University of Hawaii Patent applications |
Patent application number | Title | Published |
20160137663 | NOVEL SESQUITERPENOID STAT3 INHIBITORS - The present disclosure provides a method of purifying pharmaceutical compositions consisting essentially of STAT3 inhibitors from a mixture of compounds, pharmaceutical compositions comprising STAT3 inhibitors used to inhibit STAT3 in tumor cells, and certain pharmaceutically acceptable salts thereof, and methods of use. | 05-19-2016 |
20140323823 | MICROWAVE STETHOSCOPE FOR MEASURING CARDIO-PULMONARY VITAL SIGNS AND LUNG WATER CONTENT - A microwave stethoscope measurement method and sensor design employ a microwave transmission sensor and a microwave reception sensor placed on a patient's chest in spaced-apart side-by-side configuration for monitoring patient vital signs, lung water content and other critical measurements. The side-by-side sensors are spaced apart a separation distance of about 1-3 cm in lateral chest orientation. The sensors may be formed with a textile fabric for wearer comfort and to improve contact with the patient's skin. The microwave sensor measurements are digitally processed using a modified short time Fourier Transform (STFT) spectrum windowed-averaged algorithm. Output data extracted from the microwave sensor measurements may be transmitted wirelessly to a mobile device such as a smartphone for remote monitoring of the patient's medical condition. | 10-30-2014 |
20140248374 | COMPOSITIONS AND MULTI-STEP METHODS OF USING THE SAME FOR THE TREATMENT OF JELLYFISH STINGS - Embodiments of the invention relate to a composition containing zinc and copper and methods of using the same in treatment of exposure to a pore-forming toxin (PFT) in a subject or membrane perturbant (MP). | 09-04-2014 |
20130274271 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENTOF CARDIAC HYPERTROPHY - Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure | 10-17-2013 |
20130220837 | SYSTEMS AND METHODS FOR CARBOHYDRATE DETECTION - Carbohydrate detectors employing abiotic fuel cell designs are disclosed. The detectors produce current output using reactions between chemical dyes in alkaline solutions and carbohydrates, such as glucose. A linear relationship between current output of the detector and glucose concentration has been observed. This relationship may be used with measurements of current output when the glucose concentration is unknown to determine the unknown glucose concentration. In certain embodiments, the abiotic detectors may further employ electrodes, such as high surface area carbon materials and commercial air breathing electrodes, without the use of catalysts (i.e., precious metals or biocatalytic species) for glucose detection Organic dyes, such as methyl viologen (MV), methylene blue, methylene green, Meldola's blue, indigo carmine, safranin O, and the like, may serve as the electron mediators. | 08-29-2013 |
20130216811 | NANOTAPE AND NANOCARPET MATERIALS - Provided are nanostructure-containing nanotape materials. The materials may be incorporated at the interface between two other structures to provide strength and toughness at the interface. The materials may also be applied to a standalone structure to provide strength and toughness. Also provided are related methods of fabricating the nanotape materials, as well as gas diffusion membranes and fuel cells that include nanostructured materials. | 08-22-2013 |
20130171643 | Sequence Specific Real-Time Monitoring of Loop-Mediated Isothermal Amplification (LAMP) - Gene-based diagnostics capable of rapidly discriminating selected strains of a selected pathogen from other populations within the same species are disclosed. Sequence-specific, real-time monitoring of LAMP of DNA may be accomplished through the use of oglionucleotide probes, referred to as “assimilating probes.” The assimilating probes include two oglionucleotide strands, one which includes a quencher (referred to as the quenching probe) and another which includes a fluorophore (referred to as the fluorescent probe). A fluorescent signal results when the two strands are displaced from one another during the LAMP reaction. By monitoring the emitted fluorescence, sequence specific amplification may be detected. | 07-04-2013 |
