UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. Patent applications |
Patent application number | Title | Published |
20160096896 | TWEAK/FN14 SYSTEM REGULATES SKELETAL MUSCLE ATROPHY AND REGENERATION - The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system. | 04-07-2016 |
20160067777 | METHOD FOR SYNTHESIZING SELF-ASSEMBLING NANOPARTICLES - Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations. | 03-10-2016 |
20150374849 | NANOPARTICLES FOR DRUG DELIVERY - The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery. | 12-31-2015 |
20150368207 | METHOD FOR TREATING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS WITH IODO PYRIMIDINE DERIVATIVES - Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula I: | 12-24-2015 |
20150361241 | STIMULI-RESPONSIVE POLYMER COMPOSITES - A polymer composite is provided that includes a plurality of heat-absorbing nanomaterials, a plurality of thermally-expanding microspheres, and an elastomeric matrix. In the polymer composite, the heat-absorbing nanomaterials and the thermally-expanding microspheres are dispersed within the elastomeric matrix such that the thermally-expanding microspheres expand and stretch the matrix upon exposure to a thermal stimulus. Methods of forming a thermally-expanding polymer composite are also provided and include the steps of dispersing a plurality of heat-absorbing nanomaterials in an evaporative solvent; combining the dispersion with an amount of an elastomeric material to create a mixture; adding an amount of thermally-expanding microspheres to the mixture; and polymerizing the mixture. Circuits including resistors comprised of the polymer composites are further provided. | 12-17-2015 |
20150320525 | METHODS FOR FABRICATING DENTAL PROSTHESES - Methods of fabricating dental prostheses are provided that include the steps of providing a powder of a dental material, and then selectively melting the powder of the dental material to produce a functionally graded layer of the dental material. Additional layers of functionally graded dental material are then built on top of the initial layer of dental material to thereby produce a three-dimensional dental prosthesis having a functionally graded structure and a desired physical geometry. Dental prostheses produced by the foregoing methods are also provided. | 11-12-2015 |
20150219662 | USE OF PROTEIN LINE-1 ORF-1 AS A BIOMARKER FOR CANCER - Embodiments of the present invention relate to the detection and diagnosis of cancer. More particularly, the present invention relates to a method for the early detection and diagnosis of cancer by measuring the amount of LINE-1 ORF-1 protein in a liquid biological sample obtained from a human. | 08-06-2015 |
20150160230 | METHODS OF PREDICTING AND DECREASING THE RISK OF PRE-TERM BIRTH - Provided are methods for predicting the risk of pre-term birth in a pregnant subject, for identifying a subject having an increased risk of pre-term birth, for selecting a subject for participation in a clinical study, and for decreasing the risk of pre-term birth in a subject. These methods include providing a sample from the subject and detecting the level of one or more of growth arrest-specific protein 1 (GASI), ALLI-fused gene from chromosome 4 protein (AR4)/Fragile X Mental Retardation 2 (FMR2) family member 3 (AFF3), transthyretin (TTR), ryanodine receptor 1 (RYRI), E26 transformation specific variant 6 (ETV6), claudin-10, zinc finger protein 23 (ZNF23), collagen type XXVII α1 (COL27AI), Kazrin isoform-1, keratin-associated protein 10-9 (KRTAPIO-9), Huntingtin (HTT), microtubule associated protein 9 (MAP9), coiled-coil domain-containing protein 13 (CCDC13), inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform 2 (HISPPDI), immunoglobulin gamma-3 chain C (IG-HG3), cysteine- and histidine-rich protein-1 (CYHRI), and XP 002348181. | 06-11-2015 |
20150086506 | ALTERATION OF CELL MEMBRANE FOR NEW FUNCTIONS - Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the proteins and polypeptides embodying these sequences are disclosed for modulating the immune system. The modulations include down-regulation, up-regulation and apoptosis. | 03-26-2015 |
20150064199 | CANCER THERAPY USING BETA GLUCAN AND ANTIBODIES - The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Th1 response, leading to an enhanced antitumor cytotoxic T-cell response. | 03-05-2015 |
20150018227 | MICRORNA BIOMARKERS - The presently disclosed subject matter provides methods for characterization of and evaluation of treatment and/or progression of a lung cancer or a head and neck cancer by measuring amounts of one or more RNAs present in microvesicles isolated from a biological sample from the subject. | 01-15-2015 |
20140364866 | ENDOSCOPIC SNARE DEVICE - Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop snare device including a means for securely closing the loop. In some embodiments, a snare device comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the device along an arcuate path curving back toward the capture mechanism such that, after the snare wire is advanced, activation of the capture mechanism captures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue. | 12-11-2014 |
20140356348 | METHODS OF PREDICTING AND DECREASING THE RISK OF PREGNANCY LOSS - Described are methods for diagnosing and predicting the risk of pregnancy loss in a subject based on the presence of an aberrant humoral response to three proteins, Apolipoprotein B-100, alpha2macrogloblin (alpha2M), and fibronectin. The presence or a detectable level of maternal IgG antibodies to trophoblast-derived fibronectin and/or ApoB-100, and/or the absence or a non-detectable level of antibodies specifically binding to alpha2M is associated with a history of RPL and an increased risk of pregnancy loss. Also described are methods for identifying subjects at risk of pregnancy loss, selecting subjects for participation in a clinical study, and methods of decreasing the risk of pregnancy loss in a subject which include detecting the presence or absence of antibodies to one or more of trophoblast-derived ApoB-100, alpha2M, and fibronectin. Also provided are kits that contain ApoB-100, alpha2M, and fibronectin. | 12-04-2014 |
20140343603 | TROCAR SITE CLOSURE ASSEMBLY - Disclosed herein are trocar site closures, comprising a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Also disclosed herein is an insertion device used to insert the closure into the wound and at least partially close the wound. | 11-20-2014 |
20140329911 | PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER - Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods. | 11-06-2014 |
20140308212 | EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF DISEASE - Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject. | 10-16-2014 |
20140303170 | COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS - Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I). | 10-09-2014 |
20140302027 | METHODS OF TREATING PERIODONTAL INFLAMMATION AND PERIODONTAL BONE LOSS - Methods and compositions for use in treating periodontitis include a Del-1 polypeptide. | 10-09-2014 |
20140296242 | COMPOUNDS FOR TREATING CANCER, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS - Some embodiments of this invention include methods for treating disease and methods for administering a compound of the invention. In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of the invention. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of the invention. | 10-02-2014 |
