Kagoshima University Patent applications |
Patent application number | Title | Published |
20160017034 | COMPOSITION FOR TREATMENT AND DIAGNOSIS OF PANCREATIC CANCER - This invention relates to a pharmaceutical composition for inhibiting the growth and/or metastasis of invasive pancreatic cancer in a subject, comprising a molecular-targeted anticancer agent and a pharmaceutically acceptable carrier, wherein the molecular-targeted anticancer agent is a conjugate of a toxin or cytotoxic agent and an antibody or fragment thereof which immunologically and specifically binds to a cell-surface folate receptor β (FRβ) protein of an FRβ (+) macrophage that exists around pancreatic cancer cells at the invasive front, and to a diagnostic agent and kit for determining the degree of malignancy of pancreatic cancer or the presence of invasive pancreatic cancer, characterized by determining that the cancer tissue is invasive and metastatic when FRβ (+) macrophage is distributed around pancreatic cancer cells at the invasive front. | 01-21-2016 |
20160000782 | PHARMACEUTICAL COMPOSITION CONTAINING ANTIBACTERIAL AGENT - [Problem] The purpose of the present invention is to provide a pharmaceutical composition containing an antibacterial agent, which is effective in elucidating one cause of dementia, and in treatment thereof. | 01-07-2016 |
20150180494 | ANALOG-DIGITAL CONVERTER - A parallel-type AD converter includes: a plurality of comparators that receive comparison reference potentials different from one another and compare the comparison reference potentials and received analog input signals; an encoder that encodes outputs of the plurality of comparators to output digital signals; and a resistor ladder circuit that resistance-divides a reference voltage to generate the comparison reference potentials and supplies the comparison reference potentials to the comparators through output nodes each positioned between resistors, and is designed to supply a correction current corresponding to noise currents that the comparators generate to the output nodes of the comparison reference potentials in the resistor ladder circuit, and thereby the noise currents that the comparators generate are offset by the correction current, a bias current in the resistor ladder circuit can be decreased, and accuracy deterioration in AD conversion can be suppressed. | 06-25-2015 |
20150044701 | IgA-BINDING PEPTIDE AND IgA PURIFICATION USING THE SAME - This invention provides a peptide that comprises an amino acid sequence consisting of 14 to 18 amino acid residues represented by Formula (I) and is capable of binding to human IgA: | 02-12-2015 |
20140274790 | IgG-BINDING PEPTIDE AND METHOD FOR DETECTING AND PURIFYING IgG USING SAME - Provided is a peptide that specifically or selectively binds to human IgG. This peptide comprises an amino acid sequence consisting of 13 to 17 amino acid residues and is capable of binding to human IgG, wherein the amino acid sequence is represented by formula I: (X | 09-18-2014 |
20140273049 | DIAGNOSTIC MARKER FOR DIGESTIVE ORGAN CANCER AND INSPECTION METHOD FOR DIGESTIVE ORGAN CANCER - A diagnostic marker for digestive organ cancer according to the present invention is used for determining whether or not to have a digestive organ cancer. The diagnostic marker for digestive organ cancer contains at least one of N-binding type sugar chains released from a glycoprotein contained in blood and represented by the following formulas (1) to (6). This makes it possible to provide a diagnostic marker for digestive organ cancer capable of being used for an inspection method of easily determining whether or not to have a digestive organ cancer at an early stage, and an inspection method for digestive organ cancer of easily determining whether or not to have a digestive organ cancer at an early stage. | 09-18-2014 |
20140248655 | QUANTITATIVE SOFT AGAR COLONY FORMATION ASSAY USING TETRAZOLIUM THAT GENERATES WATER-SOLUBLE FORMAZAN - This invention provides a quantitative assay technique for soft agar colony formation that can be carried out rapidly with high accuracy. Specifically, this invention relates to a method for evaluation of cell survival comprising: a step of overlaying agar at the bottom of a vessel with agar containing cells, overlaying the agar containing cells with a medium and culturing the cells; a step of removing the medium, adding tetrazolium that produces water-soluble formazan and an electron carrier and culturing the cells; and a step of evaluating cell survival based on the color developed by the water-soluble formazan. | 09-04-2014 |
