KYOWA MEDEX CO., LTD. Patent applications |
Patent application number | Title | Published |
20150104847 | METHOD FOR STABILIZING CHOLESTEROL OXIDASE - The present invention provides a method for stabilizing a cholesterol oxidase, a method for preserving a cholesterol oxidase, and a stabilized composition of cholesterol oxidase. A method for stabilizing a cholesterol oxidase and a method for preserving a cholesterol oxidase which comprises allowing the cholesterol oxidase to coexist with an α-keto acid in an aqueous medium, and, a stabilized composition of cholesterol oxidase which comprises the cholesterol oxidase being allowed to coexist with an α-keto acid in an aqueous medium. The method for stabilizing a cholesterol oxidase, the method for preserving a cholesterol oxidase, and a stabilized composition of cholesterol oxidase according to the present invention are useful for clinical diagnosis such as metabolic syndrome. | 04-16-2015 |
20140234886 | NOVEL FRUCTOSYL PEPTIDE OXIDASE - A reagent measuring a glycated protein, comprising a protease and a protein of any one of [1] to [4] below:
| 08-21-2014 |
20140162300 | SPHINGOMYELIN MEASUREMENT METHOD AND MEASUREMENT KIT - Provided is a method for simply and accurately measuring sphingomyelin in a sample, and a kit therefor. The method is a method for measuring sphingomyelin in a sample, comprising reacting the sample with a phospholipase D which does not react with sphingomyelin and lysophosphatidylcholine but reacts with phosphatidylcholine, a lysophospholipase or a monoglyceride lipase, and a choline oxidase, eliminating the formed hydrogen peroxide, reacting the resultant with a phospholipase D which does not react with glycerol-3-phosphorylcholine and free fatty acid but reacts with sphingomyelin, and a choline oxidase, and measuring the formed hydrogen peroxide. | 06-12-2014 |
20140147936 | METHOD FOR DETERMINING PROGNOSIS OF RENAL FAILURE - The present invention relates to a method for determining the prognosis of renal failure, which comprises measuring fibroblast growth factor-23 and 25-hydroxyvitamin D in a biological sample, and a kit for determining the prognosis of renal failure, which comprises a reagent for measuring fibroblast growth factor-23 and a reagent for measuring 25-hydroxyvitamin D | 05-29-2014 |
20140057333 | NOVEL FRUCTOSYL PEPTIDE OXIDASE - The present invention encompasses:
| 02-27-2014 |
20140051070 | STREPTAVIDIN-COUPLED MAGNETIC PARTICLES AND MANUFACTURING METHOD FOR SAME - The present invention provides a streptavidin-coupled magnetic particle with high biotin-binding capacity, and a manufacturing method thereof. The streptavidin-coupled magnetic particle has a structure in which streptavidins are cross-linked with each other on a magnetic particle. A method for manufacturing the streptavidin-coupled magnetic particle includes the steps of: | 02-20-2014 |
20130344518 | METHOD FOR MEASURING CHOLESTEROL IN HDL SUBFRACTION, AND REAGENTS AND KIT THEREFOR - The present invention provides a method for simply and precisely measuring cholesterol in an HDL subfraction contained in a sample. This is a method for measuring cholesterol in HDL3 contained in a sample, which comprises reacting a sample with (1) a combination of a cholesterol ester hydrolase and a cholesterol oxidase or (2) a combination of a cholesterol ester hydrolase, an oxidized coenzyme and a cholesterol dehydrogenase in an aqueous medium containing: (a) a divalent metal salt; (b) an alkali metal salt selected from the group consisting of a sulfate, a nitrate, a carbonate, an acetate and a halide; and (c) dextran sulfate or a salt thereof, and measuring a substance formed or consumed in the reaction without separating and removing lipoproteins other than HDL3. | 12-26-2013 |
20130288283 | METHOD FOR MEASURING COMPONENT TO BE MEASURED - The present invention provides a method for measuring a component to be measured in a sample, comprising converting the component to be measured in the sample into hydrogen peroxide and measuring the formed hydrogen peroxide in the presence of an α-keto acid using an oxidative-coloring chromogen. The present invention also provides a method for suppressing the influence of a peroxide on a method of converting a component to be measured in a sample into hydrogen peroxide and measuring the formed hydrogen peroxide using an oxidative-coloring chromogen, the suppression method comprising using an α-keto acid. The measuring method and the suppression method of the present invention using an α-keto acid suppress the influence of a peroxide to give an accurate measurement of the component to be measured in the sample. | 10-31-2013 |
20130252343 | METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN - The present invention provides: a method for preserving an aqueous solution containing a leuco chromogen, comprising adding a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof to the aqueous solution containing a leuco chromogen; a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof; and a liquid reagent comprising a leuco chromogen and a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof. | 09-26-2013 |