20140286986 | POLYPEPTIDES HAVING IMMUNOACTIVATING ACTIVITY AND METHODS OF PRODUCING THE SAME - Isolated polypeptides are provided that comprise a cholera toxin B subunit variant having one or more modifications to increase the expression of the polypeptide in a plant cell. Nucleic acids sequences, vectors, and plant cells for expressing the cholera toxin B subunit variant polypeptides are also provided. Further provided are methods for producing the cholera toxin B subunit variant polypeptides that include the steps of transforming a plant cell with a nucleic acid encoding the cholera toxin B subunit variant polypeptides; expressing the variant polypeptides; and purifying the polypeptides. Still further provided are methods of isolating the variant polypeptides that include the steps of obtaining a plant cell expressing the cholera toxin B subunit variant polypeptides; extracting the cholera toxin B subunit variant polypeptides from the plant cell; and purifying the cholera toxin B subunit variant polypeptides. Methods of eliciting an immune response are also provided. | 09-25-2014 |
20140255666 | Powder Bed Fusion Systems, Apparatus, and Processes for Multi-Material Part Production - Powder bed fusion systems, apparatus, and processes for the production of multi-material parts are provided, in which the material composition varies throughout the part, including different regions within a particular layer. Present embodiments include the capability to selectively deliver fusion-inducing energy over the part bed as each layer of the part is made, rather than uniformly over the part bed, and include those wherein a digital light processing (DLP) projector interfaces with the thermal source to direct the application of energy from the thermal source. | 09-11-2014 |
20140252685 | Powder Bed Fusion Systems, Apparatus, and Processes for Multi-Material Part Production - Powder bed fusion systems, apparatus, and processes for the production of multi-material parts are provided, in which the material composition varies throughout the part, including different regions within a particular layer. Present embodiments include the capability to selectively deliver fusion-inducing energy over the part bed as each layer of the part is made, rather than uniformly over the part bed. | 09-11-2014 |
20140243432 | PEPTIDE BIOMARKERS OF CARDIOVASCULAR DISEASE - The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers. | 08-28-2014 |
20140242143 | ADIPOSE STROMAL VASCULAR FRACTION CELL CONSTRUCTS - Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS. | 08-28-2014 |
20140221226 | GENETIC DETERMINANTS OF PROSTATE AND BREAST CANCER RISK - Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa) or aggressive PCa, or to developing breast cancer (BrCa). | 08-07-2014 |
20140220013 | METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES - Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin. | 08-07-2014 |
20140199347 | ADJUVANT COMPOSITIONS WITH 4-1BBL - Streptavidin(SA)-4-1BBL and TLR agonists such as monophosphoryl lipid A (MPL) exhibit surprising synergy as adjuvants, inducing immune responses against weak antigens. Accordingly, there are provided adjuvant compositions comprising 4-1BBL and a toll-like receptor (TLR) agonist, such as MPL, methods of inducing an immune response against an antigen in a subject, comprising administering to the subject (a) the antigen, (b) a TLR agonist and, (c) 4-1BBL, and methods of treating a tumor or a cancer in a subject, comprising administering to the subject (a) an antigen associated with the tumor or cancer, (b) a TLR agonist, and (c) 4-1BBL. | 07-17-2014 |
20140194594 | SYNTHETIC PEPTIDES AND PEPTIDE MIMETICS - The present invention provides Parotid Secretory Protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening GL13 mimetics. | 07-10-2014 |
20140186264 | EXTRACELLULAR VESICLE-ASSOCIATED PROTEIN MARKERS OF CANCER - Extracellular vesicle-associated protein biomarkers for use in diagnosing and staging carcinomas, e.g., lung and ovarian cancers. | 07-03-2014 |
20140180361 | NEUROSTIMULATOR - A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator. | 06-26-2014 |
20140161845 | ANTI-BIOFILM COMPOUNDS - The present invention provides non-peptide compounds of formula (I) wherein: X is —(C | 06-12-2014 |
20140154219 | METHODS AND COMPOSITIONS FOR LARGE-SCALE ISOLATION OF VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS - Methods for purifying very small embryonic-like (VSEL) stem cells from populations of cells suspected of including VSEL stem cells are provided. In some embodiments, the methods include (a) providing a population of cells suspected of including a VSEL stem cell; and (b) isolating a CD45 | 06-05-2014 |
20140134141 | HUMAN FACILITATING CELLS - The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs. | 05-15-2014 |
20140121161 | REPAIRING BRUCH'S MEMBRANE WITH HYDROGELS - The invention provides hydrogels and methods for their use in treating disorders of the retina such as age-related macular degeneration (AMD). | 05-01-2014 |
20140106446 | METHODS AND COMPOSITIONS FOR LONG TERM HEMATOPOIETIC REPOPULATION - Methods for isolating a CD133 | 04-17-2014 |
20140099640 | DETECTING FETAL CHROMOSOMAL ABNORMALITIES USING TANDEM SINGLE NUCLEOTIDE POLYMORPHISMS - The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. | 04-10-2014 |
20140093557 | EXOSOMAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE - An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer. | 04-03-2014 |
20140093146 | THREE DIMENSIONAL MINUTIAE EXTRACTION IN THREE DIMENSIONAL SCANS - A system and method extract a plurality of three dimensional identification minutiae from a three dimensional image of a biometric identification feature. The extracted three dimensional identification minutiae from the three dimensional image may be compared to one or more sets of three dimensional identification minutiae to determine an identification and/or confirm an identification. In a preferred embodiment, the system and method extract three dimensional identification minutiae from a three dimensional image of a fingerprint, and compare the extracted three dimensional identification minutiae from the fingerprint to one or more sets of three dimensional identification minutiae associated with previously classified fingerprints to determine and/or confirm an identification. | 04-03-2014 |
20140069215 | MULTIMODAL CARDIAC PHANTOM FOR IMAGING - A multimodal cardiac phantom has a body structure with a shape and properties that mimic the elasticity, ultrasound, and magnetic properties of cardiac tissue. The multimodal cardiac phantom is advantageously produced from a polymer such as polyvinyl alcohol. The polyvinyl alcohol may include magnetic resonance imaging (MRI) markers and ultrasound markers. The multimodal cardiac phantom can be used to evaluate and to configure apparatuses for imagining cardiac tissue. | 03-13-2014 |
