DUBLIN CITY UNIVERSITY Patent applications |
Patent application number | Title | Published |
20150260706 | System and Method for Analysing and Measuring Ammonia Levels in a Sample - A system for sensing and measuring ammonia in a breath sample is described. The system comprises a sampling means for capturing and directing a breath sample from a subject to an ammonia sensor, the ammonia sensor comprising a conducting polymer polyaniline sensor. The sampling means comprises a breath sample capture chamber, the chamber having an inlet and outlet, the inlet having a first valve through which a breath is exhaled into the sample capture chamber, the outlet having a second valve through which breath surplus to the volume of the chamber is expelled, to provide capture of a breath sample of predefined volume. | 09-17-2015 |
20140314108 | WAVELENGTH TUNABLE COMB SOURCE - The present application provides an optical comb source in which the comb is produced by seeding a gain switched Fabry-Pérot laser with light from a single mode laser, whilst at the same time driving the Fabry-Pérot laser with a DC bias and RF signal. | 10-23-2014 |
20140296112 | OPTICAL TESTING SYSTEM - The present application provides a system ( | 10-02-2014 |
20140106371 | Peptide Analogues of PA-IL and Their Utility for Glycan and Glycoconjugate Analysis and Purification - Provided are peptide analogues of PA-IL and compositions containing them. The PA-IL peptide analogues have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogues contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions | 04-17-2014 |
20140099294 | Biotherapy for Pain - The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons. The invention is also directed to nucleic acid constructs encoding such polypeptides, and methods of making such derivatives and nucleic acid constructs, and methods of treating pain, such as chronic pain, by administering such derivatives to a patient suffering from, or at risk of suffering from such pain. | 04-10-2014 |
20130302027 | OPTICAL MEASUREMENT METHOD AND SYSTEM - The present application is directed to the measurement of the intensity and phase of high speed optical signals. The present application uses a tunable optical local oscillator, an optical coupler, a photodiode and RF electronics. The tunable laser enables successive measurements to be taken across the optical spectrum allowing the system to measure extremely high bandwidth signals. The signal generated by the local oscillator comprises a component at a frequency between two adjacent modes of the periodic optical signal to be measured. The local oscillator and said periodic signal are optically mixed and sent to a photodiode, the measurement of the phase being based on isolating the resulting beat frequencies. This approach offers a significant improvement over existing time resolved approaches which are limited to the bandwidth of the photodiode (˜50 GHz). | 11-14-2013 |
20130247658 | OPTOACOUSTIC INSPECTION DEVICE FOR INSPECTION OF SEMICONDUCTOR WAFERS - An inspection device is provided which comprises a receiving member defining an open cell for receiving a target therein. An optical excitation input is in optical communication with the cell for exciting the target. At least one acoustic pickup is in acoustic communication with the cell for picking up acoustic energy resultant from excitation of the target. A recorder is provided for recording the acoustic energy picked up from the at least one acoustic pickup for facilitating structural analysis of the target. | 09-26-2013 |
20130236982 | LUMINESCENCE BASED SENSOR - A sensor comprising a substrate ( | 09-12-2013 |
20130190206 | Direct Clone Analysis and Selection Technology - The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time. | 07-25-2013 |
20130101290 | METHOD AND APPARATUS TO OVERCOME LINEWIDTH PROBLEMS IN FAST RECONFIGURABLE NETWORKS - In wavelength switching optical networks, the optical data being transmitted may be routed to different end points by switching the operating frequency of the laser. However, the phase noise of the laser source increases following a switching event. This increased phase noise can prevent the successful transmission of phase modulation formats which are sensitive to it. Accordingly, it is generally necessary to wait a short period before transmitting data. However, the period may be as long as the data packet being transmitted (e.g. 3 μS), which is a limiting factor. The present application obviates this problem by including a radio frequency pilot tone with the data prior to modulation onto the optical carrier. | 04-25-2013 |
20130054224 | METHOD AND SYSTEM FOR ENHANCING TEXT ALIGNMENT BETWEEN A SOURCE LANGUAGE AND A TARGET LANGUAGE DURING STATISTICAL MACHINE TRANSLATION - A method for enhancing source-language coverage during statistical machine translation. The method including receiving an input string in a source language for translation into a target language. Extracting a paraphrase representation of the input string from a data repository comprising a corpus. Generating a word lattice structure using a directed acyclic graph representation having a plurality of nodes with edges extending there between. The words of the input string and the extracted paraphrase representation each having a respective edge in the directed acyclic graph. Labelling each of the edges with a word and a probability, the probability weighing assigned to the edges associated with the words of the input string being higher than the probability assigned to paraphrases derived from the input string. | 02-28-2013 |
20120318782 | Column heater - A direct contact segmented column heater is described. The heater is capable of a broad heating and cooling range, and exhibits a very rapid response, with heating and cooling rates better than 350° C. min | 12-20-2012 |