20130171676 | METHOD FOR MEASURING GLYCATED HEMOGLOBIN - It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising reacting the hemoglobin-containing sample with a proteolytic enzyme in the presence of a surfactant, and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein at least one of the former reaction and the latter reaction is performed in the presence of an isothiazolinone derivative; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin. | 07-04-2013 |
20130123491 | METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN - It is to provide a method for preserving an aqueous solution comprising a leuco chromogen, comprising adding at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine to the aqueous solution containing a leuco chromogen, and a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine. The present invention provides a method for preserving an aqueous solution comprising a leuco chromogen for stably preserving the leuco chromogen in an aqueous solution and a method for stabilizing a leuco chromogen. | 05-16-2013 |
20130115646 | METHOD FOR MEASURING GLYCATED HEMOGLOBIN - It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and an isoquinolinium salt; reacting the obtained reaction product with fructosyl peptide oxidase; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately measuring glycated hemoglobin in a hemoglobin-containing sample. | 05-09-2013 |
20120219966 | METHOD AND KIT FOR MEASURING COMPONENT TO BE ASSAYED IN SPECIMEN (AS AMENDED) - Methods and kits for measuring a component to be measured in a specimen are provided, which enable accurate measurements that are not affected by reaction temperatures or such when measuring the component to be measured, such as antigens. | 08-30-2012 |
20120003678 | NOVEL FRUCTOSYL PEPTIDE OXIDASE - A protein described in any one of [1] to [4] below is provided according to the present invention:
| 01-05-2012 |
20110243816 | FECES SAMPLING CONTAINER - It is to provide a device for sampling feces that enables an accurate and quantitative evaluation by decreasing the variations of feces sampling levels, wherein the confirmation of the presence or absence of feces sampling can be performed hygienically and simply from an outside of a container. A device for sampling feces comprising a feces sampling stick | 10-06-2011 |
20110223626 | METHOD FOR QUANTITATIVELY DETERMINING CHOLESTEROL IN LOW-DENSITY LIPOPROTEINS,REAGENT FOR QUANTITATIVE DETERMINATION,AND QUANTITATIVE DETERMINATION KIT - A method for measuring cholesterol in low-density lipoprotein contained in a sample, which comprises reacting a sample with (i) a combination of cholesterol ester hydrolase and cholesterol oxidase or (ii) a combination of cholesterol ester hydrolase, an oxidized coenzyme and cholesterol dehydrogenase in the presence of: [a] a polyoxyethylene-polyoxyalkylene alkylaryl ether; [b] one or more surfactants selected from the group consisting of a polyoxyethylene-polyoxyalkylene copolymer, a polyoxyethylene alkenyl ether, a polyoxyethylene branched alkyl ether, and a polyoxyethylene-polyoxyalkylene branched alkyl ether; [c] one or more surfactants selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and a quaternary ammonium; and [d] a polyanion, and measuring a substance formed or consumed in the reaction. | 09-15-2011 |
20110129816 | DEVICE FOR DETECTION OF INFLUENZA VIRUS - A device for detecting or quantifying influenza viruses in a sample, which comprises a detection region having a human anti-influenza virus nucleoprotein antibody immobilized onto a support, a sample supply region, and a sample-migrating region; and a kit for detecting or quantifying influenza viruses, which comprises a solid phase in which a human anti-influenza virus nucleoprotein antibody is fixed onto a carrier. | 06-02-2011 |
20100068738 | Method of Immunoassaying A Component to be Measured - A method of immunoassaying a component to be measured in a sample containing hemoglobin, which comprises reacting a component to be measured in a sample containing hemoglobin with an antibody capable of binding to the component in the presence of a bile acid derivative different from a bile acid derivative that is inherently contained in the sample; a method of suppressing an interference of hemoglobin in immunoassaying a component to be measured in a sample containing hemoglobin, which comprises reacting a component to be measured in a sample containing hemoglobin with an antibody capable of binding to the component in the presence of a bile acid derivative different from a bile acid derivative that is inherently contained in the sample; a reagent of immunoassay of a component to be measured in a sample containing hemoglobin, which comprises a bile acid derivative, are described. | 03-18-2010 |