20140242073 | CARTILAGE/BONE DESTRUCTION SUPPRESSOR - An object of the present invention is to provide a cartilage/bone destruction suppressor which can suppress the destruction of cartilage or bone seen in rheumatoid arthritis, osteoarthritis, bone metastasis of malignant tumor, or the like. The present invention relates to a cartilage or bone destruction suppressor comprising an antibody against folate receptor β or a complex of the antibody and a biologically or chemically active substance. | 08-28-2014 |
20140184050 | Lighting Apparatus - A lighting apparatus is provided with: a light-emitting unit, a heat spreader in heat-conductive contact with the light-emitting unit that diffuses the heat conducted from the light-emitting unit, heat pipes with one end in heat-conductive contact with the heat spreader that transport heat to their other end, and a lower row of cooling fins and upper row of cooling fins that are in heat-conductive contact with the other ends of the heat pipes, and that radiate the heat conducted from the heat pipes into the environment. | 07-03-2014 |
20140127691 | METHOD FOR DIAGNOSING TYPE OF PANCREATIC TUMOR - This invention is intended to provide a method capable of diagnosis of pancreatic tumor type at an early stage. More specifically, this invention relates to an examination method for determining pancreatic tumor type comprising detecting the degree of methylation in a 5′-untranslated region or a region comprising a 5′-untranslated region and a translated region of a gene encoding a mucin core protein in a pancreatic fluid sample from a subject, and identifying the pancreatic tumor as being of pancreatic tumor type selected from the group consisting of pancreatic ductal adenocarcinoma, an intraductal papillary mucinous neoplasm of the gastric type, an intraductal papillary mucinous neoplasm of the intestinal type, and an intraductal papillary mucinous neoplasm of the pancreatobiliary type using the degree of methylation as an index value. | 05-08-2014 |
20140023619 | VIRAL VECTOR TARGETING CANCER STEM CELLS - [Problem] To provide a novel and effective method for treating cancer, method for preventing cancer, and method for suppressing metastasis by targeting cancer stem cells, the methods being capable of labeling and damaging cancer stem cells; and to provide a method for damaging and a method for identifying cancer stem cells. [Solution] The present invention provides a viral vector having a promoter that is specifically expressed in cancer stem cells and that can be used for treatment and diagnosis. Furthermore, the present invention provides a method for treating cancer, a method for preventing cancer, and a method for suppressing metastasis using this viral vector, and further provides a method for damaging and a method for identifying cancer stem cells. Furthermore, the present invention provides a labeling agent and a toxic agent for cancer stem cells containing the vector as the active ingredient, and further provides a diagnostic drug, a therapeutic drug, and a metastasis suppressant for cancer. | 01-23-2014 |
20140010756 | COMPOSITION FOR TREATMENT AND DIAGNOSIS OF PANCREATIC CANCER - This invention relates to a pharmaceutical composition for inhibiting the growth and/or metastasis of invasive pancreatic cancer in a subject, comprising a molecular-targeted anticancer agent and a pharmaceutically acceptable carrier, wherein the molecular-targeted anticancer agent is a conjugate of a toxin or cytotoxic agent and an antibody or fragment thereof which immunologically and specifically binds to a cell-surface folate receptor β (FRβ) protein of an FRβ (+) macrophage that exists around pancreatic cancer cells at the invasive front, and to a diagnostic agent and kit for determining the degree of malignancy of pancreatic cancer or the presence of invasive pancreatic cancer, characterized by determining that the cancer tissue is invasive and metastatic when FRβ (+) macrophage is distributed around pancreatic cancer cells at the invasive front. | 01-09-2014 |
20130309203 | GROWTH-REGULATED VIRAL VECTOR CONTAINING THE AURORA KINASE PROMOTER - Disclosed is a vector, preferably a viral vector, containing a treatment factor and/or a nucleic acid encoding a cytotoxic factor under control of an Aurora kinase promoter. Also disclosed is a virus vector in which the promoter of a nucleic acid encoding a factor necessary to the replication or assembly of at least one virus is substituted by the Aurora kinase promoter. Also disclosed are a disease treatment agent, in particular a cancer treatment agent, which contains the aforementioned vector, and a clinical diagnostic agent, in particular a cancer diagnostic agent, which contains the vector containing the Aurora kinase promoter. | 11-21-2013 |
