UNIVERSITE LIBRE DE BRUXELLES Patent applications |
Patent application number | Title | Published |
20140363828 | METHOD AND DEVICE FOR ASSAYING AN ANTIGEN PRESENT ON ERYTHROCYTES OR AN ANTIBODY BINDING TO AN ANTIGEN PRESENT ON ERYTHROCYTES - An assaying kit is for pre-transfusion blood group matching between two blood samples. The kit includes at least two assemblies ( | 12-11-2014 |
20140363814 | STREPTOCOCCUS PNEUMONIAE DETECTION IN BLOOD - The present invention provides a method and a kit for detecting a | 12-11-2014 |
20140243241 | METHOD FOR MEASURING BETA-LACTAM ANTIBIOTICS - The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample. | 08-28-2014 |
20140219443 | GENERATION OF CRYPTOGRAPHIC KEYS - A method is provided of generating and distributing secret random data. The method requires a plurality of participating parties each to own an identical private-key generation device and to request a random signal over a shared publication communication network. At each iteration of the method, the parties process the public random signal with the internal states of their secret-key generation devices using two functions, the output of the first function being generated secret random data and the output of the second function being a new internal state. | 08-07-2014 |
20140217329 | DIKETOPYRROLOPYRROLE OLIGOMERS AND COMPOSITIONS, COMPRISING DIKETOPYRROLOPYRROLE OLIGOMERS - The present invention relates to compositions, comprising (a) a compound of the formula (I), and (b) a polymeric material, to specific oligomers of the formula I, and their use as organic semiconductor in organic devices, especially in organic photovoltaics (solar cells) and photodiodes, or in a device containing a diode and/or an organic field effect transistor. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when the compositions, or oligomers according to the invention are used in organic field effect transistors, organic photovoltaics (solar cells) and photodiodes. | 08-07-2014 |
20140212380 | TARGETS AND AGENTS FOR THE TREATMENT OF IMPAIRED BONE FRACTURE HEALING - The application teaches a composition comprising one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8 or CXCL8), a functional fragment of IL-8, a functional variant of IL-8, and an agonist of IL-8 receptor, for therapeutic and/orprophylactic interventions in impaired bone fracture healing, such as but not limited to non-union fractures, mal-union fractures, or delayed union fractures. | 07-31-2014 |
20140186955 | GENERATION OF NEURONAL CELLS FROM PLURIPOTENT STEM CELLS - The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population. | 07-03-2014 |
20140170219 | COMPOSITION AND METHOD FOR TREATING HPV - Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer. | 06-19-2014 |
20140105823 | MOLECULES SPECIFICALLY BINDING PANCREATIC BETA CELLS BIOMARKERS - The present invention provides a synthetic peptide molecule that specifically binds an FXYD2-gamma isoform of pancreatic beta cells, said synthetic peptide molecule has 25 amino acids. | 04-17-2014 |
20140100137 | MARKERS FOR IMPAIRED BONE FRACTURE HEALING - The present application discloses particularly interleukin-8 (IL-8) as a novel biomarker for the prediction, diagnosis, prognosis and/or monitoring of impaired bone fracture healing; and related methods, uses and kits. | 04-10-2014 |
20140057849 | WILD-TYPE APOLIPOPROTEIN L-I FOR USE IN THE PREVENTION OF KIDNEY DISEASES - A wild-type human Apolipoprotein L-I is used in a method for the prevention and/or the treatment of renal disease. | 02-27-2014 |
20140056881 | METHOD AND KIT FOR THE DETECTION OF GENES ASSOCIATED WITH PIK3CA MUTATION AND INVOLVED IN PI3K/AKT PATHWAY ACTIVATION IN THE ER-POSTITIVE AND HER2-POSITIVE SUBTYPES WITH CLINICAL IMPLICATIONS - A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour, the said method comprising the step of assaying a sample of a breast tumour from said patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA. | 02-27-2014 |
20140052067 | DEVICES FOR PUNCTURING FOR A HUMAN OR ANIMAL BODY'S MEMBRANE - Device for puncturing a membrane of a human or animal body so as to introduce a liquid formulation thereinto, provided with a patch ( | 02-20-2014 |
