THE UNIVERSITY OF HONG KONG Patent applications |
Patent application number | Title | Published |
20160129399 | DOPING OF INORGANIC MINERALS TO HYDROPHOBIC MEMBRANE SURFACE - Disclosed is a membrane surface modification method. The method is applicable to a variety of hydrophobic membranes by doping selected inorganic particles. One act of the method involves the in-situ embedment of the inorganic particles onto the membrane surface by dispersing the particles in a non-solvent bath for polymer precipitation. Further membrane surface modification can be achieved by hydrothermally growing new inorganic phase on the embedded particles. The embedment of particles is for the subsequent phase growth. | 05-12-2016 |
20160047644 | PHASE-INVERTED SIDELOBE-ANNIHILATED OPTICAL COHERENCE TOMOGRAPHY - An optical coherent tomographic imaging system includes means for introducing a 180-degree phase inversion in the interference fringes, and generating a two-peak shape point spread function (PSF) in the frequency domain for the interference-based tomographic imaging system. The system further includes means for achieving sharper resolution than the diffraction-limited spectral bandwidth in the tomographic imaging system through subtracting the two-peak shape from the original Gaussian PSF. Means are provided for removing the ghost fringes in the tomographic imaging system, which is introduced by the self-interference between the different layers of the sample arm. The apparatus is configured to realize the real-time super-resolution swept-source optical coherent tomography (OCT) such that the sensitivity of the system is enhanced by suppressing the noise floor in the frequency domain, as well as removing the ghost fringes. | 02-18-2016 |
20150342891 | OSMOTIC DRYING OF ALL-AQUEOUS EMULSIONS - A one-step method for fabricating solidified particles from all-aqueous emulsion droplets involves solidification and drying of the droplets by osmosis. According to this method the fabrication of solidified particles is induced by implementing a high osmotic pressure gradient between the internal phase and external phase of the all-aqueous emulsion. The resultant extraction of water leads to solidification of the emulsion droplets. This approach provides mild conditions for encapsulating bioactive ingredients or other delicate components to conveniently fabricate bio- and cyto-compatible particles because it does not involve the introduction of external energy used in conventional drying. Such conventional external energy inputs are time-consuming, so the method is more efficient. | 12-03-2015 |
20150228402 | Auxiliary Circuits for Selection and Enhancement of Multi-Frequency Wireless Power Transfer to Multiple Loads - This invention is related to a novel method and apparatus that provides selective and enhanced power flow in wireless power transfer systems with multiple receivers. Auxiliary circuits are introduced in the receiver circuits (and relay circuits if applicable) so as to ensure proper frequency-selective wireless power flow to the appropriate targeted receivers, with the pickup power by the non-targeted receivers substantially reduced even if the chosen tuned frequencies for different receivers are not widely apart. | 08-13-2015 |
20150207402 | Electronic Apparatus and Control Method for High Frequency AC to DC Conversion - A high-frequency ac-dc power converter takes an input ac signal and converts it to an output dc signal. The converter has at least two front-end rectifier diodes arranged as a full wave rectifier of the input ac signal. A first inductor positioned at the output of the full wave rectifier. An output capacitor is connected across a load for the converter. There are at least one additional inductor and one additional capacitor. A switching circuit selectively forms different (LC) resonant circuits with the inductors and capacitors during a cycle of the input ac signal to form a dc-dc power converter. | 07-23-2015 |
20150126707 | DAPTOMYCIN ANALOGUES AND A METHOD FOR THE PREPARATION OF DAPTOMYCIN OR A DAPTOMYCIN ANALOGUE - A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogues can include a different fatty acid in the side arm of the daptomycin analogue. | 05-07-2015 |
20150090337 | PHOTOVOLTAIC CONVERSION ELEMENT AND PHOTOVOLTAIC CELL - Described herein are organic photovoltaic (OPV) cells using gold complex(es) with as chemical structure of Structure I as active material: | 04-02-2015 |