20130078741 | IGA-BINDING PEPTIDE AND PURIFICATION OF IGA USING THE SAME - This invention relates to: a peptide which comprises an amino acid sequence consisting of 12 to 18 amino acid residues represented by (X | 03-28-2013 |
20130045490 | ANTIBODY AGAINST MUCIN 1 (MUC1) PROTEIN AND USE OF SAME - The present invention provides means and a method assuring the effectiveness of early diagnosis of cancers including gastric cancers. Specifically, the present invention provides an antibody, which is prepared using, as an antigen, (a) a peptide comprising at least contiguous amino acids at positions 69 to 75 in the amino acid sequence of SEQ ID NO: 2, or (b) a peptide consisting of an amino acid sequence in which one or several amino acids are deleted, substituted or added in at least contiguous amino acids at positions 69 to 75 in the amino acid sequence of SEQ ID NO: 2, and having the antigenicity of human MUC1 protein, and which is reactive with human mucin 1 (MUC1) protein. | 02-21-2013 |
20130045478 | NOVEL METHOD FOR ANALYZING DNA METHYLATION - This invention provides a method for efficiently detecting DNA methylation. The method for detecting DNA methylation comprises subjecting DNA to bisulfite treatment, subjecting DNA after bisulfite treatment to a first PCR, subjecting the resultant to nested PCR, and subjecting amplified DNA to denaturing gradient gel electrophoresis. | 02-21-2013 |
20120244634 | METHOD FOR DETECTION OF BASIC PEPTIDE AND REAGENT FOR DETECTION OF BASIC PEPTIDE - The present invention provides a method for detection of a basic peptide by mixing a sample suspected to contain the basic peptide and a reagent containing denatured albumin and detecting turbidness due to a complex of the basic peptide and denatured albumin. | 09-27-2012 |
20120169756 | IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, AND PROGRAM - A hue conversion unit ( | 07-05-2012 |
20120128199 | WATERMARK INFORMATION EMBEDDING DEVICE, WATERMARK INFORMATION PROCESSING SYSTEM, WATERMARK INFORMATION EMBEDDING METHOD, AND PROGRAM - The present invention provides a watermark information embedding device, a watermark information processing system, a watermark information embedding method and program that can provide a two-dimensional code enabling detection of copying. The watermark information embedding device comprises a first wavelet transform unit ( | 05-24-2012 |
20120127667 | HEAT SINK PACKAGE AND METHOD OF MANUFACTURING - A circuit element is arranged on an organic substrate and connected to a wiring pattern arranged on the organic substrate. An internal connection electrode is formed on a conductive support body by electroforming so as to obtain a unitary block of the internal connection electrode and the support body. Each end of each of the internal connection electrodes connected into a unitary block by the support body is connected to the wiring pattern. After the circuit element is sealed by resin, the support body is peeled off, so as to obtain individual internal connection electrodes separately and the other end of each of the internal connection electrodes is used as an external connection electrode on the front surface while the external connection electrode on the rear surface is connected to the wiring pattern. | 05-24-2012 |
20120106084 | Heat Pipe, Method For Manufacturing A Heat Pipe, And A Circuit Board With A Heat Pipe Function - A heat pipe for cooling an exothermic body by the vaporization and condensation of an enclosed cooling medium is disclosed. The heat pipe comprises a flat plate-like upper plate, a flat plate-like lower plate opposed to the upper plate, and a plurality of flat plate-like intermediate plates overlaid on each other between the upper plate and the lower plate and having internal through-holes. The internal through-holes formed in each of a plurality of the intermediate plates are adapted such that only part of each through-hole is overlapped on each other to form capillary tube paths, each having a cross-sectional area smaller than the cross-sectional area of the through-hole in the flat surface direction. | 05-03-2012 |