20140046101 | Process for the Production of Hydrocarbons for Fuels, Solvents, and Other Hydrocarbon Products - Catalytic processes for converting carboxylic acids obtained from biomass and other natural or industrial sources into paraffinic or olefinic hydrocarbons through decarboxylation, along with products formed from such hydrocarbons, in which the carbon chain length, the ratio of carbon-14 to carbon-12, and the ratio of odd number to even number of carbons in the chain are among factors which are indicative or otherwise useful for the detection of hydrocarbons formed by undergoing the claimed processes. | 02-13-2014 |
20140030150 | FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS - A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker. Particular devices include multiple waveguides in multiple microfluidic channels. Particular devices include microfluidic channels with serpentine bump structures that aid molecular transport. | 01-30-2014 |
20140011969 | METHODS FOR FABRICATING POLYMER COMPOSITES - A method for fabricating a polymer composite is provided that includes providing a mixture of carbon nanostructures and a polymeric material, and then photo-thermally heating the mixture to cross-link the carbon nanostructures and the polymeric material. The carbon nanostructures can be carbon nanotubes, buckyballs, graphene, or the like, and the mixture can include about 0.01 to about 1.0 percent by weight of the carbon nanostructures. Polymer composited produce by the fabrication methods are also provided. | 01-09-2014 |
20130338591 | PNEUMATIC PUMP OPERABLE WITHOUT ELECTRICITY, PUMPING APPARATUS, AND APPLICATIONS THEREOF - Infusion pumps that do not require electricity for operation are disclosed for various applications, including but not limited to pharmaceutical delivery of medications. A substance, which can be liquid, is stored in a reservoir and driven pneumatically by pressure generated by thermal transpiration, which requires a temperature difference existing between two ends of a narrow channel. In the case of pharmaceutical delivery, the medication is delivered to the treatment site via an applicator. Power sources other than electricity include, but are not limited to, the temperature of a person's body heat exceeding the ambient temperature of surrounding air. | 12-19-2013 |
20130323197 | IFG-1 DEPENDENT MODULATION OF VSELS - Characteristics of the VSELs stem cell population of a mammal are correlated with aging, including VSEL number, imprinting status of genetic loci, and expression of markers of pluripotent stem cells. The present invention provides VSEL-based methods and compositions for determining the biological age of a mammal. | 12-05-2013 |
20130310911 | PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION - An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode. | 11-21-2013 |
20130294669 | SPATIAL-SPECTRAL ANALYSIS BY AUGMENTED MODELING OF 3D IMAGE APPEARANCE CHARACTERISTICS WITH APPLICATION TO RADIO FREQUENCY TAGGED CARDIOVASCULAR MAGNETIC RESONANCE - A computer aided image processing system and automated method to improve tagged magnetic resonance image data through modeling and analyzing the magnetic resonance image data using a linear combination of discrete Gaussians model and using a Markov-Gibbs random field model. The processed magnetic resonance images include reduced noise associated with the tags, augmented gradients across a tag profile and an amplified tag to background contrast as compared to the original tagged magnetic resonance images. | 11-07-2013 |
20130288258 | METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL CANCER USING MICRO RNAs - Methods of detecting or predicting the presence of CRC based on the amounts of particular miRNAs in plasma or tissue are described. | 10-31-2013 |
20130259346 | COMPUTER AIDED DIAGNOSTIC SYSTEM INCORPORATING 3D SHAPE ANALYSIS OF THE BRAIN FOR IDENTIFYING DEVELOPMENTAL BRAIN DISORDERS - A computer aided diagnostic system and automated method classify a brain through modeling and analyzing the shape of a brain cortex, e.g., to detect a brain cortex that is indicative of a developmental disorder such as ADHD, autism or dyslexia. A model used in such analysis describes the shape of brain cortices in terms of spherical harmonics required to delineate a unit sphere corresponding to the brain cortex to a model of the brain cortex. | 10-03-2013 |
20130259345 | COMPUTER AIDED DIAGNOSTIC SYSTEM INCORPORATING SHAPE ANALYSIS FOR DIAGNOSING MALIGNANT LUNG NODULES - A computer aided diagnostic system and automated method diagnose lung cancer through modeling and analyzing the shape of pulmonary nodules. A model used in such analysis describes the shape of pulmonary nodules in terms of spherical harmonics required to delineate a unit sphere corresponding to the pulmonary nodule to a model of the pulmonary nodule. | 10-03-2013 |
20130243820 | MODIFICATION OF EXOSOMAL COMPONENTS FOR USE AS A VACCINE - The presently disclosed subject matter provides modified cell-derived exosomes substantially lacking one or more immunosuppressive polypeptides. The presently-disclosed subject matter further provides methods of producing the modified exosomes and methods of using the modified exosomes for treating cancers. | 09-19-2013 |
20130226605 | SYSTEM AND METHOD FOR DELTA CHECKING OF BIOLOGICAL SAMPLES - Methods of the invention automatically determine analytes and delta thresholds to use in delta checking patient data. The analytes and thresholds are determine from a populating specific set of patient data. Variance in analytes for multiple patient samples is determined. In additional, variance in intentionally mismatched patient samples is determined. The best analytes to differentiate between patients are determined along with delta thresholds. Preferred embodiments conduct evaluation with a multivariate delta threshold determination for ongoing testing of results from the patient. Preferred software provides an interactive interface that allows a user to set a number of flags that can be handled per a predetermined time period, and automatically adjusts the delta threshold to that number of flags. | 08-29-2013 |
20130209464 | POLYPEPTIDES HAVING ANTIVIRAL ACTIVITY AND METHODS FOR USE THEREOF - A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject. | 08-15-2013 |
20130185657 | Media Annotation Visualization Tools and Techniques, and an Aggregate-Behavior Visualization System Utilizing Such Tools and Techniques - Methods of facilitating the discovery of relationships between/among participants within systems for annotating visual media objects to create new associations, communities, and other relationships. These methods include processing annotations, metadata, and/or other information using one or more aggregate-behavior-visualization algorithms and displaying aggregate-behavior visualizations to users. These visualizations allow users to seek out and discover relationships and provide unique knowledge assets useful for a variety of purposes, including creating smart documents and fostering learning. | 07-18-2013 |
20130177552 | METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE - Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye. | 07-11-2013 |
