UNIVERSITE DE BOURGOGNE Patent applications |
Patent application number | Title | Published |
20150377892 | DOMINANT NEGATIVE HSP110 MUTANT AND ITS USE IN PROGNOSING AND TREATING CANCERS - The present invention relates to a mutated heat-shock protein 110 (HSP110) lacking its substrate binding domain, which does not exhibit its chaperon activity and/or is not capable of binding to best-shock protein 70 (HSP70) and/or to beat-shock protein 27 (HSP27), but which is capable of binding to a wild-type HSP110. Such a mutated heat-shock protein 110 can be used (i) in methods for proposing survival and/or the response to a treatment of a patient suffering from a cancer, more particularly from a cancer liable to have a microsatellite instability (MSI) phenotype, such as colorectal cancer (CRC), and (ii) for treating cancers. | 12-31-2015 |
20150265640 | LIPIODOL-BASED ANTI-TUMOUR EMULSION FOR TREATING CANCER - The present invention relates to a pharmaceutical composition including Lipiodol and a molecule with anti-tumour activity and secondarily a hydroxyethyl starch. The present invention also relates to the use of the compositions according to the invention for treating cancer. According to one embodiment, the pharmaceutical composition according to the invention has between 0.004% and 0.2% by weight of idarubicin, between 0.38% and 2.25% by weight of hydroxyethyl starch and secondarily between 60% and 68% by weight of Lipiodol, and water for injection (or even physiological saline) in a quantity sufficient (q.s.) for 100%. | 09-24-2015 |
20140308343 | METHOD FOR PREPARING NANOPARTICLES BASED ON FUNCTIONAL AMPHIPHILIC MOLECULES OR MACROMOLECULES, AND THE USE THEREOF - The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents. | 10-16-2014 |
20140286603 | METHOD AND DEVICE FOR CONTROLLING A PHYSICAL PARAMETER OF AN OPTICAL SIGNAL - The invention relates to a method and device for controlling a physical parameter of an optical signal. According to the invention, a portion of the initial optical signal (SE) having passed through an optical waveguide from the input ( | 09-25-2014 |
20140142298 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF - The present invention embodiments relate to a compound with formula (V′) | 05-22-2014 |
20140038900 | DOMINANT NEGATIVE HSP110 MUTANT AND ITS USE IN PROGNOSING AND TREATING CANCERS - The present invention relates to a mutated heat-shock protein 110 (HSP110) lacking its substrate binding domain, which does not exhibit its chaperone activity and/or is not capable of binding to heat-shock protein 70 (HSP70) and/or to heat-shock protein 27 (HSP27), but which is capable of binding to a wild-type HSP 110. Such a mutated heat-shock protein 110 can be used (i) in methods for prognosing survival and/or the response to a treatment of a patient suffering from a cancer, more particularly from a cancer liable to have a microsatellite instability (MSI) phenotype, such as colorectal cancer (CRC), and (ii) for treating cancers. | 02-06-2014 |
20130158219 | SUPPORTED LIGANDS HAVING A HIGH LOCAL DENSITY OF COORDINATING ATOMS - The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis. | 06-20-2013 |
20130128917 | Thermoelectric Component with Plasmonic Guide, Integrating a Device for Measuring the Power Coupled in the Guided Mode - A thermoelectric component comprises integrated into the component: a plasmonic waveguide, an exciter element for the guided plasmonic mode, a device for measuring the power dissipated during propagation along the plasmonic waveguide, characterized in that the measurement device comprises, associated with the plasmonic guide, a thermocouple junction with two electrodes, one of the electrodes including the plasmonic waveguide. | 05-23-2013 |
20120183470 | PARTICLE SYNTHESIS BY MEANS OF THE THERMOHYDROLYSIS OF MINERAL PRECURSORS - The present invention relates to a method for continuously preparing mineral particles by means of the thermolysis of mineral precursors in an aqueous medium, comprising contacting: a reactive flow, including mineral precursors at a temperature lower than the conversion temperature thereof; and a coolant flow that is countercurrent to said reactive flow and contains water at a temperature that is sufficient to bring the precursors to a temperature higher than the conversion temperature thereof, the mixture flow that results from said reactive flow and said coolant flow then being conveyed into a tubular reactor, inside of which particles are formed by gradually converting the precursors, and where the reactive flow and the coolant flow are placed in contact with each other inside a mixing chamber, inside of which the reactive flow and the coolant flow are fed by supply pipes having outlet cross-sections that are smaller than the maximum cross-section of said mixing chamber. The invention also relates to a device for implementing said method. | 07-19-2012 |
20090197260 | METHOD FOR PREDICTING THE VIABILITY AND VITALITY OF BACTERIA USABLE IN STRESSING ENVIRONMENT - A method for predicting viability, vitality and stability of bacteria, which are usable in stressing environments, produced in the form of bacterial preparations and packed in a frozen or lyophilised form, includes pre-suspending the bacterial preparations in non-stressing aqueous nutrient medium, carrying out a molecular measurement of at least one type of marker gene whose stress state is representative for each considered bacterium species, measuring intracellular pH and in comparing the measured values with reference and/or reference standard values. The use of the inventive method for controlling quality of stress adaptation of bacterial preparations and for selecting such preparations is also disclosed. The invention in particular relates to malolactic and probiotic ferments. | 08-06-2009 |