotropically tear-resistant plastic. | 12-26-2013 |
20130326901 | Method for Neutralizing or Recycling Carrier Materials for Film-like Coatings - The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material. | 12-12-2013 |
20130226108 | Self-destructing transdermal therapeutic system having improved functionality and efficacy - The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach the agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase. | 08-29-2013 |
20130062244 | Non-Reclosable Package for Products Prejudicial to Health, as well as Process for its Production - A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn. | 03-14-2013 |
20130029933 | Hydrogel for Natural Cosmetic Purposes - The subject matter of the present invention is a hydrogel which includes a combination of at least four polysaccharides. These polysaccharides are those which are in the natural state and which are not produced, altered or modified by chemical reactions. The combination of konjac mannan, xanthan gum, pullulan and carrageenan and optionally sclerotium gum produces, within certain concentration ranges, a stable, slightly sticky, neutral smelling, flexible and transparent hydrogel which can be used as a cosmetic product for skin care. | 01-31-2013 |
20120316520 | TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING LIPOPHILIC AND/OR SPARINGLY SKIN-PERMEABLE ACTIVE SUBSTANCES - A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms. | 12-13-2012 |
20120245537 | TRANSDERMAL THERAPEUTIC SYSTEM HAVING STABILIZED MEMBRANE - The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin. | 09-27-2012 |
20120157937 | TRANSDERMAL THERAPEUTIC SYSTEM PROVIDED WITH IMPROVED LONG-TERM CARRYING COMFORT - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 06-21-2012 |
20120027856 | PHARMACEUTICAL PRODUCT COMPRISING YEAST - A pharmaceutical product containing an active pharmaceutical ingredient and having a controllable release of the active pharmaceutical ingredient. The pharmaceutical product comprises yeast that is capable of fermentation. The carbon dioxide production of the fermentation releases the active pharmaceutical ingredient from the pharmaceutical product. | 02-02-2012 |
20110319701 | Controllable Therapeutic System - The invention relates to a therapeutic system, designed as a laminate and comprising at least one adhesive laminate layer, and to a therapeutic device having such a therapeutic system. For this purpose, at least one laminate layer or one intermediate layer and/or one intermediate layer arranged between two laminate layers contains superparamagnetic nanoparticles. The therapeutic device having said therapeutic system comprises at least one electrically controllable system which is detachably connected to the therapeutic system. The electrically controllable system has a frequency-dependent electric resistance. During operation of the therapeutic device, the electrically controllable system generates an electric or magnetic field, which can be varied in orientation and intensity over time and penetrates the superparamagnetic nanoparticles. With the present invention, a controllable therapeutic system that is independent of contact surfaces and a therapeutic device having a controllable therapeutic system have been developed. | 12-29-2011 |
20110293730 | Polylactide nanoparticles - A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles. | 12-01-2011 |
20110281021 | RAPIDLY DISINTEGRATING DOSAGE FORM FOR RELEASING ACTIVE INGREDIENTS IN THE ORAL CAVITY OR IN BODY CAVITIES - A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water-soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix. | 11-17-2011 |
20110268800 | Unsaturated fatty acids as thrombin inhibitors - A preparation having at least one unsaturated fatty acid and the use of at least one unsaturated fatty acid having a chain length of 18 or 20 carbon atoms and of plant drugs containing the unsaturated fatty acid as a free fatty acid or a fatty acid radical of a triglyceride. The fatty acid has a chain length of 18 carbon atoms which are provided with 1 to 3 double bonds and the fatty acid has a chain length of 20 carbon atoms which are provided with 1 to 4 double bonds. The double bond or one of the double bonds are located in position 9 or 11 of the carbon chain. The unsaturated fatty acid is supplied in the all-cis configuration. The at least one unsaturated fatty acid prevents and/or treats or is used for producing a preparation for preventing and/or treating thrombosis and thromboembolic diseases. | 11-03-2011 |
20110158564 | CHILD-RESISTANT UNIT DOSE PACKAGE FOR TRANSDERMAL THERAPEUTIC SYSTEMS OR FILM- AND SHEET-TYPE DOSAGE FORMS - Unit dose packages for transdermal therapeutic systems or film- or sheet-type dosage forms in the form of a peel-open side-sealed bag. The side-sealed bags comprise two packaging material elements arranged one upon the other. At least one consists of a tear-resistant packaging material having a low tear propagation resistance. The two packaging material elements, which are joined together by a continuous sealed seam extending around the packaged good have a tab at one end of said side-sealed bag which projects beyond the sealed margin. The tabs are half as wide as the side-sealed bag and, at the end thereof which faces away from the sealed margin, have a sealed region in which they are joined to each other. At least one of the packaging material elements has a structure for partial tearing of the packaging material in the region of the tab in which the tabs are not sealed to each other. The structure for partial tearing of the packaging material is without contact to the edge of the package. | 06-30-2011 |