20120315023 | CAPILLARY COLUMN CURING SYSTEM - A curing system comprising an oven which may be usefully employed in the fabrication of long polymer columns of various morphologies and formats is described. In accordance with an exemplary arrangement the invention relates to a curing system comprising an oven that allows for the formation of very long capillary columns. | 12-13-2012 |
20120282182 | NANOPARTICLE CLUSTERS FORMED FROM INDIVIDUAL NANOPARTICLES OF TWO OR MORE TYPES - Nanoparticle clusters are described. In particular nanoparticle clusters formed from two or more individual nanoparticles of different types are described and methods for fabricating such nanoparticle clusters are further described. These nanoparticle clusters are fabricated by surface activating individual ones of the plurality of nanoparticles by desorption of surfactant molecules from the surface of the coated nanoparticles through exposure of the individual ones of the plurality of nanoparticles to an activating agent. | 11-08-2012 |
20120276641 | MICROFLUIDIC DEVICE PROVIDING DEGASSING DRIVEN FLUID FLOW - A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 μL, (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms. | 11-01-2012 |
20120219727 | METHOD OF SURFACE TREATING MICROFLUIDIC DEVICES - The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities. | 08-30-2012 |
20120214710 | METHOD OF PREDICTING RESPONSE TO THALIDOMIDE IN MULTIPLE MYELOMA PATIENTS - A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myeloma (MM) employs one or more of a panel of biomarkers that have been shown to be differentially expressed in cancer patients that respond to thalidomide (hereafter “Responders”) relative to cancer patients that do not respond to thalidomide (hereafter “Non-responders). The method involves assaying a biological sample from the individual to determine the abundance of at least three biomarkers including Vitamin-D binding protein precursor (VDB) (Sequence ID 1) and Serum amyloid A protein (SAA) (Sequence ID 3), and at least one of beta-2-microglobulin (B2M) (Sequence ID 4), Haptoglobin (Hp) precursor (fragment) (Sequence ID 5), and zinc-alpha-2-glycoprotein (ZAG) (Sequence ID 2). Correlation of the abundance value for the at least three biomarkers with a reference abundance value from a Responder or Non-responder enables predication of response to thalidomide for the patient. | 08-23-2012 |
20120185496 | METHOD OF AND A SYSTEM FOR RETRIEVING INFORMATION - A method of retrieving information from a data source is described. The method includes providing a query sentence in a source language. A stemmed sentence is generated by removing affixes from base words of the query sentence and by removing predetermined words from the query sentence. A translated sentence is generated by translating the stemmed sentence into a target language. The translated sentence is provided to an information retrieval module operable to retrieve information in the target language from the data source based on the translated sentence. | 07-19-2012 |
20120063476 | OPTICAL WAVELENGTH COMB GENERATOR DEVICE - The present application relates to comb frequency generator devices generally and more particularly to the use of comb generators for use in fibre optic communications. More particularly, the application provides a frequency comb generator device. The device comprises a laser ( | 03-15-2012 |
20120040843 | CENTRIFUGAL CAPTURE SYSTEM - A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured. | 02-16-2012 |
20120016657 | METHOD OF AND A SYSTEM FOR TRANSLATION - A translation system for translating source text from a first language to target text in a second language. The system comprises a translation memory (TM) module that stores translation segments. The TM module is operable to generate a TM target text output in response to source text. A statistical translation machine (SMT) module is configured to generate translations on the basis of statistical models whose parameters are derived from the analysis of bilingual text corpora. The SMT module is operable to generate a SMT target text output in response to source text. An extractor is configured to extract features from the TM target text output and the SMT target text output. A vector generator is configured to generate a vector with a unified feature set derived from the extracted features and features associated with the SMT module and the TM module. A recommender is operable to read the vector and determine whether the TM target text output or the SMT target text output is optimum for post editing. | 01-19-2012 |
20110297542 | METHOD OF FABRICATION OF MONOLITHIC STATIONARY PHASES FOR SEPARATIONS, AND METHODS OF SEPARATION USING SUCH STATIONARY PHASES - Analysis tools for use in analytical separations are provided including a stationary phase comprising an electroconducting material, for example, a conducting polymer. There is further provided a method for manufacturing monolithic stationary phases in various formats including in chip-format, column or capillary column format and method of separation using stationary phases. Also provided is a method for analytical separation comprising selective manipulation of the stationary phase making it is possible to tune the device to specific applications. | 12-08-2011 |
20110262906 | MICROFLUIDIC MULTIPLEXED CELLULAR AND MOLECULAR ANALYSIS DEVICE AND METHOD - A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber. | 10-27-2011 |
20110201824 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY - This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl-imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxicity relative to existing imidazolium bases ILs such as 1-butyl-3-methylimidazolium (bmmim) salts. Many of the described ILs produce a score of over 60% biodegradability over 28 days in a biodegradability test such as the Sturm Test, the Closed Bottle Test (OECD 301D) or the CO | 08-18-2011 |
