Queens University at Kingston Patent applications |
Patent application number | Title | Published |
20160051726 | Collagenous Foam Materials - Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibres. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads. The foam materials may be used in applications such as bioscaffolds for wound healing, soft tissue regeneration and augmentation, for localized cell delivery, or as cell culture substrates for research. The foam materials include natural collagen fibrils that provide a stable scaffold and enhance integration of the implanted scaffold and regeneration of cells and tissue. | 02-25-2016 |
20150197817 | METHODS, PROBE SETS, AND KITS FOR DETECTION OF DELETION OF TUMOR SUPPRESSOR GENES BY FLUORESCENCE IN SITU HYBRIDIZATION - Methods, probe sets, kits, and compositions for gene deletion assays are disclosed. In some embodiments, the methods relate to preparing probes for a deletion assay, performing a deletion assay, or optimizing a deletion assay. In some embodiments, the methods and probe sets can provide reduced artifactual deletion frequency, for example, when analyzing samples subject to truncation artifacts. In some embodiments, the methods and probe sets can distinguish between small and large deletions. | 07-16-2015 |
20150190772 | Micellar Composition Having Switchable Viscosity - The present application provides a micellar composition having switchable viscosity. In accordance with an aspect of the present invention, there is provided a micellar composition comprising: (a) a mixture of water and a switchable component comprising: (i) a non-switchable surfactant and a switchable water additive; (ii) a switchable anionic surfactant; or (iii) a switchable cationic surfactant; and (b) dissolved CO | 07-09-2015 |
20150042555 | Method and Apparatus for Communication Between Humans and Devices - This invention relates to methods and apparatus for improving communications between humans and devices. The invention provides a method of modulating operation of a device, comprising: providing an attentive user interface for obtaining information about an attentive state of a user; and modulating operation of a device on the basis of the obtained information, wherein the operation that is modulated is initiated by the device. Preferably, the information about the user's attentive state is eye contact of the user with the device that is sensed by the attentive user interface. | 02-12-2015 |
20140363397 | METHOD FOR TREATMENT OF DISORDERS OF THE GASTROINTESTINAL SYSTEM - There are provided novel synthetic stool preparations comprising bacteria isolated from a fecal sample from a healthy donor. The synthetic stool preparations are used for treating disorders of the gastrointestinal tract, including dysbiosis, | 12-11-2014 |
20140343403 | Patient-Specific Surgical Guidance Tool and Method of Use - Presented is a preoperatively designed guidance tool for intraoperative use during bone or joint surgery wherein the guidance tool is specific to the anatomy of the patient being treated. The guidance tool comprises a body portion, a mating surface provided on the body portion for positioning the guidance tool on a corresponding registration surface of a patient's anatomy. The guidance tool further comprises at least one guide mechanism provided on the body portion for guiding a medical instrument at one or more preoperatively defined trajectories relative to a patient's anatomy. In the event of misalignment, the at least one guide mechanism is adjustable to alter the one or more preoperatively defined trajectories if necessary during intraoperative use. Also presented is a preoperative process for designing the guidance tool. | 11-20-2014 |
20140295403 | DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 10-02-2014 |
20140276001 | Device and Method for Image-Guided Surgery - In one aspect the invention provides a reference device that enhances image-guided surgical interventions. The reference device is tracked by the imaging system and used to verify the accuracy of the intervention tool placement before and during the intervention. The reference device holds a reference sensor in a position aligned with patient anatomy, so that images are displayed in the correct orientation to the operator, aiding in target recognition and better navigation. Also provided are methods using the reference device and programmed computer media for implementing at least a part of the methods. | 09-18-2014 |
20140272957 | METHODS AND KITS FOR DIAGNOSING, PROGNOSTICATING RISK/OUTCOME, AND/OR TREATING BREAST CANCER - Methods and kits for diagnosing, prognosticating risk of, and selecting and/or administering a therapy for breast cancer based upon detection of methylated glucocorticoid receptor gene or measurement of glucocorticoid receptor and BRCA1 gene expression levels are provided. | 09-18-2014 |
20140252973 | Ripple Cancellation Converter with High Power Factor - Provided are circuits and methods for use with a power supply that provides a main output including a main DC voltage having a first AC voltage ripple, or a main DC current having a first AC current ripple. A ripple cancellation converter provides a second AC voltage ripple connected in series with the main output, such that the first AC voltage ripple is substantially cancelled; or a second AC current ripple connected in parallel with the main output, such that the first AC current ripple is substantially cancelled. As a result, substantially ripple-free DC output power is provided. | 09-11-2014 |
