Bracco Imaging S.p.A. Patent applications |
Patent application number | Title | Published |
20160106869 | FLUORESCENT SOLID LIPID NANOPARTICLES COMPOSITION AND PREPARATION THEREOF - The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield. | 04-21-2016 |
20150374854 | HYPERPOLARIZED ESTERS AS METABOLIC MARKERS IN MR - The invention relates to a method of Magnetic Resonance (MR) detection, in particular | 12-31-2015 |
20150329464 | CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID CHLORIDE - The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol. | 11-19-2015 |
20150273086 | HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR - Hyperpolarized 1- | 10-01-2015 |
20150258221 | Paramagnetic Solid Lipid Nanoparticles (pSLNs) Containing Metal Amphiphilic Complexes For MRI - The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field. | 09-17-2015 |
20150158887 | Process For The Preparation Of Chelated Compounds - The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way. | 06-11-2015 |
20150151009 | TRIARYLMETHYL RADICALS - New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process. | 06-04-2015 |
20150118159 | HYPERPOLARIZED AMINO ACIDS - Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging. | 04-30-2015 |
20150037261 | New Class Of Diazepine Derivative Chelating Agents And Complexes With Paramagnetic Metals Thereof As MRI Contrast Agents - The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. | 02-05-2015 |
20140343402 | Composition Comprising Acetic Anhydride And A Gadolinium Complex, And Method For The Use In Hyperpolarisation In MRI Analysis - The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis. | 11-20-2014 |
20140257085 | Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis - The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents. | 09-11-2014 |
20140221477 | Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine - The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives. | 08-07-2014 |
20140178302 | INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors. | 06-26-2014 |
20140155449 | NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF - The present invention discloses the use of L-Histidine to reduce Gadolinium accumulation into target organs, preventing its toxic effects, after administration of gadolinium based contrast agents. The invention thus, also disclose the use of L-Histidine to prevent the NSF syndrome in patients with renal functionality impairment. A kit of part is also disclosed by the use of which toxicity associated to free Gd3+, deriving from GDBCA, is prevented by oral administration of L-histidine before administration of the contrast agent. A method for the prevention of toxic metal accumulation which consists in the administration, preferably by the oral route, of L-Histidine is also disclosed. L-Histidine is preferably administered a s a single oral dose comprised from 0.2-20 g. | 06-05-2014 |
20140154671 | VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS - A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure. | 06-05-2014 |
20140154670 | VALIDATION TECHNIQUES FOR FLUID DELIVERY SYSTEMS - A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure. | 06-05-2014 |
20140024717 | Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine - The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives. | 01-23-2014 |
20130195768 | CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS - The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents. | 08-01-2013 |
20130178737 | Finger-Grip Device For Medical Syringe Or Cartridge - The present invention relates to a finger-grip device designed to be placed on the flange of a cylindrical barrel of a medical syringe or cartridge, increasing the contact surface with the fingers of the operator during the injection or withdrawal of fluids to or from a patient, characterised in that it does not stop or hinder the run of the plunger within the cylindrical barrel. | 07-11-2013 |
20130136691 | GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means. | 05-30-2013 |
20130131382 | Process For The Preparation Of Contrast Agents - The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase. | 05-23-2013 |
20130096420 | Process For Preparing Hyperpolarized Substrates And Method For MRI - The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue. | 04-18-2013 |
20130072719 | Process For The Iodination Of Phenolic Derivatives - The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. | 03-21-2013 |
20120328512 | Fibrin-Binding Peptides and Conjugates Thereof - Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof. | 12-27-2012 |
20120296113 | Process For The Preparation Of Thyroid Hormones And Salts Thereof - The present invention generally refers to a process for the preparation of L-thyroxine derivatives. More in particular, the present invention relates to a iodination reaction of an aromatic derivative with an appropriate iodinating agent, so to afford the related iodinated compound as disodium salt, which may represent a useful intermediate for the synthesis of the L-thyroxine mono-sodium salt, and the free form thereof. | 11-22-2012 |
20120245333 | PROCESS FOR THE PREPARATION OF CHELATED COMPOUND - The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way. | 09-27-2012 |
20120232151 | Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form - The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions. | 09-13-2012 |
20120178906 | CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES - A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for metal complexation. | 07-12-2012 |
20120165211 | Human Antibodies Cross-Reacting With A Bacterial And A Self Antigen From Atherosclerotic Plaques - The present invention refers to human antibodies derived from human antibody libraries prepared from atherosclerotic plaques. It further refers to human antibodies able to immunologically recognize both human transgelin or fragments thereof and a protein with at least 50% similarity to OmpK36 (Outer membrane protein, | 06-28-2012 |
