Vala Sciences, Inc. Patent applications |
Patent application number | Title | Published |
20150330892 | Analysis of Action Potentials, Transients, and Ion Flux in Excitable Cells - Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell. | 11-19-2015 |
20140168402 | Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus - Continuous-scanning image acquisition in an automated microscopy system uses an image reflected off of an object that supports a specimen being imaged to automatically focus the microscopy system. | 06-19-2014 |
20130338016 | Method For Integrated Pathology Diagnosis And Digital Biomarker Pattern Analysis - A method of tissue analysis integrates a pathology diagnostic step (subjective human inspection of a stained tissue section or image of it) with one or more gene/biomarker tests to enable perform of both procedures side-by-side on the same instrument. | 12-19-2013 |
20130338014 | Calibration Standards For Digital Histocytometry - An analytical reference for digital histochemistry is constituted of an on-slide standard used to calibrate biomarker expression in biopsy material and tissue sections. The standard consists of one or more calibration standards, which are derived from cell lines that express biomarkers, and are arranged into a calibration array. Expression of the desired biomarkers is validated by Western blotting, flow cytometry, or other methods. The calibration array is applied to a microscopy slide in such a manner that test samples from biopsies or tissue sections, or other cellular material, can also be mounted on the same slide, adjacent to the calibration array. Data obtained from the calibration array can be used to quantify expression of biomarkers in the biopsy material, tissue sections, tissue microarrays, and cellular material, via digital histochemistry. | 12-19-2013 |
20130016891 | User interface method and system for management and control of automated image processing in high content screening or high throughput screening - A user interface method and system for controlling automated image processing operations of HCS and/or HTS systems includes a graphical interface to enable user designation of an image naming convention, image sources and destinations, image processing channels, processing parameter values, and processing spatial designations. | 01-17-2013 |
20130004053 | System and method for automatic color segmentation and minimum significant response for measurement of fractional localized intensity of cellular compartments - A system, a method, and a programmed device for measurement of translocational activity among cellular compartments process magnified images of cellular material exposed to an agent by segmenting and compartmentalizing the images and then measuring fractional localized intensity of two or more compartments in the segmented, compartmentalized image. The measured fractional localized intensities are compared to determine translocation of cellular material among the measured components caused by the agent. | 01-03-2013 |
20110274337 | System, method, and kit for processing a magnified image of biological material to identify components of a biological object - A system, method and kit for processing an original image of biological material to identify certain components of a biological object by locating the biological object in the image, enhancing the image by sharpening components of interest in the object, and applying a contour-finding function to the enhanced image to create a contour mask. The contour mask may be processed to yield a segmented image divided by structural units of the biological material. | 11-10-2011 |
20100289887 | Automated transient image cytometry - A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity. | 11-18-2010 |
20100192084 | Automated image analysis with gui management and control of a pipeline workflow - Automated image screening operations of pipelined image processing systems and methods are controlled with a graphical user interface enabling user control of screening analysis process setup and execution and user viewing of results. A gating interface is provided to include and/or exclude cells in an aggregation of individual cell data. | 07-29-2010 |
20100061617 | User interface method and system for management and control of automated image processing in high content screening or high throughput screening - A user interface method and system for controlling automated image processing operations of HCS and/or HTS systems includes a graphical interface to enable user designation of an image naming convention, image sources and destinations, image processing channels, processing parameter values, and processing spatial designations. | 03-11-2010 |
20100053211 | User interface method and system with image viewer for management and control of automated image processing in high content screening or high throughput screening - A user interface method and system for controlling automated image processing operations of HCS and/or HTS systems includes a graphical interface to enable user designation of an image naming convention, image sources and destinations, image processing channels, processing parameter values, and processing spatial designations. The graphical interface includes an image viewer. | 03-04-2010 |