20140235908 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO | 08-21-2014 |
20140206585 | Substituted Diarylamines and Use of Same as Antioxidants - A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. | 07-24-2014 |
20140183791 | Biomass Pellet and Method of Producing Same - Described is a substantially spherical biomass pellet, comprising compressed particulate biomass including one or more of ligno-cellulosic material, recycling waste, and dewatered municipal solid waste, useful as a fuel. Also described are methods for producing such pellets using one or more of untorrefied biomass and torrefied biomass, and apparatus for producing such biomass pellets. | 07-03-2014 |
20140166483 | ELECTROKINETICS-ASSISTED SENSOR - An electrokinetics-assisted sensor for sensing a target material. The sensor may include a microstructure deflectable in response to added mass on its body. The sensor may also include one or more features on or near the microstructure designed to generate an electric field giving rise to one or more electrokinetic effects to drive material towards the microstructure, when an electrical signal is applied to the feature(s). Presence of the target material on the body of the microstructure may cause a response in the microstructure, including a detectable change in deflection of the microstructure. | 06-19-2014 |
20140155445 | Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System - Disclosed are compounds of the general formula (I): | 06-05-2014 |
20140121501 | AUTOMATED INTRAOPERATIVE ULTRASOUND CALIBRATION - An ultrasound calibration phantom comprises a portion including at least one fiducial structure having a selected geometric arrangement; a portion adapted for mechanical coupling of the ultrasound calibration phantom to a transrectal ultrasound (TRUS) stepper; and a guide for at least one surgical instrument, the guide being mechanically coupled to the fiducial structure and/or to the TRUS stepper at a selected pose relative to the fiducial structure. A calibration method uses the calibration phantom and provides automatic, intraoperative calibration of ultrasound imaging systems. The invention is useful in ultrasound-guided clinical procedures. | 05-01-2014 |
20140113928 | METHODS AND COMPOSITIONS FOR ENHANCING FERTILITY AND/OR INHIBITING PREGNANCY FAILURE AND RESTORING GLUCOSE TOLERANCE - Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure, restoring glucose tolerance and/or preventing glucose intolerance and/or maintaining glucose homeostasis and/or inducing or enhancing weight loss, treating dyslipidemia, treating hypertestosteronism or hyperandrogenism, and/or treating type 2 diabetes in an individual in need thereof are provided. These involve compositions that inhibit expression of interferon-gamma (IFN-γ) or a downstream IFN-γ-stimulated gene, which is preferably a macrolide immunosuppressant compound. | 04-24-2014 |
20130327989 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO | 12-12-2013 |
20130324829 | Adjustable Suture - Provided are adjustable sutures comprising a suture thread | 12-05-2013 |
20130231938 | Method and Apparatus for Communication Between Humans and Devices - This invention relates to methods and apparatus for improving communications between humans and devices. The invention provides a method of modulating operation of a device, comprising: providing an attentive user interface for obtaining information about an attentive state of a user; and modulating operation of a device on the basis of the obtained information, wherein the operation that is modulated is initiated by the device. Preferably, the information about the user's attentive state is eye contact of the user with the device that is sensed by the attentive user interface. | 09-05-2013 |
20130217041 | DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 08-22-2013 |
20130217040 | METHOD AND SYSTEM FOR DETECTING BIOLOGICAL MOLECULES IN SAMPLES - A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge. | 08-22-2013 |
20130217039 | OPTICAL PATHOGEN DETECTION SYSTEM AND QUALITY CONTROL MATERIALS FOR USE IN SAME - A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge. Also provided is a method for calibrating said system and quality control cartridges for use in same. | 08-22-2013 |
20130200291 | Tertiary Amine-Based Switchable Cationic Surfactants and Methods and Systems of Use Thereof - The present application provides switchable cationic surfactants based on tertiary amines, and methods and systems of use thereof. The tertiary amine structure allows these switchable surfactants to reversibly switch from a non-surfactant form to a surfactant form by simple introduction of an ionizing trigger gas that comprises CO | 08-08-2013 |
20130158438 | Robotic Exoskeleton for Limb Movement - This invention relates to a robotic exoskeleton comprising mechanical linkages that couple to one or more selected joints of a limb of a subject. The robotic exoskeleton may be provided with means for obtaining data respecting angular position, torque, and/or acceleration of at least one of the joints or the links of the mechanical linkages, and may be used for assessing, studying, diagnosing a deficit, and/or treating an impairment in sensorimotor function of a limb of a subject. | 06-20-2013 |
