THE UNIVERSITY OF SYDNEY Patent applications |
Patent application number | Title | Published |
20160128491 | A COMBINATION OF CHILD CARRIER AND STROLLER - A combination child carrier and stroller including a stroller ( | 05-12-2016 |
20160106762 | VITAMIN D RECEPTOR/SMAD GENOMIC CIRCUIT GATES FIBROTIC RESPONSE - The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis. | 04-21-2016 |
20160022869 | BIOLOGICAL FUNCTIONALISATION OF SUBSTRATES - The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a plurality of cross-linked regions, as well as to such activated substrates that have been functionalised with a biological molecule and to devices comprising such functionalised substrates. Such substrates can be produced by a method comprising steps of: a. exposing a surface of the substrate to any or more of (i) to (iii): (i) plasma ion implantation with carbon containing species; (ii) co-deposition under conditions in which substrate material is deposited with carbon containing species while gradually reducing substrate material proportion and increasing carbon containing species proportion; (iii) deposition of a plasma polymer surface layer with energetic ion bombardment; incubating the surface treated according to step (a) with a desired biological molecule. | 01-28-2016 |
20160018417 | ASSAY AND METHOD FOR IDENTIFYING COMPOUNDS TO TREAT TAUOPATHIES - The invention relates to methods and assays for identifying compounds as candidates in the development of a drug for the treatment of various diseases including those associated with pathological Tau. The invention also relates to methods and assays for identifying compounds for the treatment of various diseases including those associated with pathological Tau. The invention also relates to cell lines and constructs for use in an assay of the invention. The methods and assays identify a compound as useful in the treatment of a tauopathy if said compound modulates Sil1 expression or activity. | 01-21-2016 |
20150343037 | TREATMENT OF BONE DISEASES - The invention relates generally to the field of bone diseases. More specifically, the invention relates to methods and compositions for the treatment of osteoporosis and related disorders. | 12-03-2015 |
20150319943 | A PLANT WATERING DEVICE - Disclosed herein is a plant watering device ( | 11-12-2015 |
20150299691 | STRUCTURES FOR IMMOBILISATION AND PROTECTION OF ORGANIC MOLECULES - The invention relates to structures for the immobilisation and protection of organic molecules, in particular, functional biological molecules. In one aspect the invention provides a structure comprising a substrate having a nanostructured spacer on a surface thereof; and an organic molecule immobilised on the surface of the substrate. Structures of the invention have a variety of potential utilities, including in protection of catalysts used in continuous flow, in medical devices and in protection of ligands for the binding of analytes in biosensors and diagnostic devices. | 10-22-2015 |
20150276767 | SYSTEMS AND METHODS FOR IDENTIFYING CANCERS HAVING ACTIVATED PROGESTERONE RECEPTORS - Systems and methods for identifying tumors having activated progesterone receptors are provided. Patients suspected of having a tumor susceptible to growth inhibition by anti-progestins can be treated with an anti-progestin. | 10-01-2015 |
20150150954 | TREATMENT OF INFLAMMATORY SKIN DISORDERS - The invention relates to methods of using an effective amount of activated protein C (APC) to treat an individual for a skin disorder characterised by the presence of hyperproliferative keratinocytes. | 06-04-2015 |
20150080756 | ESTIMATING AROUSAL STATES - Disclosed is a method of estimating an arousal state of a person, the method comprising: providing one or more measurements of a physiological or behavioural variable relevant to the arousal state of the person; and updating a nonlinear physiologically based time-dependent model of arousal using the one or more measurements of the physiological or behavioural variable, thereby estimating an augmented state vector of the model, wherein the estimated augmented state vector of the model includes the arousal state of the person and one or more parameters of the model. | 03-19-2015 |
20150037252 | Method for the Treatment of a Solid Tumour - The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localised manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors. | 02-05-2015 |
20150024413 | BIOMARKERS OF OXIDATIVE STRESS - The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the β1-subunit of the human erythrocyte ATP-dependent Na | 01-22-2015 |