20150071927 | ANTI-HER2 AND ANTI-IGF-IR BI-SPECIFIC ANTIBODIES AND USES THEREOF - Disclosed are antibodies, or binding fragments thereof, that specifically bind to human HER2 and human IGF-IR. Also provided are nucleic acid molecules encoding the disclosed antibodies and binding fragments and vectors and host cells containing these nucleic acid molecules. The disclosure also provides methods of inhibiting cancer cell growth and metastasis in a mammal using the antibodies described herein, as well as compositions containing the antibodies, nucleic acid molecules encoding the antibodies, and host cells and vectors comprising the nucleic acid molecules. The disclosure also features the use of the polypeptides to detect the presence of HER2 and IGF-IR in a mammal, and epitopes that can be used as cancer vaccine immunogens. | 03-12-2015 |
20150064215 | THERAPEUTIC DELIVERY AND EXPRESSION SYSTEM, METHODS AND USES THEREOF - Therapeutic methods for cancer treatments using a combined prokaryotic-eukaryotic delivery and expression system for the delivery of multiple therapeutic factors via a modified tumor-targeted bacteria. A targeted bacteria-vector system elicits an inter-kingdom dual expression (IKDE) of antitumor agents, in the nucleus or cytoplasm of eukaryotic cells, with priming and maintenance of the vector in the bacterium. The therapeutic factors include small interfering RNAs, tumoricidal proteins, DNA molecules, or a combination thereof. The system provides direct killing of tumor cells and alters the tumor microenvironment by expressing anti-angiogenic factors and cytokines in intracellular and/or extracellular environments. Also provided are methods of using natural exosomes comprising cargoes obtained from the bacterially infected cells. The bacteria-vector system is useful for many types of tumor and cancer as well as recombinant vaccines. The method causes significant regression of tumor and prolongs survival of tumor-bearing mice and subject without detectable systemic toxicity. | 03-05-2015 |
20140356321 | MATERIALS AND METHODS FOR TREATMENT OF LIVER CANCER - Granulin-epithelin precursor (GEP), a pluripotent growth factor, is a hepatic oncofetal protein defining a cancer stem cell (CSC) population in liver cancer. The present invention provides the use of GEP inhibitors (including anti-GEP antibody) for inhibiting immune evasion by liver cancer cells and for eliminating liver cancer stem cells. | 12-04-2014 |
20140335172 | OPHTHALMOLOGICAL RINSING AGENT AND METHODS THEREFOF - Disclosed herein is a novel rinsing agent, which may be suitable for use in surgical, and, in particular, ophthalmological procedures. The rinsing agent may by employed to remove emulsified oil droplets from the eye cavity. Also disclosed is a method for effectively removing emulsified silicone oil droplets remaining in the eye cavity after ophthalmological procedures using the disclosed rinsing agent in order to prevent the development of long-term complications associated with the emulsified oil droplets. | 11-13-2014 |
20140302070 | NOVEL PD1 ISOFORMS, AND USES THEREOF FOR POTENTIATING IMMUNE RESPONSES - In one embodiment, the present invention provides a new isoform of human PD1 (Δ42PD1) that contains a 42-nucleotide in-frame deletion located at exon 2 domain. Δ42PD1 does not engage PD-L1/PD-L2, and can induce the production of pro-inflammatory cytokines In one embodiment, Δ42PD1 can be used as an intramolecular adjuvant to develop a fusion DNA vaccine for enhancing antigen-specific CD8 | 10-09-2014 |
20140182011 | Methods Using Acyl-Coenzyme A-Binding Proteins to Enchance Drought Tolerance in Genetically Modified Plants - ACBP2 can be used to enhance drought tolerance in genetically modified plants. ACBP2 was observed to be expressed in guard cells, and ACBP2-overexpressing transgenic | 06-26-2014 |
20140170745 | Cell-Matrix Microspheres, Methods for Preparation and Applications - A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability. | 06-19-2014 |
20140155478 | ANTIFUNGAL COMPOUND AND USES THEREOF - Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections. | 06-05-2014 |
20140135271 | Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein - In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies. | 05-15-2014 |
20130338636 | MATERIALS AND METHODS FOR FILLING BIOLOGICAL CAVITIES AND PREVENTING LEAKAGE OF INJECTED THERAPEUTIC AGENTS - The subject invention pertains to medical apparatuses and methods for reducing or preventing leakage of injected therapeutic agents (including liquid-containing substances, cells) into a solid or hollow tissue/organ after puncturing. | 12-19-2013 |
20130325429 | Compounds and Methods for the Treatment of Viral Infections - High throughput and virtual screening methods are disclosed that can identify potential anti-viral agents. The virtual screening methods identify agents that interact with a viral nucleoprotein binding site. The high throughput methods identify compounds that inhibit viral infection by binding to viral nucleoprotein. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, especially influenza A. | 12-05-2013 |
