The Chinese University of Hong Kong Patent applications |
Patent application number | Title | Published |
20150315169 | Heterocyclic Compound Preparing - Disclosed is a process for selectively producing (D+1)-member heterocyclic compounds from corresponding unactivated dienes or derivatives thereof in the presence of a transition metal or lanthanide catalyst or a precursor thereof, relative to D-member heterocyclic rings. | 11-05-2015 |
20150240311 | RECURRENT TRANSFORMING UBR5-ZNF423 FUSION GENE IN EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA - The present invention provides a method for diagnosing nasopharyngeal cancer in a subject by detecting UBR5-ZNF423 fusion polypeptide or polynucleotide, which is in some cases due to a gene fusion of UBR5-ZNF423. A kit useful for such a method is also provided. In addition, the present invention provides a method for treating nasopharyngeal cancer by eliminating UBR5-ZNF423 gene expression or activity. | 08-27-2015 |
20150108673 | IMPRINTING APPARATUS AND METHOD FOR IMPRINTING - A micro-contact imprinting apparatus for transferring patterns of a stamp to a substrate. | 04-23-2015 |
20150107514 | ROLL-TO-ROLL PRINTING SYSTEMS AND METHODS FOR FABRICATING PRINT ROLLER - A multiple degrees of freedom control apparatus for a roll-to-roll printing system. | 04-23-2015 |
20150045238 | BIOMARKERS FOR DIABETES - The present invention provides a method for assessing the presence and risk of developing type 2 diabetes, cancer of all sites, or cardiovascular disease in a subject by detecting sequence variation in one or more genes such as carboxypeptidase E (CPE) and insulin degradation enzyme (IDE). A kit, array, and device useful for such a method are also provided. In addition, the present invention provides a method for treating type 2 diabetes, cancer of all sites, or cardiovascular disease in patients who have been tested and shown to have the pertinent genetic variations. | 02-12-2015 |
20150027555 | MICROFLUIDIC PLATFORM AND METHOD FOR CONTROLLING THE SAME - A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure. | 01-29-2015 |
20150021499 | CONVERTING INFRARED LIGHT INTO BROADBAND VISIBLE LIGHT AT HIGH EFFICIENCY USING LANTHANIDE-SENSITIZED OXIDES - The present invention includes upconversion materials such as lanthanide-sensitized oxides that are useful for converting low-energy photons into high-energy photons. Because silicon-based solar cells have an intrinsic optical band-gap of 1.1 eV, low-energy photons having a wavelength longer than 1100 nm, e g., infrared photons, cannot be absorbed by the solar cell and used for photovoltaic energy conversion. Only those photons that have an energy equal to or greater than the solar cell's band gap, e.g., visible photons, can be absorbed and used for photovoltaic energy conversion. The oxides described herein transform photons having an energy less than the energy of a solar cell's band gap into photons having an energy equal to or greater than the energy of the band gap. When these oxides are incorporated into a solar cell, they provide more photons for photovoltaic energy conversion than otherwise would be available in their absence. Nearly 10% of the infrared photons incident on these oxides are upconverted into visible photons. This upconversion efficiency is more than twice as large as the upconversion efficiency for NaYF | 01-22-2015 |
20140357578 | NOVEL THERAPEUTIC APPROACH FOR POLYGLUTAMINE DEGENERATION - Compositions, methods, and kits are provided for reduction of (CAG) | 12-04-2014 |
20140329696 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 11-06-2014 |
20140329695 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 11-06-2014 |
20140315200 | DETERMINING FETAL GENOMES FOR MULTIPLE FETUS PREGNANCIES - Techniques are provided for determining inheritance of maternal and paternal haplotypes in preganncies with multiple fetuses. Maternal inheritance can be determined at loci where the mother is heterozygous and the paternally inherited alleles are known (e.g., the father is homozygous). Two types of loci may be used, where one type has the paternal allele appear on a first maternal haplotype, and another type has the paternal allele appear on a second maternal haplotype. Paternal inheritance can be determined from loci where the father is heterozygous and the maother is homozygous. Amounts of different alleles at each locus can be measured. A comparison of the amounts (e.g., using a fractional concentration of each allele and cutoffs) can be used to determine the haplotype inheritance. A haplotype can be linked to a condition of interest. | 10-23-2014 |
20140302506 | METHODS AND KITS FOR SELECTIVELY AMPLIFYING, DETECTING OR QUANTIFYING TARGET DNA WITH SPECIFIC END SEQUENCES - Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment. | 10-09-2014 |
20140277271 | DEVICE AND METHODS FOR PREVENTING KNEE SPRAIN INJURIES - Devices and methods for preventing knee sprain injuries. To protect the knee joint from knee sprain injuries, the device comprises a sensing part configured to sense data associated with knee motion; an analyzing part configured to analyze the knee motion data to determine a knee articulation; and a stimulating part configured to stimulate one or more lower limb muscles to initiate an earlier muscle reaction than would naturally occur in response to the determined knee joint articulation. The determined knee joint articulation may include knee joint articulation or a particular type of articulation such as a knee sprain movement associated with knee sprain. The methods involve sensing data associated with knee joint motion, analyzing the data to determine a knee joint articulation; and stimulating one or more lower limb muscles to initiate an early muscle reaction within the determined knee joint articulation. | 09-18-2014 |
20140274908 | EPIGENETIC BIOMARKER ADAMTS9 FOR DIAGNOSIS AND PROGNOSIS OF GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ADAMTS9 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing ADAMTS9 gene expression or activity. | 09-18-2014 |
20140272975 | DIAGNOSTIC METHOD - The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising:
| 09-18-2014 |
20140256560 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 09-11-2014 |
20140256559 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 09-11-2014 |
20140254796 | METHOD AND APPARATUS FOR GENERATING AND/OR PROCESSING 2D BARCODE - A computer-complemented method for generating a 2D barcode, including retrieving a predetermined private key, a predetermined digital signature method and an issuer identity of a 2D barcode; generating a signature for at least one data with the retrieved private key in accordance with the retrieved digital signature method; inserting the at least one printable data together with the generated signature and the retrieved issuer identity into a self-contained data unit; and creating a barcode image containing the self-contained data unit. | 09-11-2014 |
20140243212 | MATERNAL PLASMA TRANSCRIPTOME ANALYSIS BY MASSIVELY PARALLEL RNA SEQUENCING - Methods are provided for diagnosing pregnancy-associated disorders, determining allelic ratios, determining maternal or fetal contributions to circulating transcripts, and/or identifying maternal or fetal markers using a sample from a pregnant female subject. Also provided is use of a gene for diagnosing a pregnancy-associated disorder in a pregnant female subject. | 08-28-2014 |
20140241404 | NETWORK-CODING BUILDING BLOCKS AND DECOMPOSITION SCHEDULING BASED THEREON - Methods and systems are disclosed involving physical-layer network coding (PNC) atoms as building blocks of PNC networks to solve the scheduling problem in PNC networks using a decomposition framework based on PNC atoms. Ten PNC atoms and their straightforward network coding (SNC) counterparts are disclosed. Performance evaluation results are discussed, which indicate that decomposition based on the ten PNC atoms outperforms the traditional multi-hop (non-NC) scheduling by about 100%. Furthermore, decomposition based on the ten PNC atoms can yield performance gain of 40% or more compared with decomposition based on the TWRC atom alone. | 08-28-2014 |
20140195164 | NONINVASIVE PRENATAL MOLECULAR KARYOTYPING FROM MATERNAL PLASMA - Disclosed herein are methods, systems, and apparatus for detecting microamplifications or microdeletions in the genome of a fetus. In some embodiments, the method comprises receiving sequence tags for each of a plurality of DNA fragments in a biological sample; determining genomic positions for the sequence tags; determining whether the density of DNA in each of a plurality of genomic regions is aberrantly high or low; identifying as a microamplification a set of consecutive genomic regions having aberrantly high density; and identifying as a microdeletion a set of consecutive genomic regions having aberrantly low density. The biological sample may be a blood sample obtained noninvasively from a female subject pregnant with the fetus. | 07-10-2014 |
20140179799 | SMALL MOLECULE MODULATORS OF MICRORNA-34A - The present invention provides methods for identifying compounds that act as miR-34a modulators. The present invention also provides miR-34a modulators and compositions containing the modulators. The present invention further provides methods for treating diseases by administration of miR-34a modulators. | 06-26-2014 |
20140152523 | DEVICE FOR DECOUPLING ANTENNAS IN COMPACT ANTENNA ARRAY AND ANTENNA ARRAY WITH THE DEVICE - Devices and methods for decoupling two antennas in a compact antenna array and antenna arrays comprising the devices are disclosed. According to an embodiment, the device comprises a first resonator coupled with a source, the source being connected with a first antenna of the two antennas; and a second resonator coupled with the first resonator and a load, the load being connected with a second antenna of the two antennas, wherein the first and second resonators are configured so that a first coupling between the source and the first resonator, a second coupling between the first and second resonators, and a third coupling between the second resonator and the load are satisfied with a constraint that an isolation coefficient in a whole network composed of a first two-port network consisting of the two antennas and a second two-port network consisting of the first and second resonators in parallel approach zero as well as reflection coefficients of each port of the whole network are minimized. | 06-05-2014 |