20130338937 | METHOD FOR DETERMINING SUSPENDED MATTER LOADS CONCENTRATIONS IN A LIQUID - The present invention relates to a method for monitoring suspended matter loads concentration in a liquid, wherein said method comprises the steps of: a) collecting environmental variables comprising: the pressure p at a depth L in said liquid, the liquid depth L at which said pressure p is collected; providing the value of the pressure p0 which is the aerial pressure; b) inserting said environmental variables in an equation; c) calculating the suspended matter loads volumetric concentration in the liquid from the absolute pressure p measured at the depth L in the liquid. | 12-19-2013 |
20130338023 | BACH2 REPRESSION IN CELLS - A method for measuring the proliferation status of a cell present in a biological sample, comprising the step of measuring in the said cell the loss of BACH2 by Fluorescence after In Situ Hybridization (FISH) analysis and mRNA quantification or by Comparative Genomic Hybridization (CGH) and corresponding kit and applications. | 12-19-2013 |
20130296328 | EPIGENETIC PORTRAITS OF HUMAN BREAST CANCERS - The present invention provides new target gene regions for use in prediction, prognosis, diagnosis and therapy of breast cancer, based on the differential methylation profile of said targets in samples from subjects with breast cancer and healthy subjects. | 11-07-2013 |
20130289030 | NOVEL PHENAZINE DERIVATIVES AND THEIR USES - The present invention is directed to novel compounds of formula I | 10-31-2013 |
20130116273 | BETA CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS - The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof. | 05-09-2013 |
20130109061 | HYPERPROLIFERATIVE RECOMBINANT CELL | 05-02-2013 |
20130053347 | PRO-DRUGS OF AMARYLLIDACEAE ISOCARBOSTYRIL PRODUCTS AND THEIR USE AGAINST BRAIN TUMORS - The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain. | 02-28-2013 |
20120301445 | TOOLS FOR ISOLATING AND FOLLOWING CARDIOVASCULAR PROGENITOR CELLS - The present invention provides new methods and tools for isolating pluripotent cardiovascular progenitors (MCPs), by transiently detecting the cell-surface expression of genes upregulated by Mesp1. Cells obtained by the method and there uses in research and clinical settings are also part of the invention. Using genome wide transcriptional analysis, the inventors found upstream and downstream members of the Mesp1 signaling pathway, which form potential new targets for both therapy and for the identification of MCPs and differentiation of MCPs into cardiovascular cells. This invention provides novel and important insights into the molecular mechanisms of cardiovascular specification and provides potential novel methods for dramatically increasing the number of cardiovascular cells for cellular therapy in humans. | 11-29-2012 |
20120221615 | NETWORK DISTRIBUTED QUANTUM RANDOM NUMBER GENERATION - A quantum random number generation system includes a source of light output as a plurality of coherent states such that each state has an indeterminate number of photons, a photodetector arranged to receive the light output from the light source and to generate a photocurrent dependent on the number of photons in each coherent state, and processing circuitry connected to receive the photocurrent and arranged to convert it to generate a sequence of random numbers. | 08-30-2012 |
20120202676 | SODA-LIME-SILICA GLASS-CERAMIC MATERIAL - The invention relates to a glass-ceramic material having SiO | 08-09-2012 |
20120196735 | PHASE-SEPARATED SODA-LIME-SILICA GLASS - The invention relates to a glass having SiO | 08-02-2012 |
20120128682 | APOLIPOPROTEIN L- I VARIANTS AND THEIR USE - An isolated human Apolipoprotein L-I corresponding to a wild type human Apolipoprotein sequence is modified by a deletion at its C-terminal end. | 05-24-2012 |
20120071346 | GENE-BASED ALGORITHMIC CANCER PROGNOSIS - The present invention is related to the methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score. | 03-22-2012 |