20130324511 | PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT - The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase. | 12-05-2013 |
20130322247 | ENHANCING AQM TO COMBAT WIRELESS LOSSES - In order to maintain a small, stable backlog at an internet router buffer, active queue management (AQM) algorithms drop packets probabilistically at the onset of congestion. This causes Transmission Control Protocol (TCP) data flow rates to reduce. However, wireless losses may be misinterpreted as congestive losses and induce spurious reductions in flow rates. A prior art AQM with random early detection (RED), fails to maintain a stable backlog under time-varying wireless losses. However, the present invention can resolve the problem and provide a robust tracking of the backlog to a preset reference level by applying a control-theoretic vehicle, Internal Model principle, to realize such tracking. An integral controller (IC) is used as an embodiment of the principle that is robust against time-varying wireless losses under various network scenarios. | 12-05-2013 |
20130313517 | WHITE NANOLED WITHOUT REQUIRING COLOR CONVERSION - A nano-LED containing an array of nano-pillars of different diameters that are distributed over an emission area of an LED chip is capable of emitting broadband and white or nearly white light. Since each pillar emits light at a different wavelength according to its diameter and strain state, the overall emission spectral characteristics of the device is a combination of individual spectrum, giving rise to broadband emission. The spectral shape can be tailored for different shades of white emission, by controlling the distribution of the different diameter nano-pillars. The nano-pillars are patterned by nanosphere lithography. | 11-28-2013 |
20130295054 | Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor - Described herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma. | 11-07-2013 |
20130274473 | PLATINUM(II) COMPLEXES FOR OLED APPLICATIONS - The current invention relates to novel platinum(II) based organometallic materials. These materials show high emission quantum efficiencies and low self-quenching constant. Also provided are high efficiency, green to orange emitting organic light-emitting diode (OLED) that are fabricated using platinum(II) based organometallic materials as the light-emitting material. The organometallic materials of the invention are soluble in common solvents; therefore, solution process methods such as spin coating and printing can be used for device fabrication. The devices fabricated from these materials show low efficiency roll-off. | 10-17-2013 |
20130274353 | SYSTEM AND METHOD FOR GENERATION OF EMULSIONS WITH LOW INTERFACIAL TENSION AND MEASURING FREQUENCY VIBRATIONS IN THE SYSTEM - A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets. | 10-17-2013 |
20130244944 | Synthetic Ion Channels - Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels. | 09-19-2013 |
20130230529 | NOVEL PARAMYXOVIRUS AND USES THEREOF - Described herein are isolated | 09-05-2013 |
20130225651 | siRNA Compositions and Methods for Potently Inhibiting Viral Infection - No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of β-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. | 08-29-2013 |
20130217626 | Novel Bioactive Protein Isolated From Chinese Yam and Uses Thereof - A protein isolated from the Chinese yam | 08-22-2013 |
20130210023 | NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS - The present invention provides nucleic acid aptamers that bind to | 08-15-2013 |
20130196362 | DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE - Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples. | 08-01-2013 |
20130193428 | LUMINESCENT GOLD(III) COMPOUNDS FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION - In one embodiment, the present invention provides a class of luminescent gold(III) compounds containing a tridentate ligand with one strong σ-donating group. The present invention also provides methods for synthesizing these compounds, as well as uses of these compounds as electrophosphorescent materials in phosphorescent organic light-emitting devices (OLEDs) to provide electroluminescence (EL). | 08-01-2013 |
20130150580 | PALLADIUM COMPLEXES FOR ORGANIC LIGHT-EMITTING DIODES - Subject matter disclosed herein relates to a series of palladium based materials, their preparation method and their applications in an organic light-emitting diode (OLED). | 06-13-2013 |