20130131343 | MICROWAVE-ASSISTED SYNTHESIS OF N-HETEROCYCLIC CARBENE TRANSITION METAL COMPLEXES - Microwave heating is used to synthesize NHC-transition metal complexes. Reaction times for the formation of NHC-transition metal complexes is greatly reduced. The speed of the reactions allows for otherwise problematic air handling of reagents. Apparatus for carrying out the reactions is less complex than conventional apparatus and requires less energy to achieve the desired temperatures. Methods utilize salts of NHC's which overcomes the oftentimes difficult preparation of free carbenes for formation of the corresponding transition metal complexes. | 05-23-2013 |
20130131315 | AUTO-PROCESSING DOMAINS FOR POLYPEPTIDE EXPRESSION - Embodiments herein include methods and constructs that can be used to co-express two or more polypeptides of interest from a single polynucleotide encoding a precursor polypeptide. Within this precursor polypeptide can reside at least one autonomous processing unit, which can mediate release of flanking polypeptides of interest in cis. The processing unit can include an N-terminal autocatalytic cleavage domain and a C-terminal cleavage domain. Some embodiments include constructs and methods for co-expressing polypeptides without N- or C-terminal overhangs, in any cellular or extracellular location, and/or in stoichiometric ratios. | 05-23-2013 |
20130122510 | ULTRASENSITIVE BIOSENSORS - The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel. | 05-16-2013 |
20130059367 | ULTRASENSITIVE BIOSENSORS - The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel. | 03-07-2013 |
20130056839 | ULTRASENSITIVE BIOSENSORS - The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel. | 03-07-2013 |
20120251807 | NANOPARTICULATE-ENHANCED COATINGS - Disclosed are coatings comprising a matrix material and nanoscale bodies disposed within the matrix material. Also provided are methods of forming such coatings. | 10-04-2012 |
20120231029 | ENHANCED MALARIA MSP-1 SUBUNIT VACCINE - Recombinant subunit proteins derived from the MSP-1 C-terminal region of the parasite | 09-13-2012 |
20110228279 | FABRY-PEROT FOURIER TRANSFORM SPECTROMETER - A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light. | 09-22-2011 |
20110169505 | Systems for Transverse Electromagnetic Mode In-Situ Soil Testing - A slotted TEM transmission line and an in-situ TEM transmission line are utilized to determine both complex permittivity and permeability of soil. The permittivity and permeability information may be used by underground sensing techniques such as GPR and EMI to enhance information from these techniques. The in-situ probe provides that both complex permittivity and permeability can be measured simultaneously over a broad frequency range without disturbing the soil conditions. | 07-14-2011 |
20110140736 | SYSTEMS AND METHODS FOR BRAIN-LIKE INFORMATION PROCESSING - Logic circuits provide networks to simulate the functions of neural networks of the brain, and can discriminate degrees of state, and combinations of degrees of state, corresponding to a number of neurons. Logic circuits comprise Recursive AND NOT Conjunctions (RANCs), or AND NOT gates. A RANC is a general logic circuit that performs conjunctions for 2 | 06-16-2011 |
20110127172 | SYSTEMS AND METHODS FOR CARBOHYDRATE DETECTION - Carbohydrate detectors employing abiotic fuel cell designs are disclosed. The detectors produce current output using reactions between chemical dyes in alkaline solutions and carbohydrates, such as glucose. A linear relationship between current output of the detector and glucose concentration has been observed. This relationship may be used with measurements of current output when the glucose concentration is unknown to determine the unknown glucose concentration. In certain embodiments, the abiotic detectors may further employ electrodes, such as high surface area carbon materials and commercial air breathing electrodes, without the use of catalysts (i.e., precious metals or biocatalytic species) for glucose detection Organic dyes, such as methyl viologen (MV), methylene blue, methylene green, Meldola's blue, indigo carmine, safranin O, and the like, may serve as the electron mediators. | 06-02-2011 |