20110135180 | Electronic Cleansing of Digital Data Sets - A method of processing a 3-dimensional Computed Tomography Colonography data set to remove tagged material is disclosed. The method involves the preliminary processing step of classifying voxels in the data set as corresponding to air, tagged material or colon tissue. Methods of overcoming erroneous classification of Partial Volume air/tagged material interface voxels are disclosed. The present invention also provides for methods of circumventing problems resulting from removal of tagged material from a CTC data set, which can result in the erosion of soft-tissue structures partially covered by tagged colonic fluid. | 06-09-2011 |
20110056272 | SYSTEM FOR ANALYSING PLASMA - A system for analysing plasma. The system comprises at least one sensor which is co-operable with a plasma source for providing an analog signal representative of a characteristic of plasma from the plasma source, and a sound card installed on a computing means in communication with the sensor for converting the analog signal into a digital signal for facilitating digital processing thereof. | 03-10-2011 |
20110034676 | ANTI-SIALIC ACID ANTIBODY MOLECULES - A method of generating and isolating a recombinant high affinity anti-sialic acid antibody molecule comprises the steps of immunising a host with an immunogen comprising a conjugate of sialic acid and a carrier protein to generate an anti-sialic acid polyclonal serum, isolating a sample of RNA from the immunised avian host, and generating and screening of a library of recombinant antibody molecules from the RNA sample, and isolating a recombinant high affinity anti-sialic acid antibody molecule. The antibody molecule is selected from the group consisting of: whole antibodies; scFv fragments; and Fab fragments, and the host is | 02-10-2011 |
20110025430 | POWER SPLITTER - A power splitter and/or combiner is described. The power splitter may be provided as a broadband, passive, divide by N power splitter that may be advantageously employed in providing power to multiple electrodes within a plasma source. The power splitter comprises a transmission line and a plurality of N secondary windings arranged about the transmission lines. | 02-03-2011 |
20100317094 | MILK ANALYSIS MICROFLUIDIC APPARATUS FOR DETECTING MASTITIS IN A MILK SAMPLE - A milk analysis apparatus for detecting mastitis in a milk sample by isolating somatic cells in the form of a pellet using centrifugal sedimentation is described. The apparatus comprises a vessel for holding the milk sample, and a centrifuge for rotating the vessel. The vessel includes an inlet for facilitating charging milk into a body portion of the vessel; and a trap for capturing somatic cells suspended in the milk sample. The somatic cells are biased towards the trap upon rotation of the vessel. | 12-16-2010 |
20100239647 | PHOTORESPONSIVE IONOGEL - A photoresponsive ionogel comprising a photo-responsive polymer polymerised within an ionic liquid matrix is described. This solid-state electrolyte material maintains its ionic liquid characteristics but these characteristics can be altered upon irradiation of the gel with light of a particular wavelength. By suitably configuring the ionogel through the incorporation of specific ions within the gel it is possible to cause dramatic changes in properties of the ionogel such as viscosity, conductivity, acidity, basicity and polarity using light as the stimulus. | 09-23-2010 |
20100190258 | METHOD OF PRODUCING RECOMBINANT BIOLOGICAL PRODUCTS - A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules of Table 1 within the mammalian producer cells once a desired concentration of mammalian producer cells has been achieved. The method may also comprise the step of increasing a level of an inhibitor of one or more of the miRNA molecules of Table 1 within the mammalian producer cells at the start of or during an initial phase of culture. | 07-29-2010 |
20100171043 | SINGLE ELEMENT SENSOR WITH MULTIPLE OUTPUTS - An analyte sensor is described. The sensor employs a single sensor element which provides a plurality of phase outputs in response to excitation by a modulated excitation source. The plurality of phase outputs may be analysed to provide information on the presence of one or more analytes. | 07-08-2010 |
20100000883 | Sensor Comprising Conducting Polymer Materials - A sensor comprises a substrate having nanoparticles of a conducting polymer such as polyanaline printed thereon. Also described is a printing composition for printing onto a substrate, the composition comprising nanoparticles of a conducting polymer such as polyanaline. | 01-07-2010 |
20090186358 | Pathway Analysis of Cell Culture Phenotypes and Uses Thereof - The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes. | 07-23-2009 |
20090017460 | DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF - The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines. | 01-15-2009 |
20080309242 | Plasma Source - A plasma source is described. The source includes a reactive impedance element formed from a plurality of electrodes. By providing such a plurality of electrodes and powering adjacent electrodes out of phase with one another, it is possible to improve the characteristics of the plasma generated. | 12-18-2008 |
20080213815 | DIAGNOSING BREAST CANCER BY SEPRASE LEVEL - A method of diagnosing subjects for breast cancer comprising the steps of (a) establishing the seprase level of a subjects test material and (b) determining those subjects with seprase levels above about 0.0008 nmoles.min | 09-04-2008 |