20120309979 | PHOSPHORESCENT MATERIAL, THEIR PREPARATIONS AND APPLICATIONS - The subject invention is directed to tetradentate bis-(NHC carbenes) alkylene ligand Pt(II) complexes, tetradentate bis-(NHC carbenes) alkylene ligands, and its ligand precursors, for preparation of the Pt(II) complexes. The Pt(II) complexes show a deep blue emission with an improved quantum efficiency and can be used for fabrication of OLEDs with an electroluminescence layer that comprise the bis-(NHC carbenes) alkylene ligand Pt(II) complexes. | 12-06-2012 |
20120292788 | Chip stacking - Methods and systems are provided to utilize and manufacture a stacked chip assembly. Microelectronic or optoelectronic chips of any dimensions are directly stacked onto each other. The chips can be of substantially identical sizes. To enable forming the stacked chip assembly, trenches are laser micro-machined onto the bottom surface of a chip to accommodate the bond wedge/ball and wire path of the chip beneath it. Consequently, chips can be tightly integrated without a gap and without having to reserve space for the bond wedges/balls. | 11-22-2012 |
20120206849 | COMPACT ELECTRONIC REVERBERATION CHAMBER - A method and apparatus provide an improved EM reverberation chamber which facilitates the dynamic three dimensional (3D) manipulation of EM field polarization within the chamber and produces a uniform field distribution inside the chamber. The chamber includes one or more walls with tunable lumped elements. A controller is provided to generate one or more control signals that are applied to the lumped elements and tunes their impedance in response to the one or more control signals. The result is to generate, within the chamber an electromagnetic field that appears to be random or pseudo-random in polarization, but which is sufficiently uniform in magnitude for EM testing. | 08-16-2012 |
20120195848 | STRONTIUM-CONTAINING BIOACTIVE BONE CEMENT - The present invention provides bioactive bone cements that not only have sufficient radiopacity, low physiological toxicity, and requisite mechanism strength, but also promote local bone in-growth. The bone cement utilizes strontium salts as radiopacifiers, and comprises a powder component and a liquid component. In an embodiment, the powder component comprises a strontium salt, poly(methyl methacrylate) (PMMA), and a polymerization initiator; and the liquid component comprises methyl methacrylate (MMA) as reactive monomers and a polymerization accelerator. | 08-02-2012 |
20120148632 | METHODS FOR COMPLEX TISSUE ENGINEERING - A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue. | 06-14-2012 |
20120148537 | METHODS TO ENHANCE CELL MIGRATION AND ENGRAFTMENT - A method is provided to functionally select cells with enhanced characteristics relevant to cell engraftment, including both spontaneous migration and directional migration towards specific chemo-attractants. The cells are preferably undifferentiated cells, such as mesenchymal stem cells. The method involves entrapping or encapsulating the cells in a biomaterial barrier, optionally inducing cell migration, and selecting cells that migrated through the barrier. The cells selected by this method have better migratory activities and enhanced in vivo engraftment to injured tissues when they are supplemented systemically. | 06-14-2012 |
20120121634 | SOLUBLE PD-1 VARIANTS, FUSION CONSTRUCTS, AND USES THEREOF - The subject invention provides novel soluble PD-1 (sPD-1) proteins, nucleic acids, and fusion constructs thereof, for enhancing humoral and cell-mediated immunity of a subject. Also provided are therapeutic compositions comprising the sPD-1 proteins, nucleic acids, and fusion constructs of the subject invention. In a preferred embodiment, the therapeutic composition is formulated as a vaccine composition. Advantageously, the sPD-1 proteins, nucleic acids, and therapeutic compositions provide protective immunity against pathogenic infection including HIV infection. In additon, the subject invention can be used in the prevention and/or treatment of tumor or cancer. | 05-17-2012 |
20120107317 | USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES - The subject invention provides novel uses of cytoplasmic c-Myc for modulation of innate immune responses. The invention is based, at least in part, on the surprising discovery that cytoplasmic c-Myc, instead of nuclear c-Myc, modulates pro-inflammatory immune responses via its role as a positive feedback regulator. Specifically, the subject invention provides methods for treatment or amelioration of inflammatory diseases and/or immune disorders via inhibition c-Myc expression or its activity. Also provided are methods for the development of therapeutic agents for treating infection, inflammation, immune diseases and autoimmune diseases. | 05-03-2012 |