20110111029 | COMPOSITION FOR TRANSDERMAL DELIVERY OF CATIONIC ACTIVE AGENTS - A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided. | 05-12-2011 |
20110104245 | PRESSURE-SENSITIVE ADHESIVES BASED ON ETHYLENE-VINYL ACETATE COPOLYMERS AND ADHESIVE RESINS, FOR MEDICAL APPLICATION PURPOSES - A pressure sensitive adhesive for medicinal application purposes, based on ethylene-vinyl acetate copolymers is characterized in that it contains as polymer component (A) an ethylene-vinyl acetate copolymer or a combination of at least two ethylene-vinyl acetate copolymers, and as component (B) an adhesive resin or a combination of adhesive resins at a portion of up to 55%-wt, relative to the sum of components (A) and (B) without active substances or other auxiliary substances. | 05-05-2011 |
20110104244 | TRANSDERMAL THERAPEUTIC SYSTEM PROVIDED WITH IMPROVED LONG-TERM CARRYING COMFORT - The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. | 05-05-2011 |
20110064830 | FILM-SHAPED PREPARATION COMPRISING OILY SUBSTANCES FOR ORAL ADMINISTRATION - Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided. | 03-17-2011 |
20110020407 | TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY - Transdermal therapeutic system with which at least one pharmaceutical active substance that is non-volatile at room temperature can be administered at a daily dose of at most 30 mg, comprising a rear surface directed away from the skin and impermeable to the active substance, an adjoining polymer layer located away from the skin and based on polyisobutylene with a coating weight of at least 80 g/m | 01-27-2011 |
20110009834 | GINGIVAL WAFER - Strip-shaped forms of administration for administering an active ingredient via the mucous membrane of the gums. | 01-13-2011 |
20100324507 | MICRO-AND/OR NANO-STRUCTURED PROTECTIVE OR PROCESS FILM - The invention relates to a protective or process film, produced of a thermoplastic material for use in the production of laminates of medical technology and to a laminate which comprises an adhesive-containing transdermal therapeutic system and a protective or process film adhering to the adhesive of the transdermal therapeutic system with a surface. The protective or process film comprises at least one surface that has a plurality of recesses and/or a plurality of non-recessed portions. The distance of two adjacent recesses and/or the distance of two adjacent non-recessed portions is less than five times the film thickness. The depth of the recesses is not less than 1.2 nanometer and not more than 95% of the film thickness. The film according to the invention effectively prevents the adhesive from sticking to the protective or process film. | 12-23-2010 |
20100320111 | MICRO-AND/OR NANO-STRUCTURED PACKAGING MATERIAL - The invention relates to a web-form packaging material which comprises at least one layer, comprising a packaging material surface, of a sealable material, to a packaging unit with a transdermal therapeutic system and with a packaging material of this kind, and also to a process for producing a packaging unit. For this purpose, at least the abovementioned surface of the packaging material has a multiplicity of recesses and/or a multiplicity of non-recessed regions. The distance between two adjacent recesses and/or the distance between two adjacent non-recessed regions is less than five times the packaging material thickness. Moreover, the depth of the recesses is not less than 1.2 nanometers and not more than 95% of the packaging material thickness. | 12-23-2010 |
20100303892 | TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ELONGATE HOLLOW BODIES - The invention relates to a transdermal therapeutic system for applying an active ingredient or several active ingredients to the skin. Elongate hollow bodies are incorporated into one of the layers of the TTS, said hollow bodies containing a filling medium or several filling mediums. The invention also relates to the production and use of said type of systems. | 12-02-2010 |
20100233244 | Smoking Withdrawal Combination Wafer - The present invention relates to a quickly decomposing oral drug preparation, for the application of active ingredient combinations for smoking withdrawal, which contains nicotine, a nicotine salt, a nicotine derivative, or a substance that reacts to nicotine, in combination with another active ingredient, and the use of such a drug preparation for the treatment of smoking withdrawal, and the use of nicotine, and/or nicotine salts or derivatives, for the production of medications for the treatment of smoking withdrawal. The active ingredient that is to be administered, in combination, for this purpose is a centrally active ingredient, preferably an antidepressant for the fighting of psychic dependency in terms of a smoking withdrawal therapy. The administration of the active ingredient combination to the patient should be handled in a simple and reliable way and should exclude side effects to a large extent. | 09-16-2010 |
20100178343 | STORAGE-STABLE LAMINATE SEGMENTS - The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers. | 07-15-2010 |
20100129445 | GASTRORETENTIVE SYSTEM COMPRISING AN ALGINATE BODY - Gastroretentive systems which have at least one release device for at least one active pharmaceutical ingredient and at least one swelling body that is connected to the release device. | 05-27-2010 |