20120115741 | Reagents For The Atherosclerotic Coronary Plaque And Uses Thereof - The present invention discloses antibodies or fragments thereof able to bind isolated coronary plaque samples and processes for their production using host cells containing DNA sequences encoding for said antibodies of fragments thereof. Methods for screening ligands to said isolated samples are also described, and compositions containing said antibodies are also provided. | 05-10-2012 |
20120088926 | PROCESS FOR THE PREPARATION OF A IODINATING AGEN - The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same. | 04-12-2012 |
20120065365 | Stable Radiopharmaceutical Compositions and Methods for Their Preparation - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor). | 03-15-2012 |
20120041224 | Process For The Iodination Of Aromatic Compounds - The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. | 02-16-2012 |
20120009122 | GASTRIN RELEASING PEPTIDE COMPOUNDS - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: | 01-12-2012 |
20110280802 | Linkers For Radiopharmaceutical Compounds - A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N—O—P-Q, wherein M is the diagnostic or therapeutic moiety, N—O—P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N—O—P-M, wherein M is independently a diagnostic or therapeutic moiety and N—O—P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds. | 11-17-2011 |
20110275850 | Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives - The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof. | 11-10-2011 |
20110256067 | Contrast agents endowed with high relaxivity - The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity. | 10-20-2011 |
20110250133 | GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means. | 10-13-2011 |
20110207960 | Process For The Preparation Of Iodinated Contrast Agent - The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide. | 08-25-2011 |
20110206650 | Probiotic Formulations - The present invention relates to probiotic compositions and kits thereof, comprising live bacteria belonging to the natural flora of the human body cavity such as intestine and vaginal tract, in particular, strains of | 08-25-2011 |
20110206606 | STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREPARATION - Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds, and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor). | 08-25-2011 |
20110178393 | Process for the Preparation of Aqueous Solutions of Hyperpolarized Molecules - The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body. | 07-21-2011 |
20110176710 | Method and system for automatic processing and evaluation of images, particularly diagnostic images - Method for automatic processing and evaluation of images, particularly diagnostic images, comprising an image processing tool in the form of a software program which is executable by the computer hardware and which image processing tool processes image data of a digital input image generating a modified digital output image whose image data are outputted in a graphical and/or alphanumerical format highlighting certain predetermined features or qualities of the corresponding regions of an imaged body or object, characterized in that the image processing tool comprises a first image detecting module which is an image processing module based on image processing non expert algorithms and which furnishes at its output a modified image file which modified image data are further processed by a classification or evaluation module which is a second image processing module comprising an image processing tool consisting in an expert image processing algorithm such as a classification or prediction algorithm the output of which is a further modified image file in which the pixels or voxels are highlighted corresponding to imaged object having a predetermined feature or quality. | 07-21-2011 |
20110152671 | MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS - An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location. | 06-23-2011 |
20110124653 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS - The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R | 05-26-2011 |
20110117015 | Diagnostic Agents Selective Against Metalloproteases - The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R | 05-19-2011 |
20110100880 | Method and Apparatus for Producing Stationary Intense Wave Fields of Arbitrary Shape - Method for producing a stationary wave field of arbitrary shape comprising the steps of defining at least one volume being limited in the direction of the axis of propagation of a beam, of the type 0≦z≦L; defining an intensity pattern within the said region 0≦z≦L by a function F(z), describing the said localized and stationary intensity pattern, which is approximated by means of a Fourier expansion or by a similar expansion in terms of (trigonometric) orthogonal functions; providing a generic superposition of Bessel or other beams highly transversally confined; calculating the maximum number of superimposed Bessel beams the amplitudes, the phase velocities and the relative phases of each Bessel beam of the superposition, and the transverse and longitudinal wavenumbers of each Bessel beam of the superposition. | 05-05-2011 |
20110082280 | Methods Of Coupling Multidentate AZA Ligands To Targeting Molecules - Methods of coupling targeting molecules to multidentate aza ligands of general formula (I): | 04-07-2011 |
20110052491 | GASTRIN RELEASING PEPTIDE COMPOUNDS - New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided. | 03-03-2011 |
20100331567 | PROCESS FOR THE IODINATION OF AROMATIC COMPOUNDS - The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2,4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3,5-disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7). | 12-30-2010 |