20140329932 | POLYMER PARTICLES - The present invention relates to a method of preparing an aqueous dispersion of polymer encapsulated particulate material, the method comprising: providing a dispersion of the particulate material in a continuous aqueous phase, the dispersion comprising ethylenically unsaturated monomer and a stabiliser for the particulate material; and polymerising the ethylenically unsaturated monomer by non-living free radical polymerisation to form polymer that encapsulates the particulate material, thereby providing the aqueous dispersion of polymer encapsulated particulate material; wherein polymerisation of the ethylenically unsaturated monomer comprises: (a) polymerising a monomer composition that includes ionisable ethylenically unsaturated monomer so as to form a base responsive water swellable non-living polymer layer that encapsulates the particulate material; and (b) polymerising a monomer composition that includes non-ionisable ethylenically unsaturated monomer so as to form an extensible, water and base permeable non-living polymer layer that encapsulates the base responsive water swellable polymer layer. | 11-06-2014 |
20140324156 | IMPLANTABLE DEVICE WITH PLASMA POLYMER SURFACE - A deformable implantable medical device such as a stent comprising metallic, polymer and/or composite substrate having a columnar structured plasma polymer surface capable of binding functional biological molecules. The polymer surface can be bound to the substrate through a mixed or graded interface formed by a co-deposition process where a substrate material is deposited with carbon containing species while gradually reducing the substrate material proportion and increasing the carbon containing species proportion. The device is able to undergo deformation without substantial delamination of the plasma polymer surface. | 10-30-2014 |
20140192952 | MODULATING GANTRY ROTATION SPEED AND IMAGE ACQUISITION IN RESPIRATORY CORRELATED (4D) CONE BEAM CT IMAGES - A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the CBCT forms an optimized 4DCBCT image set. | 07-10-2014 |
20140126822 | Image Processing - A method and apparatus for processing images, the method comprising: using a radar ( | 05-08-2014 |
20140118150 | Wireless Code Game Enuresis Alarm for the Treatment of Enuresis | 05-01-2014 |
20140105940 | BIOCOMPATIBLE MATERIAL AND USES THEREOF - The present invention relates to a biocompatible material and in particular to a two-phase or composite biocompatible ceramic material, wherein the first phase is a doped calcium zinc silicate and the second phase is a metal oxide. In an embodiment, the invention has been developed for use in tissue regeneration including bone tissue. In other embodiments, the invention has been developed as a coating to improve the long-term stability of prior art implantable medical devices. | 04-17-2014 |
20130331544 | ORGANOMETALLIC CATALYST AND PREPARATION THEREOF - The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxylic acid or anhydride and a metal-oxide, metal-hydroxide or metal-salt with a solvent at a temperature and pressure at which the solvent exists as a supercritical or near-critical fluid. The polycarboxylic acid or anhydride is reacted with the metal-oxide, metal-hydroxide or metal-salt for sufficient time and under sufficient temperature and pressure to produce the organometallic catalyst. The present invention also relates to a process for making a poly(alkylene carbonate) in the presence of a catalytic amount of the organometallic catalyst produced by the method. | 12-12-2013 |
20130319646 | HEAT TRANSFER - The invention relates to a method for transferring heat between a first material having a first temperature and a second material having a second temperature, wherein said first temperature is greater than said second temperature, said method comprising providing one or more rotatable elements, disposing said one or more rotatable elements such that a heat transfer portion thereof is thermally contactable with both said first material and said second material on rotation of said one or more rotatable elements, and rotating said one or more rotatable elements, whereby heat is transferred from said first material to said heat transfer portion and from said heat transfer portion to said second material. | 12-05-2013 |