20140120116 | TREATMENT OF CANCER USING SMAD3 INHIBITOR - The present invention resides in the discovery that Smad3, a key downstream mediator of TGF-β signaling, plays a critical role in development and progression of cancer. Thus, this application provides for a novel method of treating cancer by inhibiting Smad3 signaling, such as through administration of SIS3, an inhibitor of Smad3. Further provided are compositions and kits useful for treating cancer by way of inhibiting Smad3 signaling. | 05-01-2014 |
20140100121 | MUTATIONAL ANALYSIS OF PLASMA DNA FOR CANCER DETECTION - A frequency of somatic mutations in a biological sample (e.g., plasma or serum) of a subject undergoing screening or monitoring for cancer, can be compared with that in the constitutional DNA of the same subject. A parameter can derived from these frequencies and used to determine a classification of a level of cancer. False positives can be filtered out by requiring any variant locus to have at least a specified number of variant sequence reads (tags), thereby providing a more accurate parameter. The relative frequencies for different variant loci can be analyzed to determine a level of heterogeneity of tumors in a patient. | 04-10-2014 |
20140087426 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES (TALENS) - This application provides transcription activator-like effector nucleases (TALENs), polynucleotide sequences encoding the TALENs, expression cassettes for producing TALENs to target cleavage of nucleic acids, and methods of producing and using the TALENs. | 03-27-2014 |
20140080720 | FETAL GENOMIC ANALYSIS THAT ACCOUNTS FOR GC BIAS - Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus. | 03-20-2014 |
20140080715 | NON-INVASIVE DETERMINATION OF METHYLOME OF FETUS OR TUMOR FROM PLASMA - Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer. | 03-20-2014 |
20140069801 | COP2 LOADED RED PHOSPHORUS, PREPARATION AND USE OF THE SAME - Disclosed are a photocatalyst of CoP | 03-13-2014 |
20140066316 | DACH1 as a Biomarker for Diabetes - The present invention provides a method for assessing the presence and risk of developing type 2 diabetes or cardiovascular disease in a subject by detecting sequence variation in DACH1 (Dachshund homolog 1) gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating type 2 diabetes or cardiovascular disease in patients who have been tested and shown to have the pertinent genetic variations. | 03-06-2014 |
20140055447 | BINOCULAR VISUAL EXPERIENCE ENRICHMENT SYSTEM - In a computer-based graphics imaging system, binocular tone mapping is employed with an optimization-based framework to generate a binocular single vision image with more visual richness than a single tone-mapped image, the binocular tone mapping being guided by a binocular viewing comfort predictor (BVCP) metric in order to assure stable formation of binocularly tone-mapped image pairs, so that visual information content of the image pair can be maximized without triggering visual discomfort. | 02-27-2014 |
20140045181 | DETERMINING PERCENTAGE OF FETAL DNA IN MATERNAL SAMPLE - Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The percentage of fetal DNA can be calculated from the same or different data used to determine the cutoff value, and can use a locus where the mother is homozygous and the fetus is heterozygous. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT). | 02-13-2014 |
20140016759 | COMPOUND 6D-OFFSET SIMULATING PHANTOM AND QUALITY ASSURANCE PROGRAM FOR PRECISION IMAGE-GUIDED RADIOTHERAPY AND RADIOSURGERY - This invention provides a device for checking the performance of an image-guided radiation therapy (IGRT) apparatus. The device (referred to here as a phantom) has a central body with detectable markers, rotatably suspended on a ball joint so that the pitch, roll, and yaw may be adjusted. The body is secured against a base plate, which in turn may be positioned laterally, longitudinally, and vertically within the patient treatment area. Thus, the phantom can be adjusted through six degrees of freedom so as to simulate patient positioning. To perform quality control, the phantom is secured at a predetermined offset, and the position is detected by the IGRT apparatus. The robotic couch is then allowed to compensate, a second measurement is made. The measured values are compared with the predetermined offset to assess both the accuracy in detecting the position of the phantom, and the accuracy of the mechanical correction. | 01-16-2014 |
20130337443 | METHODS FOR DETECTING DNA PRIOGINATING FROM DIFFERENT INDIVIDUALS - In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample. | 12-19-2013 |
20130329230 | OPTICAL SENSING DEVICES AND METHODS FOR DETECTING SAMPLES USING THE SAME - An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit. | 12-12-2013 |
20130323731 | DETERMINATION OF THE DEPTH COVERAGE OF THE FETAL GENOME - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 12-05-2013 |
20130310263 | DIAGNOSING CANCER USING GENOMIC SEQUENCING - Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer. | 11-21-2013 |
20130308719 | SUPERPOSITION CODING FOR NETWORK COMMUNICATION - The apparatus, systems, and methods described herein may operate to encode a first part of a message into an index, and to encode a second part of the message into a sequence of matrices such that at least one of row spaces or rank of the matrices is determined by the index. Additional apparatus, systems, and methods are described. | 11-21-2013 |
20130267425 | NONINVASIVE PRENATAL DIAGNOSIS OF FETAL TRISOMY BY ALLELIC RATIO ANALYSIS USING TARGETED MASSIVELY PARALLEL SEQUENCING - Whether a fetus has an aneuploidy associated with a first chromosome is detected using ratios of alleles detected in a maternal sample having a mixture of maternal and fetal DNA. DNA from the sample is enriched for target regions associated with polymorphic loci and then sequenced. Polymorphic loci (e.g., single nucleotide polymorphisms) in the target regions with fetal-specific alleles are identified on a first chromosome and on one or more reference chromosomes. A first ratio of the fetal-specific alleles and shared alleles is determined for the loci on the first chromosome. A second ratio of the fetal-specific alleles and shared alleles is determined for the loci on the reference chromosome(s). A third ratio of the first and second ratio can be compared to a cutoff to determine whether an aneuploidy is present, and whether the aneuploidy is maternally-derived or paternally-derived. | 10-10-2013 |
20130253844 | IDENTIFYING A DE NOVO FETAL MUTATION FROM A MATERNAL BIOLOGICAL SAMPLE - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 09-26-2013 |
20130249651 | DIELECTRIC RESONATOR FILTERS, METHODS OF MANUFACTURING THE SAME AND DIPLEXER/MULTIPLEXERS USING DIELECTRIC RESONATOR FILTERS - A dielectric resonator filter and a method of manufacturing the same are disclosed. The dielectric resonator includes a metal housing having a top surface and a bottom surface and defining a resonator cavity, and a dielectric rod located within the resonator cavity. The dielectric rod is short-circuited at both the top surface and the bottom surface. A plurality of holes are formed in the dielectric rod parallel to an axis of the dielectric rod and a plurality of apertures are formed on the top surface corresponding to the positions of the holes, respectively. A plurality of screws are inserted into the holes through the apertures, respectively. The dielectric resonator supports dual TM | 09-26-2013 |
20130245961 | METHODS FOR ANALYZING MASSIVELY PARALLEL SEQUENCING DATA FOR NONINVASIVE PRENATAL DIAGNOSIS - This invention provides several ways of managing GC bias that occurs during seequencing and analysis of genomic DNA. Maternal plasma can be used as a source of fetal DNA for analysis. DNA segments or tags obtained from the plasma can be aligned with a chromosomal region of interest and with an artificial reference chromosome assembled from regions of the genome having matching GC content. This technology can be used, for example, to detect and evaluate aneuploidy and other chromosomal abnormalities | 09-19-2013 |
20130237431 | SIZE-BASED ANALYSIS OF FETAL DNA FRACTION IN MATERNAL PLASMA - A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA. | 09-12-2013 |
20130209447 | METHODS AND KITS FOR PREDICTING THE RISK OF DIABETES ASSOCIATED COMPLICATIONS USING GENETIC MARKERS AND ARRAYS - A method for diagnosing a genetic predisposition in a subject for diseases, disorders or conditions including a diabetic kidney complication such as kidney disease of type 2 diabetes or type 1 diabetes, end stage renal disease (ESRD) due to type 2 diabetes, ESRD due to hypertension in type 2 diabetes, ESRD due to type 1 diabetes; cardiovascular diseases due to type 2 diabetes or type 1 diabetes such as atherosclerotic peripheral vascular disease, hypertension, ischemic cardiomyopathy, and myocardial infarction due to type 2 diabetes or type 1 diabetes; and cerebrovascular accident due to type 2 diabetes. At least one polynucleotide is analyzed to detect a single nucleotide polymorphism (SNP), in which the presence of the single nucleotide polymorphism indicates that the subject is suffering from, at risk for, or suspected of suffering from the diseases, disorders or conditions. Also provided is an array or kit for diagnosing the genetic predisposition. | 08-15-2013 |