20130135008 | METHOD AND SYSTEM FOR A RUN-TIME RECONFIGURABLE COMPUTER ARCHITECTURE - A reconfigurable computer architecture is disclosed. The reconfigurable computer architecture has a plurality of logic elements, a plurality of connection switching elements, and a plurality of volatile and/or non-volatile configuration random access memories (RAMs). Each of the configuration RAMs is electrically coupled to at least one of the plurality of logic elements or at least one of the connection switching elements. | 05-30-2013 |
20130105377 | Water with Switchable Ionic Strength | 05-02-2013 |
20130096446 | Method and System for Differentiating Between Supraventricular Tachyarrhythmia and Ventricular Tachyarrhythmia - A method of differentiating between supraventricular tachyarrhythmia (SVT) and ventricular tachyarrhythmia (VT) is disclosed. A post pacing interval (PPI) is determined based on a biomarker dataset. The post pacing interval is statistically analyzed relative to a threshold to differentiate between SVT and VT. A further method of differentiating between SVT and VT is disclosed. A PPI is determined based on a biomarker dataset. A tachycardia cycle length (TCL) is also determined based on the biomarker dataset. A difference of the PPI minus the TCL is statistically analyzed relative to a threshold to differentiate between SVT and VT. A non-transitory computer readable medium and a system are also disclosed for differentiating between SVT and VT. | 04-18-2013 |
20130087072 | Reversibly Switchable Surfactants and Methods of Use Thereof - Reversible switchable surfactants are provided. A surfactant is the salt of an amidine or guanidine having at least one R group that is a hydrophobic moiety selected from the group consisting of higher aliphatic moiety, higher siloxyl moiety, higher aliphatic/siloxyl moiety, aliphatic/aryl moiety, siloxyl/aryl moiety, and aliphatic/siloxyl/aryl moiety. The other R groups are smaller moieties such as H, C | 04-11-2013 |
20130046092 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO | 02-21-2013 |
20120138586 | METHODS AND SYSTEMS FOR COHERENT IMAGING AND FEEDBACK CONTROL FOR MODIFICATION OF MATERIALS - Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided. | 06-07-2012 |
20120116076 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO | 05-10-2012 |
20120038629 | System and Method for Integrating Gaze Tracking with Virtual Reality or Augmented Reality - This invention relates to gaze tracking methods and systems integrated with virtual reality (VR) or augmented reality (AR). A system may include one or more cameras for capturing images of a subject's eyes, a display device for displaying a VR or AR image, a first reflecting surface associated with the display device for at least partially reflecting light from the eyes to the one or more cameras and for transmitting the VR or AR image; and a second reflecting surface for at least partially reflecting light from the eyes to the one or more cameras and for receiving the VR or AR image and rendering the VR or AR image to the subject as at least one component of a VR or AR environment. The methods and systems described herein may be used in research, medical, industrial, aerospace, and entertainment applications. | 02-16-2012 |
20120020915 | Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System - Disclosed are compounds of the general formula (I): | 01-26-2012 |
20110319459 | Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System - Disclosed are compounds of the general formula (I): | 12-29-2011 |
20110268768 | Compositions and Methods for Treating Atherosclerosis - Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided. | 11-03-2011 |
20110254528 | MULTI-MODULE BIDIRECTIONAL DC-DC CONVERTER - A multi-module bidirectional power converter may comprise a low side common node, a high side common node and at least first and second bidirectional DC/DC converter modules. The modules may comprise first and second low voltage switches, first and second high voltage switches and a transformer. The transformer may comprise a low side winding having first and second legs and a high side winding having first and second legs. The first leg of the low side winding may be connected with the first and second low voltage switches of the module. The second leg of the low side winding may be connected with the low side common node of the multi-module bidirectional power converter. The first leg of the high side winding may be connected with the first and second high voltage switches of the module. The second leg of the high side winding may be connected to the high side common node of the multi-module bidirectional power converter. Such an arrangement may provide operability of the multi-module bidirectional power converter with any one or more of the modules so that efficiency is maintained when electrical loads are high and so that Zero Voltage Switching is maintained when electrical loads are low. | 10-20-2011 |
20110177956 | METHOD AND SYSTEM OF PREDICTING CLINICAL OUTCOME FOR A PATIENT WITH CONGESTIVE HEART FAILURE - A method of predicting a clinical outcome for a patient with congestive heart failure is disclosed. A plurality of nonlinear first PCI models are identified based on a biomarker dataset, each of the models having a number of distinct terms. One or more second PCI models are identified based on the biomarker dataset, each of these models having a number of distinct terms which corresponds to the number of distinct terms for one or more of the nonlinear first PCI models. Each of the plurality of nonlinear first PCI models are statistically compared to one of the one or more second PCI models having a corresponding number of distinct terms to determine a preference for higher versus lower degree of nonlinearity or preference for shorter versus longer memory length. The clinical outcome is predicted based on the preference for higher versus lower degree of nonlinearity or memory length preference. | 07-21-2011 |