20130294977 | APPARATUS FOR USE IN PRODUCTION OF NITRIC ACID - A heat exchange apparatus is disclosed for use in the production of nitric acid and which provides for feed-effluent heat exchange and integrated nitrogen dioxide absorption. The apparatus includes a core structure having first and second groups of diffusion bonded corrosion resistant metal plates having fluid flow channel systems formed therein. A feed-effluent heat exchange system is provided by first channel systems of the first and second groups of plates being juxtaposed in heat exchange relationship and an absorption system is provided by second channel systems of the first and second groups of plates being juxtaposed in heat exchange relationship. | 11-07-2013 |
20130293408 | RADAR IMAGE PROCESSING - Apparatus and a method for processing a radar image, the method comprising: using a radar, generating a radar image of an area of terrain ( | 11-07-2013 |
20130280234 | Treatment and Composition for Wound Healing - A method and medicament for promoting wound healing in a subject is disclosed. The medicament comprises an effective amount of an agent comprising one or more of;
| 10-24-2013 |
20130269444 | DEVICE FOR DETERMINING MATERIAL PROPERTIES - A device for determining material properties includes a bottom panel extending from a first end to a second end of the device, for supporting a material to be tested. A closed loop flexible wall extends upwardly from the panel and is in operational engagement with a flexible wall idle means towards the first end of the device and a flexible wall driving means in spaced relation with the flexible wall idle means. The flexible wall driving means causes movement of the closed loop flexible wall along a predetermined closed loop path. The flexible wall driving means and the means of driving it are arranged at a position outside of a material containment area of the device. | 10-17-2013 |
20130261873 | APPARATUS AND METHOD FOR OBTAINING INFORMATION FROM DRILLED HOLES FOR MINING - Apparatus and method for obtaining information from drilled holes for mining A mobile vehicle ( | 10-03-2013 |
20130224114 | Translocator Protein Ligands - The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the treatment of neurodegenerative disorders, inflammation or anxiety in a subject. | 08-29-2013 |
20130209097 | Photonic Monitoring For Optical Signals - This invention concerns real-time multi-impairment signal performance monitoring, [n particular it concerns an optical device, for instance a monolithic integrated photonics chip, comprising a waveguide having an input region to receive a signal for characterization, and a narrow band CW laser signal. A non-linear waveguide region to mix the two received signals. More than one output region, each equipped with bandpass filters that extract respective discrete frequency bands of the RF spectrum of the mixed signals. And, also comprising (slow) power detectors to output the extracted discrete frequency banded signals. | 08-15-2013 |
20130197814 | METHOD OF QUANTIFYING SOIL CARBON - One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered. Furthermore, in quantifying the soil carbon sequestered, steps (ii) and (iii) may also be repeated at the second time after re-stratification of the unit of land based on sample carbon determined at the first time. | 08-01-2013 |
20130189280 | PROTEIN DOMAINS AND USES THEREFOR - The present disclosure relates generally to a structure-modeling approach to identify therapeutic and diagnostic targets on proteins. Means are provided to generate agents which bind and optionally antagonize a particular domain within a protein referred to as a Cleaved_Adhesin Family Domain. In an embodiment, the disclosure is directed to the control of | 07-25-2013 |
20130143928 | BIS-PYRINIDIUM COMPOUNDS - A method of treating, inhibiting, or preventing an infection in a subject is described. The method comprises administering to the subject an effective amount of at least one bis-pyridinium compound. The bis-pyridinium compound comprises two aromatic ring structures. Each of the ring structures comprises a pyridine ring, and the ring structures are linked by a linker group of at least 8 atoms in length, said linker group being attached to the nitrogen atoms of the pyridine rings. At least one substituent on at least one of the ring structures is an alkyl group having at least 2 carbon atoms, and no substituent on either of the ring structures is —OH, —SH or an amine group. | 06-06-2013 |
20130136848 | POLYMERISATION PROCESS AND POLYMER PRODUCT - A method of polymerising monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabiliser for said particulate material, and said continuous liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said RAFT agent to thereby form polymer at the surface of said particulate material. | 05-30-2013 |
20130128131 | LUMINESCENT SOLAR CONCENTRATOR AND METHOD FOR MAKING THE SAME, - A luminescent solar concentrator ( | 05-23-2013 |