20100327482 | POLYMER MATRIX COMPOSITES WITH NANO-SCALE REINFORCEMENTS - Embodiments of the present invention provide polymer matrix nanocomposites reinforced with nano-scale materials such as nanoparticles and carbon nanotubes and methods of fabricating. The nanomaterials are provided within relatively low weight fractions, for example in the range of approximately 0.01 to about 0.4% by weight and distributed within the matrix by a magnetic mixing procedure to provide substantially uniform reinforcement of the nanocomposites. Advantageously, these nanocomposites provide significantly enhanced tensile strength, strain to failure, and fracture toughness over corresponding neat matrices. | 12-30-2010 |
20100279203 | CARBOHYDRATE ANODE FOR FUEL CELL AND BATTERY APPLICATIONS - Abiotic fuel cell and battery designs employing chemical dyes in alkaline solutions are disclosed. The fuel cells and batteries are capable of harnessing electrical power from various carbohydrates, including, but not limited to, glucose; in an anode design that does not require catalysts or membranes to separate half-cell reaction chambers. In certain embodiments, the abiotic fuel cell or battery designs may further employ electrodes, such as high surface area carbon materials and commercial air breathing electrodes, without the use of catalysts for glucose oxidation (i.e., precious metals or biocatalytic species). In further embodiments, organic dyes, including but not limited to, methyl viologen (MV), methylene blue, methylene green, Meldola's blue, indigo carmine, safranin O, and the like, may serve as the electron mediators. In some embodiments, the fuel cells or batteries are capable of generating power on the order of about tens of mW/cm | 11-04-2010 |
20100267070 | PHARMACEUTICAL COMPOSITIONS FOR THE TREAMENT OF CONDITIONS RESPONSIVE TO PROTEASOME INHIBITION - The invention disclosed herein generally relates to methods and compositions for inhibiting proteasome activity comprising a syrbactin compound have the structure of Formula (I) or (II). | 10-21-2010 |
20100234454 | TREATMENT OF CNIDARIA INTOXICATION - The present invention relates to the use of vanilloid receptor (VR) antagonists, and more particularly vanilloid receptor 1 (VR1) antagonist, as analgesics in the treatment and/or prohylaxis of cnidaria envenomations. | 09-16-2010 |
20100041121 | METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF HYDROGEN AND HYDROGENASE - The present application relates to the use of metabolically-engineered microbial cells for the production of hydrogen and hydrogenase enzymes. The microbial cells are strains of | 02-18-2010 |
20090155871 | METHODS AND COMPOSITIONS FOR ETHANOL PRODUCING CYANOBACTERIA - The present invention relates to methods and systems for the production of ethanol by cyanobacteria. More specifically, the methods can be used to produce ethanol using genetically engineered light responsive cyanobacteria. | 06-18-2009 |
20090139693 | TWO PHASE MICRO-CHANNEL HEAT SINK - A method and system for providing a heat sink are described. The heat sink includes at least one inlet, at least one outlet, a plurality of flow micro-channels, and at least one cross-connect channel. The plurality of flow micro-channels are defined by a plurality of channels walls, connect the inlet(s) with the outlet(s) and accommodate a flow of coolant between the at least one inlet and the at least one outlet. The at least one cross-connect channel is configured to connect at least a portion of the plurality of flow micro-channels. The cross-connect channel(s) also at least partially equilibrate a pressure field for boiling of the coolant across the portion of the plurality of flow micro-channels. | 06-04-2009 |
20090133139 | NUCLEOTIDE SEQUENCE OF SHRIMP ACTIN PROMOTER AND ITS USE IN GENETIC TRANSFORMATION BIOTECHNOLOGY - The present invention relates to an isolated β-actin nucleic acid promoter molecule from shrimp; nucleic acid constructs including the β-actin promoter molecule; and expression vectors, host cells, and transgenic animals transduced with the isolated β-actin nucleic acid promoter. Also disclosed are methods for imparting to an animal resistance against a pathogen, regulating growth of an animal, increasing stress tolerance in an animal, and increasing cold tolerance in an animal that involves transforming an animal with a nucleic acid construct including the isolated β-actin nucleic acid promoter molecule of the present invention. | 05-21-2009 |