20100316563 | Method For The Preparation Of New Oligoclonal Antibodies - A process is provided for the preparation of antibodies or fragments thereof using a prokaryotic host cell containing DNA sequences encoding for said antibodies of fragments thereof, wherein said DNA sequence is derived from a coronary plaque sample. Compositions containing said antibodies are also provided. Ligands to said antibodies and compositions containing said ligands are also described. | 12-16-2010 |
20100280505 | Device for Localized Thermal Ablation of Biological Tissue, Particularly Tumoral Tissues or the Like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that it comprises in combination means for controlled distribution of the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size, which means are composed of a fluid or a mixture or a combination of heat storing and/or conveying fluids or substances there being provided means for distributing, conveying and/or containing said fluid or fluids or said substance or substances inside the area to be treated or for conveying or containing said fluid or fluids or said substance or substances outside the area to be treated. | 11-04-2010 |
20100241111 | Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that in combination it comprises means for monitoring the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size and operating on the basis of a transferring function of generated heat on a measuring sensor provided at a predetermined distance and position with respect to the source emitting the electromagnetic irradiation. | 09-23-2010 |
20100234834 | Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like - Device for localized thermal ablation of lesion tissues, particularly tumoral tissues or the like, which device comprises: a probe or needle intended to be positioned with the end tip at the lesion tissue or tumoral tissue area to be removed; which probe or needle support at least a light guide as an elongated member like a thin wire or thread, one of the ends thereof is an end emitting heating electromagnetic energy and which light guide ends at said end of the probe or needle by a tip irradiating said electromagnetic energy, particularly as a laser light and the other end thereof is connected to a source generating the electromagnetic energy; means for controlling the activation/deactivation of the source generating the electromagnetic energy. Characterized in that in combination it comprises means for the controlled distribution of the heating action on the lesion tissue area generated by the electromagnetic energy emitted by the irradiating tip inside a volume having a predetermined size. The invention relates also to a method for localized thermal ablation. | 09-16-2010 |
20100202967 | FIBRIN BINDING PEPETIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors. | 08-12-2010 |
20100166656 | Diagnostic And Radiotherapeutic Contrast Agents And Process For Their Preparation - The present invention refers to diagnostically or radiotherapeutically useful compounds which are able to selectively bind to lectins, having formula (I) wherein R, R′, R | 07-01-2010 |
20100158814 | Fibrin-Binding Peptides and Conjugates Thereof - Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof. | 06-24-2010 |
20100138422 | Image processing system, particularly for use with diagnostic images - An image processing system particularly for use with diagnostic images, comprises at least one processing unit, which receives digital images acquired by one or more imaging apparatus and provides output images, processed by means of an image processing program loaded in the memory of the processing unit and executed thereby, characterized in that it consists of a central service unit, comprising an interface to be accessed by remote users, which connect to said central unit by remote communication means. | 06-03-2010 |
20100135574 | Image processing using neural network - Image processing method wherein each image is composed of an array of image points, so called pixels or voxels particularly in a two-, three-, or more dimensional space respectively each image point being univocally defined by its position within the array of image points and by one or more numerical parameters defining the image point appearance as regards characteristics of brightness, grey, colour shade or the like, and wherein each image point is considered to be a node of an artificial neural network, the image being processed as a function of parameters defining the appearance of each pixel as values of the nodes of said artificial neural network and as a function of connections of each pixel under processing with neighbouring pixels composed of pixels of a predetermined subset of pixels, particularly with neighbouring pixels of said pixel under processing, so called pixel window, while pixels of the new image i.e. of the processed image are obtained by iterative evolution steps of parameters defining the appearance such as evolution steps of the value of nodes or by iterative evolution steps of values of the set of connections or by a combination of said evolutions, wherein the processing occurs by evolution iterative steps where each step is a function also of connections of neighbouring pixels with the pixel under examination, when each of said neighbouring pixels of the pixel under examination is considered also as a neighbouring pixel of one ore more or all pixels adjacent to said neighbouring pixel, which function is an immediate feedback contribution for determining appearance values of all other pixels. | 06-03-2010 |