20130151849 | DEVICE, METHOD, AND SYSTEM FOR PROCESSING COMMUNICATIONS FOR SECURE OPERATION OF INDUSTRIAL CONTROL SYSTEM FIELD DEVICES - A device, method, and system for processing communications for secure operation of industrial control system field devices, includes: a processing device to be placed in-line between a Master Telemetry Unit (MTU) and a field device. A software verified microkernel includes instructions for the processing device to provide a secure partitioning of memory between a communication network interface address space, a security cell address space, and a field device interface address space. The security cell address space includes instructions to: receive communication messages from the MTU via the communication network interface address space; authenticate a user identification of each communication message; verify that an operation requested in each message is authorized for the user identification; and send each communication message having an authenticated user identification and a verified operation to the field network interface address space for communication with the field device. | 06-13-2013 |
20130131606 | ERGONOMIC SYRINGE AND ADAPTOR - An ergonomic syringe includes a slide member, wherein force exerted on the slide member causes movement of a syringe plunger within a hollow or partially hollow syringe barrel, for withdrawing fluid from a source into the syringe, and also includes a reusable adaptor for use with existing conventional syringes, which has a ring that wholly or partially encircles the barrel and indirectly attaches to a plunger flange. | 05-23-2013 |
20130131446 | ENDOSCOPIC OVERTUBE ASSEMBLY - An endoscopic overtube assembly comprises: an inflatable overtube; and a subassembly configured for insertion into an orifice of a patient, said subassembly defining a central passageway, and said subassembly including an internal cassette for receiving and securing the inflatable overtube, wherein the internal cassette of said subassembly can be manipulated from a closed position to an open position in which the inflatable overtube can be readily extended and deployed from said subassembly. The inflatable overtube travels with the endoscopic device. Once appropriately positioned, the inflatable overtube is detached from the endoscopic device and inflated to become a substantially rigid conduit defining an instrument channel that provides ready access to a particular body cavity. | 05-23-2013 |
20130109976 | NON-CONTACT AND PASSIVE MEASUREMENT OF ARTERIAL PULSE THROUGH THERMAL IR IMAGING, AND ANALYSIS OF THERMAL IR IMAGERY | 05-02-2013 |
20130109592 | METHODS FOR DETECTING CANCER | 05-02-2013 |
20130085772 | SYSTEM AND METHOD FOR PERSONALIZED DOSING OF PHARMACOLOGIC AGENTS - A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile. | 04-04-2013 |
20130059879 | Small Molecule Inhibitors of PFKFB3 and Glycolytic Flux and Their Methods of Use as Anti-Cancer Therapeutics - Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound. | 03-07-2013 |
20130059852 | COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS - Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I). | 03-07-2013 |
20130058931 | METHODS OF PREDICTING AND DECREASING THE RISK OF PREGNANCY LOSS - Described are methods for diagnosing and predicting the risk of pregnancy loss in a subject based on the presence of an aberrant humoral response to three proteins, Apolipoprotein B-100, alpha2macrogloblin (alpha2M), and fibronectin. The presence or a detectable level of maternal IgG antibodies to trophoblast-derived fibronectin and/or ApoB-100, and/or the absence or a non-detectable level of antibodies specifically binding to alpha2M is associated with a history of RPL and an increased risk of pregnancy loss. Also described are methods for identifying subjects at risk of pregnancy loss, selecting subjects for participation in a clinical study, and methods of decreasing the risk of pregnancy loss in a subject which include detecting the presence or absence of antibodies to one or more of trophoblast-derived ApoB-100, alpha2M, and fibronectin. Also provided are kits that contain ApoB-100, alpha2M, and fibronectin. | 03-07-2013 |
20130029901 | METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH - Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R | 01-31-2013 |
20130028912 | TWEAK/FN14 SYSTEM REGULATES SKELETAL MUSCLE ATROPHY AND REGENERATION - The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system. | 01-31-2013 |
20130012557 | Small Molecule Choline Kinase Inhibitors, Screening Assays, and Methods for Treatment of Neoplastic Disorders - Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided. | 01-10-2013 |
20120315324 | EXOSOMAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE - An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer. | 12-13-2012 |
20120302516 | NANOPARTICLES FOR DRUG DELIVERY - The invention provides magnetic nanoparticles comprising a core, wherein the nanoparticles comprise at least one therapeutic agent linked to the core via a hydrazone linkage or via an oxime ether linkage, methods for making said nanoparticles, and methods for using said nanoparticles. | 11-29-2012 |
20120252129 | PRE-CONCENTRATOR AND METHOD OF USING THE SAME - A chemical pre-concentrator is provided having a support structure, an airflow conduit, and a layer of a reactive chemical compound on a surface of the support structure is used for collecting and pre-concentrating at least one chemical analyte from a dilute sample. A method of concentrating a gaseous sample is provide that includes exposing the chemical pre-concentrator with a dilute gaseous sample that contains at least one chemical analyte; and forming a conjugate of the at least one chemical analyte. A method of diagnosing a disease state in a mammalian patient is provided using the chemical pre-concentrator. | 10-04-2012 |
20120238467 | EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER - The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived exosomes isolated from a biological sample from the subject. | 09-20-2012 |
20120237937 | METHODS TO DETECT CANCER IN ANIMALS - Some embodiments of the invention include methods for detecting the presence of cancer in animal tissue in an animal that was administered a labeled molecule. Some of the methods disclosed comprise obtaining an NMR spectrum, an MS spectrum, or both. In some instances, spectra can be taken of a cancer cell extract of the tissue and of a non-cancer cell extract of the tissue. In some embodiments, the amounts of at least one resultant labeled molecule (e.g., a molecule resulting from transformation of the administered labeled molecule) from each extract can be compared to detect the presence of cancer. | 09-20-2012 |
20120231079 | METHODS AND COMPOSITIONS FOR CONTROLLED DELIVERY OF PHYTOCHEMICAL AGENTS - Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and one or more additional therapeutic agents. Methods of treating a cancer using the compositions are further provided. | 09-13-2012 |
20120220538 | LUNASIN-CONTAINING COMPLEX AND PURIFICATION OF LUNASIN FROM PLANTS - A method of purifying lunasin or a lunasin-containing complex produced in a plant includes providing a plant material from the plant, and isolating the lunasin-containing complex from the plant material, and/or releasing lunasin from the lunasin-containing complex. A composition for treating a cancer or an inflammation-related disease in a subject includes a lunasin-containing complex. A composition for treating a cancer or an inflammation-related disease in a subject includes a lunasin polypeptide and/or a lunasin-containing complex; and curcumin, wherein the combination of the a lunasin polypeptide or lunasin-containing complex and the curcumin has a synergistic effect. A method for treating a cancer or an inflammation-related disease includes administering a composition including a lunasin-containing complex, or a lunasin polypeptide and/or a lunasin-containing complex, and curcumin. | 08-30-2012 |