20130190194 | DETERMINATION OF GENE EXPRESSION LEVELS OF A CELL TYPE - Methods, systems, and compositions can determine gene expression level of a specified cell-type subpopulation by direct analysis of a cell mixture sample composed of multiple subpopulations of various cell-types without the need of prior separation of the component cell-type subpopulations. A target gene and a reference gene can be identified as being informative for a specific cell-type subpopulation when at least 50% of the gene's transcripts in the cell mixture are from the subpopulation. This relative expression level in the cell mixture of the informative target and reference genes can correlate to the relative expression when measured in the isolated subpopulation. Thus, a similar biomarker can be obtained without the difficult step of isolating the cells of the subpopulation. | 07-25-2013 |
20130163428 | METHOD AND SYSTEM FOR IMPROVED TCP PERFORMANCE OVER MOBILE DATA NETWORKS - Performance of transport protocols over a mobile data network is improved by a mobile accelerator, which performs protocol optimizations on-the-fly without requiring any modification to server or client protocol implementations in the operating systems of the server or client. The proposed mobile accelerator is compatible with existing TCP protocol implementations at the server and the client device, without server/client OS modification. | 06-27-2013 |
20130157879 | BIOMARKER DACT1 FOR GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the DACT1 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing DACT1 gene expression or activity. | 06-20-2013 |
20130122058 | ENGINEERING OF POLYMER-STABILIZED NANOPARTICLES FOR DRUGS WITH LOG P VALUES BELOW 6 BY CONTROLLED ANTISOLVENT PRECIPITATION - The present invention provides organic nanoparticles that include a molecule having a Log P value of about 3 or above, an amphiphilic diblock copolymer or a surfactant, and a pharmaceutically-acceptable hydrophilic polymer. The present invention also provides methods of making these nanoparticles, e.g., by flash nanoprecipitation, with control over particle size and surface properties. The methods of the present invention provide a means for co-precipitating a water-insoluble compound with an amphiphilic stabilizer within a few milliseconds. The nanoparticles of the present invention exhibit high drug loading, e.g., 50% w/w, and can be produced with a mean particle size less than 200 nm and with a narrow particle size distribution. | 05-16-2013 |
20130120088 | METAL WAVEGUIDE TO LAMINATED WAVEGUIDE TRANSITION APPARATUS AND METHODS THEREOF - Disclosed is a transition apparatus for transitioning wide frequency band electromagnetic waves between the metal waveguide and the laminated waveguide. The transition apparatus includes a top conductive layer, a bottom conductive layer, a conductive wall, and a transition interior. The conductive wall is formed along a substrate of the laminated waveguide and electrically connected the top conductive layer and the bottom conductive layer. The transition interior is defined by the top conductive layer, the bottom conductive layer, and the conductive wall. The conductive wall further comprises a plurality of stubs extending from an inner side of the wall into the transition interior, the plurality of stubs divide the transition interior into three or more resonator cavities for transitioning wide frequency band electromagnetic waves between the metal waveguide and the laminated waveguide. | 05-16-2013 |
20130102661 | IRRIGATION SOLUTIONS CONTAINING ASCORBIC ACID OR ITS SALTS AND USE THEREOF - An irrigation solution containing about 15-50 mM ascorbic acid and/or a pharmaceutically acceptable salt thereof, and electrolytes, and their uses in a surgery, a surgical manipulation, a medical process or in promoting the healing of a tendon or ligament injury in a subject. | 04-25-2013 |
20130084566 | FETAL METHYLATION MARKERS - This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions. | 04-04-2013 |
20130083654 | METHOD FOR LINK BUFFER SIZE AND QUEUE LENGTH ESTIMATION FOR BANDWIDTH-VARYING MOBILE DATA NETWORKS - A sum-of-delays algorithm in a digital mobile communication bandwidth-varying network is employed to estimate link buffer size and queue length in an undying network connection. In particular, mechanisms associated with the process compensate for link bandwidth variations. In a particular embodiment, passive estimation are employed to implement the process by simply measuring the in-band data packet timings to perform estimation, thus eliminating the need for transmission of extra measurement packets. This method enables the integration of the link buffer size estimation algorithm into existing transport protocols such as TCP to optimize flow and congestion controls. As part of the invention, a new congestion control method called TCP Queue-length-Adaptive (TCP-QA) is developed to employ the sum-of-delays algorithm in the TCP sender computer to control the data flow in a TCP connection. Compared to existing TCP variants, TCP-QA can achieve significantly better network bandwidth utilization in bandwidth-varying networks. | 04-04-2013 |
20130072544 | DETECTION OF HBX/8P11 HYBRID SEQUENCE IN HUMAN HEPATOCELLULAR CARCINOMA - The present invention provides a method for diagnosing a particular type of human hepatocellular carcinoma (HCC), HBx/8p11-positive HCC, in a subject by detecting the presence of a specific, non-naturally occurring polynucleotide sequence that indicates integration of a portion of the human hepatitis B virus (HBV) sequence into the human genome on chromosome 8 in the 8p11 integration region. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating an HBx/8p11-positive HCC. | 03-21-2013 |
20130065836 | BIOMARKER FOR GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the BCL6B gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing BCL6B gene expression or activity. | 03-14-2013 |
20130059733 | MOLECULAR TESTING OF MULTIPLE PREGNANCIES - Methods, systems, and apparatus are provided for determining zygosity of a multiple-fetus pregnancy using a biological sample taken from the mother. The fetal and maternal DNA in the sample (e.g. plasma) can be analyzed for a particular chromosomal region to identify genetic differences in the fetuses. For example, a normalized parameter for the measure of a primary or secondary allele can show variances for different chromosomal regions when fetuses are dizygotic. Such a variance can be determined relative to an expected value if the fetuses were genetically identical. Statistical methods are provided for analyzing the variation of the normalized parameters to determine fetal DNA concentration and the maternal-fetal mixed genotype at various loci. Parental genotype and haplotype information can also be used to identify inheritance of different parental haplotypes to indicate genetic differences among the fetuses. | 03-07-2013 |
20130053866 | SURGICAL ROBOT WITH HYBRID PASSIVE/ACTIVE CONTROL - A surgical robot with seven degrees of freedom, including various types of joints, offers a hybrid active-passive control for operation both manually and by programmed navigation. One of the degrees of freedom allows the robot to be moved efficiently around the axis of a patient's body to provide ample workspace for surgical procedures in an operating room. | 02-28-2013 |
20130041427 | METHODS AND DEVICES FOR PREVENTING ANKLE SPRAIN INJURIES - Devices and methods for preventing ankle sprain injuries. To protect the ankle joint from acute ankle supination or inversion sprain injuries, the device comprises a sensing part configured to sense data of an ankle motion; an analyzing part configured to analyze the data to judge whether the motion is a sprain motion; and a stimulating part configured to stimulate one or more lower limb muscles against the motion in light of a result of the analyzing. The method also involves sensing data of an ankle motion; analyzing the data to judge whether the motion is a sprain motion; and stimulating one or more lower limb muscles against the motion if the motion is a sprain motion. | 02-14-2013 |
20130040824 | DETECTION OF GENETIC OR MOLECULAR ABERRATIONS ASSOCIATED WITH CANCER - Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. Multiple loci are used for each chromosomal region. Such imbalances can then be used to diagnose (screen) a patient for cancer, as well as prognosticate a patient with cancer, or to detect the presence or to monitor the progress of a premalignant condition in a patient. The severity of an imbalance as well as the number of regions exhibiting an imbalance can be used. A systematic analysis of non-overlapping segments of a genome can provide a general screening tool for a sample. Additionally, a patient can be tested over time to track severity of each of one or more chromosomal regions and a number of chromosomal regions to enable screening and prognosticating, as well as monitoring of progress (e.g. after treatment). | 02-14-2013 |
20130025956 | GRIPPING DEVICES - A gripping device comprising: a house; at least one gripper configured with at least one claw, the claw being configured with a pair of first phalanxes linked to the house at a first joint, and a pair of second phalanxes linked to the first phalanxes at a second joint; a first actuator arranged on the first joint; a second actuator arranged on the second joint; and a motor configured to enable the first and the second actuators co-operate so as to push the second phalanxes off a gripping substrate, or to push the second phalanxes back to the gripping substrate. | 01-31-2013 |
20120330432 | FINGER PROSTHESIS - A finger prosthesis comprising a tip for simulating different functions of a finger and a ring for attaching the prosthesis to a stump. The finger prosthesis further includes a joint coupled between the tip and the ring, wherein the joint includes an interlocking mechanism configured to allow the joint to rotate at lockable intervals so as to lock the tip into different positions during a flexion period of the finger prosthesis. | 12-27-2012 |