20100135544 | Method of registering images, algorithm for carrying out the method of registering images, a program for registering images using the said algorithm and a method of treating biomedical images to reduce imaging artefacts caused by object movement - In a method for registering biomedical images such as at least a first and a second digital or digitalized image or set of cross-sectional images of the same object, within the first image or set of images a certain number of landmarks, so called features are individuated by selecting a certain number of pixels or voxels. The position of each pixel or voxel selected as a feature is tracked from the first to the second image or set of images by determining the optical flow vector from the first to the second image or set of images for each pixel or voxel selected as a feature. Registration of the first and second images or set of images is carried out by applying the inverse optical flow to the pixels or voxels of the second image or set of images. The invention provides for an automatic trackable landmark selection step consisting in defining a pixel or voxel neighbourhood around each pixel or voxel of the first image or first set of cross-sectional images; for each target pixel or voxel determining one or more characteristic parameters which are calculated as a function of the parameters describing the appearance of the said target pixel or voxel and of each or a part of the pixels or voxels of the window and as a function of one or more characteristic parameters of either the numerical matrix or of a transformation of the said numerical matrix representing the pixels or voxels of the said window. The pixels or voxels coinciding with validly trackable landmarks are determined as a function of the said characteristic parameters of the target pixels or voxels. | 06-03-2010 |
20100087505 | Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors - The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below | 04-08-2010 |
20100069628 | Multidentate AZA Ligands Able to Complex Metal Ions And The Use Thereof In Diagnostics And Therapy - Compounds of the formula: | 03-18-2010 |
20100028912 | IMAGING USING RADIOACTIVE MONOCATIONS IN COMBINATION WITH A RECEPTOR BINDING LIGAND THAT STIMULATES THE INFLUX OF CATIONS - A novel method of imaging, comprising administration of a radioactive mono-cation, such as, for example, | 02-04-2010 |
20090306424 | PROCESS FOR THE PREPARATION OF CONTRAST AGENTS - The present invention refers to a process for preparing a compound of formula (I) | 12-10-2009 |
20090239829 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE - There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R | 09-24-2009 |
20090234221 | RESPONSIVE PARAMAGNETIC MRI CONTRAST AGENTS - A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent. | 09-17-2009 |
20090202580 | METHOD FOR THE PREPARATION OF SPECIFIC ANTIBODIES AGAINST SACCHARIDIC ANTIGENS - The present invention relates to new compounds useful for the stimulation of the production of antibodies. Said compounds comprises a saccharidic tumor antigen and a polymeric scaffold. The present invention also encompasses conjugated compounds useful in ELISA assay for the selection of antibodies against saccharidic antigens. | 08-13-2009 |
20090175786 | Gastrin Releasing Peptide Compounds - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: | 07-09-2009 |
20090118537 | Process for the Preparation of Contrast Agents - The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques. | 05-07-2009 |
20080317668 | Integrin Targeted Synthetic Ligands for Diagnostic and Therapeutic Applications - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors. | 12-25-2008 |
20080292214 | Method and Computer Program Product for Registering Biomedical Images with Reduced Imaging Artifacts Caused by Object Movement - A method of registering biomedical images to reduce imaging artefacts caused by object movement is disclosed, wherein a certain number of features or landmarks is automatically defined and tracked in a first and second image to be registered to determine the optical flow vector between the first and second image. Registration then takes place by applying the inverse optical flow to the second image. The automatic feature selection step is carried out by determining the mean signal intensity in a defined neighborhood for every pixel, which mean signal intensity is then compared to a predetermined threshold. If the mean signal intensity value of said neighborhood is higher than the predetermined threshold the pixel is defined as a feature and is added to a list of features to be tracked. | 11-27-2008 |
20080267869 | RADIOACTIVE TRANSITION METAL-IMIDO HETERO-DIPHOSPHINE COMPLEXES, THEIR PREPARATION AND RADIOPHARMACEUTICAL COMPOSITIONS THEREOF - The present invention provides radioactive metal heterocomplexes of formula (I): [(Me=N—R)L | 10-30-2008 |
20080247946 | Gastrin Releasing Peptide Compounds - New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided. | 10-09-2008 |
20080212887 | Method For Coding Pixels or Voxels of a Digital Image and a Method For Processing Digital Images - A method for coding pixels or voxels of a digital or digitalized two dimensional or three dimensional image, comprises the steps of: providing a digital image consisting in a two dimensional array of pixels or in a three dimensional array of voxels, each pixel or voxel being defined by at least one variable as its intensity in a grey scale image or the HSV (Hue, Saturation and Value) or the RGB values in a colour image; each pixel or voxel and for each target pixel or voxel a neighborhood being formed by a pixel or voxel windows comprising the said target pixel or voxel and a certain number of surrounding pixels or voxels for each target pixel or voxel generating a vector univocally associated to the said target pixel or voxel, the components of the said vectors being generated as a function of the values of the said target pixel or voxel and of each of the pixels or voxels of the said pixel or voxel window. The function of the values of the said target pixel or voxel and of each of the pixels or voxels of the said pixel or voxel window correspond to the characteristic parameters of the numerical matrix representing the pixels or voxels of the said window or of a transformation of the said numerical matrix. The invention relates also to an image processing method in which image data coded according to the above method are processed by means of a predictive algorithm as for example an artificial neural network. | 09-04-2008 |