20120065084 | METHODS AND TOOLS FOR PREDICTING THE EFFICIENCY OF ANTHRACYCLINES IN CANCER - A gene set, kit and method predict the efficiency of anthracyclines-based treatment of breast cancer. | 03-15-2012 |
20120014983 | RECOMBINANT ALPHA-HEMOLYSIN POLYPEPTIDE OF STAPHYLOCOCCUS AUREUS, HAVING A DELETION IN THE STEM DOMAIN AND HETEROLOGOUS SEQUENCES INSERTED - It refers to a recombinant alpha-hemolysin polypeptide of | 01-19-2012 |
20120003397 | METHOD FOR DEPOSITING NANOPARTICLES ON A SUPPORT - A method for depositing nanoparticles on a support includes taking a colloidal solution of nanoparticles. The method also includes nebulizing the colloidal solution of nanoparticles on a surface of the support in an atmospheric plasma. | 01-05-2012 |
20110306507 | METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN HER2+PARTIENTS - A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, and possibly 40, 45, 50, 55, 60, 65 genes or proteins, antibodies or hypervariable portion thereof directed against the proteins encoded by these genes. | 12-15-2011 |
20110284161 | BIOLOGICAL GLUE AND METHOD FOR OBTAINING A BIOLOGICAL GLUE - A method obtains a biological glue from a bacteria. | 11-24-2011 |
20110263007 | DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED - A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology. | 10-27-2011 |
20110257126 | WATER SOLUBLE CURCUMIN COMPOSITIONS FOR USE IN ANTI-CANCER AND ANTI-INFLAMMATORY THERAPY - The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives. | 10-20-2011 |
20110129839 | DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED - The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity. | 06-02-2011 |
20110125108 | SURGICAL INSTRUMENT PREFERABLY WITH TEMPERATURE CONTROL - A surgical needle has shape memory. An endoscope tool controls the temperature of a foreign body or surgical instrument such as an endoscopic needle. | 05-26-2011 |
20110040284 | GUIDE FOR CATHETERISM - A guide is used for the selective catheterism of anatomic structures and for placing therapeutic instruments. | 02-17-2011 |
20110038862 | METHOD AND KIT FOR THE DETECTION OF GENES ASSOCIATED WITH PIK3CA MUTATION AND INVOLVED IN PI3K/AKT PATHWAY ACTIVATION IN THE ER-POSTITIVE AND HER2-POSITIVE SUBTYPES WITH CLINICAL IMPLICATIONS - A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour. The method includes the step of assaying a sample of a breast tumour from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA. | 02-17-2011 |
20110014395 | METHOD FOR DEPOSITING A FLUORINATED LAYER FROM A PRECURSOR MONOMER - A method for depositing a fluorinated layer on a substrate includes the injection of a gas mixture including a fluorinated compound and a carrier gas in a discharge or post-discharge area of a cold atmospheric plasma at a pressure comprised between 0.8 and 1.2 bars. The fluorinated compound has a boiling temperature at a pressure of 1 bar above 25° C. | 01-20-2011 |
20110008351 | ANTICOMPLEMENT POLYPEPTIDES OF IXODES RICINUS - An isolated and purified polypeptide is obtained from tick salivary glands and presents more than 75% sequence identity with at least a sequence selected from the group consisting of SEQ. ID. NO. 1. | 01-13-2011 |
20100330044 | MESP1 AS A MASTER REGULATOR OF MULTIPOTENT CARDIOVASCULAR PROGENITOR SPECIFICATION AND USES THEREOF - A method for differentiating or promoting or inducing differentiation of stem cells into pluripotent cardiovascular progenitors (MCPs) by transiently inducing the expression of a single gene, namely Mesp1, is disclosed. Cells obtained by the method and their uses in research and clinical settings are also disclosed. Using genome wide transcriptional analysis, the inventors found that Mesp1 rapidly activates and represses a discrete set of genes, which form potential new targets for both therapy and for the identification of MCPs. Insights into the molecular mechanisms underlying the earliest step of cardiovascular specification and potential methods for dramatically increasing the number of cardiovascular cells for cellular therapy in humans are provided. | 12-30-2010 |