20120330193 | DEVICES AND METHODS FOR MEASURING JOINT ROTATION OF AN OBJECT - A device and method for measuring joint rotation of an object, which provides an objective quantification of a laxity of the joint, especially in external and internal rotation. The device for measuring rotation of a first joint of an object comprises an orthosis for immobilizing a second joint of the object, the second joint being connected to the first joint by a bone of the object; a torque sensor fixed to the orthosis for monitoring a value of torque applied to the second joint, the applied torque being transferred to the first joint via the bone; and a motion sensor for tracking a rotational displacement of the bone occurring under the applied torque. | 12-27-2012 |
20120304492 | LAST, METHOD FOR MANUFACTURING THE LAST AND FOOTWEAR MADE FROM THE LAST - Provided are a last for making an article of footwear, an article of footwear that is made from the last and a method for manufacturing the last. The last has dimensions defined by a last length, a joint girth, an instep girth and a heel breadth. In the last, a ratio of the last length to the joint girth is between 0.920 and 0.976, a ratio of the last length to the instep girth is between 0.945 and 1.006, and a ratio of the last length to the heel breadth is between 0.255 and 0.259. The last can provide a shape suitable for comfortably accommodating the elderly foot. | 12-06-2012 |
20120297432 | REPLICATION DECISION IN P2P VOD SYSTEMS - Provided are systems and methods for making a replication decision in a P | 11-22-2012 |
20120266044 | NETWORK-CODING-BASED DISTRIBUTED FILE SYSTEM - A network-coding-based distributed file system (NCFS) is disclosed. The NCFS may include a file system layer, a disk layer, and a coding layer. The file system layer may be configured to receive a request, for an operation on data within a data block, to specify the data block to be accessed in a storage node of a plurality of storage nodes. The disk layer may provide an interface to the file system to provide access the plurality of storage nodes via a network. The coding layer may be connected between the file system layer and the disk layer, to encode and/or decode functions of fault-tolerant storage schemes based on a class of maximum distance separable (MDS) codes. Additional apparatus, systems, and methods are disclosed. | 10-18-2012 |
20120257164 | METHOD AND DEVICE FOR RETINAL IMAGE ANALYSIS - The present application provides methods and devices for diagnosing and/or predicting the presence, progression and/or treatment effect of a disease characterized by retinal pathological changes in a subject. | 10-11-2012 |
20120226136 | METHODS AND DEVICES OF DETECTION, GRADING, MONITORING, AND FOLLOW-UP OF FIBROSIS - Methods and devices of detection, grading, monitoring and follow-up fibrosis in a tissue or an organ of a subject using nuclear magnetic resonance imaging, particularly spin-lattice relaxation time in the rotating frame, which is also called spin lock relaxation time (T1rho). | 09-06-2012 |
20120208708 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 08-16-2012 |
20120190029 | METHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS - In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample. | 07-26-2012 |
20120189587 | CELL SHEET FOR TISSUE REPAIR AND BIO-ARTIFICIAL TISSUE ENGINEERING, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME - Disclosed is a cell sheet for tissue repair and bio-artificial tissue engineering. The cell sheet comprises treated stem cell embedded in its self-secreted extracellular matrix (ECM) and formed a cell sheet. The cell sheet is formed by isolating the stem cell, expanding the stem cell and treating the stem cell with biological factors or factors leading to the production of biological factors, to induce its differentiation, production of extracellular matrix and formation of a cell sheet in vitro. The cell sheet is used as a bioactive material or as an acellular material for the promotion of tissue repairs or used to form a bio-artificial organ for tissue replacement. The cell sheet of the present invention eliminates the need to use scaffolds for cell delivery. The cell sheet facilitates in vivo cell transplantation and provides some tensile mechanical strength for bearing early mechanical load during tissue repair. | 07-26-2012 |
20120189130 | METHOD AND SYSTEM FOR SELF-MANAGED SOUND ENHANCEMENT - A system and method are provided for capturing hearing characteristics from self-administered hearing tests or from professionally administered hearing tests, including loudness tolerance levels as at different sound frequencies, as an individualized audiological profile for automatically enhancing audio to complement and address as closely as possible an individual's hearing deficits. The user may self-administer a hearing test on a convenient personal apparatus, such as a smartphone. The system includes the ability for capturing an environment profile. The user's hearing is protected against harm in the enhanced audio setting while being provided with the option of a “enhanced hearing” experience. The invention is useful for any individual seeking an enhanced hearing experience, whether having hearing within normal range or hearing that is impaired. Thus the system is useful as a hearing aid. | 07-26-2012 |
20120170668 | HIGH PERFORMANCE LOOP FILTERS IN VIDEO COMPRESSION - Disclosed are a filter and a method to improve the objective and subjective video coding performance The filter comprises: a parameter estimation unit configured to determine means and variances from a pilot frame; a filter unit configured to receive quantized residual coefficients in video coding process and restore coefficients from the quantized residual coefficients and the determined means and variances; an inverse ICT unit configured to apply an inverse ICT to the restored coefficients to obtain a filtered frame; a rate-distortion optimization unit configured to determine a quadtree block partition index; and an adaptive block selection unit configured to select final blocks according to quadtree block partition index, the final blocks being utilized to form the filtered frame. | 07-05-2012 |
20120163385 | SYSTEMS AND METHODS TO IMPROVE PERFORMANCE OF TCP OVER LARGE BANDWIDTH-DELAY-PRODUCT NETWORKS - The apparatus, systems, and methods described herein may operate to receive at least one data packet from a transmitter connected to a first network. A packet forwarding time may be scheduled for the at least one data packet. The at least one data packet may be forwarded to a receiver connected to a second network based on the packet forwarding time such that transmission of the at least one data packet prevents a buffer overflow at the receiver. | 06-28-2012 |
20120134669 | METHODS AND SYSTEMS FOR MULTICAST CONTROL - Disclosed are a system and a method for controlling multicast data. The system may comprise: a plurality of transceivers, each of which comprises a laser configured to generate an optical carrier, the generated optical carrier being modulated by electrical downstream p-t-p data so as to generate optical downstream p-t-p IRZ signal; a PM configured to modulate the generated optical downstream p-t-p IRZ signal by electrical multicast data so as to generate orthogonally modulated signal; and a DI configured to demodulate the orthogonally modulated data and has a frequency response peak or dip in response to the demodulating, wherein an offset of a laser center wavelength of the laser from the frequency response peak or dip is adjustable so as to selectively enable or disable the multicast data. | 05-31-2012 |
20120128009 | SUBSET CODING FOR COMMUNICATION SYSTEMS - A method for data encoding and associated decoding is based on the concept of batches that allows transmission of a large data file from a source node to multiple destination nodes through communication networks that may employ network coding wherein sparse matrix codes are employed in a network setting. A batch is a set of packets generated by a subset of the input packets using sparse matrix encoder. A sparse matrix encoder can be called repeatedly to generate multiple batches. The batches are generally independent of one another. During the transmission in a communication network, network coding can be applied to packets belonging to the same batch to improve the multicast throughput. A decoder recovers all or at least a fixed fraction of the input packets using received batches. The input packets can be pre-coded using a pre-code before applying sparse matrix codes. The data file can then be reconstructed by further decoding the pre-code. | 05-24-2012 |
20120102132 | LOAD BALANCING AND ADMISSION SCHEDULING IN PULL-BASED PARALLEL VIDEO SERVERS - A pull-based parallel video server system and method of implementation useful in an on-demand video system includes a plurality of slave admission schedulers operating in parallel with a master admission scheduler to back up the master admission scheduler that controls access to an array of pull-based video servers according to a protocol that accounts for jitter and loss of packets, as well as network delays. A transport protocol is provided that improves video data throughput under such conditions. To determine the architecture and functional requirements of the redundant admission schedulers, an analytical tool in the form of a performance model has been developed that incorporates network delays, delay jitters and packet losses on the communication links between the clients, schedulers and servers. | 04-26-2012 |
20120101074 | METHOD AND MEDICATION FOR PREVENTION AND TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA - An effective dose of a pharmaceutically acceptable phenylbutyrate salt such as sodium phenylbutyrate applied to human ocular tissues or through injection or other means prevents ocular hypertension and treats glaucoma in humans, leading to a new medical therapy for lowering the intraocular pressure via a mechanism different from the existing glaucoma medications. This compound can be formulated in combination with topical or other forms of steroids in prevention and treatment of steroid induced ocular hypertension and glaucoma. | 04-26-2012 |