20130087736 | WATER SWELLABLE POLYMER MATERIALS - The invention provides a method of preparing an aqueous dispersion of polymer encapsulated particulate material, the method comprising: | 04-11-2013 |
20130059890 | ANTIVIRAL AGENTS - The invention relates to agents for the treatment of hepatitis C virus infection. More specifically, the invention relates to antagonists of cannabinoid type 1 receptor signalling pathway proteins and their use for the treatment of hepatitis C virus infection. | 03-07-2013 |
20130058954 | DIAGNOSTIC AND THERAPEUTIC METHODS FOR CORNEAL ECTASIA FOLLOWING REFRACTIVE SURGERY, KERATOCONUS OR PELLUCID DEGENERATION - The present invention relates to methods of diagnosis and treatment of corneal ectasia following refractive surgery, keratoconus or pellucid marginal degeneration in a subject by determining or modulating the level of expression of molecules associated with the Wnt signalling pathway. Marker molecules of the present invention include SFRP1, PITX2, LEF1, WNT16 and WNT5A. | 03-07-2013 |
20130058527 | SENSOR DATA PROCESSING - A method and apparatus for processing sensor data comprising measuring a value of a first parameter of a scene using a first sensor (e.g. a camera) to produce a first image of the scene, measuring a value of a second parameter of the scene using a second sensor (e.g. a laser scanner) to produce a second image, identifying a first point of the first image that corresponds to a class of features of the scene, identifying a second point of the second image that corresponds to the class of features, projecting the second point onto the first image, determining a similarity value between the first point and the projection of the second point on to the first image, and comparing the determined similarity value to a predetermined threshold value. The method or apparatus may be used on an autonomous vehicle. | 03-07-2013 |
20120259442 | RECONSTRUCTION OF A RECORDED SOUND FIELD - Equipment ( | 10-11-2012 |
20120189548 | 2-ARYLPYRAZOLO[L,5-ALPHA]PYRIMIDIN-3-YL ACETAMIDE DERIVATIVES AS LIGANDS FOR TRANSLOCATOR PROTEIN (18 KDA) - The invention provides compounds of formula (I) radiolabelled with | 07-26-2012 |
20120171690 | Transgenic Animals for Analyzing CYP3A4 Cytochrome P450 Gene Regulation - The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. | 07-05-2012 |
20120139325 | SYSTEM AND METHOD FOR TERRAIN ANALYSIS - Described herein is a computerised method for identifying and classifying edges in a dataset representative of an open-pit mine terrain. The method includes the step of identifying one or more surfaces of the terrain having common topological attributes ( | 06-07-2012 |
20110196088 | POLYMER PRODUCT AND INTERFACIAL POLYMERISATION PROCESS USING RAFT AGENT - The invention provides a method of polymerising monomer to form polymer at the surface of solid particulate material, said method comprising: providing a dispersion of said solid particulate material in a continuous hydrophilic liquid phase, said dispersion comprising a hydrophilic RAFT agent as a stabiliser for said solid particulate material, and said continuous hydrophilic liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said hydrophilic RAFT agent to thereby form polymer at the surface of said solid particulate material. | 08-11-2011 |
20110111005 | BIOCOMPATIBLE MATERIAL AND USES THEREOF - The present invention relates to a biocompatible ceramic material comprising Sr, Mg or Ba doped Hardystonite (Ca | 05-12-2011 |
20110070028 | REVERSE OSMOSIS IRRIGATION - A plant watering device is disclosed. The device has a preferentially water permeable membrane arranged to separate a supply of water from a root system of a plant. The membrane is arranged to allow water to permeate to water the roots. | 03-24-2011 |
20100324677 | BIOCOMPATIBLE MATERIAL AND USES THEREOF - The present invention relates to a biocompatible ceramic material comprising Baghdadite (Ca | 12-23-2010 |
20100303321 | System and Method for Conducting Multiplexed Electrical Impedance Tomography - A method is provided for taking electrical impedance tomography measurements using multiple electrodes located at selected positions external to a volume of a subject body. Multiple orthogonal or near-orthogonal signals are introduced simultaneously by way of selected different electrodes and resultant predetermined responses (if any) at receiving electrodes are recorded or determined. The signals are encoded using the technique of code division multiplexing and received signals at each receiving electrode are cross-correlated with original signals to determine the contribution of each original signal to a composite received signal. The invention also relates to apparatus suitable for use in applying a method. | 12-02-2010 |