20100119585 | TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING THE ACTIVE SUBSTANCE BUPRENORPHINE - The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance. | 05-13-2010 |
20100055280 | CONSUMABLE SPICE-CONTAINING FILM AND ALSO PROCESSES FOR PRODUCTION THEREOF - A consumable spice-containing film for covering or encasing foods. The film comprises a consumable carrier film having a polymer matrix which, as a polymeric base material, contains a polymer which is water-soluble or is soluble in an ethanol-water mixture, or a mixture of at least two such polymers. The carrier film has a smooth bottom side and a top side opposite the bottom side. The top side is provided with a coating of spice particles. The predominant fraction of the spice particles adheres to the surface of the carrier film and penetrates into this only partially, but is not completely enclosed within the carrier film. | 03-04-2010 |
20100015315 | EDIBLE FILM-SHAPED PREPARATION WITH COLA TASTE - The invention relates to edible film-shaped cola-flavoured preparations which disintegrate quickly and without leaving a residue when coming in contact with moisture. | 01-21-2010 |
20090304720 | Active Agent-Loaded Nanoparticles Based On Hydrophilic Proteins - Active agent-loaded nanoparticles that are based on a hydrophilic protein or a combination of hydrophilic proteins, and methods for producing the nanoparticles and the use thereof. Functional proteins or peptide fragments are bound to the nanoparticles via polyethylene glycol-α-maleimide-ω-NHS esters. | 12-10-2009 |
20090274732 | Type-2 Diabetes Combination Wafer - Rapidly disintegrating oral dosage forms for the application of active agent combinations for diabetes therapy. The dosage forms contain at least two active agents suitable for treating type-2 diabetes. The antidiabetic active agents are selected from the group comprising sulfonylureas, glitazones, glinides, biguanides, and absorption-delaying agents. The use of the active agent combination to produce an oral dosage form for the treatment of diabetes, a method for the therapeutic treatment of diabetes, and a method for the production of a sheet-like dosage form are also disclosed. | 11-05-2009 |
20090263491 | Polylactide Nanoparticles - A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles. | 10-22-2009 |
20090203670 | Combination Antidepressants Wafer - A sheet-like pharmaceutical preparation (dosage form) that quickly disintegrates on contact with moisture, based on hydrophilic polymers for the release of at least one active agent. The dosage form contains an active agent combination for treating depression, and at least one active agent selected from the antidepressant group of drugs. In addition, the use of such a combination of active agents for the production of an orally administrable pharmaceutical product for the treatment of depression, and the therapeutic treatment of depression by oral administration of one of the named pharmaceutical preparations, is provided. | 08-13-2009 |
20090169601 | Transdermal Therapeutic System for Administering Lipophilic and/or Sparingly Skin- Permeable Active Substances - A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups:
| 07-02-2009 |
20090087486 | Foam Wafer Containing a Polyvinyl Alcohol-Polyethyleneglycol-Graft Copolymer - Sheet-like dosage forms dissolving or disintegrating in an aqueous medium for releasing at least one active substance in a body orifice or body cavity. The sheet-like dosage forms comprise a polymer matrix in the form of a solidified foam containing spaces or cavities, as well as at least one pharmaceutical or cosmetic active substance. The polymer of the polymer matrix is a polyvinyl alcohol-polyethylene glycol graft copolymer. Methods for producing such dosage forms are also provided. | 04-02-2009 |
20090041874 | Karaya Gum-Based Hydrophilic Gel System for Skin Care - A hydrophile gel system for cosmetic and/or skin care applications. The gel system comprises a detachable carrier film and a hydrogel which contains at least 15 percent by weight of karaya gum and whose water content is less than 5 percent by weight. | 02-12-2009 |
20080286342 | Form of Administration Based on Crosslinked Hydrophilic Polymers - The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative. | 11-20-2008 |
20080286317 | Self-Adhesive Film for Teeth - Monolayered or multilayered, film-shaped, pressure-sensitive adhesive preparations for application in the oral region and a process for manufacturing such preparations. The preparations contain at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance. | 11-20-2008 |
20080274167 | TRANSDERMAL THERAPEUTIC SYSTEM (TTS) WITH FENTANYL AS ACTIVE INGREDIENT - The invention relates to transdermal therapeutic systems with fentanyl or an analogous fentanyl derivative as active ingredient. In order to prevent inadvertent overdosage by uncontrolled release of active ingredient as a result of damage, the active ingredient is contained in fluid-filled micro-reservoirs in the layer containing the active ingredient. The layer containing the active ingredient can optionally be provided with a membrane. | 11-06-2008 |
20080241216 | Preparation Containing Active and/or Auxiliary Substances, With Controllable Release of Said Substances, As Well As Its Use and Manufacture - A preparation containing active and/or auxiliary substance(s) for the time- and/or dose-controllable release of said substances, comprising at least two layers ( | 10-02-2008 |
20080233177 | Fibre-Free Transdermal Therapeutic System and Method For Its Production - A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. | 09-25-2008 |