20120079543 | METHODS FOR REPLICATING MEDIA CONTENTS AND P2P VOD SYSTEMS - There is disclosed a method for replicating media contents in a P2P VoD system comprising a plurality of peers. The method may comprise: determining that a candidate media unit shall be replicated into a local storage of one of the peers; checking whether said local storage has enough space to store the candidate media unit; if not, selecting one media unit previously stored in said local storage to be replaced; and replacing the selected media unit by the candidate media unit. | 03-29-2012 |
20120069908 | Generation of an Order-2N Transform from an Order-N Transform - Apparatus, systems and techniques based on an integer transform for encoding and decoding video or image signals, including transform of encoding and decoding of image and video signals and generation of an order-2N transform W from an order-N transform T in the field of image and video coding. For example, a retrieving unit is configured to retrieve an order-N transform T, where N is an integer; a deriving unit is configured to derive an order-2N transform W from the retrieved order-N transform T, and a transforming unit configured to generate an order-2N data Z using the derived transform W. | 03-22-2012 |
20120031719 | SELF-POWERED AND SELF-SENSING MAGNETORHEOLOGICAL DAMPERS - Disclosed is a self-powered and self-sensing MR damping device, comprising: an MR damper part having a damper piston assembly and a damper cylinder, the damper piston assembly being movable relative to the damper cylinder under an external excitation; a power generator configured to generate electrical power according to the relative movement between the damper piston and the cylinder assembly; and an electrical circuit configured to estimate said relative movement to output a damper driving current based on the estimated velocity, wherein the MR damper part is further configured to generate a damper force according to the damper driving current. An electrical circuit for the device is also provided. | 02-09-2012 |
20120003650 | MARKER FOR PRENATAL DIAGNOSIS AND MONITORING - The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status. | 01-05-2012 |
20120003637 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 01-05-2012 |
20120003636 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 01-05-2012 |
20120002968 | SYSTEM AND METHODS FOR QUANTUM KEY DISTRIBUTION OVER WDM LINKS - A system and a method for quantum key distribution between a transmitter and a receiver over wavelength division multiplexing (WDM) link are disclosed. The method includes providing one or more quantum channels and one or more conventional channels over the WDM link; assigning a different wavelength to each of the one or more quantum channels and each of the one or more conventional channels; transmitting single photon signals on each of the one or more quantum channels; and transmitting data on each of the one or more conventional channels. The data comprises either conventional data or trigger signals for synchronizing the transmission of the single photon signals on the quantum channels. All channels have wavelengths around 1550 nm. The WDM link can be a 3-channel WDM link comprising two quantum channels for transmitting single photon signals and one conventional channel for transmitting conventional data or triggering signals. | 01-05-2012 |
20110318742 | MICRO RNA MARKERS FOR COLORECTAL CANCER - There are disclosed methods for diagnosing or providing a prognosis for colorectal cancer cells in a biological sample, the method comprising the steps of detecting the presence in the biological sample of an RNA sequence at least about 98% similar over the full sequence length to a sequence selected from the group consisting of SEQ ID NOS:1-7, wherein the presence of the RNA sequence is indicative of the presence of colorectal cancer cells in the sample. Probes for detecting and providing a prognosis for colorectal cancer are also disclosed. | 12-29-2011 |
20110318734 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 12-29-2011 |
20110317919 | PRODUCING STRUCTURE-BASED ASCII PICTURES - Provided are methods and devices for producing an ASCII picture from a vector outline image. The method comprises rasterizing the vector outline image into a plurality of grid cells, at least one of which has a reference image; matching each reference image with an ASCII character based on log-polar histograms thereof; and gathering all matched ASCII characters to form the ASCII picture. | 12-29-2011 |
20110317538 | OPTICAL PICKUP ASSEMBLIES AND DRIVE SYSTEMS WITH THE SAME - Disclosed are a pickup device assembly and an optical drive system. The assembly may comprise: a laser generator for generating laser beams; an objective lens; and at least one piezoelectric actuator for generating bending moments once applied with voltages, wherein the generated bending moments move the objective lens such that the laser beams are focused by the objective lens and then aim at concentric spiral data tracks of a disc with a strongest reflected signal of the laser beams from the disc. | 12-29-2011 |
20110306999 | STIMULATION OF SPECIFIC ACUPUNCTURE POINTS FOR VISION IMPROVEMENT - This invention relates to the stimulation of a specific combination of 5 acupuncture points including EX-HN5 (taiyang), BL59 (fuyang), BL2 (cuanzhu), GV20 (baihui), and LI4 (hegu) and its effectiveness in improving vision in the treatment of anisometropic amblyopia. | 12-15-2011 |
20110292394 | OPTICAL SENSING DEVICES AND METHODS FOR DETECTING SAMPLES USING THE SAME - Disclosed are optical sensing devices and methods for detecting samples using the same. The optical sensing device comprises a source unit configured to generate a polychromatic light beam containing p-polarized and s-polarized components; an interferometric unit configured to split the light beam into a probe beam passing a first path and a reference beam passing a second path and to recombine the probe beam output from the first path and the reference beam output from the second path; a sensing unit disposed in the first path to introduce a first SPR effect associated with a target sample to the probe beam; and a detection unit configured to detect target sample characteristics by obtaining an intensity spectrum of the recombined light beam. The introduction of a polychromatic light source in the optical sensing device increases the detection dynamic range and the detection sensitivity. | 12-01-2011 |
20110276277 | SIZE-BASED GENOMIC ANALYSIS - Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus. | 11-10-2011 |
20110269123 | MARKER FOR GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER - In embodiments the expression or methylation of the PAX5 gene is used as a marker for the diagnosis and prognosis of gastric cancer. In further embodiments methods for detecting gastric cancer are disclosed as are methods for inhibiting the growth of gastric cancer. | 11-03-2011 |
20110262910 | MARKER FOR COLON CANCER AND METHOD FOR DETECTING COLON CANCER - In embodiments the expression or methylation of the TBX5 gene is used as a marker for the presence and prognosis of colon cancer. In further embodiments methods for detecting colon cancer are disclosed as are methods for inhibiting the growth of colon cancer cells. | 10-27-2011 |
20110246603 | METHODS AND DEVICES FOR LIVE STREAMING USING PRE-INDEXED FILE FORMATS - Provided are methods and devices for live streaming a plurality of media data units using a media file format. The method may comprise the steps of pre-generating indexing information of each of the media data units; encoding each of the media data units; transmitting the pre-generated indexing information to a receiver; and transmitting a sequence of the encoded media data units to the receiver after the transmission of the indexing information. | 10-06-2011 |
20110219142 | Path Selection In Streaming Video Over Multi-Overlay Application Layer Multicast - A method and a tool based on achievable bandwidth as a metric are provided for selecting paths for overlay construction in an application layer multicast system. An in-band bandwidth probing tool according to the invention can estimate achievable bandwidth, i.e., the data throughput that can be realized between two peers over the transport protocol employed. The tool can determine the amount of extra bandwidth available in the target network path so that excess data traffic can be diverted from congested path without causing new congestion in the target path. | 09-08-2011 |
20110201840 | TERMINAL 1,1-DISUBSTITUTED ALKENES, METHOD OF MAKING AND USING THEREOF - Disclosed is a process for preparing terminal 1,1-disubstituted alkenes and is to compounds prepared therewith. | 08-18-2011 |
20110183330 | Analysis for Nucleic Acids by Digital PCR - The present invention provides a method for analyzing nucleic acids for their lengths and relative abundance in a sample, based on digital amplification of individual template molecules. This invention has many applications, including those in noninvasive prenatal diagnosis, transplantation monitoring, and the detection and monitoring of cancers and virus-associated diseases. | 07-28-2011 |
20110170413 | SYSTEMS AND METHODS FOR DETERMINING TOP SPREADERS - Disclosed are a method and a system for determining top spreaders in high speed network. The method may comprise: sampling a plurality of packets from the plurality of hosts during an interval of time; determining a difference between a count and a count error for each host based on the sampled packets; ranking the hosts based on the determined difference to identify a first set of hosts that are top in the ranked hosts; and selecting a second set of hosts from the first set of hosts as the top spreaders. | 07-14-2011 |
