SUNNYBROOK HEALTH SCIENCES CENTRE Patent applications |
Patent application number | Title | Published |
20150217500 | METHOD OF FORMING PATIENT-SPECIFIC IMPLANT - Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient. | 08-06-2015 |
20140323877 | MEDICAL IMAGING PROBE WITH ROTARY ENCODER - The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities. | 10-30-2014 |
20140323860 | IMAGING PROBE WITH COMBINED ULTRASOUND AND OPTICAL MEANS OF IMAGING - The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image signals during scanning a region of interest. | 10-30-2014 |
20140248248 | HUMAN PROGENITOR T-CELLS - Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy. | 09-04-2014 |
20140163433 | ULTRASOUND THERAPY TRANSDUCER HEAD WITH TEMPERATIRE CONTROL STRUCTURE - An ultrasound therapy transducer head comprises an ultrasound source emitting ultrasonic radiation, the ultrasound source comprising a plurality of transducer elements, integrated driving electronics coupled to the transducer elements, the electronics generating at least one output ultrasound waveform and driving at least some of the transducer elements independently based on the at least one output ultrasound waveform and temperature control structure providing cooling for the electronics. | 06-12-2014 |
20130115226 | METHODS AND USES OF TIE2 BINDING AND/OR ACTIVATING AGENTS - The present disclosure provides methods and uses of Tie2 binding and/or activating agents. In particular, the present disclosure provides methods and uses for inhibiting the expansion of colony forming unit-granulocytes, reducing eosinophils and/or basophils, for treating allergic disease or response or eosinophil/basophil associated condition and for reducing inflammatory cytokine and/or chemokine levels. | 05-09-2013 |
20130088227 | MAGNETIC RESONANCE-BASED METHOD AND SYSTEM FOR DETERMINATION OF OXYGEN SATURATION IN FLOWING BLOOD - A method and system for determination of oxygen saturation in blood flowing in a vessel using magnetic resonance (MR). An MR image sequence is acquired with different echo time (TE) encoding, and different Fourier velocity encoding (FVE). A Fourier transformation is applied along the velocity dimension to determine a velocity distribution of tissue signals in each voxel of the image sequence. Tissue signals indicative of moving tissues are separated from tissue signals indicative of static tissue, based on the velocity distribution. Oxygen saturation in blood may then be determined using only the tissue signals indicative of flowing blood. | 04-11-2013 |
20130069484 | Ultrasound Transducer and Method for Making the Same - The present application provides a multilayer lateral mode coupling method for phased array construction and transducer devices built accordingly. This disclosure describes and demonstrates that the electrical impedance of a phased array can be substantially reduced and readily controlled to be close to the source impedance. The fabrication process is relatively simple and inexpensive. In addition, the elements are robust for use in 1.5, 2, 3 or other dimensional configurations, over an extended period of operation, without structural failure, and providing a high power output required for imaging and/or medical therapy applications. | 03-21-2013 |
20110034833 | System for Treatment of Diseased Tissue Using Controlled Ultrasonic Heating - The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator. | 02-10-2011 |
20100260776 | THERAPEUTIC METHOD FOR REDUCING ANGIOGENESIS - A method of controlling or treating an angiogenic dependent condition in a mammal, preferably in a human by administering an anti angiogenic molecule such as an angiogenesis growth factor antagonist, and a chemotherapeutic agent in amounts and frequencies effective, in combination, to produce a regression or arrest of said condition while minimizing or preventing significant toxicity of the chemotherapeutic agent. Also a kit for controlling or treating an angiogenic dependent condition in a mammal, preferably in a human, comprising an anti-angiogenic molecule, such as an angiogenesis growth factor antagonist, and a chemotherapeutic agent in amounts effective, in combination, to produce a regression or arrest of said condition while minimizing or preventing significant toxicity of the chemotherapeutic agent. | 10-14-2010 |
20100198618 | DIALYSIS INFORMATION MANAGEMENT SYSTEM - A server device, and related systems and methods for managing dialysis patient information. The patient information includes information relating to stages of data collection including baseline characteristics, eligibility for treatment modalities, and outcomes. A remote terminal is configured for displaying in the remote terminal a first user interface for receiving the patient information for the subject patient. The server is configured to receive from the remote terminal the patient information for the subject patient and store said patient information in a patient record in the memory, and determine, based on medical logic rules, whether the patient information is consistent with the patient record in order to proceed to a next stage of data collection, and if so permitting displaying in the remote terminal a second user interface for receiving patient information relating to the next stage of data collection. | 08-05-2010 |
20100063383 | CATHETER FOR MAGNETIC RESONANCE GUIDED PROCEDURES - A catheter for magnetic resonance (MR) guided procedures comprising: a catheter body having a lumen for accommodating an intravascular device; a magnetic coupling component in the catheter body, the magnetic coupling component being designed to magnetically couple with a conductive length on the intravascular device, the magnetic coupling resulting in a signal; the catheter having a connection to deliver the signal to a processor. | 03-11-2010 |
20080221382 | Method and system of radiotherapy enhancement through cellular perturbation using ultrasound and microbubbles - An embodiment of the invention is related to a system for providing radiotherapy to a treatment region. The system includes a radiation source and a sound source. The radiation source is positioned to irradiate the treatment region. The sound source is positioned to provide ultrasound to the treatment region so that the treatment region is subject to coincidental treatment by irradiation and ultrasound. | 09-11-2008 |