20110028543 | Formulations and methods of using nitric oxide mimetics in cancer treatment - The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals. | 02-03-2011 |
20110021711 | CROSSLINKED POLYMER PARTICLES - The present invention is crosslinked polymer particles, prepared from a free-radical activated reaction of an unsaturated coagent and low molecular weight hydrocarbons or certain polymers. This invention allows particles to be made from mixtures of coagents and saturated compounds. The invention is also a process for preparing crosslinked polymer particles. | 01-27-2011 |
20110009514 | Silane-Coupled Propylene-Based Polymer and Method - The present disclosure provides propylene-based polymers which exhibit a strain hardening distribution factor that is less than zero and/or a strain hardening factor greater than 1.5. The propylene-based polymers are rheology-modified by way of silane coupling to improve melt strength. | 01-13-2011 |
20110009513 | Imide-Coupled Propylene-Based Polymer and Process - Disclosed are propylene-based polymers with improved melt strength, improved strain hardening characteristics and processes for producing the same. The processes include reacting a polyamine with a maleic anhydride-grafted-propylene-based polymer. The processes produce a rheology-modified propylene-based polymer with long chain branching by forming a polyimide linkage which couples polymer chains of the propylene-based polymer. The polyimide-coupled propylene-based polymer exhibits improved melt strength and improved strain hardening characteristics. | 01-13-2011 |
20100243113 | THERMOMECHANICAL PROCESSING OF ALUMINUM ALLOYS - A cast aluminum alloy containing up to about 0.35% by weight chromium is heated to a first elevated temperature to homogenize the casting and dissolve the chromium content in an aluminum-based matrix phase. The alloy is then heated at a lower elevated temperature to cause the precipitation of a portion of the chromium as an aluminum-containing and chromium-containing intermetallic compound. A suitable amount of chromium is retained in solid solution in aluminum. Thus, the concentration of dissolved chromium in an aluminum alloy may be controlled to fall within specified ranges which result in improvements in both the strength and ductility of the alloy. Impurity amounts of iron may also be precipitated as intermetallic particles from the aluminum matrix to enhance the ductility of the aluminum-based alloy. | 09-30-2010 |
20100203511 | Retinoid metabolizing protein - Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same. | 08-12-2010 |
20100144821 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS - The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation. | 06-10-2010 |
20100063393 | Method for Improved Ultrasonic Detection - This invention relates to a method of analyzing an ultrasound signal. The method comprises obtaining a time series of sequential data frames associated with an ultrasound signal reflected from and/or backscattered from a fixed location of a material under investigation, each data frame comprising a plurality of samples of the ultrasound signal, and subjecting to an analysis a sequence of one or more samples of the ultrasound signal, or a sequence of at least one parameter derived from one or more samples of the ultrasound signal, wherein a result of the analysis is related to one or properties or characteristics of the material. In one embodiment the method may be used for detecting, diagnosing, and/or assessing cancer and/or abnormalities in biological tissue. | 03-11-2010 |
20100041631 | METHODS AND AGENTS FOR TREATING TUBERCULOSIS - The present invention relates to the treatment of tuberculosis (mycobacterial infections) by the use of KshAB complex inhibitors, or a KstD molecule, or a HsaAB complex, or a HsaC molecule, or a HsaD molecule. The application also includes a method for identifying an inhibitor or modulator of the previously mentioned molecules and complexes. | 02-18-2010 |
20090203850 | HALOBUTYL ELASTOMERS - The present invention relates to the modification of butyl elastomers, particularly halobutyl elastomers, under solvent free conditions with a phase transfer catalyst in the presence of an alkyl metal salt of an oxygen or sulfur-based nucleophile. | 08-13-2009 |
20090117600 | Detection of biological molecules by differential partitioning of enzyme substrates and products - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 05-07-2009 |
20090036297 | Sol Gel Functionalized Silicate Catalyst and Scavenger - This invention relates to materials suitable as metal scavengers and catalysts. The materials are prepared by functionalizing silicate materials such as silica or SBA-15 with a thiol or amine, or other functionalizing agent, in a sol gel process. In a preferred embodiment, the metal is palladium and the functionalizing agent is a thiol. The material may be used as a catalyst for the Suzuki-Miyaura and Mizoroki-Heck coupling reactions. The catalyst materials have extremely low metal leaching, are very stable, and are completely recyclable. | 02-05-2009 |