20120055867 | DOPING OF INORGANIC MINERALS TO HYDROPHOBIC MEMBRANE SURFACE - Disclosed is a membrane surface modification method. The method is applicable to a variety of hydrophobic membranes by doping selected inorganic particles. One act of the method involves the in-situ embedment of the inorganic particles onto the membrane surface by dispersing the particles in a non-solvent bath for polymer precipitation. Further membrane surface modification can be achieved by hydrothermally growing new inorganic phase on the embedded particles. The embedment of particles is for the subsequent phase growth. | 03-08-2012 |
20120018711 | PLATINUM (II) TETRADENTATE ONCN COMPLEXES FOR ORGANIC LIGHT-EMITTING DIODE APPLICATIONS - Described are novel platinum (II) containing organometallic materials. These materials show green to orange emissions with high emission quantum efficiencies. Using the materials as emitting materials; pure green emitting organic light-emitting diodes can be fabricated. Since the novel platinum (II) containing organometallic materials are soluble in common solvents, solution process methods such as spin coating and printing can be used for device fabrication. | 01-26-2012 |
20110294872 | HIGH-AFFINITY NUCLEIC ACID APTAMERS AGAINST SCLEROSTIN PROTEIN - Described are nucleic acid aptamers that are able to bind to and inhibit the function of sclerostin, which is an important negative regulator of bone growth. The aptamers have application as therapeutics for diseases of bone including osteoporosis, osteopenia, osteoarthritis and other osteoporosis-related conditions and complications. | 12-01-2011 |
20110282065 | SOLID SUPPORTED GOLD NANOPARTICLES, METHODS OF USE THEREOF, AND METHODS FOR MAKING SAME - Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO | 11-17-2011 |
20110280862 | GEP AND DRUG TRANSPORTER REGULATION, CANCER THERAPY AND PROGNOSIS - Described herein are methods for manipulating GEP and/or drug transporters (e.g., ABCB5 and/or ABCF1) on a cell, as well as related products. Also described herein are methods for treating cancer cells using GEP and/or drug transporter and/or their binding molecules and suppression thereof. Methods of cancer treatment targeting the GEP and/or drug transporters, alone or in combination with chemotherapy are also described herein. Also provided herein are sets of markers whose expression patterns can be used to differentiate clinical conditions, such as high or low levels of GEP and drug transporters. Based on the levels of GEP and drug transporters, the likelihood of cancer recurrences, drug sensitivity, and prognosis can be determined. Methods of classifying and treating patients based on the prognosis are also provided herein. | 11-17-2011 |
20110212181 | COMPOSITIONS AND METHODS FOR TREATING CHRONIC RESPIRATORY INFLAMMATION - Neutrophil elastase (NE) is a protease secreted by neutrophils during inflammation. Aberrant expression of NE such as in chronic respiratory inflammatory diseases, results in tissue destruction and decline in lung function. Compositions including an NE-targeting agent that targets the pathologic elements of respiratory inflammation are provided. Non-anticoagulant heparin derivatives or fragments are exemplary NE-targeting agents. The compositions preferably include a carrier, such as chitosan, to facilitate delivery of the active agent. Methods of manufacturing non-anticoagulant heparin are also provided. Methods of administering the disclosed compositions to treat respiratory diseases are also disclosed. In preferred methods, an effective amount of the pharmaceutical composition is administered to subject in need thereof to reduce, inhibit, or alleviate one or more symptoms of chronic respiratory inflammation. In the most preferred embodiment, the composition is administered as a dry powder, intranasally or by inhalation. | 09-01-2011 |
20110192455 | BIS-(8-QUINOLINOLATO-N,O)PLATINUM(II) BASED ORGANIC PHOTOVOLTAIC CELL - Organic photovoltaic (OPV) cells and methods of forming the same are provided. An OPV cell can include an organic photoactive layer comprising bis-(8-quinolinolato-N,O)platinum (II) (PtQ | 08-11-2011 |
20110150844 | COMPOSITIONS AND METHODS FOR CONTROLLING PROLIFERATION AND DIFFERENTIATION OF CELLS - Methods and compositions for modulating cell differentiation, proliferation and morphology in vitro or in vivo are described. The methods include modifying the extracellular nanoenvironment of stem cells with a self-assembling peptide nanofiber scaffold. The extracellular nanoenvironment can be modified by changing the percentage of self-assembling peptides used to form the nanofiber scaffold, the concentration of cells in the nanofiber scaffold, the pH, or the amounts of serum. Modulating the extracellular nanoenvironment of cells in nanofiber scaffold allows for increased targeting of cell placement and therapeutic delivery, amplified by cell encapsulation and implantation. | 06-23-2011 |