20120207625 | THERMALLY DRIVEN KNUDSEN PUMP - The present invention relates to thermally driven pumps. More specifically, one embodiment of the present invention relates to the use of a thermoelectric material to create a thermally driven, bi-directional pump, such as a micro pump, with no moving parts using the thermal transpiration effect (a Knudsen pump). One embodiment of the thermally driven pump of the present invention utilizes a thermoelectric material to assist with the thermal transpiration process resulting in a substantially symmetrical, bidirectional pump. A thermoelectric module is used to induce a temperature gradient across a nanoporous article having at least one nanochannel thus creating fluid flow via thermal transpiration across the nanochannel. The use of the thermoelectric module eliminates the need for a heat sink thereby making the pump substantially symmetrical and enabling bidirectional flow which is accomplished by reversing the polarity of the power supply to the thermoelectric module resulting in reversing the direction of heat transfer. | 08-16-2012 |
20120203040 | Process for the Production of Paraffinic Hydrocarbons - Reaction catalysts and supports as disclosed herein are utilized in a process for converting carboxylic acids, which are derived from molecules found in various feedstocks of biological origin as well as various byproducts of industrial processes, to linear paraffinic hydrocarbons, the latter being capable of use in various applications, including as an alternative source of fuel. | 08-09-2012 |
20120201890 | METHODS AND COMPOSITIONS TO SUPPORT TRANSPLANTED TISSUE INTEGRATION AND INNOSCULATION WITH ADIPOSE STROMAL CELLS - The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. In some embodiments, the SVF cells can be on the surface or embedded within a three-dimensional matrix. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors. | 08-09-2012 |
20120201445 | COMPUTER AIDED DIAGNOSTIC SYSTEM INCORPORATING APPEARANCE ANALYSIS FOR DIAGNOSING MALIGNANT LUNG NODULES - A computer aided diagnostic system and automated method diagnose lung cancer through modeling and analyzing the visual appearance of pulmonary nodules. A learned appearance model used in such analysis describes the appearance of pulmonary nodules in terms of voxel-wise conditional Gibbs energies for a generic rotation and translation invariant second-order Markov-Gibbs random field (MGRF) model of malignant nodules with analytically estimated characteristic voxel neighborhoods and potentials. | 08-09-2012 |
20120177749 | FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES - A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3. | 07-12-2012 |
20120132798 | PRECONCENTRATOR FOR ANALYSIS INSTRUMENTS - An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path. | 05-31-2012 |
20120122723 | METHODS OF DETECTING AUTOANTIBODIES FOR DIAGNOSING AND CHARACTERIZING DISORDERS - Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder. | 05-17-2012 |
20120101747 | DETECTION AND IMAGING OF TURBULENCE IN A FLUID - A system and method detect turbulence in a fluid by processing image data to isolate and detect fluctuations in a frequency range indicative of turbulence. By making use of a Fourier or other frequency transformation to convert a set of time-dependent intensity data into frequency-dependent intensity data, a range of frequencies can be selected wherein fluctuations in intensity are characteristic of turbulence, even under difficult conditions where turbulence is cannot be naively detected. A detector is capable of relying on ambient light conditions to provide sufficient transmission and fluctuation to detect the characteristics of turbulence. Detection of turbulence aids in aircraft navigation and meteorology, analysis of industrial and commercial exhaust, and detection of unexpected fluid events such as containment leaks. | 04-26-2012 |
20120083440 | METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH - Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R | 04-05-2012 |
20120059395 | ENDOSCOPIC CLOSURE DEVICE - An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue. | 03-08-2012 |
20120028272 | DEVICE AND METHODS FOR ISOLATING CELLS - The invention provides a device and methods for separating and isolating cells. | 02-02-2012 |
20120028124 | ANODE MATERIALS FOR LITHIUM-ION BATTERIES - An anode material for lithium-ion batteries is provided that comprises an elongated core structure capable of forming an alloy with lithium; and a plurality of nanostructures placed on a surface of the core structure, with each nanostructure being capable of forming an alloy with lithium and spaced at a predetermined distance from adjacent nanostructures. | 02-02-2012 |
20120009606 | PEPTIDE BIOMARKERS PREDICTIVE OF RENAL FUNCTION DECLINE AND KIDNEY DISEASE - The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease. | 01-12-2012 |
20110318761 | METHODS AND KITS FOR PREDICTING A RESPONSE TO AN ERYTHROPOIETIC AGENT - Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17. | 12-29-2011 |
20110311442 | DIRECT CELLULAR ENERGY DELIVERY SYSTEM - A lipid vesicle comprising a phospholipid which is a stable vesicle former and at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid which is not a stable vesicle former, a PEG, a raft former and a fusion protein is provided. The vesicle can further comprise a biomolecule, such as for example ATP. Methods of using the vesicle for delivery of biomolecules are also provided. | 12-22-2011 |
20110301860 | USING DIFFERENTIAL SCANNING CALORIMETRY (DSC) FOR DETECTION OF INFLAMMATORY DISEASE - Disclosed herein in various embodiments are systems and methods for categorizing biological fluids obtained from subjects into one or more disease or treatment categories. Embodiments of the systems and methods may transform easily obtainable body fluids such as blood, plasma, spinal fluid, and other fluids into signature differential scanning calorimetry (DSC) thermograms that may be used to distinguish a positive or negative correlation with a specific inflammatory disease, such as an autoimmune disease. Also disclosed are methods of detecting, diagnosing, and/or monitoring an inflammatory disease in a subject. | 12-08-2011 |
20110295027 | Catalytic Isomerisation of Fatty Acid Esters - Catalytic isomerisation of fatty acid esters to form branched fatty acid esters comprises the steps of contacting a feedstock having at least one fatty acid ester with a catalyst and isolating from other reaction products branched fatty acid esters that are produced. The catalyst is a crystalline porous silicoaluminophosphate catalyst having silicon, aluminum, and phosphorous atoms in lattice framework positions. The branched fatty acid esters formed thereby demonstrate properties suitable for use in various applications. | 12-01-2011 |