20110156871 | FREQUENCY CALIBRATING - Disclosed are a device and a method for calibrating a frequency of a transponder applicable to an RFID system. The device may comprises: a pulse generating unit configured to generate a sequence of pulses based on a PIE symbol sequence from an interrogator of the RFID system; a counting unit configured to count clock cycles of a clock signal based on the generated pulses, wherein the transponder operates based on the clock signal; and a calibrating unit configured to calibrate a frequency of the clock signal towards a target frequency based on a comparison of the counted number of clock cycles with a reference number associated with the target frequency. | 06-30-2011 |
20110150324 | METHOD AND APPARATUS FOR RECOGNIZING AND LOCALIZING LANDMARKS FROM AN IMAGE ONTO A MAP - Method and apparatus for recognizing landmark buildings in an image and then locating the recognized landmark buildings onto a map together with related information wherein a first database is employed to store models formed by mathematical set descriptions of landmark buildings which are learned from a set of training images of a model-learning module captured by an imaging device for each building, and a second database is employed to store the related information of each landmark building. The model of each landmark building is represented as a set of features and the geometric relationship between them by clustering the salient features extracted from a set of training images of the landmark building. | 06-23-2011 |
20110148897 | Apparatus and methods for processing images - The disclosure relates to apparatus and methods for processing images. The method for generating a manga-style image from an input image comprises: generating a line drawing from the input image; generating a manga-style screening from an input image; and overlaying the line drawing and the manga-style screening to generate the manga-style image. The method can provide a high efficient way for auto-generating manga images. | 06-23-2011 |
20110143342 | NEW FETAL METHYLATION MARKERS - This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions. | 06-16-2011 |
20110137612 | METHODS AND SYSTEMS FOR ESTIMATING LONGITUDINAL RELAXATION TIMES IN MRI - A method and a system for estimating a longitudinal relaxation time in magnetic resonance imaging. The method includes scanning at least one object to form a sequence of data with a plurality of flip angles; regressing linearly the formed sequence of data based on a first signal intensity model associated with the flip angles to obtain an initial estimation for said longitudinal relaxation time; and regressing nonlinearly the formed sequence of data based on a second signal intensity model associated with the flip angles so as to obtain a final estimation for the longitudinal relaxation time, in which the initial estimation is used as an initial guess for the longitudinal relaxation time based on the second signal intensity model. | 06-09-2011 |
20110098192 | METHODS FOR ASSESSING LIVER PATHOLOGIES - The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mRNA with a standard control. | 04-28-2011 |
20110096236 | Parametric Interpolation Filter For Motion-Compensated Prediction - In a motion compensated prediction process, a parametric interpolation filter (PIF) device is provided that takes into account the time-variant statistics of video sources, the filter being represented by a model determined by five parameters instead of by individual coefficients. The parameters are calculated and coded on a frame-by-frame basis to minimize the energy of the prediction error for each frame. The model design is based on the fact that high frequency energy of an HD video source is mainly distributed along the vertical and horizontal directions of a frame. A PIF device with the method according to the invention overcomes this obstacle because it represents each filter using only five parameters, all of which are encoded using sufficiently high precision without substantially increasing overhead. | 04-28-2011 |
20110085741 | METHODS AND APPARATUS FOR EDITING IMAGES - Methods and apparatus for editing an image having focused and defocused objects are provided in the present application. According to an embodiment, the method comprises: determining blurriness of edge pixels in the image; propagating the determined blurriness to non-edge pixels adjacent to each of the edge pixels so as to determine blurriness of the non-edge pixels; estimating a focus map based on the blurriness of the edge pixels and the non-edge pixels to identify the defocused objects and the focused objects; and refocusing the defocused objects based on the focus map or defocusing at least one of the defocused objects and the focused objects. | 04-14-2011 |
20110071417 | Systems and methods for reproducing body motions via networks - Disclosed are systems and methods for reproducing a body motion via a network, and systems, devices and methods for identifying a body motion. In an embodiment, the system for reproducing a body motion via a network comprises a sensor configured to capture a surface electromyography signal generated by a body motion of a user at a first terminal in the network; a processor configured to receive the signal from the sensor and identify the body motion based on the received signal, and send information associated with the body motion to a second terminal in the network, the processor being located in the first terminal; and a mechanical member configured to receive the information associated with the body motion from the second terminal and reproduce the body motion based on the received information. | 03-24-2011 |
20110039724 | METHOD FOR DETECTING CHROMOSOMAL ANEUPLOIDY - The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy. | 02-17-2011 |
20110033841 | METHODS AND KITS FOR DIAGNOSIS, PROGNOSIS OR MONITORING OF EPSTEIN-BARR VIRUS (EBV)-ASSOCIATED CANCER - Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monitoring of cancer are also disclosed. | 02-10-2011 |
20110027176 | HOMING PEPTIDE FOR TUMOR VASCULATURE - This invention provides for a 9 mer peptide (CTPSPFSHC SEQ ID NO:1) that selectively binds to the tumor vasculature supporting tumors of the alimentary canal. The homing peptide has both diagnostic and therapeutic uses. | 02-03-2011 |
20100329117 | Network Traffic Accelerator - In a packet communication system with large bandwidth delay product (BDP) and employing Transmission Control Protocol (TCP), the reported advertised window size as advertised by a receiver is employed only as an indication of window size and not as a throughput limit so that more data is sent than the amount specified by the advertised window size. Since the receiver can process all incoming TCP packets, the receiving buffer is consistently near empty. Since the TCP's advertised window size is not accepted as the absolute amount of buffer space available at the receiver, the sender is not constrained by the absolute value of the receiver's advertised window size and instead can transmit more data than the absolute value of the advertised window, enabling the system to increase the actual window size without modifying the link ends. This improved large-BDP-capable protocol is denoted TCP-SC. | 12-30-2010 |
20100323352 | Marker for Prenatal Diagnosis and Monitoring - The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status. | 12-23-2010 |
20100318602 | LOAD BALANCING AND ADMISSION SCHEDULING IN PULL-BASED PARALLEL VIDEO SERVERS - A pull-based parallel video server system and method of implementation useful in an on-demand video system includes a plurality of slave admission schedulers operating in parallel with a master admission scheduler to back up the master admission scheduler that controls access to an array of pull-based video servers according to a protocol that accounts for jitter and loss of packets, as well as network delays. A transport protocol is provided that improves video data throughput under such conditions. To determine the architecture and functional requirements of the redundant admission schedulers, an analytical tool in the form of a performance model has been developed that incorporates network delays, delay jitters and packet losses on the communication links between the clients, schedulers and servers. | 12-16-2010 |
20100311046 | METHOD FOR THE DETECTION OF CHROMOSOMAL ANEUPLOIDIES - The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy. | 12-09-2010 |
20100305694 | SCLERAL BUCKLES FOR SUTURELESS RETINAL DETACHMENT SURGERY - A set formed of a scleral buckle and an encircling band is provided for use in connection with retinal detachment surgery to enable the implantation of both the scleral buckle and encircling band free of any suture. A self-assembling scleral buckle-encircling band combination is secured in place by surface scleral tunnels operative as belt loops to enable the securing of a scleral buckle and encircling band on the eyeball to exert an intended indentation effect for treatment of retinal detachment. | 12-02-2010 |
20100286291 | MULTIPLEX DETECTION OF HEPATITIS VIRUS VARIATIONS - Disclosed is a method for the detection of virus variations. Disclosed also is a method for the treatment of virus infection in a subject based on the detection of virus variations. Additionally, a kit is provided for the detection of virus variations. | 11-11-2010 |
20100267045 | CUDR AS BIOMARKER FOR CANCER PROGRESSION AND THERAPEUTIC RESPONSE - Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy. | 10-21-2010 |
20100267034 | MARKERS FOR PRENATAL DIAGNOSIS AND MONITORING - Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control. | 10-21-2010 |