20110144023 | Nano Cancer Barrier Device (NCBD) to Immobilize and Inhibit the Division of Metastic Cancer Stem Cells - The present invention provides methods, compositions, and kits wherein nanomaterials are used for inhibiting cancer stem cell division, colony formation, spheroid formation and self-renewal. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for treating cancer, coating tumors, and inhibiting metastasis. The present invention also provides methods, compositions, and kits wherein nanomaterials are used for inducing cells to go into stasis. The present invention further provides methods for isolating tumors, inhibiting bleeding, and marking margins of tumors and organs during surgery with a nanomaterial. | 06-16-2011 |
20110135663 | ANTI-IGF-IR ANTIBODIES AND USES THEREOF - The subject invention provides antibodies, or binding fragments thereof, that specifically bind to human IGF-IR. Also provided are nucleic acid molecules encoding the antibodies and binding fragments of the subject invention and vectors and host cells containing these nucleic acid molecules. The disclosure also provides methods of inhibiting cancer cell growth and metastasis in a mammal using the antibodies described herein, as well as compositions containing the antibodies, nucleic acid molecules encoding the antibodies, and host cells and vectors comprising the nucleic acid molecules. The disclosure also features the use of the polypeptides to detect the presence of IGF-IR in a mammal, and epitopes that can be used as cancer vaccine immunogens. | 06-09-2011 |
20110098264 | PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT - The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase. | 04-28-2011 |
20110059378 | CATALYST FOR HYDROGEN GENERATION FROM SMALL ORGANIC MOLECULES - A catalyst for the generation of hydrogen from a small organic molecule comprises a tertiary metal composition where: the first metal is either Pt or Ru; the second metal is at least one of Pt, Ru, Au, Pd, Rh, Ir, Os, and/or Re; and Bi, primarily present in the form of an oxide or of a mixture of oxides and carbonates and in the +3 oxidation state. A portion of the first and/or second metal may be in the form of an oxide. The catalyst can be in the form of a nanoparticle and supported on an inert substrate, such as carbon. The catalyst can be used for dehydrogenation of formic acid or other small organic molecules in a liquid state at ambient pressures and at temperatures below the boiling point of the liquid. The liquid can be an aqueous solution of the small organic molecule. | 03-10-2011 |
20100198777 | SEQUENCE ONLINE ANALYTICAL PROCESSING SYSTEM - A sequence online analytical processing (S-OLAP) system | 08-05-2010 |
20100092978 | CADHERIN-17 AS DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR LIVER CANCER - Compositions and methods for diagnosing, treating and/or preventing cancers characterized by CDH17 overexpression based on the detection of CDH17 or the use of CDH17 as a target for therapeutic intervention or prophylactic intervention are provided. Methods for diagnosing and/or monitoring liver cancers using the expressing of CDH17 involve detecting and/or quantitating the CDH17 protein or encoding nucleic acids (DNA or RNA) in a biological sample such as urine from the subject. Methods for treating liver cancers using CDH17 as a target and of sensitizing cells with aberrant expression of CDH17 have also been developed. The methods include suppression or knockdown of the expression of CDH17 by administering an effective amount of a CDH17 inhibitor. | 04-15-2010 |
20100080824 | HUMAN VIRUS CAUSING SEVERE ACUTE RESPIRATORY SYNDROME (SARS) AND USES THEREOF - The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention provides the nucleic acids and peptides encoded by and/or derived from the hSARS virus and their use in diagnostic methods and therapeutic methods, including vaccines. In addition, the invention provides chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies immunospecific to the polypeptides encoded by the nucleotide sequences. | 04-01-2010 |
20090192990 | Method and apparatus for realtime or near realtime video image retrieval - A distributed absorbing surveillance apparatus comprising a plurality of surveillance branches at which data of a video image frame is characterised, indexed and stored locally in real-time upon capturing means browsing and searching can be conducted locally at a relatively low computational overhead upon receipt of searching instructions from a central query processor. Such a distributed surveillance apparatus also facilitates enhanced target searching speed and efficiency. | 07-30-2009 |