20110283957 | DECUBITUS ULCER PREVENTION GARMENT FOR DOGS - Decubitus ulcer prevention garments for a dog are provided that include a fluid-filled bladder. The garments can include an inner layer that contacts and interacts with the body of the dog; an intermediate layer that interfaces with the inner layer and includes the fluid-filled bladder; and an outer layer joined to the inner layer and interfacing with the intermediate layer. The garments have a shape that is adapted to fit over and envelop the pelvic region of the dog such that the garments alleviate or reduce pressure on the soft tissues overlying the boney prominences of the pelvic region of a dog when the dog is lying in a recumbent position on a surface. | 11-24-2011 |
20110257211 | Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics - Small molecule choline kinase inhibitors having the following formula: | 10-20-2011 |
20110224091 | METHOD AND DEVICE FOR DETECTING CELLULAR TARGETS IN BODILY SOURCES USING CARBON NANOTUBE THIN FILM - A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad. | 09-15-2011 |
20110217719 | METHODS AND KITS FOR DIAGNOSING OBSTRUCTIVE SLEEP APNEA - The presently-disclosed subject matter provides methods and kits for diagnosing obstructive sleep apnea (OSA) in a subject, such as a human child, wherein a biological sample is provided from the subject and the amount of a Urocortin III peptide is determined from the sample. Further provided are methods for diagnosing OSA in a subject wherein the amount of a Urocortin III peptide and one or more peptides selected from a Uromodulin peptide, an Orosomucoid 1 peptide, and a Kallikrein 1 peptide are determined in a biological sample from a subject. | 09-08-2011 |
20110214482 | LARGE VOLUME ANALYTE PRECONCENTRATOR - A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuable damper is disposed within the housing for selectively restricting a collection flow. | 09-08-2011 |
20110213019 | Compositions and Methods for Treating Cancer, Inhibiting Proliferation, and Inducing Cell Death - Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a guanine-rich promoter gene oligonucleotide (GPGO), and (ii) a carrier, wherein the oligonucleotide forms at least one quadruplex. | 09-01-2011 |
20110209604 | COMPOSITE ARMOR PANEL - A composite armor panels is comprised of a first layer, composed of a matrix of an elastomeric material and a crushed aggregate material, and a second backing layer. One or more geogrids can be included in the first layer of the armor panel to prevent the aggregate material from moving within the first layer. A method of making a composite armor panel includes exposing a mixture of elastomeric material and crushed aggregate material to elevated temperatures and pressures for predetermined time periods, such that a matrix of elastomeric material and crushed aggregate material is formed. | 09-01-2011 |
20110178020 | METHODS AND COMPOSITIONS FOR INHIBITION OF NEUTROPHIL EXOCYTOSIS - Isolated fusion polypeptides are provided that are comprised of a cell-penetrating polypeptide and a SNARE polypeptide aptamer. Further provided are methods for inhibiting neutrophil granule exocytosis that comprise contacting a neutrophil with a fusion polypeptide including a cell-penetrating polypeptide and a SNARE polypeptide aptamer such that the fusion polypeptide enters the neutrophil and inhibits neutrophil granule exocytosis. Also provided are methods for treating a neutrophil-mediated inflammatory disorder by inhibiting SNARE-associated exocytosis in neutrophils. | 07-21-2011 |
20110159016 | HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS - The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue. | 06-30-2011 |
20110143341 | Microsatellite Markers of Schizophrenia - The invention includes methods of determining if a subject is at risk for developing schizophrenia (SZ). | 06-16-2011 |
20110130457 | Wax-Based Emulsion for the Treatment of Dry Eye Conditions - Disclosed herein is a wax-based emulsion for the treatment of dry eye conditions by reducing the evaporation rate of saline and increasing the viscosity of the tear film. The composition of the present invention comprises an emulsion of wax dispersed in saline. One embodiment of the wax-based emulsion of the present invention comprises a wax in an amount ranging from about 0.001% to about 80% by weight and the remainder saline. In another embodiment, the wax-based emulsion further comprises a hydrocarbon in an amount ranging from about 0.01% to about 80% by weight. In still another embodiment, the wax-based emulsion of the present invention further comprises a cholesterol ester ranging in an amount from about 0.01% to about 80% by weight. In an alternative embodiment, the wax-based emulsion of the present invention further comprises an opthalmic drug in an amount ranging from about 0.01% to about 80% by weight. In yet another embodiment, the wax based emulsion comprises a wax in an amount ranging from about 40% to about 60% by weight, a cholesterol ester in an amount ranging from about 10% to about 20% by weight and the remainder saline. The wax based emulsion may further comprise a hydrocarbon in an amount of up to about 20% by weight. In yet another embodiment, the emulsion further comprises an amount ranging between about 1% to about 20% by weight of standard opthalmic drugs such as antibiotics for delivery to the eye. In some embodiments, the wax of the emulsion is a synthetic wax. | 06-02-2011 |
20110117548 | Detecting Fetal Chromosomal Abnormalities Using Tandem Single Nucleotide Polymorphisms - The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. | 05-19-2011 |
20110117215 | Microsatellite Markers of Schizophrenia - The invention includes method of determining if a subject is at risk for developing schizophrenia (SZ), schizotypal personality disorder (SPD), or schizoaffective disorder (SD). | 05-19-2011 |
20110104074 | METHODS FOR TARGETED CANCER TREATMENT AND DETECTION - A method for treating a cancer is provided that comprises identifying a subject in need of treatment for a cancer and administering to the subject a composition that is comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor and a plurality of a chemotherapeutic agent, where each ligand and each chemotherapeutic agent are conjugated to a nanoparticle. Further provided are methods for detecting a cancer in a subject that comprise administering to a subject an imaging agent comprised of a plurality of a ligand for a luteinizing hormone-releasing hormone receptor conjugated to a nanoparticle. | 05-05-2011 |
20110104070 | SITE SPECIFIC FLUORESCENCE AND CONTRAST MARKER FOR SAME - A contrast marker for indicating a presence of a target cell in an environment comprises a fluorophore, an NMP, and a short spacer and a long spacer linking the fluorophore to the NMP. The short spacer holds the fluorophore at a quenching distance from the NMP and the long spacer holds the fluorophore at a fluorescence enhancing distance from the NMP. The short spacer is configured to be cleaved by a molecule characterizing the target cells. | 05-05-2011 |
20110100817 | MICROFLUIDIC DEVICES AND METHODS OF USING SAME - The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample. | 05-05-2011 |
20110081669 | SYSTEMS AND METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER - Methods for diagnosing a cancer in a subject are provided that include determining an amount of autoantibodies immunoreactive to procathepsin D (pCD) in a sample obtained from the subject. Further provided are systems for diagnosing a cancer in a subject that include an autoantibody immunoreactive pCD antigen and a means for detecting binding of an autoantibody to the antigen. | 04-07-2011 |