20100255495 | METHODS FOR PREDICTING THE RISK OF DIABETIC NEPHROPATHY USING GENETIC MARKERS AND ARRAYS CONTAINING THE SAME - A method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one of the following polymorphic sequences: an I/D genotype of an ACE gene, an M235T genotype of an AGT gene, a (CA)n-5′(z−2) genotype of an ALR2 gene, an C106T genotype of an ALR2 gene in the promoter region, a G-308A genotype of a TNF-α gene, or a complement thereof, provided that the ALR2 gene cannot be used alone, in which the presence of the polymorphic sequence indicates the subject suffering from, at risk for suffering from a nephropathy. An array for detecting a Chinese diabetic subject suffering from, or at risk for suffering from, a nephropathy. | 10-07-2010 |
20100255494 | METHODS FOR PREDICTING THE RISK OF DIABETIC NEPHROPATHY USING GENETIC MARKERS AND ARRAYS CONTAINING THE SAME - A method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one of the following polymorphic sequences: an I/D genotype of an ACE gene, an M235T genotype of an AGT gene, a (CA)n-5′(z−2) genotype of an ALR2 gene, an C106T genotype of an ALR2 gene in the promoter region, a G-308A genotype of a TNF-α gene, or a complement thereof, provided that the ALR2 gene cannot be used alone, in which the presence of the polymorphic sequence indicates the subject suffering from, at risk for suffering from a nephropathy. An array for detecting a Chinese diabetic subject suffering from, or at risk for suffering from, a nephropathy. | 10-07-2010 |
20100231069 | MAGNETORHEOLOGICAL ACTUATORS - Provided is an actuator, comprising a motor/generator element and a clutch/brake element. The motor/generator element comprises a stator made of a high magnetic permeable material, an outer coil being wound around the stator; a rotor made of a high magnetic permeable material and with a plurality of permanent magnets fixed thereon; and a cavity configured to receive a fluid. The clutch/brake element is arranged in the cavity. An inner coil is wound around the clutch/brake element. The fluid is capable of producing a shear stress in response to an electromagnetic field induced from the inner coil. | 09-16-2010 |
20100196448 | WOUND HEALING DRESSING AND METHODS OF MANUFACTURING THE SAME - Disclosed are a hydrogel dressing for covering or treating a wound and a method for preparing the same. The hydrogel dressing includes a matrix structure of a cross-linked mixture, and an elastic sheet coated with an elementary metal or ionic metal embodied in the matrix structure. The mixture comprises a hydrophilic polymer, about 0.5 to about 5 wt % of a photocatalyst agent and at least 80 wt % of water based on the total weight of the mixture. | 08-05-2010 |
20100120703 | COMPOSITIONS AND METHODS FOR TREATING CANCER - Pharmaceutical compositions comprising sinigrin and a pharmaceutically acceptable carrier and use thereof for treating liver cancer. A method for treatment of liver cancer in a subject comprising administering to the subject in need thereof and suffering from cancer, a pharmaceutically effective amount of sinigrin, is also provided. | 05-13-2010 |
20100112590 | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 05-06-2010 |
20100074447 | SYSTEM AND METHODS FOR QUANTUM KEY DISTRIBUTION OVER WDM LINKS - A system and a method for quantum key distribution between a transmitter and a receiver over wavelength division multiplexing (WDM) link are disclosed. The method includes providing one or more quantum channels and one or more conventional channels over the WDM link; assigning a different wavelength to each of the one or more quantum channels and each of the one or more conventional channels; transmitting single photon signals on each of the one or more quantum channels; and transmitting data on each of the one or more conventional channels. The data comprises either conventional data or trigger signals for synchronizing the transmission of the single photon signals on the quantum channels. All channels have wavelengths around 1550 nm. The WDM link can be a 3-channel WDM link comprising two quantum channels for transmitting single photon signals and one conventional channel for transmitting conventional data or triggering signals. | 03-25-2010 |
20100054625 | METHODS FOR FLATTENING A 3D SURFACE INTO A 2D PIECE - Disclosed is a method for flattening a 3D surface into a 2D piece. In one embodiment, the method is implemented by constructing a plurality of wire-patches by feature curves on a surface patch of the 3D surface, wherein each of feature curves comprises a plurality of wire-nodes; computing an optimal 2D angle for each of said wire-nodes of the constructed wire-patches; determining an optimal position for each of said wire-nodes based on the computed optimal 2D angles thereof, respectively; and laying out each of said feature curves in 2D based on the determined optimal position. A device to flatten a 3D surface into a 2D piece is also provided. | 03-04-2010 |
20100042182 | METHODS AND DEVICES FOR PREVENTING ANKLE SPRAIN INJURIES - Devices and methods for preventing ankle sprain injuries. To protect the ankle joint from acute ankle supination or inversion sprain injuries, the device comprises a sensing part configured to sense data of an ankle motion; an analyzing part configured to analyze the data to judge whether the motion is a sprain motion; and a stimulating part configured to stimulate one or more lower limb muscles against the motion in light of a result of the analyzing. The method also involves sensing data of an ankle motion; analyzing the data to judge whether the motion is a sprain motion; and stimulating one or more lower limb muscles against the motion if the motion is a sprain motion. | 02-18-2010 |
20090300571 | METHODS AND SYSTEMS FOR FPGA REWIRING - There are disclosed a method and system for FPGA rewiring of a circuit. The method comprises: mapping the circuit into a first circuit, the first circuit being logically represented with a plurality of Look-Up Tables; rewiring the first circuit to obtain a second circuit, a mapping area of the second circuit being less than that of the first circuit; mapping the second circuit into a third circuit, the third circuit being logically represented with less Look-Up Tables than the first circuit; and routing the third circuit to generate a FPGA architecture file related to the circuit. | 12-03-2009 |
20090297615 | NANOPARTICLES, METHODS OF MAKING SAME AND CELL LABELING USING SAME - There are disclosed polyhedral superparamagnetic nanoparticles and methods for making and using the nanoparticles. There are also disclosed coated and functionalized forms of the nanoparticles, methods of using nanoparticles and methods of treatment using nanoparticles. | 12-03-2009 |
20090290837 | OPTICAL DEVICES FOR COUPLING OF LIGHT - An optical device and an optical system are provided for coupling of light. The optical device comprises a planar substrate; and an optical waveguiding layer disposed on the planar substrate. The optical waveguiding layer comprises a grating portion for coupling light between a planar waveguide and an optical fiber; and a tapered guiding portion for converting the mode size between the fiber and the planar waveguide. The grating portion comprises a first grating section having non-uniform periods. | 11-26-2009 |
20090290827 | NONLINEAR OPTICAL LOOP MIRRORS - There are disclosed a nonlinear optical loop mirror. The nonlinear optical loop mirror comprises: an optical coupler which includes a first optical path and a second optical path coupled to each other; and a loop optical path configured to connect the first and second optical paths, wherein the loop optical path is provided with a nonlinear element configured to vary a wavelength of an optical signal and a linear element configured to produce a wavelength dependent time delay for an optical signal. The nonlinear optical loop mirror may function as a delay interferometer for demodulating a differential phase-shift-keying (DPSK) signal. | 11-26-2009 |
20090257505 | Generation of an Order-2N Transform from an Order-N Transform - Apparatus, systems and techniques based on an integer transform for encoding and decoding video or image signals, including transform of encoding and decoding of image and video signals and generation of an order-2N transform W from an order-N transform T in the field of image and video coding. For example, a retrieving unit is configured to retrieve an order-N transform T, where N is an integer; a deriving unit is configured to derive an order-2N transform W from the retrieved order-N transform T, and a transforming unit configured to generate an order-2N data Z using the derived transform W. | 10-15-2009 |
20090257504 | Methods and Apparatus for Deriving an Order-16 Integer Transform - Apparatus, systems and techniques based on an integer transform for encoding and decoding video or image signals, including an order-16 integer transform from a Microsoft Media Video order-8 integer transform with a high energy-packing ability and an improved data compression in the field of image and video coding. For example, a method and an apparatus are provided for deriving an order-16 integer transform from an order-8 integer transform in the standard transform of Microsoft Media Video. Eight additions and eight subtractions are used to assign the data elements to be transformed to an intermediate matrix; and then two fast algorithms for the computation of the order-8 transform may be applied to the first 8 vectors of the intermediate matrix, and the last 8 vectors of the intermediate matrix, respectively. The derived order-16 integer transform tends to produce small magnitude and high frequency transformed coefficients, and thus achieve high compressibility. | 10-15-2009 |
20090249276 | METHODS AND SYSTEMS FOR FPGA REWIRING AND ROUTING IN EDA DESIGNS - Disclosed are a method and a system for improving FPGA routings of a circuit. The method comprises: identifying candidate alternative wires for a target wire to be replaced in the circuit according to a first preset rule; selecting a first set of alternative wires from the identified candidates according to a second preset rule; filtering the selected first set of candidates so as to reserve a second set of candidates; estimating wire replacing costs of the second set of candidates to select a third set of candidates that can improve FPGA delay performance of the circuit; and replacing the target wire with the selected third set of candidate alternative wires. | 10-01-2009 |