20100041080 | METHOD FOR QUANTIFICATION OF CHOLESTEROL IN SMALL DENSE LOW-DENSITY LIPOPROTEIN - A method for determination of sdLDL-C, which comprises the steps of: (i) in a reaction solution containing a surfactant which preferentially inhibits the reaction of sdLDL-C with enzymes for cholesterol measurement such as cholesterol ester hydrolase, allowing the enzymes for cholesterol measurement to act on a sample to eliminate HDL-C, VLDL-C, CM-C and LgLDL-C in the sample; (ii) adding a reagent which causes the reaction of sdLDL-C remaining in the reaction solution after the above step (i) to form hydrogen peroxide or reduced coenzyme, and measuring the formed hydrogen peroxide or reduced coenzyme; and (iii) determining the sdLDL-C concentration in the sample from the measurement value in (ii) and a previously prepared calibration curve. | 02-18-2010 |
20090286330 | Immunoassay using insoluble carrier particles and reagent therefor - The present invention provides a reagent for an immunoassay comprising insoluble carrier particles which can give the values to be determined with high accuracy and reliability, and can be stored for a long time; an immunoassay using the reagent; and a method for keeping the reagent stable. The present invention provides an immunoassay which comprises carrying out an antigen-antibody reaction using insoluble carrier particles in an aqueous medium comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer) and a carbonic acid compound releasing a bicarbonate ion; a reagent for an immunoassay comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer), a carbonic acid compound releasing bicarbonate ion, and insoluble carrier particles; and a method for keeping the reagent for an immunoassay comprising insoluble carrier particles stable, which comprises allowing insoluble carrier particles to co-exist in an aqueous medium comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer) and a carbonic acid compound releasing a bicarbonate ion. | 11-19-2009 |
20090280514 | METHOD FOR MEASUREMENT OF CHOLESTEROL IN HIGH-DENSITY LIPOPROTEIN - The present invention provides a method, a reagent and a kit for the simple and accurate measurement of HDL cholesterol. The method for the measurement of cholesterol in high-density lipoprotein in a sample comprises reacting the sample with i) cholesterol esterase and cholesterol oxidase or ii) cholesterol esterase, oxidized coenzyme and cholesterol dehydrogenase in an aqueous medium comprising a specific nitrogen-containing surfactant having the structure of amine or ammonium salt and a polyanion, and measuring the formed hydrogen peroxide or reduced coenzyme. | 11-12-2009 |
20090170139 | METHOD, REAGENT AND KIT FOR MEASUREMENT OF CHOLESTEROL IN REMNANT-LIKE PARTICLES - The present invention provides a method for simple and accurate measurement of cholesterol in remnant-like lipoprotein (RLP) (RLP-C) in a sample, which comprises the steps of: (i) eliminating cholesterol in lipoproteins other than RLP by reacting the sample with cholesterol oxidase, or cholesterol dehydrogenase and oxidized coenzyme, in an aqueous medium comprising surfactant A; (ii) reacting the reaction solution from which cholesterol in lipoproteins other than RLP has been eliminated in the above step (i) with cholesterol esterase and cholesterol oxidase, or cholesterol esterase, cholesterol dehydrogenase and oxidized coenzyme, in the presence of surfactant B to form hydrogen peroxide or reduced coenzyme; and (iii) measuring the hydrogen peroxide or reduced coenzyme formed in the above step (ii). | 07-02-2009 |
20090035803 | METHOD FOR STABILIZATION OF PEPTIDES IN A BIOLOGICAL SAMPLE - The present invention provides a simple method for the stabilization of a peptide in a biological sample and a reagent for the stabilization, a simple method for the preservation of a biological sample comprising a peptide and a reagent for the preservation, and a method for the accurate measurement of a peptide in a biological sample and a reagent for the measurement. Addition of a saccharide to a biological sample enables the stabilization of a peptide in the biological sample, the preservation of the biological sample comprising a peptide in a stable condition and the accurate measurement of a peptide in the biological sample. As the present invention can stabilize a peptide in a biological sample collected in the clinical examination, the peptide as a marker in the biological sample can be measured accurately in the clinical examination. | 02-05-2009 |
20090023167 | METHOD, REAGENT AND KIT FOR DETERMINATION OF CHOLESTEROL IN REMNANT-LIKE PARTICLES (RLP) - The present invention provides a method, a reagent and a kit for simple and sensitive determination of cholesterol in remnant-like particles without separation of components of a sample. A method for quantitatively determining remnant-like particle cholesterol in a sample, which comprises: in an aqueous medium containing the sample and in the presence of a combination of specific surfactants and a phospholipid-hydrolyzing enzyme, allowing remnant-like particle cholesterol in the sample to react with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase (in the presence of oxidized coenzyme); and determining the formed hydrogen peroxide or reduced coenzyme. | 01-22-2009 |