20100298160 | METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN ER-PATIENTS - A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 possibly 100, 105, 110 genes or proteins or the entire set or antibodies (or hypervariable portion thereof) directed against the proteins encoded by these genes. | 11-25-2010 |
20100298097 | JOINT REHABILITATION DEVICE AND METHOD - A device for exercise rehabilitation and evaluation of a joint between bone elements of the hand, of the arm or of the leg of a user includes: a portable housing ( | 11-25-2010 |
20100202071 | DEFORMABLE MIRROR - The present invention is related to a deformable mirror comprising individual units ( | 08-12-2010 |
20100178360 | NUTRITIVE COMPOSITION - An energetic or nutritive composition includes at least one compound having laxative properties, mineral salts (or electrolytes) such as sodium, potassium, chlorine, calcium, magnesium, phosphor. The composition may also include carbohydrates that may be assimilated by the human digestive system such as glucose, galactose, fructose, maltose, saccharose, polysaccharides. | 07-15-2010 |
20100166720 | GENERATION OF NEURONAL CELLS FROM PLURIPOTENT STEM CELLS - The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population. | 07-01-2010 |
20100137345 | PROPHYLACTIC AND THERAPEUTIC USE OF SIRTUIN INHIBITORS IN TNF-ALPHA MEDIATED PATHOLOGIES - The invention relates to the use of sirtuin inhibitors for reducing TNF-alpha production by cells and organisms. The invention also concerns prophylactic and therapeutic applications of sirtuin inhibitors in TNF-alpha mediated pathologies, such as various inflammatory and autoimmune disorders. | 06-03-2010 |
20100129788 | METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) - A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably M×A, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon. | 05-27-2010 |
20100120891 | USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER - The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy. | 05-13-2010 |
20100119587 | SOLID LIPIDIC PARTICLES AS PHARMACEUTICALLY ACCEPTABLE FILLERS OR CARRIERS FOR INHALATION - The present invention relates to new compositions of (active) solid lipidic particles (SLP), e.g. for inhalation, and their use as carriers or as fillers in pharmaceutical compositions. It also relates new formulations obtained by mixing a SLP composition of the invention and a (micronized) active compound. It further relates to a method for fabricating said compositions of (active) solid lipidic particles. | 05-13-2010 |
20100069312 | AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS FOR TREATING AUTOIMMUNE DISEASES - The invention provides prophylactic and therapeutic applications of select aminoalkyl glucosamine phosphate (AGP) compounds in autoimmune diseases. | 03-18-2010 |
20090162333 | PHARMACEUTICAL COMPOSITION COMPRISING APOLIPOPROTEINS FOR THE TREATMENT OF HUMAN DISEASES - A pharmaceutical composition has an adequate pharmaceutical carrier or diluent and an element selected from a pharmaceutical composition having an adequate pharmaceutical carrier or diluent and an element selected from: —apolipoprotein apoL-III; —a pharmaceutically active fragment of this apolipoprotein apoL-III; —a nucleotide sequence encoding this apolipoprotein apoL-III or the fragment; —a vector having the nucleotide sequence; —a cell transformed by the nucleotide sequence or the vector; —an inhibitor or activator directed against the apolipoprotein apoL-III, its fragment or its nucleotide sequence, —an anti-inhibitor or anti-activator directed against the inhibitor or activator or its encoding nucleotide sequence. | 06-25-2009 |
20090117646 | DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED - A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology. | 05-07-2009 |
20080275652 | GENE-BASED ALGORITHMIC CANCER PROGNOSIS - Gene-Based Algorithmic Cancer Prognosis relates to methods and systems for prognosis determination in tumor samples. The methods and systems measure gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score. | 11-06-2008 |
20080261935 | 2" OXO-VORUSCHARIN AND DERIVATIVES THEREOF - Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer. | 10-23-2008 |