20100267611 | TREATMENT OF METABOLIC DISEASE - The invention relates to metabolic disease, including non alcoholic fatty liver disease, to risk factors associated with same and to phospholipid-containing compositions. | 10-21-2010 |
20100247101 | HIGH FREQUENCY OPTICAL PROCESSING - This invention concerns a high frequency optical processor suitable for time-division demultiplexing and channel dropping data signals at bit rates of 80-160 Gb/s and beyond, and for carving high frequency pulse streams with low duty cycle from an unmodulated laser source. In further aspects the invention concerns methods for using the high frequency optical processor. In particular the invention comprises a high frequency optical processor, comprising a Mach-Zehnder amplitude modulator (MZM) embedded in a fibre mirror loop in which the loop input and output are joined by a polarization maintaining coupler. | 09-30-2010 |
20100227372 | BIOLOGICAL FUNCTIONALISATION OF SUBSTRATES - The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a plurality of cross-linked regions, as well as to such activated substrates that have been functionalised with a biological molecule and to devices comprising such functionalised substrates. Such substrates can be produced by a method comprising steps of: a. exposing a surface of the substrate to any or more of (i) to (iii): (i) plasma ion implantation with carbon containing species; (ii) co-deposition under conditions in which substrate material is deposited with carbon containing species while gradually reducing substrate material proportion and increasing carbon containing species proportion; (iii) deposition of a plasma polymer surface layer with energetic ion bombardment; incubating the surface treated according to step (a) with a desired biological molecule. | 09-09-2010 |
20100146652 | XENOBIOTIC RELATED INDUCTION OF GENE EXPRESSION - An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals. | 06-10-2010 |
20100111867 | CARBORANE-PHOSPHONIUM COMPOUNDS AND THEIR USE IN BORON NEUTRON CAPTURE THERAPY AND IMAGING - The invention describes compounds for use in BCNT. These compounds comprise a carborane group coupled to a phosphorus containing group. The compounds may comprise a carborane group coupled to a phosphonium group. | 05-06-2010 |
20100067555 | TUNABLE OPTICAL SUPERCONTINUUM ENHANCEMENT - A method and apparatus for providing optical supercontinuum. The method comprises creating a spectrally narrow phase feature within a supercontinuum spectrum produced from a laser pulse that has been subjected to supercontinuum generation, thereby producing a modified supercontinuum spectrum, and propagating the modified supercontinuum spectrum through an optical waveguide that is suitable for supercontinuum generation, thereby further modifying the modified supercontinuum spectrum. The method may include modifying the modified supercontinuum spectrum by increasing its energy in a vicinity of the phase feature. | 03-18-2010 |
20100048750 | VESICULATED POLYMER PARTICLES - The invention provides a method of preparing an aqueous dispersion of vesiculated polymer particles, the method comprising: preparing a dispersion of polymerisable particles within a continuous aqueous phase, the polymerisable particles having a structure that is defined by an outer organic phase that comprises one or more ethylenically unsaturated monomers and surrounds an inner aqueous phase, said inner aqueous phase defining a single void within the polymerisable particle, wherein a RAFT agent functions as a stabiliser for the outer organic phase within the continuous aqueous phase, and wherein a RAFT agent functions as a stabiliser for the inner aqueous phase within the outer organic phase; and polymerising the one or more ethylenically unsaturated monomers under the control of a RAFT agent functioning as said stabiliser to form the aqueous dispersion of vesiculated polymer particles. | 02-25-2010 |
20100028362 | MODULATION OF T HELPER CELL-MEDIATED IMMUNE RESPONSES - Provided herein are methods for modulating one or more of a T-helper cell or monocyte lineage cell-mediated immune response in a subject, the method comprises administering to the subject an effective amount of a compound which binds to surface membrane immunoglobulin D (smIgD). Also provided are methods of diagnosis of one or more of a T-helper cell or monocyte lineage cell-mediated immune disease, and compositions and kits for use in such methods. | 02-04-2010 |