20120095186 | POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF THE SAME - A polyion complex (PIC) or a PIC nanoparticle that may be easily prepared, and that is finally disappeared in vivo due to its suitable biodegradability while exhibiting high stability in vivo, an immunotherapy agent comprising the PIC nanoparticle to which various antigen proteins or peptides may be easily conjugated or incorporated and/or which may be easily mixed with the antigen proteins or peptides, as well as a process for preparing thereof are provided. Specifically, a polyion complex (PIC) comprising a hydrophobized poly(acidic amino acid) and a basic polypeptide, a nanoparticle thereof having a particle shape, an immunotherapy agent comprising the PIC nanoparticle, as well as a process for preparing the PIC, comprising steps of introducing a hydrophobic amino acid to a poly(acidic amino acid) to prepare a hydrophobized poly(acidic amino acid), and dissolving the hydrophobized poly(acidic amino acid) prepared to a buffer, and it is mixed with a basic polypeptide dissolved in a buffer. | 04-19-2012 |
20110308772 | Heat Pipe And Electronic Device - The Present Invention provides a heat pipe and an electronic device which can efficiently cool a light emitting element arranged in an end portion, so that it is possible to efficiently mount the heat pipe in a narrow space. The heat pipe is provided with an upper plate ( | 12-22-2011 |
20110229487 | THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT - Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect. | 09-22-2011 |
20110117602 | HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS - A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases. | 05-19-2011 |
20110077204 | Agent for Targeted Drug Delivery To Cerebral Neurons - The present invention relates to targeting agents of drugs, more specifically, to targeting agents that cause drugs to be incorporated into brain neurons. The present invention further relates to medicines comprising the targeting agents and drugs. The present invention also relates to a method for targeting drugs to brain neurons. | 03-31-2011 |
20100216977 | THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY - An objective of the present invention is to provide effective methods for treating interstitial pulmonary diseases including interstitial pneumonia such as IPF. The present invention suggests that antibodies against HMGB-1 are effective for treating pulmonary fibrosis. Thus, the present invention provides preparations which comprise an anti-HMGB-1 antibody for treating interstitial pulmonary diseases. | 08-26-2010 |
20100173277 | Agent for Suppressing Rejection in Organ Transplantation Comprising Anti-HMGB-1 Antibody - An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic islets. Thus, the present invention provides agents that comprise an anti-HMGB-1 antibody for suppressing rejection in organ transplantation. | 07-08-2010 |
20100063394 | OSTEOPOROSIS PROGRESS STAGE MEASURING DEVICE AND OSTEOPOROSIS PROGRESS STAGE MEASURING METHOD - An osteoporosis progress stage measuring device is configured such that an ultrasonic wave oscillating section ( | 03-11-2010 |
20090133082 | AUDIO/VIDEO COMMUNICATION SYSTEM - An audio/video communication system includes a large number of nodes connected in a balanced binary tree structure. In constructing a group in a balanced binary tree structure, a root node performs the following process: if a left lower node connector of the root node is vacant, the root node connects a new node to the left lower node connector and increases left weight information by “1”; if the left lower node connector of the root node is occupied and if a right lower node connector of the root node is vacant, the root node connects a new node to the right lower node connector and increases right weight information by “1”; if both of the left lower node connector and the right lower node connector of the root node are occupied and if the left weight information of the root node is equal to or less than the right weight information of the root node, the root node sends a request for an addition of a new node to its left lower node and increases the left weight information by “1”; or if both of the left lower node connector and the right lower node connector of the root node are occupied and if the left weight information of the root node is greater than the right weight information of the root node, the root node sends a request for an addition of a new node to its right lower node and increases the right weight information by “1”. Accordingly, it is possible to provide an audio/video communication system that permits simultaneous communication among a large number of nodes and that performs flexible management of adding a new node to the system and removing a node from the system. | 05-21-2009 |
20090054596 | Composite Particulate and Manufacturing Method for the Same - A temperature-responsive polymer (hydrated graft structure) layer ( | 02-26-2009 |