20110065115 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 03-17-2011 |
20110048133 | VIBRATION ELEMENT COUPLED WITH NON-LINEAR FORCE TO IMPROVE NON-RESONANT FREQUENCY RESPONSE - Embodiments of the invention couple a non-linear force to a vibration element such as a piezoelectric cantilever to introduce chaotic, i.e., non-resonant vibration in the vibration element and thereby improve the non-resonant response of the vibration element. By doing so, the vibration element is responsive to a wider frequency range of vibrations and thus may be more efficient in scavenging energy in environments where the vibration frequency is not constant, e.g., in environment subject to multi-mode or random vibration sources. | 03-03-2011 |
20110009412 | MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME - Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases. | 01-13-2011 |
20100322895 | T CELL DEPLETING COMPOSITIONS USEFUL FOR TREATING CANCER - The presently-disclosed subject matter provides methods and compositions for treating or reducing the risk of recurrence of a cancer in a subject. The methods comprise administering an effective amount of a T cell depleting composition to the subject to thereby treat the cancer. | 12-23-2010 |
20100317567 | DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS - Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum. | 12-16-2010 |
20100298151 | EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER - The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived exosomes isolated from a biological sample from the subject. | 11-25-2010 |
20100267815 | PFKFB4 Inhibitors And Methods Of Using The Same - Methods of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) and methods of treating a cancer in a cell are provided, the methods including contacting a cell with an effective amount of a PFKFB4 inhibitor. Short hairpin RNA (shRNA) and small interfering RNA (siRNA) inhibitors of PFKFB4 and their methods of use are also provided. | 10-21-2010 |
20100267107 | METHODS FOR ISOLATING VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS - The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject. | 10-21-2010 |
20100267075 | MICROFLUIDIC LYSIS - The invention provides methods for isolating and identifying nucleated cells from biological samples using a microfluidic device. | 10-21-2010 |
20100233382 | METHOD FOR ELECTROSTATIC DEPOSITION OF GRAPHENE ON A SUBSTRATE - A method for electrostatic deposition of graphene on a substrate comprises the steps of securing a graphite sample to a first electrode; electrically connecting the first electrode to a positive terminal of a power source; electrically connecting a second electrode to a ground terminal of the power source; placing the substrate over the second electrode; and using the power source to apply a voltage, such that graphene is removed from the graphite sample and deposited on the substrate. | 09-16-2010 |
20100225337 | CHEMICAL SENSORS FOR DETECTING VOLATILE ORGANIC COMPOUNDS AND METHODS OF USE - The presently-disclosed subject matter provides sensors and methods for detecting volatile organic compounds (VOCs) by determining the conductivity of a chemiresistant film upon exposure to VOCs, including for example chemiresistant films comprised of surfactant-coated metal alloy nanoparticles. | 09-09-2010 |
20100224507 | CHEMICAL SENSORS FOR DETECTING HYDROGEN AND METHODS OF USE - The presently-disclosed subject matter provides sensors and methods for detecting hydrogen by determining the conductivity of a chemiresistant film upon exposure to hydrogen, including for example chemiresistant films comprised of alkylamine-, alkylthiolate-, and/or surfactant-coated metal alloy nanoparticles. | 09-09-2010 |
20100221280 | PLANT-PRODUCED COMPOSITIONS FOR TREATING PAPILLOMAVIRUS INFECTION AND RELATED METHODS - Compositions for treating papillomavirus (PV) infection in a subject include a PV L2 polypeptide produced from a eukaryotic expression system. | 09-02-2010 |
20100201542 | SYSTEM AND METHOD FOR REMOTE SAMPLING OF CONDITIONS USING WIRED SENSORS CONNECTED TO WIRELESS NODES - A system for collecting data includes a remote sensor assembly and a central data collection device. The remote sensor assembly has a data bus, a remote wireless node, and a plurality of remote sensor modules in wired communication with the remote wireless node via the data bus. Each of the remote sensor modules converts a sensed condition into data in response to a request from the remote wireless node. The central data collection device has a master wireless node for periodically wirelessly communicating with the remote wireless node. The remote wireless node collects data from each of the plurality of remote sensor modules and periodically transmits the data to the master wireless node. The remote sensor modules are interchangeable and new remote sensor modules may be added. The remote wireless node may detect the sequence of the attached remote sensor modules to enable three-dimensional mapping of the sensed conditions. | 08-12-2010 |
20100166751 | CANCER THERAPY USING WHOLE GLUCAN PARTICLES AND ANTIBODIES - The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines. | 07-01-2010 |
20100151480 | EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER - The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more RNAs present in cancer-derived exosomes isolated from a biological sample from the subject. | 06-17-2010 |
20100124552 | PEPTIDE BIOMARKERS OF CARDIOVASCULAR DISEASE - The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers. | 05-20-2010 |
20100112592 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 05-06-2010 |
20100108529 | SENSORS AND SWITCHES FOR DETECTING HYDROGEN - Sensors and switches for detecting hydrogen include an electrically-insulating support; a first and second electrode; and a palladium structure alone or in combination with an organic insulating film. The palladium structures of the sensors are deposited on and contact a first electrode and a portion of the palladium structure extends to and contacts the second electrode to create a conductive path. The palladium structures of the switches are deposited on and contact a first electrode and a portion of the palladium structures extend to and contact an organic insulating film deposited on the second electrode. Upon exposure of the switch to hydrogen, portions of the palladium structure extend through the film and contact the second electrode to create a conductive path. Methods of detecting hydrogen and methods of fabricating a sensor for detecting an analyte of interest are also provided. | 05-06-2010 |
20100093100 | PROFILING METHOD USEFUL FOR CONDITION DIAGNOSIS AND MONITORING, COMPOSITION SCREENING, AND THERAPEUTIC MONITORING - The presently-disclosed subject matter includes methods and systems for identifying biomarkers of interest, diagnosing and/or monitoring conditions of interest, assessing the efficacy of a treatment program, and composition screening. Exemplary methods include providing a sample of interest, fractionating the sample, generating thermograms, and comparing thermograms. | 04-15-2010 |