20100021440 | USE OF TROPOELASTIN FOR REPAIR OR RESTORATION OF TISSUE - The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic material from the tropoelastin in the solution. Also disclosed are elastic materials prepared according to this process and their applications. | 01-28-2010 |
20100016367 | BIS-PYRINIDIUM COMPOUNDS - A method of treating, inhibiting, or preventing an infection in a subject is described. The method comprises administering to the subject an effective amount of at least one bis-pyridinium compound. The bis-pyridinium compound comprises two aromatic ring structures. Each of the ring structures comprises a pyridine ring, and the ring structures are linked by a linker group of at least 8 atoms in length, said linker group being attached to the nitrogen atoms of the pyridine rings. At least one substituent on at least one of the ring structures is an alkyl group having at least 2 carbon atoms, and no substituent on either of the ring structures is —OH, —SH or an amine group. | 01-21-2010 |
20100004132 | MODIFIED INORGANINC MATERIALS - A method of conditioning a tubular clay material to enable its loading with an active, the method comprising the step of exposing the tubular clay material to a chemical agent in a manner such that the agent sorbs to a surface of the clay material that is internal of the tube, the chemical agent being selected such that, when the agent is sorbed to the clay material internal surface, the affinity of the tubular clay material for the active is altered. | 01-07-2010 |
20090311176 | 2-Arylpyrazolo[L,5-Alpha] Pyrimidin-3-YL Acetamide Derivatives as Ligands for Translocator Protein (18 Kda) - The invention provides compounds of formula (I) radiolabelled with | 12-17-2009 |
20090307785 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation - The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. | 12-10-2009 |
20090288181 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation - The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. | 11-19-2009 |
20090258979 | POLYMER PRODUCT AND INTERFACIAL POLYMERISATION PROCESS USING RAFT AGENT - The invention provides a method of polymerising monomer to form polymer at the surface of solid particulate material, said method comprising: providing a dispersion of said solid particulate material in a continuous hydrophilic liquid phase, said dispersion comprising a hydrophilic RAFT agent as a stabiliser for said solid particulate material, and said continuous hydrophilic liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said hydrophilic RAFT agent to thereby form polymer at the surface of said solid particulate material. | 10-15-2009 |
20090151777 | Solar Absorptive Material For a Solar Selective Surface Coating - The present invention provides a solar absorptive material for a solar selective surface of an absorber of solar radiation. The solar absorptive material comprises a dispersed metallic material and a receiving the top surface boundary through which the solar radiation is received. Further, the solar absorptive material comprises a first region and a second region. The first region being located at a position closer to the receiving boundary than the second region and the first region has an average volume fraction of the dispersed metallic material that is larger than that of the second region. | 06-18-2009 |
20090130106 | DEMIBODIES: DIMERIZATION-ACTIVATED THERAPEUTIC AGENTS - The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same. | 05-21-2009 |
20090092550 | PORPHYRIN LINKED METRONIDAZOLE AGAINST GUM DISEASE: PORPHYROMONAS GINGIVALIS - The present invention relates generally to targeted molecular agents (TMAs) directed to a particular organism or group of organisms and uses thereof. More particularly, the present invention provides TMAs having a targeting moiety which comprises a natural or induced auxotrophic requirement of the particular organism as a vehicle for directing an agent linked to the moiety to be delivered to the target organism. The TMAs of the present invention are useful for targeting molecules such as antimicrobial agents and diagnostic agents to selected organisms. | 04-09-2009 |
20090092074 | AERONAUTICAL AD-HOC NETWORKS - A communications network architecture ( | 04-09-2009 |
20090050133 | REFLECTOR AND A RECEIVER FOR A SOLAR ENERGY COLLECTION SYSTEM - The present invention provides a reflector ( | 02-26-2009 |
20080275003 | Bis-Cationic Compounds and Use Thereof - The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use of bis cationic compounds for the treatment or prevention of microbial infection. | 11-06-2008 |