20090246793 | CUDR AS BIOMARKER FOR CANCER PROGRESSION AND THERAPEUTIC RESPONSE - Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy. | 10-01-2009 |
20090187653 | SYSTEMS AND PROCESSES OF IDENTIFYING P2P APPLICATIONS BASED ON BEHAVIORAL SIGNATURES - Disclosed are a system and a process for identifying P2P applications and specific P2P software as well from an original mixed packet trace based on behavioral-signatures. The behavioral-signature based system and process according to the invention is mainly to check whether the application has these specific periodic behaviors or not. The process of this invention comprises the steps of filtering out all irrelative packets; translating the filtered packet trace into discrete-time sequences; processing the sequences to obtain frequency-domain characteristics of original packet trace; and analyzing the frequency-domain characteristics and determining the identification. | 07-23-2009 |
20090170102 | METHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS - In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample. | 07-02-2009 |
20090162842 | Circulating mRNA as diagnostic markers - Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclampsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin β subunit (hCG-β), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control. | 06-25-2009 |
20090155776 | Fetal methylation markers - This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions. | 06-18-2009 |
20090140900 | SENSOR INTERFACE DEVICES AND AMPLIFIERS - Disclosed are a sensor interface device and an amplifier used in a sensor system. The sensor interface device in one implementation has a first chopper configured to shift input signals of the sensor system from a baseband frequency to a first frequency, an instrumentation amplifier configured to amplify the shifted signals, a bandpass Delta-Sigma modulator configured to digitize the amplified signals, and a second chopper configured to shift the digitized signals from the a first frequency back to the baseband frequency. The instrumentation amplifier removes the DC offset generated from the first chopper and therefore all sources of DC offset are eliminated in this interface device without bandwidth limitation. | 06-04-2009 |
20090112958 | Processes and apparatus for deriving order-16 integer transforms - Apparatus, systems and techniques based on an integer transform for encoding and decoding video or image signals, including apparatus, systems and techniques for deriving an order-16 integer transform from an order-8 integer transform in image and video coding. In some implementations, eight additions and eight subtractions are used to assign the data elements to be transformed to an intermediate matrix; and then two fast algorithms for the computation of the order-8 transform may be applied to the first 8 vectors of the intermediate matrix, and the last 8 vectors of the intermediate matrix, respectively. The derived order-16 integer transform tends to produce small magnitude and high frequency transformed coefficients, and thus achieve high compressibility. | 04-30-2009 |
20090091410 | MAGNETIC LEVITATION VIBRATION SYSTEMS AND METHODS FOR TREATING OR PREVENTING MUSCULOSKELETAL INDICATIONS USING THE SAME - A magnetic levitation vibration system comprising a top plate, a base plate, at least one first magnet, at least one second magnet, at least one electromagnetic actuator comprising an upper half and a lower half, a controller, a sensor, and a control circuit. A method for the treatment or prevention of musculoskeletal indications comprising providing a top plate, providing a base plate, generating a first magnetic field to levitate the top plate, generating a second magnetic field to drive the top plate into vibration, adjusting frequency of vibration of the top plate; and adjusting magnitude of vibration of the top plate. | 04-09-2009 |
20090087847 | DETERMINING A NUCLEIC ACID SEQUENCE IMBALANCE - Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The cutoff value may also be determined based on an average concentration of a sequence per reaction. In one aspect, the cutoff value is determined from a proportion of informative wells that are estimated to contain a particular nucleic acid sequence, where the proportion is determined based on the above-mentioned percentage and/or average concentration. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT). | 04-02-2009 |
20090086210 | SURFACE PLASMON RESONANCE SENSORS AND METHOD FOR DETECTING SAMPLES USING THE SAME - Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection. | 04-02-2009 |
20090077246 | LOAD BALANCING AND ADMISSION SCHEDULING IN PULL-BASED PARALLEL VIDEO SERVERS - A pull-based parallel video server system and method of implementation useful in an on-demand video system includes a plurality of slave admission schedulers operating in parallel with a master admission scheduler to back up the master admission scheduler that controls access to an array of pull-based video servers according to a protocol that accounts for jitter and loss of packets, as well as network delays. A transport protocol is provided that improves video data throughput under such conditions. To determine the architecture and functional requirements of the redundant admission schedulers, an analytical tool in the form of a performance model has been developed that incorporates network delays, delay jitters and packet losses on the communication links between the clients, schedulers and servers. | 03-19-2009 |
20090061425 | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences - Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment. | 03-05-2009 |
20090061419 | GENOMIC MARKERS OF HEPATITIS B VIRUS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA - The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). | 03-05-2009 |
20090053719 | ANALYSIS OF NUCLEIC ACIDS BY DIGITAL PCR - The present invention provides a method for analyzing nucleic acids for their lengths and relative abundance in a sample, based on digital amplification of individual template molecules. This invention has many applications, including those in noninvasive prenatal diagnosis, transplantation monitoring, and the detection and monitoring of cancers and virus-associated diseases. | 02-26-2009 |
20090029377 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. | 01-29-2009 |
20090023133 | GENOMIC MARKERS OF HEPATITIS B VIRUS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA - The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). | 01-22-2009 |
20090006643 | SYSTEMS AND METHODS FOR UNIVERSAL REAL-TIME MEDIA TRANSCODING - Digital content is encoded and transmitted in form suitable for presentation in a variety of formats, particularly suited to mobile device environments. In specific embodiments, server-side, independent and integrated architectures are disclosed. In further specific embodiments, techniques for prefix, postfix, interrupted and midway insertions of generic data and multi-media data are disclosed together with techniques for seamlessly handling media duration, whether or not media duration is known. Still further, techniques are disclosed for retaining synchronization among inserted media segments, for reducing startup delay and for traffic smoothing, all as part of systems and techniques for media transcoding. | 01-01-2009 |
20080304072 | OPTICAL SENSING DEVICES WITH SPR SENSORS BASED ON DIFFERENTIAL PHASE INTERROGATION AND MEASURING METHOD USING THE SAME - Disclosed is an optical sensing device, which comprises a light source emitting a light; a beam splitter; an SPR sensor unit comprising a sensing surface; and a detecting mechanism; and a converting unit converting the first beam and the second beam from the optical device into a two-dimensional interference fringe pattern. From the above-mentioned configuration, an extra phase shift of a detection beam in SPR phase measurement is obtained. The differential measurement approach has shown to achieve a sensitivity figure significantly better than the best result that can be obtained from the prior art in the field of the measurement based on an SPR sensor. | 12-11-2008 |
20080286756 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SEVERE ACUTE RESPIRATORY SYNDROME (SARS) - The present invention relates to the fields of immunochemistry and pharmacology. Methods and compositions are described for the diagnosis and treatment of SARS CoV infection. More specifically, the application discloses nucleic acids and peptides of the spike glycoprotein of SARS CoV that provide prognostic and therapeutic compositions in treatment of individuals contracting, or in danger of contracting SARS CoV. The peptides of the invention are also useful in producing antibodies against the SARS CoV glycoprotein. | 11-20-2008 |
20080231389 | DUAL BAND COUPLED-LINE BALANCED-TO-UNBALANCED BANDPASS FILTER - A dual band balun filter, that includes a first coupled-line section pair provided with a first terminal; a second coupled-line section pair configured to be connected to the first coupled-line section pair, a third coupled-line section pair, and a fourth coupled-line section pair, respectively, and the fourth coupled-line section pair is provided with a second terminal; the third coupled-line section pair is provided with a transmission line and is connected to a fifth coupled-line section pair that is provided with a third terminal; and each of the first to fifth coupled-line section pairs is formed with partial coupled stepped impedance resonators (SIRs). | 09-25-2008 |
20080206749 | Methods and kits for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer - Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monitoring of cancer are also disclosed. | 08-28-2008 |