20100092524 | MODIFICATION OF EXOSOMAL COMPONENTS FOR USE AS A VACCINE - The presently disclosed subject matter provides modified cell-derived exosomes substantially lacking one or more immunosuppressive polypeptides. The presently-disclosed subject matter further provides methods of producing the modified exosomes and methods of using the modified exosomes for treating cancers. | 04-15-2010 |
20100075293 | BIOREACTORS, SYSTEMS, AND METHODS FOR VASCULARIZING TISSUE CONSTRUCTS - A modular bioreactor is provided that includes an upper biochamber; a lower biochamber; and an intermediate biochamber that is positioned between the upper biochamber and the lower biochamber. Each biochamber of the bioreactor is in fluid communication with each other biochamber of the bioreactor and includes an interior wall, which defines a centrally-disposed cavity for each biochamber, and an inflow port and an outflow port that are in fluid communication with each centrally disposed cavity. Systems and methods for vascularizing a tissue construct are also provided. | 03-25-2010 |
20100055724 | METHODS OF DETECTING AUTOANTIBODIES FOR DIAGNOSING AND CHARACTERIZING DISORDERS - Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder. | 03-04-2010 |
20100028407 | LAYERED BIO-ADHESIVE COMPOSITIONS AND USES THEREOF - The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided. | 02-04-2010 |
20100023012 | DEVICE AND METHOD TO PREVENT HIP FRACTURES - A device for preventing a hip fracture includes: a shaft having a first end and a second end and an expanding means for engaging the femoral head at the first end. The shaft is positioned in a hole of a predetermined depth in a femur. The hole extends from the greater trochanter to the femoral head of the femur, such that the first end is positioned in the femoral head and the second end is positioned in the greater trochanter. The device is oriented substantially perpendicular to the long axis of the femoral shaft. | 01-28-2010 |
20090299326 | ENDOVASCULAR ANEURYSM TREATMENT DEVICE AND METHOD - An self-expanding frame is mounted on the distal end of a shaft. The frame is sized and configured so that it can be inserted into the cavity of an aneurysm. Suction is applied to the interior of the aneurysm through the shaft or through another catheter, and the wall of the aneurysm is collapsed onto the exterior surface of the frame. The frame is then collapsed upon further suction being applied to the interior of the aneurysm, which collapses the aneurysm wall with it. The frame folds down on itself, carrying with it the aneurysm wall. The frame is detachable from the shaft and can be left in the collapsed aneurysm. | 12-03-2009 |
20090274746 | METHODS AND COMPOSITIONS FOR CONTROLLED DELIVERY OF PHYTOCHEMICAL AGENTS - The presently-disclosed subject matter provides compositions and methods for treating a cancer by providing a composition comprising a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and a chemotherapeutic agent. Further, provided is a device for uterine cervical insertion for local delivery. | 11-05-2009 |
20090258379 | ISOLATION OF MEMBRANE VESICLES FROM BIOLOGICAL FLUIDS AND METHODS OF USING SAME - Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample. | 10-15-2009 |
20090202621 | CELL-SURFACE DECORATION WITH ACTIVE AGENTS - A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided. | 08-13-2009 |
20090163439 | Methods of using beta glucan as a radioprotective agent - The invention relates to methods for treating and preventing radiation and/or chemotherapy related injury and/or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable β(1,3; 1,6) glucan. The invention also relates to methods in which β(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate β-glucan particles or a combination thereof. | 06-25-2009 |
20090081713 | PEPTIDE BIOMARKERS PREDICTIVE OF RENAL FUNCTION DECLINE AND KIDNEY DISEASE - The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease. | 03-26-2009 |
20090053816 | HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS - The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue. | 02-26-2009 |
20090035331 | Systems and Methods for Targeted and Controlled Delivery of Agents - An Agent Delivery System allows for targeted and controlled delivery of an agent or agents to target site, such as specific cells or a specific tissue of an individual. An exemplary Agent Delivery System includes a platform, having a silica crystal lattice base plate, coated with a collagen-containing layer. At least one agent of interest is disposed within the platform, for delivering to the target site. The agent is released when the Agent Delivery Platform is exposed to collagen-degrading compounds. Collagen-degrading compounds can be secreted by cells within a target site. | 02-05-2009 |
20090012371 | GENETIC MARKERS OF SCHIZOPHRENIA - The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD). | 01-08-2009 |
20090011996 | DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS - Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum. | 01-08-2009 |
20080312099 | Microarray, System, and Method for Detecting, Identifying, and Quantitating Micro-Rnas - Micro-RNA (miRNA) microarrays useful for detecting, identifying and quantitating miRNAs in a sample include oligonucleotide probes that specifically bind miRNAs. Exemplary miRNA microarray can be specific for miRNAs of human, canine, mouse, rat, or another species. | 12-18-2008 |
20080233561 | Method for Measuring Cytopathic Effect Due to Viral Infection in Cells Using Electric Cell-Substrate Impedance Sensing - A method of measuring cytopathic effect in cells includes providing cells in culture, using electric cell-substrate impedance sensing (ECIS) to measure the resistance of current associated with the cells, and quantifying the cytopathic effect (CPE) associated with the cells based on the measured resistance. The cells may be identified as being infected with a virus if the CPE associated with the cells is above a predetermined level. Alternatively, the cells may be provided in a healthy monolayer and infected with a virus in order to measure the effect of the virus on CPE associated with the cells. Cells may also be treated with candidate antiviral agents and the effects of the agents on the virus-infected cells may be measured to screen for and identify actual antiviral agents. | 09-25-2008 |
20080221030 | Inhibition of Wet Type Age Related Macular Degeneration (Amd) by Adiponectin or Acrp 30 - The present invention provides new methods of treating wet type of age related macular degeneration by administering adiponectin (APN) or a functional fragment derived therefrom. One of the pathological complications of age related macular degeneration (AMD) is choroidal angiogenesis or choroidal neovascularization (CNV). The inventors discovered that the level of APN expression is significantly lower in the choroids of the laser-induced mouse model of choroidal angiogenesis or choroidal neovascularization (CNV) than that of the control mice and that administration of recombinant adiponectin (rAPN) or a peptide derived from the globular domain of the intact APN protein to the mouse model of CNV reduced the size of CNV significantly. These studies are the first to demonstrate the inhibitory effect of adiponectin on choroidal angiogenesis and thus provide the basis for treating a condition or disease involving angiogenesis, particularly age related macular degeneration, with administration of adiponectin. | 09-11-2008 |